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FR18C1020I2 - PHARMACEUTICALLY ACCEPTABLE SALTS OF 2-{4-[(3S)-PIPERIDIN-3-YL]PHENYL}-2H-INDAZOLE-7-CARBOXAMIDE - Google Patents

PHARMACEUTICALLY ACCEPTABLE SALTS OF 2-{4-[(3S)-PIPERIDIN-3-YL]PHENYL}-2H-INDAZOLE-7-CARBOXAMIDE

Info

Publication number
FR18C1020I2
FR18C1020I2 FR18C1020C FR18C1020C FR18C1020I2 FR 18C1020 I2 FR18C1020 I2 FR 18C1020I2 FR 18C1020 C FR18C1020 C FR 18C1020C FR 18C1020 C FR18C1020 C FR 18C1020C FR 18C1020 I2 FR18C1020 I2 FR 18C1020I2
Authority
FR
France
Prior art keywords
indazole
piperidin
carboxamide
phenyl
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR18C1020C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40404013&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR18C1020(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp and Dohme Ltd, Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme Ltd
Publication of FR18C1020I1 publication Critical patent/FR18C1020I1/fr
Application granted granted Critical
Publication of FR18C1020I2 publication Critical patent/FR18C1020I2/en
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
FR18C1020C 2008-01-08 2018-05-14 PHARMACEUTICALLY ACCEPTABLE SALTS OF 2-{4-[(3S)-PIPERIDIN-3-YL]PHENYL}-2H-INDAZOLE-7-CARBOXAMIDE Active FR18C1020I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1033308P 2008-01-08 2008-01-08
PCT/GB2009/000041 WO2009087381A1 (en) 2008-01-08 2009-01-08 Pharmaceutically acceptable salts of 2-{4-[(3s)-piperidin-3- yl]phenyl} -2h-indazole-7-carboxamide

Publications (2)

Publication Number Publication Date
FR18C1020I1 FR18C1020I1 (en) 2018-07-13
FR18C1020I2 true FR18C1020I2 (en) 2019-06-07

Family

ID=40404013

Family Applications (1)

Application Number Title Priority Date Filing Date
FR18C1020C Active FR18C1020I2 (en) 2008-01-08 2018-05-14 PHARMACEUTICALLY ACCEPTABLE SALTS OF 2-{4-[(3S)-PIPERIDIN-3-YL]PHENYL}-2H-INDAZOLE-7-CARBOXAMIDE

Country Status (16)

Country Link
US (1) US8436185B2 (en)
EP (1) EP2240466B1 (en)
JP (1) JP5989965B2 (en)
KR (1) KR101653548B1 (en)
CN (2) CN101932572A (en)
AU (1) AU2009203598B2 (en)
BR (1) BRPI0906020A2 (en)
CA (1) CA2711491C (en)
ES (1) ES2548131T3 (en)
FR (1) FR18C1020I2 (en)
IL (1) IL206201A (en)
MX (1) MX337421B (en)
NL (1) NL300938I2 (en)
NZ (1) NZ586675A (en)
WO (1) WO2009087381A1 (en)
ZA (1) ZA201003902B (en)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010045095A1 (en) 2008-10-14 2010-04-22 Ning Xi Compounds and methods of use
WO2010111063A1 (en) 2009-03-21 2010-09-30 Ning Xi Amino ester derivatives, salts thereof and methods of use
JP5745283B2 (en) 2010-02-12 2015-07-08 ファイザー・インク 8-Fluoro-2- {4-[(methylamino) methyl] phenyl} -1,3,4,5-tetrahydro-6H-azepino [5,4,3-cd] indol-6-one salts and many Form
WO2014088983A1 (en) 2012-12-07 2014-06-12 Merck Sharp & Dohme Corp. Regioselective n-2 arylation of indazoles
KR20170016498A (en) 2014-06-17 2017-02-13 버텍스 파마슈티칼스 인코포레이티드 Method for treating cancer using a combination of chk1 and atr inhibitors
IL283006B2 (en) 2015-04-01 2023-10-01 Anaptysbio Inc Antibodies directed against T-cell immunoglobulin and myokine protein 3 (T-IM-3)
KR102678021B1 (en) 2015-09-30 2024-06-26 버텍스 파마슈티칼스 인코포레이티드 Pharmaceutical composition for cancer treatment comprising an ATR inhibitor, used in combination with a DNA damaging agent
WO2017056498A1 (en) * 2015-09-30 2017-04-06 国立大学法人東北大学 Marker for determining diabetic nephropathy
PT3478286T (en) 2016-06-29 2024-01-31 Tesaro Inc Methods of treating ovarian cancer
RS66574B1 (en) 2016-07-29 2025-03-31 Janssen Pharmaceutica Nv Niraparib for use in a method of treating prostate cancer
CN107663190B (en) * 2016-07-29 2020-06-09 钟桂发 Preparation method of nilapanib and intermediate thereof and intermediate compound
CN106432057A (en) * 2016-09-17 2017-02-22 青岛云天生物技术有限公司 Method for preparing (3S)-3-(4-aminophenyl)-piperidyl-1-tert-butyl formate
US11155624B2 (en) 2016-11-01 2021-10-26 Anaptysbio, Inc. Antibodies directed against programmed death-1 (PD-1)
EP3689419A1 (en) 2016-11-01 2020-08-05 AnaptysBio, Inc. Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3)
WO2018122168A1 (en) 2016-12-29 2018-07-05 Bayer Pharma Aktiengesellschaft Combinations of bub1 kinase and parp inhibitors
SG10201913083SA (en) 2017-01-09 2020-03-30 Tesaro Inc Methods of treating cancer with anti-tim-3 antibodies
CN110382545A (en) 2017-01-09 2019-10-25 泰萨罗公司 With the method for anti-PD-1 antibodies for treating cancer
WO2018183354A1 (en) 2017-03-27 2018-10-04 Tesaro, Inc. Niraparib compositions
EP3606523A1 (en) * 2017-03-27 2020-02-12 Tesaro, Inc. Niraparib formulations
US11384062B2 (en) 2017-04-04 2022-07-12 Combiphos Catalysts, Inc. Deuterated (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
JOP20190244A1 (en) 2017-04-13 2019-10-13 Janssen Pharmaceutica Nv Prostate Cancer Therapy Formula
AU2018258274C1 (en) 2017-04-24 2021-12-02 Tesaro, Inc. Methods of manufacturing of niraparib
KR102769634B1 (en) 2017-04-27 2025-02-19 테사로, 인코포레이티드 Antibody agonists to lymphocyte activation gene-3 (LAG-3) and uses thereof
TW202444417A (en) 2017-05-09 2024-11-16 美商提薩羅有限公司 Combination therapies for treating cancer
MA49144A (en) * 2017-05-18 2020-03-25 Tesaro Inc POLYTHERAPIES FOR THE TREATMENT OF CANCER
CN108530425A (en) * 2017-05-27 2018-09-14 广州科锐特生物科技有限公司 A kind of Ni Lapani tosilate hydrate crystal forms and preparation method thereof
CN109081828B (en) * 2017-06-14 2021-03-26 上海时莱生物技术有限公司 Poly (ADP-ribose) polymerase inhibitor, preparation method and application
US10927095B2 (en) 2017-08-14 2021-02-23 Teva Pharmaceuticals International Gmbh Processes for the preparation of Niraparib and intermediates thereof
US20200271666A1 (en) * 2017-09-13 2020-08-27 B.R.A.H.M.S Gmbh Proadrenomedullin as indicator for renal replacement therapy in critically ill patients
WO2019053116A1 (en) * 2017-09-13 2019-03-21 B.R.A.H.M.S Gmbh Method for guidance of fluid therapy based on proadrenomedullin
US20200264199A1 (en) * 2017-09-13 2020-08-20 B.R.A.H.M.S Gmbh Pct and pro-adm as markers for monitoring antibiotic treatment
EP3687505A1 (en) 2017-09-26 2020-08-05 Tesaro Inc. Niraparib formulations
EP3697442A4 (en) 2017-09-30 2021-07-07 Tesaro, Inc. Combination therapies for treating cancer
MX2020003799A (en) * 2017-10-06 2020-11-06 Tesaro Inc Combination therapies and uses thereof.
WO2019133697A1 (en) 2017-12-27 2019-07-04 Tesaro, Inc. Methods of treating cancer
EP3749352A1 (en) 2018-02-05 2020-12-16 Tesaro Inc. Pediatric niraparib formulations and pediatric treatment methods
TWI852940B (en) 2018-09-04 2024-08-21 美商泰沙羅公司 Methods of treating cancer
CN118994103A (en) * 2018-10-03 2024-11-22 特沙诺有限公司 Nilaparil salt
US12297184B2 (en) 2018-10-03 2025-05-13 Tesaro, Inc. Niraparib salts
WO2020072860A1 (en) * 2018-10-05 2020-04-09 Johnson Matthey Public Limited Company Niraparib solid state form
WO2020225753A2 (en) 2019-05-06 2020-11-12 Tesaro, Inc. Methods for characterizing and treating a cancer type using cancer images
CN110407704B (en) * 2019-08-19 2022-05-17 常州沃腾化工科技有限公司 Synthetic method of 3-formyl-2-nitrobenzoic acid methyl ester
MX2022014003A (en) 2020-05-08 2022-11-30 Janssen Pharmaceutica Nv Treatment of prostate cancer with a combination of abiraterone acetate and niraparib.
US20240325369A1 (en) 2021-07-19 2024-10-03 Janssen Pharmaceutica Nv Treatment of metastatic castration-resistant prostate cancer with niraparib
EP4472634A1 (en) 2022-02-04 2024-12-11 JANSSEN Pharmaceutica NV Niraparib and abiraterone acetate plus prednisone to improve clinical outcomes in patients with metastatic castration-resistant prostate cancer and hrr alterations
WO2023159066A1 (en) 2022-02-15 2023-08-24 Tesaro, Inc. Use of niraparib for the treatment of brain cancer
WO2024238587A1 (en) 2023-05-17 2024-11-21 Tesaro, Inc. Novel use of an inhibior of the a poly-adp ribose polymerase (parp) in the treatment of cancer
WO2025027138A1 (en) 2023-08-02 2025-02-06 Janssen Pharmaceutica Nv Combination of niraparib and abiraterone for use in the treatment of metastatic castration-resistant prostate cancer
CN117843713A (en) * 2023-12-18 2024-04-09 上海亲合力生物医药科技股份有限公司 Kinase inhibitor based on tumor microenvironment activation, composition and application

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9404485D0 (en) 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
AT401651B (en) * 1994-06-14 1996-11-25 Biochemie Gmbh 7- (2- (2-AMINOTHIAZOL-4-YL) -2- (Z) - HYDROXIMINOACETAMIDO) -3-N, N- DIMETHYLCARBAMOYLOXYMETHYL-3-CEPHEM-4-
JPH11510154A (en) * 1995-08-02 1999-09-07 ニューキャッスル ユニバーシティ ベンチャーズ リミテッド Benzimidazole compounds
CA2332279A1 (en) 1998-05-15 1999-11-25 Jia-He Li Carboxamide compounds, compositions, and methods for inhibiting parp activity
EP1124805B1 (en) 1998-10-30 2003-05-21 Lonza AG Method for producing 4-[(2',5'- diamino-6'- halopyrimidine- 4'-yl)amino]- cyclopent- 2-enylmethanols
DE59911249D1 (en) 1998-11-03 2005-01-13 Abbott Gmbh & Co Kg SUBSTITUTED 2-PHENYLBENZIMIDAZOLE, THEIR PREPARATION AND APPLICATION
RU2001116581A (en) 1998-11-17 2004-02-20 БАСФ Акциенгезельшафт (DE) SUBSTITUTED 2-PHENYLBENZIMIDAZOLE AND 2-PHENYLINDOLES, THEIR PRODUCTION AND APPLICATION
RU2001117757A (en) * 1998-11-27 2004-02-27 БАСФ Акциенгезельшафт (DE) Substituted benzimidazoles and their use as poly (adenosine diphosphatribose) polymerase inhibitors
DE19918211A1 (en) * 1999-04-22 2000-10-26 Basf Ag New 2-carbocyclyl-benzimidazole-carboxamide derivatives, are PARP inhibitors useful e.g. for treating neurodegenerative disease, epilepsy, ischemia, tumors, inflammation or diabetes
DE19920936A1 (en) 1999-05-07 2000-11-09 Basf Ag Heterocyclically substituted benzimidazoles, their preparation and use
WO2001021615A1 (en) 1999-09-17 2001-03-29 Yamanouchi Pharmaceutical Co., Ltd. Benzimidazole derivatives
US6508365B1 (en) * 1999-12-28 2003-01-21 Pitney Bowes Inc. Method of removing mail from a mailstream using an incoming mail sorting apparatus
AU2001240542A1 (en) * 2000-02-01 2001-08-14 Basf Aktiengesellschaft Heterocyclic compounds and their use as parp inhibitors
DE10022925A1 (en) * 2000-05-11 2001-11-15 Basf Ag New indole-carboxamide or azepino-indole derivatives and analogs, are poly-ADP ribose polymerase inhibitors useful e.g. for treating neurodegenerative disease, ischemia, epilepsy, tumors, sepsis or diabetes mellitus
WO2002068407A1 (en) 2001-02-28 2002-09-06 Yamanouchi Pharmaceutical Co., Ltd. Benzimidazole compound
WO2003007959A1 (en) 2001-07-16 2003-01-30 Fujisawa Pharmaceutical Co., Ltd. Quinoxaline derivatives which have parp inhibitory action
WO2003062234A1 (en) 2002-01-23 2003-07-31 Yamanouchi Pharmaceutical Co., Ltd. Quinoxaline compounds
US20040034078A1 (en) 2002-06-14 2004-02-19 Agouron Pharmaceuticals, Inc. Benzimidazole inhibitors of poly(ADP-ribosyl) polymerase
DE10228103A1 (en) 2002-06-24 2004-01-15 Bayer Cropscience Ag Fungicidal active ingredient combinations
WO2004014861A1 (en) 2002-08-09 2004-02-19 Kyorin Pharmaceutical Co., Ltd. 4-substituted-quinoline-8-carboxylic amide derivatives and pharmacologically acceptable addition salts thereof
US7563748B2 (en) 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
CN1852893A (en) * 2003-07-21 2006-10-25 史密丝克莱恩比彻姆公司 (2S,4S)-4-fluoro-1-[4-fluoro-beta-(4-fluorophenyl)-L-phenylalanyl]-2-pyrrolidinecarbonitrile p-toluenesulfonic acid salt and anhydrous crystalline forms thereof
WO2005047290A2 (en) * 2003-11-11 2005-05-26 Cellular Genomics Inc. Imidazo[1,2-a] pyrazin-8-ylamines as kinase inhibitors
GB0327740D0 (en) * 2003-11-28 2003-12-31 Glaxo Group Ltd Novel compounds
WO2005066136A1 (en) 2003-12-22 2005-07-21 Eli Lilly And Company Bicyclic derivatives as ppar modulators
KR100876520B1 (en) 2004-09-22 2008-12-31 화이자 인코포레이티드 Process for preparing poly (ADP-ribose) polymerase inhibitor
ATE479687T1 (en) * 2004-10-15 2010-09-15 Takeda Pharmaceutical KINASE INHIBITORS
JP3701964B1 (en) * 2005-03-08 2005-10-05 アステラス製薬株式会社 Novel salts of quinuclidine derivatives
TWI375673B (en) * 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
WO2006110683A1 (en) 2005-04-11 2006-10-19 Abbott Laboratories 2-substituted-1h-benzimidazole-4-carboxamides are parp inhibitors
BRPI0611707A2 (en) 2005-06-29 2012-04-24 Compumedics Ltd conductive bridge sensor assembly
ES2378692T3 (en) 2005-09-29 2012-04-17 Abbott Laboratories Phenyl-substituted 1H-benzimidazol-4-carboxamides in position 2 are potent PARP inhibitors
EP1966157B1 (en) * 2005-11-15 2010-03-24 Abbott Laboratories Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
JP4611441B2 (en) * 2006-04-03 2011-01-12 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー Amide-substituted indazole and benzotriazole derivatives as poly (ADP-ribose) polymerase (PARP) inhibitors
ATE553104T1 (en) * 2006-05-02 2012-04-15 Abbott Lab SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDE AS POTENT PARP INHIBITORS
TW200801513A (en) 2006-06-29 2008-01-01 Fermiscan Australia Pty Ltd Improved process
US7892667B2 (en) * 2006-09-13 2011-02-22 Altek Corporation Battery security device
RS51780B (en) * 2007-01-10 2011-12-31 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L. INDASOLS SUBSTITUTED BY AMIDE AS INHIBITORS OF POLY (ADP-Ribose) POLYMERASES (PARP)
JP2008228154A (en) * 2007-03-15 2008-09-25 Fujitsu Ltd Display device and remote control device

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Publication number Publication date
JP5989965B2 (en) 2016-09-07
RU2495035C2 (en) 2013-10-10
WO2009087381A1 (en) 2009-07-16
RU2010133241A (en) 2012-02-20
KR101653548B1 (en) 2016-09-02
US20100286203A1 (en) 2010-11-11
US8436185B2 (en) 2013-05-07
EP2240466B1 (en) 2015-07-29
CA2711491A1 (en) 2009-07-16
BRPI0906020A2 (en) 2015-06-30
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