FR17C1020I2 - RECOMBINANT FSH INCLUDING ALPHA 2.3 AND ALPHA 2.6 SIALYLATION - Google Patents

RECOMBINANT FSH INCLUDING ALPHA 2.3 AND ALPHA 2.6 SIALYLATION

Info

Publication number: FR17C1020I2
Authority: FR; France
Prior art keywords: alpha; sialylation; recombinant fsh; fsh including; including alpha
Prior art date: 2008-04-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

FR17C1020C

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ferring BV

Original Assignee

Ferring BV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-16

Filing date

2017-06-06

Publication date

2020-04-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR17C1020(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2017-06-06 Application filed by Ferring BV filed Critical Ferring BV

2020-04-10 Application granted granted Critical

2020-04-10 Publication of FR17C1020I1 publication Critical patent/FR17C1020I1/fr

2020-04-10 Publication of FR17C1020I2 publication Critical patent/FR17C1020I2/en

Status Active legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
- C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Reproductive Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Wood Science & Technology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Toxicology (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Immunology (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

FR17C1020C 2008-04-16 2017-06-06 RECOMBINANT FSH INCLUDING ALPHA 2.3 AND ALPHA 2.6 SIALYLATION Active FR17C1020I2 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US4542408P	2008-04-16	2008-04-16
EP08251528		2008-04-25
EP09733497.3A EP2268666B1 (en)	2008-04-16	2009-04-16	Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation
EP13193214.7A EP2722339A1 (en)	2008-04-16	2009-04-16	Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation
EP14178729.1A EP2808340B1 (en)	2008-04-16	2009-04-16	Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation

Publications (2)

Publication Number	Publication Date
FR17C1020I1 FR17C1020I1 (en)	2020-04-10
FR17C1020I2 true FR17C1020I2 (en)	2020-04-10

Family

ID=39717519

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
FR17C1020C Active FR17C1020I2 (en)	2008-04-16	2017-06-06	RECOMBINANT FSH INCLUDING ALPHA 2.3 AND ALPHA 2.6 SIALYLATION
FR25C1003C Active FR25C1003I1 (en)	2008-04-16	2025-01-16	RECOMBINANT FSH COMPRISING ALPHA 2,3 AND ALPHA 2,6 SIALYLATION
FR25C1025C Active FR25C1025I1 (en)	2008-04-16	2025-07-02	RECOMBINANT FSH COMPRISING ALPHA 2,3 AND ALPHA 2,6 SIALYLATION

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
FR25C1003C Active FR25C1003I1 (en)	2008-04-16	2025-01-16	RECOMBINANT FSH COMPRISING ALPHA 2,3 AND ALPHA 2,6 SIALYLATION
FR25C1025C Active FR25C1025I1 (en)	2008-04-16	2025-07-02	RECOMBINANT FSH COMPRISING ALPHA 2,3 AND ALPHA 2,6 SIALYLATION

Country Status (29)

Country	Link
US (6)	US8951967B2 (en)
EP (7)	EP2268666B1 (en)
JP (7)	JP2011519359A (en)
KR (5)	KR20170110741A (en)
CN (3)	CN102066414A (en)
AR (1)	AR071479A1 (en)
AU (5)	AU2009237479B2 (en)
BR (1)	BRPI0910461B8 (en)
CA (1)	CA2725257A1 (en)
CY (1)	CY1115413T1 (en)
DK (6)	DK2268666T3 (en)
ES (5)	ES3023526T3 (en)
FI (4)	FI4015527T3 (en)
FR (3)	FR17C1020I2 (en)
HR (5)	HRP20250313T1 (en)
HU (9)	HUE071059T2 (en)
IL (2)	IL208538A (en)
LT (8)	LT3098234T (en)
MX (3)	MX2010011343A (en)
NO (4)	NO2017025I1 (en)
NZ (1)	NZ588381A (en)
PL (6)	PL3144318T3 (en)
PT (6)	PT3144318T (en)
RU (3)	RU2537268C2 (en)
SA (1)	SA109300228B1 (en)
SI (6)	SI3098234T1 (en)
TW (1)	TWI488640B (en)
WO (1)	WO2009127826A1 (en)
ZA (1)	ZA201007373B (en)

Families Citing this family (29)

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TWI488640B (en)	2008-04-16	2015-06-21	Ferring Int Ct Sa	Pharmaceutical preparation
TWI532495B (en) *	2009-10-05	2016-05-11	菲瑞茵國際中心股份有限公司	Pharmaceutical preparation
EP2417982A1 (en)	2010-07-30	2012-02-15	Ferring B.V.	Stabilization of gonadotropins
WO2012016576A1 (en) *	2010-08-04	2012-02-09	Glycotope Gmbh	Improved recombinant human follicle-stimulating hormone
US9320778B2 (en)	2010-09-29	2016-04-26	Ferring B.V.	Method for controlled ovarian stimulation with combined FSH and hCG
JP5918697B2 (en)	2010-10-15	2016-05-18	Ｊｃｒファーマ株式会社	Method for producing a glycoprotein in which the non-reducing end of the sugar chain is a mannose residue
CA2831486A1 (en) *	2011-03-31	2012-10-04	Ferring B.V.	Pharmaceutical preparation
WO2012168680A1 (en)	2011-06-06	2012-12-13	Ferring B.V.	Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (en) *	2011-08-08	2017-03-15	Ferring Bv	Complex for controlled stimulation of the ovary
AU2012340501A1 (en) *	2011-12-19	2013-07-11	Grifols, S.A.	Compositions, methods, and kits for preparing sialylated recombinant proteins
WO2013161958A1 (en) *	2012-04-27	2013-10-31	日本ケミカルリサーチ株式会社	Novel expression vector
EP2824176A1 (en)	2013-07-11	2015-01-14	Siamed'xpress	Methods for producing sialylated therapeutic proteins
JP6652334B2 (en)	2014-05-31	2020-02-19	Ｊｃｒファーマ株式会社	Medium containing uridine and N-acetyl-D-mannosamine
EP3237608B1 (en) *	2014-12-22	2019-10-09	F. Hoffmann-La Roche AG	Cmp-dependent sialidase activity
ES2784625T3 (en)	2015-04-17	2020-09-29	Ferring Bv	FSH for the treatment of infertility
JP6845813B2 (en)	2015-06-26	2021-03-24	フェリングベスローテンフェンノートシャップ	Methods of purification and / or virus inactivation
EP3205719A1 (en) *	2016-02-15	2017-08-16	CEVEC Pharmaceuticals GmbH	Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins
GB201603280D0 (en)	2016-02-24	2016-04-13	Ferring Bv	Stable liquid gonadotropin formulation
EP3382014A1 (en) *	2017-03-29	2018-10-03	CEVEC Pharmaceuticals GmbH	Recombinant glycoproteins with reduced antennary fucosylation
EP3441471A1 (en)	2017-08-08	2019-02-13	CEVEC Pharmaceuticals GmbH	Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
EP4427806A3 (en)	2017-09-01	2024-10-09	Ferring B.V.	Composition for controlled ovarian stimulation
SI3787667T1 (en)	2018-04-30	2025-06-30	Ferring B.V.	Composition for controlled ovarian stimulation
TWI846743B (en)	2018-10-17	2024-07-01	荷蘭商菲林公司	Compositions and methods for controlled ovarian stimulation
US20220380785A1 (en) *	2019-11-01	2022-12-01	The University Of British Columbia	Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (en)	2020-12-09	2022-10-01	荷蘭商菲林公司	Compositions and methods for controlled ovarian stimulation
US20250241993A1 (en)	2022-04-01	2025-07-31	Ferring B.V.	Mixed protocol for treatment of infertility
EP4531895A1 (en)	2022-05-26	2025-04-09	Ferring B.V.	Compositions and methods for treatment of infertility in males
MA71382A (en)	2022-07-08	2025-04-30	Ferring B.V.	COMPOSITIONS AND METHODS FOR INTRAUTERINE INSEMINATION (IUI)
WO2025017533A1 (en)	2023-07-20	2025-01-23	Ferring B.V.	Extended release drug-loaded microparticles

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US5541083A (en)	1989-10-24	1996-07-30	The Regents Of The University Of California	Method for producing secretable glycosyltransferases and other golgi processing enzymes
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US20040248784A1 (en)	2003-06-03	2004-12-09	Marco Filicori	Unitary combinations of FSH and hCG
WO2005056760A2 (en) *	2003-12-03	2005-06-23	Neose Technologies, Inc.	Glycopegylated follicle stimulating hormone
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TWI488640B (en)	2008-04-16	2015-06-21	Ferring Int Ct Sa	Pharmaceutical preparation
TWI532495B (en)	2009-10-05	2016-05-11	菲瑞茵國際中心股份有限公司	Pharmaceutical preparation
EP2417982A1 (en)	2010-07-30	2012-02-15	Ferring B.V.	Stabilization of gonadotropins
WO2012016575A1 (en)	2010-08-03	2012-02-09	King Saud University	Stoma coat
WO2012016576A1 (en) *	2010-08-04	2012-02-09	Glycotope Gmbh	Improved recombinant human follicle-stimulating hormone
US9320778B2 (en)	2010-09-29	2016-04-26	Ferring B.V.	Method for controlled ovarian stimulation with combined FSH and hCG
CA2831486A1 (en)	2011-03-31	2012-10-04	Ferring B.V.	Pharmaceutical preparation
WO2012168680A1 (en)	2011-06-06	2012-12-13	Ferring B.V.	Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (en)	2011-08-08	2017-03-15	Ferring Bv	Complex for controlled stimulation of the ovary
SG11201608132UA (en)	2014-04-18	2016-11-29	Glycotope Gmbh	Controlled ovarian hyperstimulation with improved recombinant human follicle-stimulating hormone

2009
- 2009-04-15 TW TW098112483A patent/TWI488640B/en active
- 2009-04-16 CN CN200980121391XA patent/CN102066414A/en active Pending
- 2009-04-16 EP EP09733497.3A patent/EP2268666B1/en not_active Revoked
- 2009-04-16 PL PL16194925T patent/PL3144318T3/en unknown
- 2009-04-16 FI FIEP21212873.0T patent/FI4015527T3/en active
- 2009-04-16 PT PT161949250T patent/PT3144318T/en unknown
- 2009-04-16 ES ES21212873T patent/ES3023526T3/en active Active
- 2009-04-16 CN CN201510933827.2A patent/CN105906703A/en active Pending
- 2009-04-16 LT LTEP16179121.5T patent/LT3098234T/en unknown
- 2009-04-16 DK DK09733497.3T patent/DK2268666T3/en active
- 2009-04-16 EP EP16158141.8A patent/EP3045471B1/en not_active Revoked
- 2009-04-16 HU HUE21212873A patent/HUE071059T2/en unknown
- 2009-04-16 SI SI200932205T patent/SI3098234T1/en unknown
- 2009-04-16 WO PCT/GB2009/000978 patent/WO2009127826A1/en not_active Ceased
- 2009-04-16 PL PL14178729T patent/PL2808340T3/en unknown
- 2009-04-16 KR KR1020177026920A patent/KR20170110741A/en not_active Ceased
- 2009-04-16 LT LTEP21212873.0T patent/LT4015527T/en unknown
- 2009-04-16 HU HUE16158141A patent/HUE033830T2/en unknown
- 2009-04-16 RU RU2010141908/10A patent/RU2537268C2/en active
- 2009-04-16 PL PL16179121.5T patent/PL3098234T3/en unknown
- 2009-04-16 KR KR1020107025581A patent/KR101622944B1/en active Active
- 2009-04-16 DK DK21212873.0T patent/DK4015527T3/en active
- 2009-04-16 RU RU2014141994A patent/RU2682270C2/en active
- 2009-04-16 MX MX2010011343A patent/MX2010011343A/en active IP Right Grant
- 2009-04-16 LT LTEP16158141.8T patent/LT3045471T/en unknown
- 2009-04-16 EP EP16194925.0A patent/EP3144318B1/en active Active
- 2009-04-16 PT PT212128730T patent/PT4015527T/en unknown
- 2009-04-16 AU AU2009237479A patent/AU2009237479B2/en active Active
- 2009-04-16 NZ NZ588381A patent/NZ588381A/en unknown
- 2009-04-16 HU HUE14178729A patent/HUE030652T4/en unknown
- 2009-04-16 ES ES16158141.8T patent/ES2629392T3/en active Active
- 2009-04-16 PT PT161581418T patent/PT3045471T/en unknown
- 2009-04-16 KR KR1020167012148A patent/KR20160056960A/en not_active Ceased
- 2009-04-16 MX MX2017007881A patent/MX355457B/en unknown
- 2009-04-16 EP EP21212873.0A patent/EP4015527B1/en active Active
- 2009-04-16 DK DK14178729.1T patent/DK2808340T3/en active
- 2009-04-16 HU HUE16179121A patent/HUE068565T2/en unknown
- 2009-04-16 CN CN201510933782.9A patent/CN105906702A/en active Pending
- 2009-04-16 SI SI200930931T patent/SI2268666T1/en unknown
- 2009-04-16 KR KR1020197022294A patent/KR102108377B1/en active Active
- 2009-04-16 HR HRP20250313TT patent/HRP20250313T1/en unknown
- 2009-04-16 AR ARP090101333A patent/AR071479A1/en not_active Application Discontinuation
- 2009-04-16 MX MX2014011348A patent/MX348622B/en unknown
- 2009-04-16 KR KR1020187023820A patent/KR20180095140A/en not_active Ceased
- 2009-04-16 ES ES09733497.3T patent/ES2468318T3/en active Active
- 2009-04-16 US US12/988,218 patent/US8951967B2/en active Active
- 2009-04-16 HR HRP20140535AT patent/HRP20140535T1/en unknown
- 2009-04-16 SI SI200931670A patent/SI3045471T1/en unknown
- 2009-04-16 JP JP2011504527A patent/JP2011519359A/en active Pending
- 2009-04-16 FI FIEP16179121.5T patent/FI3098234T3/en active
- 2009-04-16 PL PL21212873.0T patent/PL4015527T3/en unknown
- 2009-04-16 PT PT161791215T patent/PT3098234T/en unknown
- 2009-04-16 DK DK16194925.0T patent/DK3144318T3/en active
- 2009-04-16 PL PL16158141T patent/PL3045471T3/en unknown
- 2009-04-16 LT LTEP14178729.1T patent/LT2808340T/en unknown
- 2009-04-16 PT PT97334973T patent/PT2268666E/en unknown
- 2009-04-16 EP EP13193214.7A patent/EP2722339A1/en active Pending
- 2009-04-16 CA CA2725257A patent/CA2725257A1/en active Pending
- 2009-04-16 ES ES16179121T patent/ES2989729T3/en active Active
- 2009-04-16 SI SI200932094T patent/SI3144318T1/en unknown
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