[go: up one dir, main page]

FR14C0060I1 - - Google Patents

Info

Publication number
FR14C0060I1
FR14C0060I1 FR14C0060C FR14C0060I1 FR 14C0060 I1 FR14C0060 I1 FR 14C0060I1 FR 14C0060 C FR14C0060 C FR 14C0060C FR 14C0060 I1 FR14C0060 I1 FR 14C0060I1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
Other languages
French (fr)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31188461&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR14C0060(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of FR14C0060I1 publication Critical patent/FR14C0060I1/fr
Application granted granted Critical
Publication of FR14C0060I2 publication Critical patent/FR14C0060I2/en
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR14C0060C 2002-07-25 2014-08-18 QUINOLINE DERIVATIVES AND THEIR USE AS MYCOBACTERIAL INHIBITORS Active FR14C0060I2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39871102P 2002-07-25 2002-07-25
PCT/EP2003/050322 WO2004011436A1 (en) 2002-07-25 2003-07-18 Quinoline derivatives and their use as mycobacterial inhibitors
EP03771115A EP1527050B1 (en) 2002-07-25 2003-07-18 Quinoline derivatives and their use as mycobacterial inhibitors

Publications (2)

Publication Number Publication Date
FR14C0060I1 true FR14C0060I1 (en) 2014-10-10
FR14C0060I2 FR14C0060I2 (en) 2015-11-20

Family

ID=31188461

Family Applications (1)

Application Number Title Priority Date Filing Date
FR14C0060C Active FR14C0060I2 (en) 2002-07-25 2014-08-18 QUINOLINE DERIVATIVES AND THEIR USE AS MYCOBACTERIAL INHIBITORS

Country Status (37)

Country Link
US (1) US7498343B2 (en)
EP (2) EP2301544B1 (en)
JP (1) JP4484703B2 (en)
KR (1) KR100733577B1 (en)
CN (2) CN1325475C (en)
AP (1) AP2421A (en)
AR (1) AR040673A1 (en)
AT (1) ATE463482T1 (en)
AU (1) AU2003262529B2 (en)
BE (1) BE2014C051I2 (en)
BR (1) BRPI0312927B8 (en)
CA (1) CA2493225C (en)
CY (3) CY1111882T1 (en)
DE (1) DE60332023D1 (en)
DK (2) DK1527050T3 (en)
EA (1) EA008937B1 (en)
ES (2) ES2395237T3 (en)
FR (1) FR14C0060I2 (en)
HR (2) HRP20050045B1 (en)
HU (1) HUS1400047I1 (en)
IL (2) IL166457A (en)
IS (1) IS2914B (en)
LU (1) LU92520I2 (en)
ME (1) ME00131B (en)
MX (1) MXPA05001052A (en)
MY (1) MY143564A (en)
NL (1) NL300684I2 (en)
NO (2) NO329935B1 (en)
NZ (1) NZ538391A (en)
PL (1) PL222801B1 (en)
PT (2) PT2301544E (en)
RS (1) RS52431B (en)
SI (2) SI1527050T1 (en)
TW (1) TWI323730B (en)
UA (1) UA82198C2 (en)
WO (1) WO2004011436A1 (en)
ZA (1) ZA200500680B (en)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7338949B2 (en) * 2004-01-23 2008-03-04 Janssen Pharmaceutica N.V. Mycobacterial inhibitors
PL1711181T3 (en) * 2004-01-23 2010-02-26 Janssen Pharmaceutica Nv Quinoline derivatives and use thereof as mycobacterial inhibitors
EA011572B9 (en) * 2004-01-29 2018-01-31 Янссен Фармацевтика Н.В. Quinoline derivatives for use as mycobacterial inhibitors
AU2005249231B2 (en) * 2004-05-28 2010-11-11 Janssen Pharmaceutica N.V. Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases
PT1797115T (en) * 2004-09-28 2017-08-29 Janssen Pharmaceutica Nv A bacterial atp synthase binding domain
EE05394B1 (en) * 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Quinoline compounds for use in the treatment of latent tuberculosis
EA009779B1 (en) * 2004-12-24 2008-04-28 Янссен Фармацевтика Н.В. Treatment of latent tuberculosis
KR101712835B1 (en) * 2005-05-25 2017-03-07 얀센 파마슈티카 엔.브이. Process for preparing (alpha s, beta r)-6-bromo-alpha-(2-(dimethylamino)ethyl)-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol
TWI380819B (en) * 2005-06-08 2013-01-01 Janssen Pharmaceutica Nv Quinoline derivatives as antibacterial agents
CA2528849C (en) * 2005-06-08 2014-01-14 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents
JP5349730B2 (en) * 2005-06-09 2013-11-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Quinoline derivatives as antibacterial agents
KR101318181B1 (en) * 2005-06-09 2013-10-16 얀센 파마슈티카 엔.브이. Quinoline derivatives as antibacterial agent
EA010601B1 (en) * 2005-06-09 2008-10-30 Янссен Фармацевтика Н.В. Quinoline derivatives as antibacterial agents
JO2752B1 (en) 2005-06-28 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline Derivatives as Antibacterial Agents
HRP20170044T1 (en) * 2005-06-28 2017-03-10 Janssen Pharmaceutica Nv Quinoline derivatives as antibacterial agents
JO3270B1 (en) * 2005-06-28 2018-09-16 Janssen Pharmaceutica Nv Quinoline Derivatives as Antibacterial Agents
JO3077B1 (en) * 2005-07-28 2017-03-15 Janssen Pharmaceutica Nv Antibacterial Quinoline Derivatives
JO2837B1 (en) * 2005-08-03 2014-09-15 جانسن فارمسيتكا ان في Quinoline Derivatives as Antibacterial Agents
JO2855B1 (en) * 2005-08-03 2015-03-15 شركة جانسين فارماسوتيكا ان. في Qunioline Derivatives as Antibacterial Agents
JO2952B1 (en) * 2005-08-03 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline Derivatives as Antibacterial Agents
US8686002B2 (en) 2005-08-21 2014-04-01 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as binding partners for 5-HT5 receptors
DE102005044817A1 (en) 2005-09-20 2007-03-22 Sanofi-Aventis Deutschland Gmbh Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as medicament, and medicament containing them
UA97813C2 (en) * 2006-12-05 2012-03-26 Янссен Фармацевтика Н.В. Fumarate salt of (alpha s, beta r)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol
JO2970B1 (en) 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Antibacterial Quinoline Derivatives
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Antibacterial Quinoline Derivatives
JO2684B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Antibacterial Quinoline Derivatives
JO3271B1 (en) * 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv Antibacterial Quinoline Derivatives
JO2725B1 (en) * 2006-12-06 2013-09-15 جانسين فارماسوتيكا ان. في Antibacterial Quinoline Derivatives
JO2685B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Antibacterial Quinoline Derivatives
RU2404971C2 (en) * 2008-12-02 2010-11-27 ЗАО "Фарм-Синтез" Novel quinoline derivatives, synthesis method thereof, use thereof in treating mycobacterial infections, pharmaceutical composition based on said derivatives
CN102249935B (en) * 2010-05-17 2015-05-20 中国人民解放军军事医学科学院毒物药物研究所 Aromatic 2-butanols compound and medical application thereof
RU2486175C2 (en) * 2011-09-12 2013-06-27 Закрытое Акционерное Общество "Фарм-Синтез" Quinoline derivatives, particularly 5,6,7-substituted 1-(2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-oles, method for preparing and using compounds
EP2841425B1 (en) 2012-04-27 2016-03-23 Janssen Pharmaceutica, N.V. Antibacterial quinoline derivatives
MX358506B (en) 2012-04-27 2018-08-22 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives.
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases
AP2015008503A0 (en) 2012-12-21 2015-06-30 Janssen Sciences Ireland Uc Antibacterial compounds
RU2530493C1 (en) * 2013-04-22 2014-10-10 Закрытое Акционерное Общество "Фарм-Синтез" Quinoline derivatives, particularly 6,7-substituted 1-(2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-ols, method for production thereof and use of compounds to treat infectious mycobacterial dieseases, particularly tuberculosis
CN105017147B (en) * 2014-04-30 2019-02-01 中国医学科学院药物研究所 A method of recycling and utilize Bedaquiline three-dimensional chemical isomer
CN105085396B (en) * 2014-05-07 2017-08-08 国药集团国瑞药业有限公司 For preparing shellfish up to intermediate of quinoline and its preparation method and application
CN105085395B (en) * 2014-05-07 2017-09-26 国药集团国瑞药业有限公司 Shellfish reaches the preparation method of quinoline
CN105198808B (en) * 2014-05-27 2017-08-25 北京万生药业有限责任公司 A kind of method that efficient production shellfish reaches quinoline
CN105175329B (en) * 2014-06-10 2017-09-19 重庆圣华曦药业股份有限公司 A kind of shellfish reaches the synthetic route and method of quinoline raceme
CN105330595B (en) * 2014-07-14 2019-12-10 上海嘉坦医药科技有限公司 pyridine derivatives and their use as antimycobacterial agents
EP3170810B1 (en) * 2014-07-14 2018-09-19 Cisen Pharmaceutical Co., Ltd. Pyridine derivatives and anti-mycobacterial use thereof
CN105440051B (en) * 2014-09-19 2019-07-05 重庆医药工业研究院有限责任公司 A kind of thiophene pyridine derivate for the treatment of tuberculosis
CZ2014708A3 (en) 2014-10-16 2016-04-27 Zentiva, K.S. Bedaqujiline salts
CZ201534A3 (en) 2015-01-21 2016-08-03 Zentiva, K.S. Novel possibilities of bedaquiline chiral resolution
CZ201535A3 (en) 2015-01-21 2016-08-03 Zentiva, K.S. Novel possibilities of bedaquiline chiral resolution
CZ201533A3 (en) 2015-01-21 2016-08-03 Zentiva, K.S. Method of isolating mixture of enantiomers
UA126891C2 (en) 2015-01-27 2023-02-22 Янссен Фармацевтика Нв CAPABLE OF DISPERSING THE COMPOSITION
WO2016174673A1 (en) * 2015-04-29 2016-11-03 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Anti-phytopathogenic compositions
CN106279017A (en) * 2015-05-21 2017-01-04 重庆圣华曦药业股份有限公司 Bedaquinoline crystal form, composition and preparation method thereof
CZ2015391A3 (en) 2015-06-09 2016-12-21 Zentiva, K.S. Salt of bedaquiline with citric acid
CN108235704B (en) 2015-07-02 2021-10-26 爱尔兰詹森科学公司 Antibacterial compounds
CN105061387A (en) * 2015-07-17 2015-11-18 苏州大学 Diaryl ether fused ring compounds, preparation methods and applications
CN107848978B (en) * 2015-07-24 2021-04-02 浙江海正药业股份有限公司 A kind of method for separating bedaquiline diastereomer A
RU2018111482A (en) * 2015-10-20 2019-11-21 Чжэцзян Хисунь Фармасьютикал Ко., Лтд. CRYSTAL FORMS OF BEDAQUILINE FUMARATE AND METHODS FOR PRODUCING THEM
CN108473428B (en) * 2016-01-13 2021-07-23 上海嘉坦医药科技有限公司 A kind of preparation method of pyridine derivative compound and its intermediate and crystal form
EP3423449B1 (en) * 2016-03-03 2021-04-07 Council of Scientific and Industrial Research Substituted aurone alkaloids as anti-mycobacterial agents
ES2934785T3 (en) * 2016-03-07 2023-02-27 Global Alliance For Tb Drug Development Inc Antibacterial compounds and uses thereof
BR112018075939A2 (en) 2016-06-16 2019-04-09 Janssen Sciences Ireland Unlimited Company heterocyclic compounds as antibacterials
MA45377A (en) 2016-06-16 2019-04-24 Janssen Sciences Ireland Unlimited Co HETEROCYCLIC COMPOUNDS AS ANTIBACTERIAL AGENTS
EP4417262A3 (en) 2017-03-01 2024-11-27 Janssen Sciences Ireland Unlimited Company Combination therapy
ES2891976T3 (en) 2017-07-14 2022-02-01 Janssen Pharmaceutica Nv long-term formulations
CN109384716B (en) * 2017-08-11 2021-06-29 海创药业股份有限公司 Deuterated quinoline compound and preparation and application thereof
WO2020144197A1 (en) 2019-01-09 2020-07-16 Janssen Pharmaceutica Nv Combination in the treatment of nontuberculous mycobacterial diseases
WO2020161743A1 (en) 2019-02-08 2020-08-13 Mylan Laboratories Limited Process for the preparation of bedaquiline fumarate
US12479816B2 (en) 2019-02-08 2025-11-25 University of Pittsburgh—of the Commonwealth System of Higher Education 20-HETE formation inhibitors
ES2978573T3 (en) 2019-09-13 2024-09-16 Janssen Sciences Ireland Unlimited Co Antibacterial compounds
CN112574175B (en) * 2019-09-29 2023-11-14 南京长澳医药科技有限公司 Quinoline compound, preparation method and application thereof
CA3149988A1 (en) 2019-09-30 2021-04-08 Jerome Emile Georges Guillemont 4-quinolinone antibacterial compounds
MX2022003816A (en) 2019-09-30 2022-05-06 Janssen Sciences Ireland Unlimited Co Antibacterial compounds.
CN110804016B (en) * 2019-12-05 2022-11-04 福建省微生物研究所 Diarylquinoline derivatives against Mycobacterium tuberculosis
KR20220122649A (en) 2019-12-27 2022-09-02 테크니메데 소시에다데 테크니코-메디시날 에스.에이. NEW PHARMACEUTICAL COMPOUNDS
KR102303635B1 (en) 2020-07-01 2021-09-17 동아에스티 주식회사 PROCESS FOR PREPARING (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-dimethylamino-2-(1-naphthyl)-1-phenyl-butan-2-ol AND PHARMACEUTICALLY ACCEPTABLE SALT
CA3182425A1 (en) 2020-07-09 2022-01-13 Rene Holm Long-acting formulations
WO2022008645A1 (en) 2020-07-09 2022-01-13 Janssen Pharmaceutica Nv Long-acting formulations
EP4178540A1 (en) 2020-07-09 2023-05-17 JANSSEN Pharmaceutica NV Long-acting formulations
EP4243800A1 (en) 2020-11-12 2023-09-20 JANSSEN Pharmaceutica NV Combination of bedaquiline, ethambutol and a macrolide in the treatment of nontuberculous mycobacterial diseases
WO2022194803A1 (en) 2021-03-16 2022-09-22 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
WO2022194906A1 (en) 2021-03-17 2022-09-22 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
BR112023018655A2 (en) 2021-03-17 2023-12-12 Janssen Sciences Ireland Unlimited Co ANTIBACTERIAL COMPOUNDS
WO2022214519A1 (en) 2021-04-07 2022-10-13 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
WO2022214520A1 (en) 2021-04-07 2022-10-13 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
CA3223626A1 (en) 2021-06-29 2023-01-05 Augusto Eugenio Pardal Filipe Heterocyclic compounds for the treatment of tuberculosis
KR20240090864A (en) 2021-10-28 2024-06-21 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 Imidazopyridine amides and related compounds for use in the treatment of bacterial infections
WO2023150747A1 (en) 2022-02-07 2023-08-10 Insmed Incorporated Dry powder compositions of bedaquiline and salts and methods of use thereof
CN114835641B (en) * 2022-05-07 2024-03-15 南京杰运医药科技有限公司 Synthesis method of 3-benzyl-6-bromo-2-methoxyquinoline
CN117050006A (en) * 2022-05-13 2023-11-14 广州嘉越医药科技有限公司 A pyridine derivative, intermediate, preparation method and application
WO2023232838A1 (en) 2022-05-31 2023-12-07 Janssen Pharmaceutica Nv Bedaquiline for use in the treatment of leprosy
CN117399070B (en) * 2022-07-07 2025-06-24 上海交通大学 Chiral metal synergistic catalytic system containing chelating ligand and application of chiral metal synergistic catalytic system in asymmetric synthesis of bedaquiline
WO2024068693A1 (en) 2022-09-28 2024-04-04 Janssen Pharmaceutica Nv Long-acting formulations
JP2025532272A (en) 2022-09-28 2025-09-29 ヤンセン ファーマシューティカ エヌ．ベー． Long-acting formulations
WO2024089170A1 (en) 2022-10-27 2024-05-02 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
WO2024107555A1 (en) * 2022-11-15 2024-05-23 Eli Lilly And Company Ahr agonists
WO2024223859A1 (en) 2023-04-26 2024-10-31 Janssen Pharmaceutica Nv Antibacterial compounds
WO2025068448A1 (en) 2023-09-28 2025-04-03 Janssen Pharmaceutica Nv Atp synthase inhibitors for use in the treatment of non-tuberculosis mycobacteria
WO2025181475A1 (en) 2024-02-27 2025-09-04 The University Of Liverpool Novel tuberculosis sterilization formulations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2270123A1 (en) * 1996-10-28 1998-05-07 Department Of The Army, U.S. Government Compounds, compositions and methods for treating antibiotic-resistant infections
AU757059B2 (en) * 1997-06-19 2003-01-30 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
WO1999037365A1 (en) * 1998-01-23 1999-07-29 Fire Armour Pte Ltd. Nozzle with axially and perpendicularly directed apertures
DE69908555T2 (en) * 1998-01-26 2004-05-06 Smithkline Beecham P.L.C., Brentford CHINOLINE DERIVATIVES AS AN ANTIBACTERIAL MEDICINAL PRODUCT
US6819431B2 (en) * 2001-07-06 2004-11-16 Zygo Corporation Polymer retarder
EE05394B1 (en) * 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Quinoline compounds for use in the treatment of latent tuberculosis
CA2528849C (en) * 2005-06-08 2014-01-14 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents

Also Published As

Publication number Publication date
JP2006504658A (en) 2006-02-09
DK2301544T3 (en) 2013-01-02
PT2301544E (en) 2012-12-10
IL202655A (en) 2012-04-30
PT1527050E (en) 2010-06-22
MXPA05001052A (en) 2005-04-08
IL166457A (en) 2011-10-31
CY1113497T1 (en) 2016-06-22
NO20050476L (en) 2005-01-27
AU2003262529A1 (en) 2004-02-16
NL300684I2 (en) 2016-10-11
EP1527050A1 (en) 2005-05-04
EA008937B1 (en) 2007-10-26
KR100733577B1 (en) 2007-06-29
AU2003262529B2 (en) 2009-11-19
CN101070304B (en) 2011-10-26
FR14C0060I2 (en) 2015-11-20
NO2014021I2 (en) 2014-08-20
JP4484703B2 (en) 2010-06-16
UA82198C2 (en) 2008-03-25
HRP20120190B1 (en) 2017-06-02
CY2014033I1 (en) 2016-04-13
BRPI0312927B8 (en) 2021-05-25
AP2421A (en) 2012-06-08
ES2343458T3 (en) 2010-08-02
HRP20050045B1 (en) 2013-09-30
HRP20120190A2 (en) 2012-05-31
DK1527050T3 (en) 2010-07-19
SI2301544T1 (en) 2013-01-31
NO329935B1 (en) 2011-01-24
ZA200500680B (en) 2006-08-30
EP2301544A1 (en) 2011-03-30
RS20050058A (en) 2007-06-04
LU92520I2 (en) 2015-11-02
PL222801B1 (en) 2016-09-30
US20050148581A1 (en) 2005-07-07
HK1083496A1 (en) 2006-07-07
IL166457A0 (en) 2006-01-15
RS52431B (en) 2013-02-28
CN1325475C (en) 2007-07-11
CY2014033I2 (en) 2016-04-13
EA200500257A1 (en) 2005-06-30
EP1527050B1 (en) 2010-04-07
EP2301544B1 (en) 2012-09-19
CN101070304A (en) 2007-11-14
CA2493225C (en) 2012-03-20
CN1671667A (en) 2005-09-21
AP2005003210A0 (en) 2005-03-31
KR20050033607A (en) 2005-04-12
DE60332023D1 (en) 2010-05-20
CY1111882T1 (en) 2015-11-04
HK1113795A1 (en) 2008-10-17
HRP20050045A2 (en) 2006-06-30
WO2004011436A1 (en) 2004-02-05
HUS1400047I1 (en) 2016-09-28
HRP20120190A8 (en) 2012-07-31
SI1527050T1 (en) 2010-08-31
MEP9208A (en) 2010-06-10
ATE463482T1 (en) 2010-04-15
NZ538391A (en) 2005-10-28
BE2014C051I2 (en) 2022-08-09
US7498343B2 (en) 2009-03-03
CA2493225A1 (en) 2004-02-05
ES2395237T3 (en) 2013-02-11
NO2014021I1 (en) 2014-08-20
IS7620A (en) 2004-12-29
ME00131B (en) 2010-10-10
BRPI0312927B1 (en) 2018-07-10
PL375523A1 (en) 2005-11-28
TWI323730B (en) 2010-04-21
MY143564A (en) 2011-05-31
AR040673A1 (en) 2005-04-13
TW200410939A (en) 2004-07-01
IS2914B (en) 2014-12-15
BR0312927A (en) 2005-07-12

Similar Documents

Publication Publication Date Title
BE2019C547I2 (en)
BE2019C510I2 (en)
BE2018C021I2 (en)
BE2017C049I2 (en)
BE2017C005I2 (en)
BE2016C069I2 (en)
BE2016C040I2 (en)
BE2016C013I2 (en)
BE2015C078I2 (en)
BE2016C002I2 (en)
BE2018C018I2 (en)
BE2015C017I2 (en)
BE2014C053I2 (en)
BE2014C051I2 (en)
BE2014C041I2 (en)
BE2014C030I2 (en)
BE2014C016I2 (en)
BE2014C015I2 (en)
BE2013C063I2 (en)
BE2013C039I2 (en)
BE2011C038I2 (en)
BE2015C068I2 (en)
JP2003229907A5 (en)
BE2013C046I2 (en)
JP2003229483A5 (en)