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FR11C0023I2 - BENZIMIDAZOLE DERIVATIVES WITH ANTIHISTAMINIC ACTIVITY - Google Patents

BENZIMIDAZOLE DERIVATIVES WITH ANTIHISTAMINIC ACTIVITY

Info

Publication number
FR11C0023I2
FR11C0023I2 FR11C0023C FR11C0023C FR11C0023I2 FR 11C0023 I2 FR11C0023 I2 FR 11C0023I2 FR 11C0023 C FR11C0023 C FR 11C0023C FR 11C0023 C FR11C0023 C FR 11C0023C FR 11C0023 I2 FR11C0023 I2 FR 11C0023I2
Authority
FR
France
Prior art keywords
benzimidazole derivatives
antihistaminic activity
antihistaminic
activity
benzimidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR11C0023C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fabrica Espanola De Productos Qui
Original Assignee
Fabrica Espanola De Productos Qui
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabrica Espanola De Productos Qui filed Critical Fabrica Espanola De Productos Qui
Publication of FR11C0023I1 publication Critical patent/FR11C0023I1/fr
Application granted granted Critical
Publication of FR11C0023I2 publication Critical patent/FR11C0023I2/en
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR11C0023C 1996-06-04 2011-07-08 BENZIMIDAZOLE DERIVATIVES WITH ANTIHISTAMINIC ACTIVITY Active FR11C0023I2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (en) 1996-06-04 1996-06-04 NEW DERIVATIVES OF BENZMIDAZOLE WITH ANTIHISTAMINE ACTIVITY.

Publications (2)

Publication Number Publication Date
FR11C0023I1 FR11C0023I1 (en) 2011-08-19
FR11C0023I2 true FR11C0023I2 (en) 2012-03-16

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
FR11C0023C Active FR11C0023I2 (en) 1996-06-04 2011-07-08 BENZIMIDAZOLE DERIVATIVES WITH ANTIHISTAMINIC ACTIVITY

Country Status (27)

Country Link
US (1) US5877187A (en)
EP (1) EP0818454B1 (en)
JP (1) JP4218991B2 (en)
CN (1) CN1105716C (en)
AR (1) AR008386A1 (en)
AT (1) ATE264317T1 (en)
AU (1) AU725700B2 (en)
BR (1) BR9703276A (en)
CA (1) CA2206754C (en)
CZ (1) CZ289278B6 (en)
DE (2) DE69728608T2 (en)
DK (1) DK0818454T3 (en)
ES (1) ES2124167B1 (en)
FR (1) FR11C0023I2 (en)
HR (1) HRP970307B1 (en)
HU (1) HU227598B1 (en)
IN (1) IN186319B (en)
LU (1) LU91798I2 (en)
MX (1) MXPA97004127A (en)
NO (2) NO313195B1 (en)
PL (1) PL188908B1 (en)
PT (1) PT818454E (en)
RU (1) RU2182150C2 (en)
SI (1) SI0818454T1 (en)
TR (1) TR199700464A2 (en)
TW (1) TW438794B (en)
ZA (1) ZA974893B (en)

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EP1092711A4 (en) 1998-07-01 2002-07-31 Takeda Chemical Industries Ltd Retinoid-associated receptor regulators
CN1184208C (en) 1998-11-27 2005-01-12 巴斯福股份公司 Substituted benzimidazoles and their preparation and use
ES2151442B1 (en) * 1999-01-11 2001-07-01 Espanola Prod Quimicos NEW DERIVATIVE OF BENCENOETHANOL.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
RU2288917C2 (en) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. POLYMORPH OF 4-[2-[4-[1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOL-2-YL]-PIPERIDINYL]ETHYL]-α,α-DIMETHYLBENZENEACETIC ACID, METHOD FOR ITS PREPARING, PHARMACEUTICAL PREPARATION BASED ON THEREOF AND ITS USING
BRPI0215703B8 (en) * 2002-04-19 2021-05-25 Faes Farma Sa 4-[2-[1-(2-ethoxyethyl)-1h-benzidimazol-2-yl]-1-piperidinyl]ethyl]-a, α-dimethyl-benzeneacetic acid polymorph, pharmaceutical preparation, and its use of polymorph 1
MXPA04012628A (en) * 2002-06-13 2005-03-23 Patricia Olivershaffer 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase iv inhibitors for the treatment of bacterial infections.
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
CN101952273B (en) 2008-02-12 2014-11-12 柳韩洋行 Process for the preparation of 2-methyl-2' -phenylpropionic acid derivatives and intermediate compounds
JP2010013472A (en) * 2009-09-09 2010-01-21 Faes Farma Sa POLYMORPH OF 4-[2-[1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOL-2-YL]-1-PIPERIDINYL] ETHYL-alpha,alpha-DIMETHYL BENZENOACETIC ACID
CN102675101B (en) * 2012-05-16 2014-01-29 王蕾 Preparation method of 2-(4-haloethyl) phenyl-2-methyl propionic ester and synthesis method of bilastine
CZ307500B6 (en) 2012-08-15 2018-10-24 Zentiva, K.S. A method of the preparation of a 2-methyl-2'-phenylpropionic acid derivative employing novel intermediates
RU2671577C2 (en) * 2013-03-15 2018-11-02 Геркулес Ллк Composition and method of producing personal care compositions with improved deposition properties
CN103214454A (en) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 Bilastine crystal and preparation method thereof
CN103214455B (en) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 A kind of preparation method of bilastine
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (en) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 A method of preparing bilastine
CN104447683A (en) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 Stable Bilastine compound
CN103896915A (en) * 2014-04-01 2014-07-02 中国药科大学 Benzimidazole derivative and preparation method thereof as well as application of benzimidazole derivative in medicine
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (en) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 Preparation method of bilastine impurity
EP3327012B1 (en) * 2015-07-24 2021-03-17 Urquima, S.A. Crystalline forms of bilastine and preparation methods thereof
CN105272977A (en) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 Bilastine intermediate preparation method
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
EP3452462A4 (en) * 2016-05-05 2019-10-23 MSN Laboratories Private Limited, R&D Center SOLID STATE FORMS OF 2- [4- (2- {4- [1- (2-ETHOXYETHYL) -1H-BENZIMIDAZOL-2-YL] -1-PIPERIDINYL} ETHYL) PHENYL] -2-METHYLPROPANOIC ACID AND PREPARATION METHOD THEREOF
CN107365298A (en) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 A kind of preparation method of the benzyl propionate derivant of 2 methyl 2 '
CN109456316A (en) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 A kind of preparation method of bilastine impurity
EP3453384B1 (en) 2017-09-07 2020-05-27 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine
BR112020007569A2 (en) 2017-10-16 2020-09-24 Faes Farma, S.A. bilastine aqueous compositions
EP3641735B1 (en) 2017-12-18 2021-02-24 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine form 3 and a water-soluble filler
ES2835287T3 (en) 2017-12-18 2021-06-22 Tiefenbacher Alfred E Gmbh & Co Kg Pharmaceutical tablet composition comprising polymorphic form 3 of bilastine and magnesium aluminometasilicate
DK3740191T3 (en) 2018-01-18 2021-06-07 Faes Farma Sa Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent
CN109081827A (en) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 A kind of preparation method and application of bilastine
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
EP4188339A1 (en) 2020-07-30 2023-06-07 Faes Farma, S.A. Decongestant drug delivery system
CN112110893A (en) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 Preparation method of bilastine
WO2022106923A1 (en) 2020-11-18 2022-05-27 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
EP4267109A1 (en) 2020-12-23 2023-11-01 Noucor Health S.A. A non-micronized bilastine composition
MX2024009978A (en) 2022-02-17 2024-08-26 Faes Farma Sa Bilastine composition for once-daily parenteral administration.
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
EP0525129A4 (en) * 1990-04-13 1993-03-24 Smith-Kline Beecham Corporation Substituted benzimidazoles
ES2048109B1 (en) * 1992-07-20 1994-12-16 Espanola Prod Quimicos PROCEDURE FOR THE PREPARATION OF NEW PIPERIDIC DERIVATIVES OF BENCIMIDAZOLE.
DK0701443T4 (en) * 1992-08-03 2000-12-18 Sepracor Inc Terfenadine metabolites and their optically pure isomers for the treatment of allergic disorders
DK0705245T3 (en) * 1993-06-25 2003-04-14 Merrell Pharma Inc New intermediates for the preparation of antihistaminic 4-diphenylmethyl / diphenylmethoxy-piperidine compounds

Also Published As

Publication number Publication date
HUP9700997A1 (en) 1999-09-28
TR199700464A3 (en) 1997-12-21
HRP970307A2 (en) 1998-04-30
DE122011000006I1 (en) 2011-06-16
EP0818454A1 (en) 1998-01-14
BR9703276A (en) 2004-08-17
FR11C0023I1 (en) 2011-08-19
HU227598B1 (en) 2011-09-28
NO2011008I2 (en) 2012-05-14
ZA974893B (en) 1997-12-30
CA2206754A1 (en) 1997-12-04
PL320358A1 (en) 1997-12-08
DK0818454T3 (en) 2004-07-12
JPH1059961A (en) 1998-03-03
ATE264317T1 (en) 2004-04-15
EP0818454B1 (en) 2004-04-14
SI0818454T1 (en) 2004-08-31
CN1105716C (en) 2003-04-16
RU2182150C2 (en) 2002-05-10
AU725700B2 (en) 2000-10-19
PT818454E (en) 2004-08-31
AU2467297A (en) 1997-12-11
PL188908B1 (en) 2005-05-31
NO972525D0 (en) 1997-06-03
JP4218991B2 (en) 2009-02-04
CA2206754C (en) 2007-01-23
CZ289278B6 (en) 2001-12-12
IN186319B (en) 2001-08-04
TR199700464A2 (en) 1997-12-21
CZ172397A3 (en) 1997-12-17
LU91798I2 (en) 2011-05-23
ES2124167A1 (en) 1999-01-16
NO2011008I1 (en) 2011-06-06
ES2124167B1 (en) 1999-09-16
HU9700997D0 (en) 1997-07-28
AR008386A1 (en) 2000-01-19
DE69728608T2 (en) 2005-04-21
TW438794B (en) 2001-06-07
US5877187A (en) 1999-03-02
CN1176964A (en) 1998-03-25
DE69728608D1 (en) 2004-05-19
NO972525L (en) 1997-12-05
NO313195B1 (en) 2002-08-26
HRP970307B1 (en) 2002-02-28
MXPA97004127A (en) 2005-07-25

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