FR10C0012I2 - - Google Patents
Info
- Publication number
- FR10C0012I2 FR10C0012I2 FR10C0012C FR10C0012C FR10C0012I2 FR 10C0012 I2 FR10C0012 I2 FR 10C0012I2 FR 10C0012 C FR10C0012 C FR 10C0012C FR 10C0012 C FR10C0012 C FR 10C0012C FR 10C0012 I2 FR10C0012 I2 FR 10C0012I2
- Authority
- FR
- France
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9308948A FR2707988B1 (en) | 1993-07-21 | 1993-07-21 | New antimitotic derivatives of binary alkaloids of catharantus rosesus, process for their preparation and pharmaceutical compositions comprising them. |
| PCT/FR1994/000898 WO1995003312A1 (en) | 1993-07-21 | 1994-07-19 | Novel antimitotic binary alkaloid derivatives extracted from catharanthus roseus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR10C0012I1 FR10C0012I1 (en) | 2010-04-16 |
| FR10C0012I2 true FR10C0012I2 (en) | 2011-04-01 |
Family
ID=9449457
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR9308948A Expired - Lifetime FR2707988B1 (en) | 1993-07-21 | 1993-07-21 | New antimitotic derivatives of binary alkaloids of catharantus rosesus, process for their preparation and pharmaceutical compositions comprising them. |
| FR10C0012C Active FR10C0012I2 (en) | 1993-07-21 | 2010-03-04 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR9308948A Expired - Lifetime FR2707988B1 (en) | 1993-07-21 | 1993-07-21 | New antimitotic derivatives of binary alkaloids of catharantus rosesus, process for their preparation and pharmaceutical compositions comprising them. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5620985A (en) |
| EP (1) | EP0710240B1 (en) |
| JP (1) | JP3606872B2 (en) |
| AT (1) | ATE146477T1 (en) |
| AU (1) | AU693460B2 (en) |
| BR (1) | BR1100311A (en) |
| CA (1) | CA2167694C (en) |
| DE (2) | DE69401216T2 (en) |
| DK (1) | DK0710240T3 (en) |
| ES (1) | ES2097659T3 (en) |
| FR (2) | FR2707988B1 (en) |
| GR (1) | GR3022659T3 (en) |
| LU (1) | LU91660I2 (en) |
| NZ (2) | NZ269172A (en) |
| WO (1) | WO1995003312A1 (en) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2737208A1 (en) * | 1995-07-28 | 1997-01-31 | Pf Medicament | Fluorinated vindoline derivs - and their reaction products with catharanthine having anti-cancer properties |
| FR2761990B1 (en) * | 1997-04-10 | 1999-06-25 | Pf Medicament | ANTIMITOTIC HALOGEN DERIVATIVES OF VINCA ALKALOIDS |
| FR2783522A1 (en) * | 1998-09-21 | 2000-03-24 | Pf Medicament | New Vinca alkaloid derivatives useful as antitumor agents for treating cancer |
| GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
| US6890558B2 (en) * | 2002-05-31 | 2005-05-10 | R.P. Scherer Technologies, Inc. | Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment |
| WO2005055939A2 (en) | 2003-12-04 | 2005-06-23 | Amr Technology, Inc. | Vinca derivatives |
| US7235564B2 (en) | 2003-12-04 | 2007-06-26 | Amr Technology, Inc. | Vinorelbine derivatives |
| FR2863891B1 (en) * | 2003-12-23 | 2006-03-24 | Pf Medicament | PHARMACEUTICAL COMPOSITION OF VINFLUNIN FOR PARENTAL ADMINISTRATION, PROCESS FOR PREPARATION AND USE |
| US20110015221A1 (en) * | 2003-12-23 | 2011-01-20 | Pierre Fabre Medicament | Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same |
| EP1732947B1 (en) * | 2004-03-05 | 2011-04-27 | Vegenics Pty Ltd | Growth factor binding constructs materials and methods |
| FR2894966B1 (en) * | 2005-12-20 | 2008-03-14 | Pierre Fabre Medicament Sa | NEW CRYSTALLINE FORM OF VINFLUNINE |
| EP1989212B1 (en) | 2006-02-17 | 2013-06-19 | Cascade Prodrug Inc. | Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs |
| CN101108859A (en) * | 2006-07-17 | 2008-01-23 | 上海恒瑞医药有限公司 | Vinblastine compound, method of preparing the same and use in medicament thereof |
| WO2008033935A2 (en) * | 2006-09-12 | 2008-03-20 | Amr Technology, Inc. | Vinorelbine derivatives |
| WO2008033930A2 (en) * | 2006-09-12 | 2008-03-20 | Amr Technology, Inc. | Vinca derivatives |
| FR2905949B1 (en) | 2006-09-20 | 2008-11-21 | Pierre Fabre Medicament Sa | FLUORINE DERIVATIVES OF CATHARANTHIN, PREPARATION THEREOF AND THEIR USE AS PRECURSORS OF ALKALOIDS DIMERES DE VINCA |
| CN101235046B (en) * | 2007-01-29 | 2010-09-08 | 中国科学院上海药物研究所 | Vinblastine derivative, its preparation method and use, and pharmaceutical composition containing the derivative |
| FR2912406B1 (en) * | 2007-02-13 | 2009-05-08 | Pierre Fabre Medicament Sa | VINFLUNIN ANHYDROUS CRYSTAL SALTS, PROCESS FOR THEIR PREPARATION AND USE AS MEDICAMENT AND MEANS FOR PURIFYING VINFLUNIN. |
| EP1997534A1 (en) * | 2007-05-31 | 2008-12-03 | Pierre Fabre Medicament | Cancer treatment combination therapy comprising vinflunine and trastuzumab |
| FR2918567B1 (en) * | 2007-07-11 | 2012-08-03 | Pf Medicament | STABLE PHARMACEUTICAL COMPOSITION OF A WATER SOLUBLE SALT OF VINORELBINE. |
| FR2918566B1 (en) * | 2007-07-11 | 2009-10-09 | Pierre Fabre Medicament Sa | STABLE PHARMACEUTICAL COMPOSITION OF A WATER SOLUBLE SALT OF VINFLUNINE. |
| US20090076055A1 (en) * | 2007-09-14 | 2009-03-19 | Protia, Llc | Deuterium-enriched vinflunine |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| US8716263B2 (en) | 2008-12-23 | 2014-05-06 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
| US8551973B2 (en) | 2008-12-23 | 2013-10-08 | Gilead Pharmasset Llc | Nucleoside analogs |
| PA8855601A1 (en) | 2008-12-23 | 2010-07-27 | NUCLEOSID FORFORMIDATES | |
| ES2575160T3 (en) | 2010-03-15 | 2016-06-24 | The Board Of Trustees Of The University Of Illinois | Inhibitors of the interactions that bind the alpha subunit of beta integrin-protein G |
| WO2011123668A2 (en) | 2010-03-31 | 2011-10-06 | Pharmasset, Inc. | Stereoselective synthesis of phosphorus containing actives |
| WO2012087943A2 (en) | 2010-12-20 | 2012-06-28 | The Regents Of The University Of Michigan | Inhibitors of the epidermal growth factor receptor-heat shock protein 90 binding interaction |
| CN103788117A (en) * | 2012-10-30 | 2014-05-14 | 何小解 | Technology for continuously synthesizing Dehydrate Catharanthine, vinorelbine and Vinflunine |
| HU230462B1 (en) | 2013-05-30 | 2016-07-28 | Richter Gedeon Nyrt. | A new bis-indole alkaloids as anticancer drugs |
| AU2015205995A1 (en) | 2014-01-15 | 2016-07-28 | Centre National De La Recherche Scientifique (Cnrs) | Water soluble 4-azapodophyllotoxin analogs |
| EP3250611B1 (en) | 2015-01-26 | 2021-04-21 | The University of Chicago | Car t-cells recognizing cancer-specific il 13r-alpha2 |
| CN107683289B (en) | 2015-01-26 | 2021-08-06 | 芝加哥大学 | IL13Rα2 binding agents and their use in cancer therapy |
| CN108779129A (en) * | 2016-03-09 | 2018-11-09 | 赛比亚斯药业股份公司 | Vinorelbine list tartrate and its medicinal usage |
| EP3481422A1 (en) | 2016-07-06 | 2019-05-15 | Pierre Fabre Medicament | Vinflunine and pd1 and/or pdl1 inhibitor as pharmaceutical combination |
| MA49849A (en) | 2017-08-07 | 2020-06-17 | Amgen Inc | TREATMENT OF NEGATIVE TRIPLE BREAST CANCER OR COLORECTAL CANCER CONTAINING HEPATIC METASTASIS WITH ANTI-PD-L1 ANTIBODY AND ONCOLYTIC VIRUS |
| EP3941944A4 (en) | 2019-03-20 | 2022-11-30 | The Regents of the University of California | BISPECIFIC CLAUDIN-6 ANTIBODIES |
| BR112021018608A2 (en) | 2019-03-20 | 2021-11-23 | Univ California | Antibodies to claudin-6 and drug conjugates |
| WO2020222668A1 (en) | 2019-04-30 | 2020-11-05 | Instituto de Medicina Molecular João Lobo Antunes | Rank pathway inhibitors in combination with cdk inhibitors |
| JP7763666B2 (en) | 2019-06-24 | 2025-11-04 | アムジェン インコーポレイテッド | Inhibition of SIRPγ for cancer treatment |
| FR3140369B1 (en) | 2022-10-04 | 2025-07-25 | Univ Poitiers | Process for the fluorination and/or cyclization of an alkene or amino alkyne in continuous flow and installation for implementing the process |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2296418B1 (en) * | 1974-12-30 | 1978-07-21 | Anvar | |
| US4110330A (en) * | 1977-05-27 | 1978-08-29 | Eli Lilly And Company | 5'-Acetonylvincristine and related compounds |
| US4203898A (en) * | 1977-08-29 | 1980-05-20 | Eli Lilly And Company | Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids |
| US4307100A (en) * | 1978-08-24 | 1981-12-22 | Agence Nationale De Valorisation De La Recherche (Anvar) | Nor bis-indole compounds usable as medicaments |
| US4320058A (en) * | 1980-12-29 | 1982-03-16 | Eli Lilly And Company | 20'-Hydroxyvinblastine and related compounds |
| HU193772B (en) * | 1985-06-12 | 1987-11-30 | Richter Gedeon Vegyeszet | Process for producing new nitro-bis-indole derivatives |
-
1993
- 1993-07-21 FR FR9308948A patent/FR2707988B1/en not_active Expired - Lifetime
-
1994
- 1994-07-19 NZ NZ269172A patent/NZ269172A/en not_active IP Right Cessation
- 1994-07-19 AT AT94922935T patent/ATE146477T1/en active
- 1994-07-19 CA CA002167694A patent/CA2167694C/en not_active Expired - Lifetime
- 1994-07-19 ES ES94922935T patent/ES2097659T3/en not_active Expired - Lifetime
- 1994-07-19 WO PCT/FR1994/000898 patent/WO1995003312A1/en not_active Ceased
- 1994-07-19 EP EP94922935A patent/EP0710240B1/en not_active Expired - Lifetime
- 1994-07-19 DE DE69401216T patent/DE69401216T2/en not_active Expired - Lifetime
- 1994-07-19 JP JP50497395A patent/JP3606872B2/en not_active Expired - Lifetime
- 1994-07-19 DK DK94922935.5T patent/DK0710240T3/en active
- 1994-07-19 DE DE122010000012C patent/DE122010000012I1/en active Pending
- 1994-07-19 AU AU72666/94A patent/AU693460B2/en not_active Expired
- 1994-07-19 US US08/578,669 patent/US5620985A/en not_active Expired - Lifetime
-
1997
- 1997-02-26 GR GR970400346T patent/GR3022659T3/en unknown
- 1997-04-22 BR BR1100311-1A patent/BR1100311A/en active IP Right Grant
- 1997-08-27 NZ NZ328612A patent/NZ328612A/en not_active IP Right Cessation
-
2010
- 2010-03-04 FR FR10C0012C patent/FR10C0012I2/fr active Active
- 2010-03-10 LU LU91660C patent/LU91660I2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09500634A (en) | 1997-01-21 |
| LU91660I2 (en) | 2010-05-10 |
| NZ328612A (en) | 2000-05-26 |
| EP0710240A1 (en) | 1996-05-08 |
| US5620985A (en) | 1997-04-15 |
| AU7266694A (en) | 1995-02-20 |
| WO1995003312A1 (en) | 1995-02-02 |
| ES2097659T3 (en) | 1997-04-01 |
| DE122010000012I1 (en) | 2010-07-08 |
| DK0710240T3 (en) | 1997-06-02 |
| NZ269172A (en) | 1997-10-24 |
| FR2707988A1 (en) | 1995-01-27 |
| GR3022659T3 (en) | 1997-05-31 |
| JP3606872B2 (en) | 2005-01-05 |
| AU693460B2 (en) | 1998-07-02 |
| FR2707988B1 (en) | 1995-10-13 |
| ATE146477T1 (en) | 1997-01-15 |
| DE69401216T2 (en) | 1997-07-03 |
| BR1100311A (en) | 1999-08-31 |
| FR10C0012I1 (en) | 2010-04-16 |
| DE69401216D1 (en) | 1997-01-30 |
| CA2167694C (en) | 2007-03-06 |
| CA2167694A1 (en) | 1995-02-02 |
| EP0710240B1 (en) | 1996-12-18 |