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FI981521A0 - Substituted beta diketones and their use - Google Patents

Substituted beta diketones and their use

Info

Publication number
FI981521A0
FI981521A0 FI981521A FI981521A FI981521A0 FI 981521 A0 FI981521 A0 FI 981521A0 FI 981521 A FI981521 A FI 981521A FI 981521 A FI981521 A FI 981521A FI 981521 A0 FI981521 A0 FI 981521A0
Authority
FI
Finland
Prior art keywords
treatment
relates
diseases
halogen
prevention
Prior art date
Application number
FI981521A
Other languages
Finnish (fi)
Swedish (sv)
Inventor
Paeivi Aho
Reijo Baeckstroem
Anita Koponen
Inge-Britt Linden
Timo Lotta
Kari Loennberg
Aino Pippuri
Pentti Pohto
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Priority to FI981521A priority Critical patent/FI981521A0/en
Publication of FI981521A0 publication Critical patent/FI981521A0/en
Priority to PL99344856A priority patent/PL195216B1/en
Priority to IL13996399A priority patent/IL139963A0/en
Priority to HK01106992.4A priority patent/HK1036054B/en
Priority to GEAP19995733A priority patent/GEP20032907B/en
Priority to SI9930503T priority patent/SI1091933T1/en
Priority to EA200100094A priority patent/EA002693B1/en
Priority to BR9911626-0A priority patent/BR9911626A/en
Priority to PT99934722T priority patent/PT1091933E/en
Priority to HU0103006A priority patent/HUP0103006A3/en
Priority to JP2000558072A priority patent/JP2002519407A/en
Priority to DK99934722T priority patent/DK1091933T3/en
Priority to AT99934722T priority patent/ATE255088T1/en
Priority to DE69913145T priority patent/DE69913145T2/en
Priority to AU50392/99A priority patent/AU745338B2/en
Priority to UA2001010725A priority patent/UA64805C2/en
Priority to EP99934722A priority patent/EP1091933B1/en
Priority to YUP-788/00A priority patent/RS49845B/en
Priority to CNB998080535A priority patent/CN1258526C/en
Priority to ES99934722T priority patent/ES2212590T3/en
Priority to CZ20004774A priority patent/CZ296378B6/en
Priority to CA002336300A priority patent/CA2336300A1/en
Priority to HR20000911A priority patent/HRP20000911B1/en
Priority to PCT/FI1999/000575 priority patent/WO2000001667A1/en
Priority to SK1985-2000A priority patent/SK284934B6/en
Priority to EEP200000789A priority patent/EE200000789A/en
Priority to TR2000/03773T priority patent/TR200003773T2/en
Priority to ARP990103209 priority patent/AR020103A1/en
Priority to US09/346,397 priority patent/US6201027B1/en
Priority to ZA200006961A priority patent/ZA200006961B/en
Priority to BG105080A priority patent/BG64529B1/en
Priority to IS5793A priority patent/IS2037B/en
Priority to NO20006665A priority patent/NO20006665D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Paper (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Stringed Musical Instruments (AREA)
  • Detergent Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Tents Or Canopies (AREA)

Abstract

The invention relates to the compounds of formula I:wherein one of X1 and X2 is MeSO2 and the other one is hydrogen or halogen and X3 is hydrogen or halogen. These compounds have been found to be useful in the prevention and the treatment of respiratory diseases, especially asthma, ARDS (Acute Respiratory Distress Syndrome), COPD (chronic obstructive pulmonary diseases), allergic rhinitis and related inflammatory conditions. More specifically, the invention relates to the use of said compound in the prevention and the treatment of asthma in steroid-resistant patients. The invention also relates to pharmaceutical formulations used in the treatment of said diseases.
FI981521A 1998-07-01 1998-07-01 Substituted beta diketones and their use FI981521A0 (en)

Priority Applications (33)

Application Number Priority Date Filing Date Title
FI981521A FI981521A0 (en) 1998-07-01 1998-07-01 Substituted beta diketones and their use
TR2000/03773T TR200003773T2 (en) 1998-07-01 1999-06-30 Substituted beta-Diketones and their use.
AU50392/99A AU745338B2 (en) 1998-07-01 1999-06-30 Substituted beta-diketones and their use
UA2001010725A UA64805C2 (en) 1998-07-01 1999-06-30 SUBSTITUTED b-DIKETONES AND USE THEREOF FOR THE TREATMENT OF RESPIRATORY DISEASES
HK01106992.4A HK1036054B (en) 1998-07-01 1999-06-30 Substituted beta-diketones and their use
GEAP19995733A GEP20032907B (en) 1998-07-01 1999-06-30 Substituted Beta Diketones and Their Use
SI9930503T SI1091933T1 (en) 1998-07-01 1999-06-30 Substituted beta-diketones and their use
EA200100094A EA002693B1 (en) 1998-07-01 1999-06-30 SUBSTITUTED beta-DIKETONES AND THEIR USE
BR9911626-0A BR9911626A (en) 1998-07-01 1999-06-30 B - substituted diketones and their use
PT99934722T PT1091933E (en) 1998-07-01 1999-06-30 BETA-DICHETONES AND THEIR UTILIZATION
YUP-788/00A RS49845B (en) 1998-07-01 1999-06-30 SUBSTITUTED BETA DICETONES AND THEIR USE
JP2000558072A JP2002519407A (en) 1998-07-01 1999-06-30 Substituted β-diketones and their uses
DK99934722T DK1091933T3 (en) 1998-07-01 1999-06-30 Substituted beta diketones and their use
AT99934722T ATE255088T1 (en) 1998-07-01 1999-06-30 SUBSTITUTED BETA-DIKETONES AND THEIR APPLICATION
DE69913145T DE69913145T2 (en) 1998-07-01 1999-06-30 SUBSTITUTED BETA DIKETONES AND THEIR USE
PL99344856A PL195216B1 (en) 1998-07-01 1999-06-30 Substituted beta-diketones and their use
EP99934722A EP1091933B1 (en) 1998-07-01 1999-06-30 Substituted beta-diketones and their use
CNB998080535A CN1258526C (en) 1998-07-01 1999-06-30 Substituted beta-diketones and their use
HU0103006A HUP0103006A3 (en) 1998-07-01 1999-06-30 Substituted betha-diketones, pharmaceutical compositions containing them and their use
IL13996399A IL139963A0 (en) 1998-07-01 1999-06-30 SUBSTITUTED β-DIKETONES AND THEIR USE
ES99934722T ES2212590T3 (en) 1998-07-01 1999-06-30 BETA-SUBSTITUTED DICETONES AND ITS USE.
CZ20004774A CZ296378B6 (en) 1998-07-01 1999-06-30 Substituted beta-diketones and their use
CA002336300A CA2336300A1 (en) 1998-07-01 1999-06-30 Substituted .beta.-diketones and their use
HR20000911A HRP20000911B1 (en) 1998-07-01 1999-06-30 SUBSTITUTED beta-DIKETONES AND THEIR USE
PCT/FI1999/000575 WO2000001667A1 (en) 1998-07-01 1999-06-30 SUBSTITUTED β-DIKETONES AND THEIR USE
SK1985-2000A SK284934B6 (en) 1998-07-01 1999-06-30 Substituted beta-diketones, inhalation pharmaceutical formulation and use of beta-diketones
EEP200000789A EE200000789A (en) 1998-07-01 1999-06-30 Substituted β-diketones and their use
US09/346,397 US6201027B1 (en) 1998-07-01 1999-07-01 Substituted β diketones and their use
ARP990103209 AR020103A1 (en) 1998-07-01 1999-07-01 SUBSTITUTED BETA-DICETONES, INHALABLE PHARMACEUTICAL FORMULATIONS CONTAINING THEM, USEFUL COMPOUNDS AS INTERMEDIARIES TO PREPARE SUCH REPLACED BETA-DICETONES, AND THE USE OF REPLACED BETA-DICETONES.
ZA200006961A ZA200006961B (en) 1998-07-01 2000-11-27 Substituted β-diketones and their use.
BG105080A BG64529B1 (en) 1998-07-01 2000-12-21 Substituted beta-diketones and their use
IS5793A IS2037B (en) 1998-07-01 2000-12-27 Replaces beta-diketones and their use
NO20006665A NO20006665D0 (en) 1998-07-01 2000-12-27 Substituted β-diketones and their use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI981521A FI981521A0 (en) 1998-07-01 1998-07-01 Substituted beta diketones and their use
US09/346,397 US6201027B1 (en) 1998-07-01 1999-07-01 Substituted β diketones and their use

Publications (1)

Publication Number Publication Date
FI981521A0 true FI981521A0 (en) 1998-07-01

Family

ID=26160612

Family Applications (1)

Application Number Title Priority Date Filing Date
FI981521A FI981521A0 (en) 1998-07-01 1998-07-01 Substituted beta diketones and their use

Country Status (28)

Country Link
US (1) US6201027B1 (en)
EP (1) EP1091933B1 (en)
JP (1) JP2002519407A (en)
CN (1) CN1258526C (en)
AT (1) ATE255088T1 (en)
AU (1) AU745338B2 (en)
BG (1) BG64529B1 (en)
BR (1) BR9911626A (en)
CA (1) CA2336300A1 (en)
CZ (1) CZ296378B6 (en)
DE (1) DE69913145T2 (en)
DK (1) DK1091933T3 (en)
EA (1) EA002693B1 (en)
EE (1) EE200000789A (en)
ES (1) ES2212590T3 (en)
FI (1) FI981521A0 (en)
HR (1) HRP20000911B1 (en)
HU (1) HUP0103006A3 (en)
IL (1) IL139963A0 (en)
IS (1) IS2037B (en)
NO (1) NO20006665D0 (en)
PL (1) PL195216B1 (en)
PT (1) PT1091933E (en)
SI (1) SI1091933T1 (en)
SK (1) SK284934B6 (en)
TR (1) TR200003773T2 (en)
WO (1) WO2000001667A1 (en)
ZA (1) ZA200006961B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2519601A (en) * 1999-12-30 2001-07-16 Orion Corporation A process for preparing 3-((3-chloro-4-(methylsulfonyl)-phenyl)methylene)-2,4- pentanedione
FI20011386A0 (en) * 2001-06-28 2001-06-28 Orion Corp Inhalation particles
FI20020126A0 (en) * 2002-01-23 2002-01-23 Orion Corp Compositions for pulmonary administration
SI3255043T1 (en) * 2011-07-12 2021-04-30 Astrazeneca Ab N-(6-((2r,3s)-3,4-dihydroxybutan-2-yloxy)-2-(4-fluorobenzylthio)pyrimidin-4-yl)-3- methylazetidine-1-sulfonamide as chemokine receptor modulator

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6230767A (en) 1985-08-01 1987-02-09 Taisho Pharmaceut Co Ltd Imidazole derivative
US4741769A (en) 1986-06-09 1988-05-03 Stauffer Chemical Company Certain 1-phenyl-3-alkyl-1,3-propanediones
YU213587A (en) 1986-11-28 1989-06-30 Orion Yhtymae Oy Process for obtaining new pharmacologic active cateholic derivatives
MTP1031B (en) 1987-12-24 1990-10-04 Orion Yhtymae Oy New use of cathecol-o-methyl transferase (comt) inhibitors and their physiologically acceptable salts and esters
GB9002337D0 (en) * 1990-02-02 1990-04-04 Orion Yhtymae Oy Compounds useful in treating inflammatory bowel disease
US5185370A (en) * 1988-09-01 1993-02-09 Orion-Yhtyma Oy Substituted β-diketones and their use
IL91382A (en) 1988-09-01 1995-06-29 Orion Yhtymae Oy Alkenyl or arylmethylene-substituted beta-diketones their preparation and pharmaceutical compositions containing them
US5804532A (en) * 1991-01-25 1998-09-08 Rhone-Poulenc Agriculture Limited Herbicidal 2-cyano-1,3-diones

Also Published As

Publication number Publication date
PL195216B1 (en) 2007-08-31
BG64529B1 (en) 2005-06-30
PT1091933E (en) 2004-04-30
NO20006665L (en) 2000-12-27
WO2000001667A1 (en) 2000-01-13
SI1091933T1 (en) 2004-04-30
NO20006665D0 (en) 2000-12-27
HRP20000911A2 (en) 2001-12-31
SK284934B6 (en) 2006-02-02
EA002693B1 (en) 2002-08-29
JP2002519407A (en) 2002-07-02
PL344856A1 (en) 2001-11-19
TR200003773T2 (en) 2001-06-21
CA2336300A1 (en) 2000-01-13
SK19852000A3 (en) 2002-05-09
EE200000789A (en) 2002-06-17
BR9911626A (en) 2001-03-20
EP1091933A1 (en) 2001-04-18
US6201027B1 (en) 2001-03-13
BG105080A (en) 2001-09-28
EP1091933B1 (en) 2003-11-26
ATE255088T1 (en) 2003-12-15
HUP0103006A2 (en) 2002-03-28
DE69913145D1 (en) 2004-01-08
ZA200006961B (en) 2001-08-10
ES2212590T3 (en) 2004-07-16
IS2037B (en) 2005-08-15
AU5039299A (en) 2000-01-24
CN1307559A (en) 2001-08-08
EA200100094A1 (en) 2001-06-25
IS5793A (en) 2000-12-27
HRP20000911B1 (en) 2006-07-31
HK1036054A1 (en) 2001-12-21
HUP0103006A3 (en) 2002-12-28
CN1258526C (en) 2006-06-07
CZ296378B6 (en) 2006-03-15
IL139963A0 (en) 2002-02-10
DE69913145T2 (en) 2004-09-02
DK1091933T3 (en) 2004-03-22
AU745338B2 (en) 2002-03-21
CZ20004774A3 (en) 2001-06-13

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