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FI971831L - Heterosyklillä substituoituja propeenihappojohdannaisia NMDA-antagonisteina - Google Patents

Heterosyklillä substituoituja propeenihappojohdannaisia NMDA-antagonisteina Download PDF

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Publication number
FI971831L
FI971831L FI971831A FI971831A FI971831L FI 971831 L FI971831 L FI 971831L FI 971831 A FI971831 A FI 971831A FI 971831 A FI971831 A FI 971831A FI 971831 L FI971831 L FI 971831L
Authority
FI
Finland
Prior art keywords
heterocycle
acid derivatives
propenoic acid
nmda antagonists
substituted propenoic
Prior art date
Application number
FI971831A
Other languages
English (en)
Swedish (sv)
Other versions
FI971831A7 (fi
FI971831A0 (fi
Inventor
Boyd Lynn Harrison
Philip Lee Nyce
Robert Allan Farr
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of FI971831L publication Critical patent/FI971831L/fi
Publication of FI971831A7 publication Critical patent/FI971831A7/fi
Publication of FI971831A0 publication Critical patent/FI971831A0/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
FI971831A 1994-10-31 1995-09-21 Heterosyklillä substituoituja propeenihappojohdannaisia NMDA-antagonisteina FI971831A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08332016 US5563157B1 (en) 1994-10-31 1994-10-31 Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
PCT/US1995/012085 WO1996013501A1 (en) 1994-10-31 1995-09-21 Heterocycle substituted propenoic acid derivatives as nmda antagonists

Publications (3)

Publication Number Publication Date
FI971831L true FI971831L (fi) 1997-04-29
FI971831A7 FI971831A7 (fi) 1997-04-29
FI971831A0 FI971831A0 (fi) 1997-04-29

Family

ID=23296353

Family Applications (1)

Application Number Title Priority Date Filing Date
FI971831A FI971831A0 (fi) 1994-10-31 1995-09-21 Heterosyklillä substituoituja propeenihappojohdannaisia NMDA-antagonisteina

Country Status (21)

Country Link
US (3) US5563157B1 (fi)
EP (1) EP0790994B1 (fi)
JP (1) JP3934678B2 (fi)
KR (1) KR100401138B1 (fi)
CN (1) CN1068001C (fi)
AT (1) ATE217307T1 (fi)
AU (1) AU696423B2 (fi)
CA (1) CA2202992C (fi)
DE (1) DE69526668T2 (fi)
DK (1) DK0790994T3 (fi)
ES (1) ES2173198T3 (fi)
FI (1) FI971831A0 (fi)
HU (1) HU222372B1 (fi)
IL (1) IL115791A (fi)
MX (1) MX9703146A (fi)
NO (1) NO313197B1 (fi)
NZ (1) NZ293842A (fi)
PT (1) PT790994E (fi)
TW (1) TW336232B (fi)
WO (1) WO1996013501A1 (fi)
ZA (1) ZA959046B (fi)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922752A (en) * 1997-06-11 1999-07-13 Hoechst Marion Roussell, Inc. NMDA (n-methyl-d-aspartate) antagonists
GB9902455D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
US6787651B2 (en) 2000-10-10 2004-09-07 Smithkline Beecham Corporation Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-γ binding agents
AU2002250256B2 (en) * 2001-03-08 2008-04-03 Emory University pH-dependent NMDA receptor antagonists
KR20100045983A (ko) * 2007-06-29 2010-05-04 에모리 유니버시티 신경보호를 위한 nmda 수용체 길항물질

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0539503B1 (en) * 1990-07-16 1996-04-03 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
ATE154010T1 (de) * 1990-10-15 1997-06-15 Astra Ab 2-phenyl- und 2-thienyl-(2)-piperidinderivate mit neuroprotektiven eigenschaften
US5284862A (en) * 1991-03-18 1994-02-08 Warner-Lambert Company Derivatives of 2-carboxyindoles having pharmaceutical activity
GB9208492D0 (en) * 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
HU216633B (hu) * 1993-05-27 1999-07-28 Merrel Pharmaceuticals Inc. NMDA-antagonista hatású 3-(indol-3-il)-propénsav-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
US5519048A (en) * 1993-05-27 1996-05-21 Merrell Pharmaceuticals Inc. 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
KR100401138B1 (ko) 2003-12-24
NO971991D0 (no) 1997-04-29
HUT77174A (hu) 1998-03-02
CA2202992A1 (en) 1996-05-09
ES2173198T3 (es) 2002-10-16
CN1068001C (zh) 2001-07-04
CA2202992C (en) 2003-05-13
WO1996013501A1 (en) 1996-05-09
ZA959046B (en) 1996-05-17
JP3934678B2 (ja) 2007-06-20
DK0790994T3 (da) 2002-08-26
ATE217307T1 (de) 2002-05-15
IL115791A (en) 2000-09-28
TW336232B (en) 1998-07-11
AU696423B2 (en) 1998-09-10
IL115791A0 (en) 1996-01-19
US6180786B1 (en) 2001-01-30
EP0790994B1 (en) 2002-05-08
US5981553A (en) 1999-11-09
JPH10508019A (ja) 1998-08-04
MX9703146A (es) 1997-06-28
AU3638795A (en) 1996-05-23
FI971831A7 (fi) 1997-04-29
NZ293842A (en) 1998-09-24
NO313197B1 (no) 2002-08-26
NO971991L (no) 1997-04-29
EP0790994A1 (en) 1997-08-27
PT790994E (pt) 2002-08-30
US5563157B1 (en) 1999-02-02
FI971831A0 (fi) 1997-04-29
DE69526668T2 (de) 2003-01-02
US5563157A (en) 1996-10-08
DE69526668D1 (de) 2002-06-13
HU222372B1 (hu) 2003-06-28
CN1161696A (zh) 1997-10-08

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MA Patent expired