FI960399A7 - Perhydroisoindolijohdannaisia P-aineen antagonisteina - Google Patents

Perhydroisoindolijohdannaisia P-aineen antagonisteina Download PDF

Info

Publication number: FI960399A7
Authority: FI; Finland
Prior art keywords: antagonists; substance; perhydroisoindole derivatives; perhydroisoindole; derivatives
Prior art date: 1993-07-30

Application number

FI960399A

Other languages

English (en)

Swedish (sv)

Other versions

FI960399A0 (fi

Inventor

Daniel Achard

Serge Grisoni

Evelyne James-Surcouf

Jean-Luc Malleron

Anne Morgat

Jean-Francois Peyronel

Jean-Francois Sabuco

Michel Tabart

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-30

Filing date

1996-01-29

Publication date

1996-01-29

1993-07-30 Priority claimed from FR9309400A external-priority patent/FR2709752B1/fr

1993-10-07 Priority claimed from FR9311946A external-priority patent/FR2710913B1/fr

1996-01-29 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1996-01-29 Publication of FI960399A0 publication Critical patent/FI960399A0/fi

1996-01-29 Publication of FI960399A7 publication Critical patent/FI960399A7/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FI960399A 1993-07-30 1996-01-29 Perhydroisoindolijohdannaisia P-aineen antagonisteina FI960399A7 (fi)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9309400A FR2709752B1 (fr)	1993-07-30	1993-07-30	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR9311946A FR2710913B1 (fr)	1993-10-07	1993-10-07	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
PCT/FR1994/000952 WO1995004040A1 (fr)	1993-07-30	1994-07-28	Derives de perhydroisoindole comme antagonistes de la substance p

Publications (2)

Publication Number	Publication Date
FI960399A0 FI960399A0 (fi)	1996-01-29
FI960399A7 true FI960399A7 (fi)	1996-01-29

Family

ID=26230522

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI960399A FI960399A7 (fi)	1993-07-30	1996-01-29	Perhydroisoindolijohdannaisia P-aineen antagonisteina

Country Status (19)

Country	Link
US (1)	US5624950A (fi)
EP (1)	EP0711280B1 (fi)
JP (1)	JPH09500893A (fi)
KR (1)	KR960703858A (fi)
AT (1)	ATE171445T1 (fi)
AU (1)	AU7386594A (fi)
CA (1)	CA2168233A1 (fi)
CZ (1)	CZ26396A3 (fi)
DE (1)	DE69413542T2 (fi)
DK (1)	DK0711280T3 (fi)
ES (1)	ES2123149T3 (fi)
FI (1)	FI960399A7 (fi)
HU (1)	HUT75304A (fi)
IL (1)	IL110494A0 (fi)
NO (1)	NO960365L (fi)
PL (1)	PL312739A1 (fi)
SK (1)	SK13096A3 (fi)
TW (1)	TW365603B (fi)
WO (1)	WO1995004040A1 (fi)

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US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
MXPA02004330A (es)	1999-11-03	2004-07-30	Albany Molecular Res Inc	Tetrahidroisoquinolinas aril-y heteroaril-sustituidas y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina..
CN100430401C (zh)	2000-07-11	2008-11-05	Amr科技公司	新的4-苯基取代的四氢异喹啉类化合物及其治疗用途
CN103880827B (zh)	2004-07-15	2017-01-04	阿尔巴尼分子研究公司	芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用
EP1888050B1 (en)	2005-05-17	2012-03-21	Merck Sharp & Dohme Ltd.	cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid for the treatment of cancer
UA95454C2 (uk)	2005-07-15	2011-08-10	Амр Текнолоджи, Інк.	Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну
BRPI0616463A2 (pt)	2005-09-29	2011-06-21	Merck & Co Inc	composto, composição farmacêutica, e, uso de um composto
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
US7265247B1 (en)	2006-07-28	2007-09-04	Im&T Research, Inc.	Substituted phenylsulfur trifluoride and other like fluorinating agents
EP2698157B1 (en)	2006-09-22	2015-05-20	Merck Sharp & Dohme Corp.	Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
RS51780B (sr)	2007-01-10	2011-12-31	Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L.	Indazoli supstituisani amidom kao inhibitori poli(adp-riboza)polimeraze (parp)
KR20140061493A (ko)	2007-03-23	2014-05-21	우베 인더스트리즈 리미티드	아릴설퍼 펜타플루오라이드의 제조공정
US8399720B2 (en)	2007-03-23	2013-03-19	Ube Industries, Ltd.	Methods for producing fluorinated phenylsulfur pentafluorides
JP5319518B2 (ja)	2007-04-02	2013-10-16	Ｍｓｄ株式会社	インドールジオン誘導体
WO2009002495A1 (en)	2007-06-27	2008-12-31	Merck & Co., Inc.	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US8030516B2 (en)	2007-10-19	2011-10-04	Ube Industries, Ltd.	Methods for producing perfluoroalkanedi(sulfonyl chloride)
AU2009222122A1 (en)	2008-03-03	2009-09-11	Tiger Pharmatech	Tyrosine kinase inhibitors
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
EP2334661B1 (en)	2008-09-22	2017-08-30	Ube Industries, Ltd.	Processes for preparing poly(pentafluorosulfanyl)aromatic compounds
US8203003B2 (en)	2009-01-09	2012-06-19	Ube Industries, Ltd.	4-fluoropyrrolidine-2-carbonyl fluoride compounds and their preparative methods
EP2413932A4 (en)	2009-04-01	2012-09-19	Merck Sharp & Dohme	HAMMER OF ACT ACTIVITY
EP2429295B1 (en)	2009-05-12	2013-12-25	Albany Molecular Research, Inc.	Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
US8815894B2 (en)	2009-05-12	2014-08-26	Bristol-Myers Squibb Company	Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
KR101830447B1 (ko)	2009-05-12	2018-02-20	알바니 몰레큘라 리써치, 인크.	7-(［1,2,4］트리아졸로［1,5-α］피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린 및 이의 용도
UA109417C2 (uk)	2009-10-14	2015-08-25	Мерк Шарп Енд Доме Корп.	ЗАМІЩЕНІ ПІПЕРИДИНИ, ЯКІ ПІДВИЩУЮТЬ АКТИВНІСТЬ p53, І ЇХ ЗАСТОСУВАННЯ
US8999957B2 (en)	2010-06-24	2015-04-07	Merck Sharp & Dohme Corp.	Heterocyclic compounds as ERK inhibitors
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US9351965B2 (en)	2010-12-21	2016-05-31	Merck Sharp & Dohme Corp.	Indazole derivatives useful as ERK inhibitors
WO2012143879A1 (en)	2011-04-21	2012-10-26	Piramal Healthcare Limited	A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
US9023865B2 (en)	2011-10-27	2015-05-05	Merck Sharp & Dohme Corp.	Compounds that are ERK inhibitors
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SI2925888T1 (en)	2012-11-28	2018-02-28	Merck Sharp & Dohme Corp.	Compounds and methods for the treatment of cancer
TW201429969A (zh)	2012-12-20	2014-08-01	Merck Sharp & Dohme	作爲ｈｄｍ２抑制劑之經取代咪唑吡啶
EP2951180B1 (en)	2013-01-30	2018-05-02	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
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Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2654726B1 (fr) *	1989-11-23	1992-02-14	Rhone Poulenc Sante	Nouveaux derives de l'isoindolone et leur preparation.
FR2654725B1 (fr) *	1989-11-23	1992-02-14	Rhone Poulenc Sante	Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2676442B1 (fr) *	1991-05-17	1993-08-06	Rhone Poulenc Rorer Sa	Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2676443B1 (fr) *	1991-05-17	1993-08-06	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole et leur preparation.
FR2689888B1 (fr) *	1992-04-10	1994-06-10	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689889B1 (fr) *	1992-04-10	1994-06-10	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, et leur preparation.

1994
- 1994-07-21 TW TW083106682A patent/TW365603B/zh active
- 1994-07-28 DE DE69413542T patent/DE69413542T2/de not_active Expired - Fee Related
- 1994-07-28 HU HU9503986A patent/HUT75304A/hu unknown
- 1994-07-28 EP EP94923755A patent/EP0711280B1/fr not_active Expired - Lifetime
- 1994-07-28 ES ES94923755T patent/ES2123149T3/es not_active Expired - Lifetime
- 1994-07-28 IL IL11049494A patent/IL110494A0/xx unknown
- 1994-07-28 SK SK130-96A patent/SK13096A3/sk unknown
- 1994-07-28 KR KR1019960700531A patent/KR960703858A/ko not_active Withdrawn
- 1994-07-28 CZ CZ96263A patent/CZ26396A3/cs unknown
- 1994-07-28 WO PCT/FR1994/000952 patent/WO1995004040A1/fr not_active Ceased
- 1994-07-28 AU AU73865/94A patent/AU7386594A/en not_active Abandoned
- 1994-07-28 CA CA002168233A patent/CA2168233A1/fr not_active Abandoned
- 1994-07-28 AT AT94923755T patent/ATE171445T1/de not_active IP Right Cessation
- 1994-07-28 US US08/586,708 patent/US5624950A/en not_active Expired - Fee Related
- 1994-07-28 PL PL94312739A patent/PL312739A1/xx unknown
- 1994-07-28 DK DK94923755T patent/DK0711280T3/da active
- 1994-07-28 JP JP7505618A patent/JPH09500893A/ja active Pending
1996
- 1996-01-29 NO NO960365A patent/NO960365L/no unknown
- 1996-01-29 FI FI960399A patent/FI960399A7/fi unknown

Also Published As

Publication number	Publication date
ATE171445T1 (de)	1998-10-15
WO1995004040A1 (fr)	1995-02-09
AU7386594A (en)	1995-02-28
CZ26396A3 (en)	1996-05-15
HUT75304A (en)	1997-05-28
FI960399A0 (fi)	1996-01-29
US5624950A (en)	1997-04-29
EP0711280B1 (fr)	1998-09-23
ES2123149T3 (es)	1999-01-01
IL110494A0 (en)	1994-10-21
NO960365D0 (no)	1996-01-29
DE69413542D1 (de)	1998-10-29
CA2168233A1 (fr)	1995-02-09
DK0711280T3 (da)	1999-06-14
NO960365L (no)	1996-01-29
EP0711280A1 (fr)	1996-05-15
DE69413542T2 (de)	1999-03-25
SK13096A3 (en)	1996-09-04
KR960703858A (ko)	1996-08-31
HU9503986D0 (en)	1996-03-28
PL312739A1 (en)	1996-05-13
JPH09500893A (ja)	1997-01-28
TW365603B (en)	1999-08-01

Publication	Publication Date	Title
FI960399A7 (fi)	1996-01-29	Perhydroisoindolijohdannaisia P-aineen antagonisteina
FI944729L (fi)	1994-10-07	Perhydroisoindolijohdannaiset substanssi P:n antagonisteina
FI960156A7 (fi)	1996-01-12	Bentsyylioksikinuklidiinit aineet P antagonisteina
NL350032I2 (nl)	2007-10-01	Pyrazool-4-yl-benzoylderivaten de toepassing ervanals herbiciden
FI960840A7 (fi)	1996-02-23	Indolijohdannaisia tromboksaani-A2-antagonisteina
FI944394A7 (fi)	1994-09-22	Kinuklidiinijohdannaisia P-aineen antagonisteina
FI945555L (fi)	1995-05-27	Substituoituja oksindoleja
FI944969A7 (fi)	1995-04-23	Indolijohdannaisia
DE69325658D1 (de)	1999-08-19	Substituierte thiazolidindion derivate
BR9612465A (pt)	1999-07-13	Compostos heterocíclicos
ATE258166T1 (de)	2004-02-15	Substituierte benzylaminpiperidin-verbindungen
FI933001L (fi)	1994-01-07	Antigastrit-aemne
FI943976A7 (fi)	1995-03-01	5-aryyli-indolijohdannaiset
FI961628A7 (fi)	1996-04-12	Indolijohdannaisia NMDA-antagonisteina
FI960516A7 (fi)	1996-08-07	Substituoituja bifenyylisulfonamidiendoteliiniantagonisteja
FI973207A7 (fi)	1997-10-01	Heterosyklisiä yhdisteitä
FI945674L (fi)	1995-06-03	Substituoidut 2beta-morfoliini-androstaanijohdannaiset
FI950089A7 (fi)	1995-03-07	Dioksosyklobuteenijohdannaiset angiotensiini-II-antagonisteina
DE59405008D1 (de)	1998-02-19	Dosierpalette
FI942444A7 (fi)	1994-11-28	Terahydropyraanijohdannaisia
ATA181095A (de)	1998-11-15	Probiotisch wirksame formulierung
FI943885L (fi)	1995-02-25	Penaami-johdannaiset
FI944044L (fi)	1995-03-03	Fenyylialkanoliamiinijohdannaiset
FI961844L (fi)	1996-04-30	Fenyyli-indoliyhdisteitä
EE03615B1 (et)	2002-02-15	Pürasool-4-üülhetaroüülderivaadid herbitsiididena