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FI943728A0 - Enkefalinaasin ja ACE:n inhibiittoreina käyttökelpoisia uusia aminoasetyylimerkaptojohdannaisia - Google Patents

Enkefalinaasin ja ACE:n inhibiittoreina käyttökelpoisia uusia aminoasetyylimerkaptojohdannaisia

Info

Publication number
FI943728A0
FI943728A0 FI943728A FI943728A FI943728A0 FI 943728 A0 FI943728 A0 FI 943728A0 FI 943728 A FI943728 A FI 943728A FI 943728 A FI943728 A FI 943728A FI 943728 A0 FI943728 A0 FI 943728A0
Authority
FI
Finland
Prior art keywords
enkephalinase
aminoacetylmercato
new
derivatives useful
ace inhibitors
Prior art date
Application number
FI943728A
Other languages
English (en)
Swedish (sv)
Other versions
FI943728L (fi
FI106717B (fi
Inventor
Gary A Flynn
Robert J Cregge
Thomas L Fevig
Shyam Sunder
Patrick W Shum
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI943728L publication Critical patent/FI943728L/fi
Publication of FI943728A0 publication Critical patent/FI943728A0/fi
Application granted granted Critical
Publication of FI106717B publication Critical patent/FI106717B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI943728A 1992-02-14 1994-08-12 Menetelmä terapeuttisesti aktiivisten 7-aminoasetyylimerkaptoasetyyliamidioktahydro-6-oksopyridiini[2,1a] [2] - bentsatsepiini- ja heksahydro-6-okso-1H- [1,4] -oksatsiini - [3,4-a] [2]bentsatsepiini-ja heksahydro-6-okso-1H-[1,4] - tiatsiini[3,4-a] [2]bentsatsepiini-4-karboksyylihappojen ja niiden farmaseuttisesti hyväksyttävien suolojen valmistamiseksi FI106717B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US83602892A 1992-02-14 1992-02-14
US83602892 1992-02-14
US98567892A 1992-12-11 1992-12-11
US98567892 1992-12-11
US9300153 1993-01-08
PCT/US1993/000153 WO1993016103A1 (en) 1992-02-14 1993-01-08 Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace

Publications (3)

Publication Number Publication Date
FI943728L FI943728L (fi) 1994-08-12
FI943728A0 true FI943728A0 (fi) 1994-08-12
FI106717B FI106717B (fi) 2001-03-30

Family

ID=27125838

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943728A FI106717B (fi) 1992-02-14 1994-08-12 Menetelmä terapeuttisesti aktiivisten 7-aminoasetyylimerkaptoasetyyliamidioktahydro-6-oksopyridiini[2,1a] [2] - bentsatsepiini- ja heksahydro-6-okso-1H- [1,4] -oksatsiini - [3,4-a] [2]bentsatsepiini-ja heksahydro-6-okso-1H-[1,4] - tiatsiini[3,4-a] [2]bentsatsepiini-4-karboksyylihappojen ja niiden farmaseuttisesti hyväksyttävien suolojen valmistamiseksi

Country Status (18)

Country Link
US (3) US5424425A (fi)
EP (1) EP0625987B1 (fi)
JP (1) JP3460838B2 (fi)
KR (1) KR100276029B1 (fi)
AT (1) ATE164593T1 (fi)
AU (1) AU668707B2 (fi)
CA (1) CA2130116C (fi)
DE (1) DE69317764T2 (fi)
DK (1) DK0625987T3 (fi)
ES (1) ES2117123T3 (fi)
FI (1) FI106717B (fi)
HU (1) HU220596B1 (fi)
IL (1) IL104716A (fi)
MX (1) MX9300777A (fi)
NO (1) NO311524B1 (fi)
NZ (1) NZ246811A (fi)
TW (1) TW225534B (fi)
WO (1) WO1993016103A1 (fi)

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HU220596B1 (hu) * 1992-02-14 2002-03-28 Merrell Dow Pharmaceuticals Inc. 7-Szubsztituált pirido-benzazepin-karbonsav-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
CA2140553A1 (en) * 1993-06-11 1994-12-22 Hitoshi Oinuma Amino acid derivative
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
DE69516128T2 (de) * 1994-02-14 2000-12-21 Merrell Pharmaceuticals Inc., Cincinnati Mercaptoacetylamid-1,3,4,5-tetrahydrobenzo(c)azepin-3-ein disulfidderivate als enkephalinase und ace inhibitoren
CA2183314C (en) * 1994-02-14 1999-08-31 Gary A. Flynn Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
FI963168A0 (fi) * 1994-02-14 1996-08-13 Merrell Pharma Inc Enkefalinaasin inhibiittoreina käyttökelpoisia uusia indaani-2-merkaptoasetyyliamiddisulfidijohdannaisia
CA2184696C (en) * 1994-03-24 2001-01-02 Gary A. Flynn Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives
US5616775A (en) * 1994-05-05 1997-04-01 Bristol-Myers Squibb Co. Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US6245764B1 (en) 1995-03-24 2001-06-12 Molecumetics Ltd. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6020331A (en) * 1995-03-24 2000-02-01 Molecumetics, Ltd. β-sheet mimetics and use thereof as protease inhibitors
US6699869B1 (en) 1995-03-24 2004-03-02 Myriad Genetics Inc. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US6117896A (en) * 1997-02-10 2000-09-12 Molecumetics Ltd. Methods for regulating transcription factors
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
WO1999041276A1 (en) * 1998-02-12 1999-08-19 Molecumetics Ltd. β-SHEET MIMETICS AND METHODS RELATING TO THE USE THEREOF
US6248729B1 (en) 1998-06-17 2001-06-19 Bristol-Myers Squibb Co. Combination of an ADP-receptor blocking antiplatelet drug and antihypertensive drug and a method for preventing a cerebral infarction employing such combination
US6486193B2 (en) 1998-12-31 2002-11-26 Aventis Pharmaceuticals Inc. 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases
AU1836900A (en) * 1998-12-31 2000-07-24 Aventis Pharmaceuticals Inc. N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase
DE69905621T2 (de) * 1998-12-31 2003-11-27 Aventis Pharmaceuticals Inc., Bridgewater 3-(thio-substituierte amido)-lactame, verwendbar als inhibitoren der matrix-metalloproteinase
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
CN1642550A (zh) 2002-02-14 2005-07-20 美瑞德生物工程公司 β－折叠模拟物和组合物及其有关方法
DE10229180A1 (de) * 2002-06-28 2004-01-29 Aventis Pharma Deutschland Gmbh Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen

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US3334091A (en) * 1965-03-25 1967-08-01 Sandoz Ag Sedatives
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IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
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ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
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CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
EP0605589A1 (en) * 1991-09-16 1994-07-13 Schering Corporation Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation
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HU220596B1 (hu) * 1992-02-14 2002-03-28 Merrell Dow Pharmaceuticals Inc. 7-Szubsztituált pirido-benzazepin-karbonsav-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds

Also Published As

Publication number Publication date
CA2130116C (en) 1998-04-07
FI943728L (fi) 1994-08-12
EP0625987B1 (en) 1998-04-01
HU220596B1 (hu) 2002-03-28
DE69317764D1 (de) 1998-05-07
JPH07503955A (ja) 1995-04-27
ES2117123T3 (es) 1998-08-01
HU9402355D0 (en) 1994-10-28
US5529995A (en) 1996-06-25
IL104716A0 (en) 1993-06-10
AU668707B2 (en) 1996-05-16
CA2130116A1 (en) 1993-08-19
JP3460838B2 (ja) 2003-10-27
NZ246811A (en) 1996-02-27
NO311524B1 (no) 2001-12-03
NO942994L (no) 1994-10-13
DK0625987T3 (da) 1999-01-11
TW225534B (fi) 1994-06-21
EP0625987A1 (en) 1994-11-30
WO1993016103A1 (en) 1993-08-19
AU3439193A (en) 1993-09-03
IL104716A (en) 1997-09-30
NO942994D0 (no) 1994-08-12
HUT71105A (en) 1995-11-28
US5424425A (en) 1995-06-13
MX9300777A (es) 1993-08-01
US5488048A (en) 1996-01-30
KR950700323A (ko) 1995-01-16
KR100276029B1 (ko) 2000-12-15
FI106717B (fi) 2001-03-30
DE69317764T2 (de) 1998-07-30
ATE164593T1 (de) 1998-04-15

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