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FI943122L - Menetelmiä trombiinin tuottamiseksi - Google Patents

Menetelmiä trombiinin tuottamiseksi Download PDF

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Publication number
FI943122L
FI943122L FI943122A FI943122A FI943122L FI 943122 L FI943122 L FI 943122L FI 943122 A FI943122 A FI 943122A FI 943122 A FI943122 A FI 943122A FI 943122 L FI943122 L FI 943122L
Authority
FI
Finland
Prior art keywords
methods
producing thrombin
thrombin
producing
Prior art date
Application number
FI943122A
Other languages
English (en)
Swedish (sv)
Other versions
FI943122A0 (fi
FI117831B (fi
Inventor
Richard D Holly
Donald C Foster
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of FI943122A0 publication Critical patent/FI943122A0/fi
Publication of FI943122L publication Critical patent/FI943122L/fi
Application granted granted Critical
Publication of FI117831B publication Critical patent/FI117831B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
FI943122A 1991-12-31 1994-06-29 Menetelmiä trombiinin tuottamiseksi FI117831B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US81628191A 1991-12-31 1991-12-31
US81628191 1991-12-31
US86070192A 1992-03-31 1992-03-31
US86070192 1992-03-31
US9211357 1992-12-30
PCT/US1992/011357 WO1993013208A1 (en) 1991-12-31 1992-12-30 Methods for producing thrombin

Publications (3)

Publication Number Publication Date
FI943122A0 FI943122A0 (fi) 1994-06-29
FI943122L true FI943122L (fi) 1994-06-29
FI117831B FI117831B (fi) 2007-03-15

Family

ID=27124054

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943122A FI117831B (fi) 1991-12-31 1994-06-29 Menetelmiä trombiinin tuottamiseksi

Country Status (13)

Country Link
US (2) US5476777A (fi)
EP (1) EP0624199B1 (fi)
JP (1) JP3404038B2 (fi)
AT (1) ATE179754T1 (fi)
AU (1) AU683834B2 (fi)
CA (1) CA2125783C (fi)
DE (1) DE69229126T2 (fi)
DK (1) DK0624199T3 (fi)
ES (1) ES2134836T3 (fi)
FI (1) FI117831B (fi)
GR (1) GR3030820T3 (fi)
NO (1) NO317018B1 (fi)
WO (1) WO1993013208A1 (fi)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5457294A (en) * 1992-10-29 1994-05-24 Board Of Regents, The University Of Texas System Adenovirus-mediated ldl receptor gene transfer and targeting
DE19710190A1 (de) * 1997-03-12 1998-09-17 Immuno Ag Aktivierter Vitamin K-abhängiger Blutfaktor und Verfahren zu dessen Herstellung
US6096309A (en) * 1997-06-18 2000-08-01 Cohesion Technologies, Inc. Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparation and use thereof
US20030207402A1 (en) * 1997-08-22 2003-11-06 Erhard Kopetzki Autocatalytically activatable zymogenic precursors of proteases and their use
JP2002506038A (ja) * 1998-03-10 2002-02-26 バクスター・インターナショナル・インコーポレイテッド トロンビン調製およびトロンビン産物ならびにそれを使用するフィブリンシーラント方法
WO1999058699A2 (en) * 1998-05-14 1999-11-18 Battelle Memorial Institute Transgenic plant-derived human blood coagulation factors
US20030096771A1 (en) * 2001-07-26 2003-05-22 Butler Madeline M. Antisense modulation of hormone-sensitive lipase expression
KR20000018933A (ko) * 1998-09-07 2000-04-06 김승수 내피세포 성장억제 활성을 가지는 사람 프로트롬빈 크링글단백질 및 이를 암호하는 유전자
IL129427A0 (en) * 1999-04-13 2000-02-17 Yeda Res & Dev Preparation of biologically active molecules
WO2001011952A1 (en) * 1999-08-19 2001-02-22 Us Transgenics, Inc. Transgenic prothrombin and related thrombin precursors and transgenics, methods, compositions, uses and the like relating thereto
KR20040080940A (ko) * 2001-05-14 2004-09-20 덴드레온 코포레이션 트랜스막 세린 프로테아제 10을 암호화하는 핵산 분자,암호화된 폴리펩티드 및 이에 근거한 방법
AU2003211128A1 (en) * 2002-02-20 2003-09-09 American Integrated Biologics, Inc. Transgenic production in saliva
US8529956B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US20100254900A1 (en) * 2002-03-18 2010-10-07 Campbell Phil G Biocompatible polymers and Methods of use
US20030175410A1 (en) * 2002-03-18 2003-09-18 Campbell Phil G. Method and apparatus for preparing biomimetic scaffold
US8293530B2 (en) * 2006-10-17 2012-10-23 Carnegie Mellon University Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
ES2226587B1 (es) 2004-10-22 2005-12-16 Probitas Pharma, S.A. Composicion de trombina estable.
US20070011752A1 (en) * 2005-05-06 2007-01-11 American Integrated Biologics, Inc. Production of human proteins in transgenic animal saliva
US20060270014A1 (en) * 2005-05-26 2006-11-30 Dan Pawlak Thrombin purification
US20060270015A1 (en) * 2005-05-26 2006-11-30 Dan Pawlak Thrombin purification
US7825231B2 (en) * 2005-06-01 2010-11-02 Darren P. Wolfe Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy
JP5475283B2 (ja) 2005-07-28 2014-04-16 カーネギー メロン ユニバーシティ 生体適合性ポリマーおよび使用方法
AU2006298160A1 (en) 2005-09-30 2007-04-12 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Process for preparing recombinant human thrombin with culture cell
CA2644926A1 (en) * 2006-03-06 2007-09-13 Humagene, Inc. A method for the preparation of recombinant human thrombin and fibrinogen
US8529958B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US20100062981A1 (en) * 2007-01-31 2010-03-11 Anders Jeppsson Use of fibrinogen as a prophylactic treatment to prevent bleeding during and after surgery and as a biomarker to identify patient with an increased risk for excessive bleeding and blood transfusion
US20090101809A1 (en) * 2007-09-05 2009-04-23 Zymogenetics, Inc. Mass spectrometry-based quantitative assay for determining abundance of molecular species in a composition
CA2721462C (en) * 2008-04-25 2019-02-05 Zymogenetics, Inc. Medical devices for delivering fluids during surgery and methods for their use
WO2014115087A2 (en) 2013-01-22 2014-07-31 Cencor Biotech Ltd. A method for the preparation of recombinant human prothrombin and fibrinogen
WO2020229521A1 (en) 2019-05-14 2020-11-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for inhibiting or reducing bacterial biofilms on a surface

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910005081B1 (ko) * 1988-09-23 1991-07-22 삼성전관 주식회사 칼라브라운관의 형광면 제작방법
FI923347A0 (fi) * 1990-01-26 1992-07-23 Immuno Ag Blodfaktorer producerade med rekombinant-dna-teknik och foerfarande foer expression av naemnda blodfaktorer samt i naemnda foerfarande anvaenda rekombinanta kokoppvirus.
EP0443724B1 (en) * 1990-02-20 1999-03-17 Baxter International Inc. Viral-safe purified human thrombin

Also Published As

Publication number Publication date
FI943122A0 (fi) 1994-06-29
DE69229126D1 (de) 1999-06-10
CA2125783A1 (en) 1993-07-08
NO942456D0 (no) 1994-06-29
ES2134836T3 (es) 1999-10-16
FI117831B (fi) 2007-03-15
NO942456L (no) 1994-06-29
ATE179754T1 (de) 1999-05-15
US5476777A (en) 1995-12-19
EP0624199B1 (en) 1999-05-06
DE69229126T2 (de) 1999-12-30
US5502034A (en) 1996-03-26
CA2125783C (en) 2003-03-25
DK0624199T3 (da) 1999-11-01
JPH07502659A (ja) 1995-03-23
WO1993013208A1 (en) 1993-07-08
AU3428793A (en) 1993-07-28
GR3030820T3 (en) 1999-11-30
AU683834B2 (en) 1997-11-27
JP3404038B2 (ja) 2003-05-06
EP0624199A1 (en) 1994-11-17
NO317018B1 (no) 2004-07-26

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