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FI942768L - Syklopropyyli-N-hydroksiurea ja N-hydroksiasetamidit, jotka inhiboivat lipoksygenaasia - Google Patents

Syklopropyyli-N-hydroksiurea ja N-hydroksiasetamidit, jotka inhiboivat lipoksygenaasia Download PDF

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Publication number
FI942768L
FI942768L FI942768A FI942768A FI942768L FI 942768 L FI942768 L FI 942768L FI 942768 A FI942768 A FI 942768A FI 942768 A FI942768 A FI 942768A FI 942768 L FI942768 L FI 942768L
Authority
FI
Finland
Prior art keywords
hydroxyacetamides
hydroxyurea
cyclopropyl
inhibit lipoxygenase
lipoxygenase
Prior art date
Application number
FI942768A
Other languages
English (en)
Swedish (sv)
Other versions
FI942768A0 (fi
FI942768A7 (fi
Inventor
Takafumi Ikeda
Akiyoshi Kawai
Takashi Mano
Yoshiyuki Okumura
Rodney W Stevens
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI942768L publication Critical patent/FI942768L/fi
Publication of FI942768A0 publication Critical patent/FI942768A0/fi
Publication of FI942768A7 publication Critical patent/FI942768A7/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43Y being a hetero atom
    • C07C323/44X or Y being nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
FI942768A 1991-12-13 1992-10-27 Syklopropyyli-N-hydroksiurea ja N-hydroksiasetamidit, jotka inhiboivat lipoksygenaasia FI942768A7 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3330485A JPH05163229A (ja) 1991-12-13 1991-12-13 新規なシクロプロピル誘導体
PCT/US1992/008979 WO1993012077A1 (en) 1991-12-13 1992-10-27 Cyclopropyl n-hydroxyurea and n-hydroxyacetamides which inhibit lipoxygenase

Publications (3)

Publication Number Publication Date
FI942768L true FI942768L (fi) 1994-06-10
FI942768A0 FI942768A0 (fi) 1994-06-10
FI942768A7 FI942768A7 (fi) 1994-06-10

Family

ID=18233155

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942768A FI942768A7 (fi) 1991-12-13 1992-10-27 Syklopropyyli-N-hydroksiurea ja N-hydroksiasetamidit, jotka inhiboivat lipoksygenaasia

Country Status (11)

Country Link
EP (1) EP0625140B1 (fi)
JP (1) JPH05163229A (fi)
AT (1) ATE146167T1 (fi)
CA (1) CA2124835C (fi)
DE (1) DE69215900T2 (fi)
DK (1) DK0625140T3 (fi)
ES (1) ES2094935T3 (fi)
FI (1) FI942768A7 (fi)
GR (1) GR3022010T3 (fi)
PT (1) PT101120A (fi)
WO (1) WO1993012077A1 (fi)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW418089B (en) * 1993-08-19 2001-01-11 Pfizer Pharmaceutical composition comprising phenoxyphenyl cyclopentenyl hydroxyureas (the dextrorotary isomers)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0456760A4 (en) * 1989-02-01 1992-01-08 Abbott Laboratories Lipoxygenase inhibiting compounds
US5120752A (en) * 1989-12-28 1992-06-09 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
US5220059A (en) * 1990-04-19 1993-06-15 Abbott Laboratories Lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids

Also Published As

Publication number Publication date
ES2094935T3 (es) 1997-02-01
GR3022010T3 (en) 1997-03-31
DE69215900D1 (en) 1997-01-23
CA2124835A1 (en) 1993-06-24
DE69215900T2 (de) 1997-04-03
JPH05163229A (ja) 1993-06-29
WO1993012077A1 (en) 1993-06-24
DK0625140T3 (da) 1996-12-30
FI942768A0 (fi) 1994-06-10
ATE146167T1 (de) 1996-12-15
EP0625140B1 (en) 1996-12-11
PT101120A (pt) 1994-03-31
FI942768A7 (fi) 1994-06-10
EP0625140A1 (en) 1994-11-23
CA2124835C (en) 1998-04-28

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