FI941766L - sPLA2:n 1H-indoli-3-etikkahappohydratsidi-inhibiittoreita - Google Patents

sPLA2:n 1H-indoli-3-etikkahappohydratsidi-inhibiittoreita Download PDF

Info

Publication number: FI941766L
Authority: FI; Finland
Prior art keywords: spla2; indole; acetic acid; acid hydrazide; inhibitors
Prior art date: 1993-04-16

Application number

FI941766A

Other languages

English (en)

Swedish (sv)

Other versions

FI941766A7 (fi

FI941766A0 (fi

Inventor

Nicholas James Bach

Robert Delane Dillard

Susan Elizabeth Draheim

Robert Bell Hermann

Richard Walter Schevitz

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-16

Filing date

1994-04-15

Publication date

1994-10-17

1994-04-15 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1994-04-15 Publication of FI941766A0 publication Critical patent/FI941766A0/fi

1994-10-17 Publication of FI941766A7 publication Critical patent/FI941766A7/fi

1994-10-17 Publication of FI941766L publication Critical patent/FI941766L/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Oncology (AREA)
Child & Adolescent Psychology (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicinal Preparation (AREA)

FI941766A 1993-04-16 1994-04-15 sPLA2:n 1H-indoli-3-etikkahappohydratsidi-inhibiittoreita FI941766L (fi)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US4860893A	1993-04-16	1993-04-16

Publications (3)

Publication Number	Publication Date
FI941766A0 FI941766A0 (fi)	1994-04-15
FI941766A7 FI941766A7 (fi)	1994-10-17
FI941766L true FI941766L (fi)	1994-10-17

Family

ID=21955471

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI941766A FI941766L (fi)	1993-04-16	1994-04-15	sPLA2:n 1H-indoli-3-etikkahappohydratsidi-inhibiittoreita

Country Status (27)

Country	Link
US (1)	US5578634A (fi)
EP (1)	EP0620214B1 (fi)
JP (1)	JP3621128B2 (fi)
KR (1)	KR100330816B1 (fi)
CN (1)	CN1067986C (fi)
AT (1)	ATE177081T1 (fi)
AU (1)	AU669782B2 (fi)
BR (1)	BR9401484A (fi)
CA (1)	CA2121321A1 (fi)
CO (1)	CO4230091A1 (fi)
CZ (1)	CZ289791B6 (fi)
DE (1)	DE69416705T2 (fi)
DK (1)	DK0620214T3 (fi)
ES (1)	ES2128510T3 (fi)
FI (1)	FI941766L (fi)
GR (1)	GR3029689T3 (fi)
HU (1)	HU220221B (fi)
IL (1)	IL109309A (fi)
NO (1)	NO300210B1 (fi)
NZ (1)	NZ260299A (fi)
PL (1)	PL179472B1 (fi)
RU (1)	RU2127725C1 (fi)
SI (1)	SI0620214T1 (fi)
TW (1)	TW306914B (fi)
UA (1)	UA40575C2 (fi)
YU (1)	YU20094A (fi)
ZA (1)	ZA942614B (fi)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI0675110T1 (en) *	1994-04-01	2002-12-31	Eli Lilly And Company	1H-Indole-3-glyoxylamide sPLA2 inhibitors
US5641800A (en) *	1994-07-21	1997-06-24	Eli Lilly And Company	1H-indole-1-functional sPLA2 inhibitors
US6214876B1 (en)	1994-07-21	2001-04-10	Eli Lilly And Company	Indene-1-acetamide sPLA2 inhibitors
JP2000515529A (ja) *	1996-08-01	2000-11-21	メルクル・ゲーエムベーハー	細胞質ホスホリパーゼａ▲下２▼の阻害剤としてのアシルピロリドンジカルボン酸およびアシルインドールジカルボン酸ならびにその誘導体
US6630496B1 (en)	1996-08-26	2003-10-07	Genetics Institute Llc	Inhibitors of phospholipase enzymes
US6713645B1 (en) *	1996-10-30	2004-03-30	Eli Lilly And Company	Substituted tricyclics
PL332896A1 (en) *	1996-10-30	1999-10-25	Lilly Co Eli	Substituted tricyclic compounds
US6177440B1 (en)	1996-10-30	2001-01-23	Eli Lilly And Company	Substituted tricyclics
CA2279211A1 (en) *	1997-02-20	1998-08-27	Shionogi & Co., Ltd.	Indole dicarboxylic acid derivatives
US6828344B1 (en)	1998-02-25	2004-12-07	Genetics Institute, Llc	Inhibitors of phospholipase enzymes
US6916841B2 (en) *	1998-02-25	2005-07-12	Genetics Institute, Llc	Inhibitors of phospholipase enzymes
JP2002504541A (ja) *	1998-02-25	2002-02-12	ジェネティックス・インスチチュート・インコーポレーテッド	ホスホリパーゼ酵素阻害剤
US6500853B1 (en)	1998-02-28	2002-12-31	Genetics Institute, Llc	Inhibitors of phospholipase enzymes
CA2326522A1 (en) *	1998-03-31	1999-10-14	Shionogi & Co., Ltd.	Pyrrolo[1,2-a]pyrazine spla2 inhibitor
DZ2769A1 (fr) *	1998-04-17	2003-12-01	Lilly Co Eli	Composés tricycliques substitués.
ID23219A (id) *	1998-04-17	2000-03-30	Lilly Co Eli	Trisiklik tersubstitusi
US6472389B1 (en)	1998-05-21	2002-10-29	Shionogi & Co., Ltd.	Pyrrolo[1,2-b] pyridazine derivatives having sPLA2 inhibitory effect
DE69931496T2 (de)	1998-08-03	2006-11-23	Eli Lilly And Co., Indianapolis	INDOLVERBINDUNGEN ALS sPLA2 INHIBITOREN
US6608099B1 (en)	1998-08-03	2003-08-19	Eli Lilly And Company	Indole sPLA2 inhibitors
AU6240099A (en)	1998-08-24	2000-03-14	Susan E Draheim	Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase A2
AU6004799A (en) *	1998-10-14	2000-05-01	Shionogi & Co., Ltd.	Remedies or preventives for ischemic reflow failure
US6448284B1 (en)	1998-12-22	2002-09-10	Eli Lilly And Company	Substituted tricyclics
AU2373600A (en) *	1998-12-22	2000-07-12	Eli Lilly And Company	Novel spla2 inhibitors
AU6015600A (en)	1999-07-19	2001-02-05	Shionogi & Co., Ltd.	Tricyclic compounds having spla2-inhibitory activities
US6534535B1 (en)	1999-08-12	2003-03-18	Millennium Pharmaceuticals, Inc.	Inhibitors of factor Xa
AU6473600A (en)	1999-08-23	2001-03-19	Shionogi & Co., Ltd.	Pyrrolotriazine derivatives having spla2-inhibitory activities
WO2001026653A1 (en) *	1999-10-15	2001-04-19	Shionogi & Co., Ltd.	V TYPE AND/OR X TYPE sPLA2 INHIBITORS
AU1304801A (en)	1999-11-15	2001-05-30	Shionogi & Co., Ltd.	Tricyclic azaindolizine derivatives having an SPLA2- inhibiting effect
EP1300159B1 (en) *	2000-06-29	2007-10-10	Anthera Pharmaceuticals, Inc.	Remedies for cancer
AU2001267825A1 (en)	2000-06-29	2002-01-08	Shionogi And Co., Ltd.	Remedies for cirrhosis
JPWO2002000621A1 (ja) *	2000-06-29	2004-04-22	塩野義製薬株式会社	Ｘ型ｓＰＬＡ２阻害作用を有する化合物
CA2413582A1 (en) *	2000-07-14	2002-01-24	Eli Lilly And Company	Use of a spla2 inhibitor for the treatment of sepsis
EP1349834A2 (en) *	2000-12-18	2003-10-08	Eli Lilly And Company	Cycloalkyfused [g]-indole compounds as spla2-inhibitors in the treatment of inflammatory diseases
TWI314457B (fi)	2001-03-19	2009-09-11	Shionogi & Co
US7205329B2 (en)	2003-05-30	2007-04-17	Microbia, Inc.	Modulators of CRTH2 activity
WO2005009958A1 (en)	2003-07-17	2005-02-03	Plexxikon, Inc.	Ppar active compounds
US7348338B2 (en)	2003-07-17	2008-03-25	Plexxikon, Inc.	PPAR active compounds
GB2407318A (en) *	2003-10-23	2005-04-27	Oxagen Ltd	Substituted Indol-3-yl acetic acid derivatives
US7531568B2 (en)	2004-11-30	2009-05-12	Plexxikon, Inc.	PPAR active compounds
US7964629B2 (en) *	2005-03-18	2011-06-21	Duke Universtiy	Inhibitors of isoprenylcysteine carboxyl methyltransferase
TW200718687A (en) *	2005-05-27	2007-05-16	Wyeth Corp	Inhibitors of cytosolic phospholipase A2
US7666898B2 (en)	2005-11-03	2010-02-23	Ilypsa, Inc.	Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors
US20090306171A1 (en) *	2005-11-03	2009-12-10	Han-Ting Chang	Indole compounds having c4-amide substituents and use thereof as phospholipase-a2 inhibitors
US7977359B2 (en)	2005-11-04	2011-07-12	Amira Pharmaceuticals, Inc.	5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) *	2005-11-04	2010-03-17	Amira Pharmaceuticals Inc	5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en)	2005-11-04	2013-03-19	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
PE20090159A1 (es)	2007-03-08	2009-02-21	Plexxikon Inc	COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
US8048880B2 (en) *	2007-05-03	2011-11-01	Anthera Pharmaceuticals, Inc.	Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A2 (SPLA2) inhibitors and SPLA2 inhibitor combination therapies
US7750027B2 (en)	2008-01-18	2010-07-06	Oxagen Limited	Compounds having CRTH2 antagonist activity
US8546431B2 (en)	2008-10-01	2013-10-01	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
BR112015004432A2 (pt) *	2012-08-30	2017-07-04	Chong Kun Dang Pharmaceutical Corp	derivados de n-acilidrazona para inibidor seletivo de célula t e droga para neoplasia antilinfoide.
GB201407820D0 (en)	2014-05-02	2014-06-18	Atopix Therapeutics Ltd	Polymorphic form
GB201407807D0 (en)	2014-05-02	2014-06-18	Atopix Therapeutics Ltd	Polymorphic form

Family Cites Families (11)

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Publication number	Priority date	Publication date	Assignee	Title
US2825734A (en) *	1955-04-11	1958-03-04	Upjohn Co	Reduction of carbonylic radicals in indolyl-3 compounds
US2890223A (en) *	1956-03-22	1959-06-09	Research Corp	1-benzyl, 2-methyl, 5-methoxy tryptamine
US3196162A (en) *	1961-03-13	1965-07-20	Merck & Co Inc	Indolyl aliphatic acids
US3242162A (en) *	1961-03-13	1966-03-22	Merck & Co Inc	Indolyl aliphatic acids
US3242193A (en) *	1961-03-13	1966-03-22	Merck & Co Inc	Indolyl aliphatic acids
US3242163A (en) *	1961-03-13	1966-03-22	Merck & Co Inc	Indolyl aliphatic acids
US3271416A (en) *	1961-10-24	1966-09-06	Merck & Co Inc	Indolyl aliphatic acids
IT1036004B (it) *	1968-05-21	1979-10-30	Abc Ist Biolog Chem Spa	Acidt 3 indolil adetoidrossamici
US4012513A (en) *	1971-11-03	1977-03-15	Imperial Chemical Industries Limited	Indole derivatives for providing analgesic and anti-inflammatory effects
US4792555A (en) *	1987-03-20	1988-12-20	American Home Products Corporation	Phospholipase A2 inhibitors
IL109311A0 (en) *	1993-04-16	1994-07-31	Lilly Co Eli	1H-indole-3-acetamide sPla2 inhibitors

1994
- 1994-04-12 IL IL10930994A patent/IL109309A/xx not_active IP Right Cessation
- 1994-04-13 NZ NZ260299A patent/NZ260299A/en unknown
- 1994-04-13 HU HU9401058A patent/HU220221B/hu not_active IP Right Cessation
- 1994-04-13 TW TW083103279A patent/TW306914B/zh active
- 1994-04-14 DK DK94302646T patent/DK0620214T3/da active
- 1994-04-14 CA CA002121321A patent/CA2121321A1/en not_active Abandoned
- 1994-04-14 CO CO94014980A patent/CO4230091A1/es unknown
- 1994-04-14 DE DE69416705T patent/DE69416705T2/de not_active Expired - Fee Related
- 1994-04-14 BR BR9401484A patent/BR9401484A/pt not_active Application Discontinuation
- 1994-04-14 EP EP94302646A patent/EP0620214B1/en not_active Expired - Lifetime
- 1994-04-14 ES ES94302646T patent/ES2128510T3/es not_active Expired - Lifetime
- 1994-04-14 CZ CZ1994894A patent/CZ289791B6/cs not_active IP Right Cessation
- 1994-04-14 AT AT94302646T patent/ATE177081T1/de not_active IP Right Cessation
- 1994-04-14 SI SI9430246T patent/SI0620214T1/xx unknown
- 1994-04-15 KR KR1019940007934A patent/KR100330816B1/ko not_active Expired - Fee Related
- 1994-04-15 YU YU20094A patent/YU20094A/sh unknown
- 1994-04-15 RU RU94012931A patent/RU2127725C1/ru active
- 1994-04-15 CN CN94104433A patent/CN1067986C/zh not_active Expired - Fee Related
- 1994-04-15 FI FI941766A patent/FI941766L/fi unknown
- 1994-04-15 PL PL94303027A patent/PL179472B1/pl unknown
- 1994-04-15 UA UA94005182A patent/UA40575C2/uk unknown
- 1994-04-15 JP JP07764694A patent/JP3621128B2/ja not_active Expired - Fee Related
- 1994-04-15 NO NO941360A patent/NO300210B1/no not_active IP Right Cessation
- 1994-04-15 AU AU59486/94A patent/AU669782B2/en not_active Ceased
- 1994-04-15 ZA ZA942614A patent/ZA942614B/xx unknown
1995
- 1995-05-12 US US08/440,154 patent/US5578634A/en not_active Expired - Fee Related
1999
- 1999-03-12 GR GR990400773T patent/GR3029689T3/el unknown

Also Published As

Publication number	Publication date
PL179472B1 (en)	2000-09-29
AU5948694A (en)	1994-10-20
RU2127725C1 (ru)	1999-03-20
EP0620214A1 (en)	1994-10-19
JPH0710838A (ja)	1995-01-13
DE69416705T2 (de)	1999-07-29
ES2128510T3 (es)	1999-05-16
FI941766A7 (fi)	1994-10-17
CZ289791B6 (cs)	2002-04-17
CN1067986C (zh)	2001-07-04
NO941360L (no)	1994-10-17
HU9401058D0 (en)	1994-08-29
KR100330816B1 (ko)	2002-11-01
NZ260299A (en)	1996-03-26
CO4230091A1 (es)	1995-10-19
CZ89494A3 (en)	1994-11-16
EP0620214B1 (en)	1999-03-03
ZA942614B (en)	1995-10-16
CA2121321A1 (en)	1994-10-17
BR9401484A (pt)	1994-11-22
CN1098714A (zh)	1995-02-15
DE69416705D1 (de)	1999-04-08
ATE177081T1 (de)	1999-03-15
US5578634A (en)	1996-11-26
AU669782B2 (en)	1996-06-20
HU220221B (hu)	2001-11-28
JP3621128B2 (ja)	2005-02-16
NO300210B1 (no)	1997-04-28
TW306914B (fi)	1997-06-01
UA40575C2 (uk)	2001-08-15
NO941360D0 (no)	1994-04-15
SI0620214T1 (en)	1999-08-31
IL109309A (en)	2000-06-29
DK0620214T3 (da)	1999-09-27
YU20094A (sh)	1997-03-07
FI941766A0 (fi)	1994-04-15
HUT70205A (en)	1995-09-28
GR3029689T3 (en)	1999-06-30
IL109309A0 (en)	1994-07-31

Publication	Publication Date	Title
FI941766A7 (fi)	1994-10-17	sPLA2:n 1H-indoli-3-etikkahappohydratsidi-inhibiittoreita
FI962315A0 (fi)	1996-06-03	Entsyymi-inhibiittorit
FI941767A7 (fi)	1994-10-17	1H-indoli-3-asetamidi sPLA2 inhibiittoreita
FI942625A7 (fi)	1994-12-05	Peptidisiä fosfinyylioksimetyyliketoneja interleukiini-1beta-muuttuvan entsyymin inhibiittoreina
FI970430L (fi)	1997-04-01	Atsa-asparaziinihappo analogeja 1-beta-interleukiinia muuttavan entsyymin inhibiittoreina
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EP0693083A4 (en)	1996-07-17	ALPHACETOAMIDE DERIVATIVES USEFUL AS THROMBOSIS INHIBITORS
EE9800187A (et)	1998-12-15	Trombiini inhibiitorite eelravimid
FI950262A7 (fi)	1995-01-20	Hydroksaamihappojohdokset metalloproteinaasi-inhibiittoreina
FI942423A7 (fi)	1994-11-26	Sakkariinijohdannisia proteolyyttisen entsyymin inhibiittoreina
FI965019A7 (fi)	1996-12-13	Entsyymi-inhibiittoreita
FI20012510L (fi)	2001-12-19	Fenyyliheterosyklejä syklo-oksigenaasi-2-inhibiittoreina
NO942064D0 (no)	1994-06-03	yminhibitorer
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FI964137L (fi)	1997-01-15	Rotamaasi-entsyymiaktiivisuuden inhibiittoreita
EE9800125A (et)	1998-10-15	Rotamaasse ensümaatilise aktiivsuse inhibiitorid
FI942107A7 (fi)	1994-11-08	Peptidiketoneita interleukiini-1-betaa muuttavan entsyymin inhibiittoreina
NO954571D0 (no)	1995-11-13	Sialyl-LeX-analoger som inhibitorer av cellulær adhesjon
BR9510256A (pt)	1997-11-04	Derivados de ácido 3-aril-tetrônico
FI955720A7 (fi)	1995-11-27	Urokinaasireseptoriaktiivisuuden peptidi-inhibiittoreita
FI960803L (fi)	1996-04-22	TNF-alfa-sekreetion inhibiittoreita
BR9510175A (pt)	1997-10-14	Inibidores contendo ácido hidroxâmico de metaloproteases de matriz
FI971784A0 (fi)	1997-04-25	Apolipoproteiini B-synteesin estäjiä
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MX9100998A (es)	1992-05-04	Novedosos inhibidores de escualen sintetasa