[go: up one dir, main page]

FI945829L - Production of human hemoglobin in transgenic pigs - Google Patents

Production of human hemoglobin in transgenic pigs Download PDF

Info

Publication number
FI945829L
FI945829L FI945829A FI945829A FI945829L FI 945829 L FI945829 L FI 945829L FI 945829 A FI945829 A FI 945829A FI 945829 A FI945829 A FI 945829A FI 945829 L FI945829 L FI 945829L
Authority
FI
Finland
Prior art keywords
production
human hemoglobin
transgenic pigs
pigs
transgenic
Prior art date
Application number
FI945829A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI945829A0 (en
FI945829A7 (en
Inventor
John S Logan
Steven H Holtzman
J Kevin O'donnell
Stephen H Pilder
Carl A Pinkert
Mark E Swanson
Hilary Keller
Ajay Sharma
Cynthia T Parsons
Ramesh Kumar
Steven P White
Original Assignee
Dnx Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dnx Corp filed Critical Dnx Corp
Publication of FI945829A0 publication Critical patent/FI945829A0/en
Publication of FI945829A7 publication Critical patent/FI945829A7/en
Publication of FI945829L publication Critical patent/FI945829L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI945829A 1992-06-12 1993-06-11 Production of human hemoglobin in transgenic pigs FI945829L (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US89764892A 1992-06-12 1992-06-12
US98789092A 1992-12-08 1992-12-08
US3089793A 1993-03-15 1993-03-15
PCT/US1993/005629 WO1993025071A1 (en) 1992-06-12 1993-06-11 Production of human hemoglobin in transgenic pigs

Publications (3)

Publication Number Publication Date
FI945829A0 FI945829A0 (en) 1994-12-12
FI945829A7 FI945829A7 (en) 1995-02-10
FI945829L true FI945829L (en) 1995-02-10

Family

ID=27363743

Family Applications (1)

Application Number Title Priority Date Filing Date
FI945829A FI945829L (en) 1992-06-12 1993-06-11 Production of human hemoglobin in transgenic pigs

Country Status (7)

Country Link
EP (1) EP0655888A4 (en)
JP (1) JPH07507921A (en)
AU (1) AU687743B2 (en)
CA (1) CA2137911A1 (en)
FI (1) FI945829L (en)
NZ (1) NZ253642A (en)
WO (1) WO1993025071A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922854A (en) * 1991-06-14 1999-07-13 Kumar; Ramesh Purifying Human Hemogloblin from transgenic pig red cells and plasmids containing pig globin nucleic acids
US5821351A (en) * 1994-06-10 1998-10-13 Dnx Biotherapeutics Production of hemoglobin having a delta-like globin
US6187993B1 (en) 1995-02-25 2001-02-13 Imperial Cancer Research Technology Limited Transgenic animals as model of psoriasis
US6022738A (en) * 1995-03-03 2000-02-08 Mount Sinai School Of Medicine Of The City University Of New York Vectors for expression of globin genes
US5741894A (en) * 1995-09-22 1998-04-21 Baxter International, Inc. Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
US5861483A (en) 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
DK1463759T3 (en) 2002-01-07 2013-08-12 Euroscreen Sa Ligand for the G-protein-coupled receptor GPR43 and uses thereof
US20050227251A1 (en) 2003-10-23 2005-10-13 Robert Darnell Method of purifying RNA binding protein-RNA complexes
WO2006105511A1 (en) 2005-03-31 2006-10-05 The General Hospital Corporation Monitoring and modulating hgf/hgfr activity
WO2007041350A2 (en) 2005-10-01 2007-04-12 Charles Stout Regulatable fusion promoters
CN101886075B (en) * 2010-07-02 2011-12-21 东北农业大学 Porcine ROSA26 promoter and application thereof
GB201417042D0 (en) * 2014-09-29 2014-11-12 Fkd Therapies Oy Method
US20210041463A1 (en) 2018-02-02 2021-02-11 Bloodworks Antibody screens using transgenic antigen(s)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8711614D0 (en) * 1987-05-16 1987-06-24 Medical Res Council Proteins
WO1991005041A1 (en) * 1989-09-26 1991-04-18 Townes Tim M Erythroid-specific gene expression system
CA2111348A1 (en) * 1991-06-14 1992-12-23 John S. Logan Production of human hemoglobin in transgenic pigs

Also Published As

Publication number Publication date
EP0655888A1 (en) 1995-06-07
AU687743B2 (en) 1998-03-05
FI945829A0 (en) 1994-12-12
NZ253642A (en) 1996-10-28
CA2137911A1 (en) 1993-12-23
FI945829A7 (en) 1995-02-10
AU4534393A (en) 1994-01-04
WO1993025071A1 (en) 1993-12-23
EP0655888A4 (en) 1997-06-11
JPH07507921A (en) 1995-09-07

Similar Documents

Publication Publication Date Title
AU2249592A (en) Production of human hemoglobin in transgenic pigs
FI912703A7 (en) Essential fatty acid treatment
IT1236831B (en) INTESTINE FOR TREATMENT OF THE INTESTINE IN PARTICULAR FOR ENTEROCLISM
DE69033150D1 (en) Animal litter and procedures
FI943625L (en) Methods for treating inflammatory skin diseases
FI970771L (en) New substituted piperidines useful in the treatment of allergic diseases
FI944334A7 (en) Skin pH-appropriate cleansing pad
FI963419A7 (en) Fibrinogen production in transgenic animals
DE69524138D1 (en) Skin treatment agents
FI900808A7 (en) Human mannose-binding protein
FI945829L (en) Production of human hemoglobin in transgenic pigs
FI922582L (en) FATTY ACID TREATMENT
FI970979A7 (en) Modified human C3 proteins
BR9606298A (en) Transgenic fish in the treatment of diabetes
KR940011674U (en) Cattle ornaments with hand-moving ornaments
FI913566A7 (en) Increased protein production in animals
DK444288A (en) HUMAN REG - PROTEIN
NO944811D0 (en) Production of human hemoglobin in transgenic pigs
PT8772U (en) CONTAINER-PACKING AND TOY
ATE327324T1 (en) PRODUCTION OF PROTEIN C IN TRANSGENIC ANIMALS
AU2207997A (en) Production of human hemoglobin in transgenic animals
NO179147C (en) Fish Trapp Construction
NO923108D0 (en) SKIN TREATMENT
NO920961D0 (en) SKIN AND SKIN CARE
NO920003D0 (en) SKIN AND SKIN CARE