|
GB9304919D0
(en)
*
|
1993-03-10 |
1993-04-28 |
Celltech Ltd |
Chemical compounds
|
|
ATE169009T1
(de)
*
|
1994-03-09 |
1998-08-15 |
Pfizer |
Isoxazoline verbindung zur hemmung tnf-freigabe
|
|
US5786354A
(en)
*
|
1994-06-21 |
1998-07-28 |
Celltech Therapeutics, Limited |
Tri-substituted phenyl derivatives and processes for their preparation
|
|
US6245774B1
(en)
*
|
1994-06-21 |
2001-06-12 |
Celltech Therapeutics Limited |
Tri-substituted phenyl or pyridine derivatives
|
|
GB9412571D0
(en)
|
1994-06-22 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
|
GB9412573D0
(en)
|
1994-06-22 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
|
GB9523675D0
(en)
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
CA2258728C
(en)
|
1996-06-19 |
2011-09-27 |
Rhone Poulenc Rorer Limited |
Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
|
|
GB9622363D0
(en)
|
1996-10-28 |
1997-01-08 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
JP2001507349A
(ja)
*
|
1996-12-23 |
2001-06-05 |
セルテック セラピューティックス リミテッド |
縮合多環式2−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用
|
|
GB9705361D0
(en)
*
|
1997-03-14 |
1997-04-30 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US6022977A
(en)
|
1997-03-26 |
2000-02-08 |
Dupont Pharmaceuticals Company |
Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids
|
|
GB9713087D0
(en)
*
|
1997-06-20 |
1997-08-27 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
DZ3019A1
(fr)
*
|
1999-03-01 |
2005-05-20 |
Smithkline Beecham Corp |
Utilisation d'un inhibiteur de pde4 dans la préparation d'un médicament contre la copd.
|
|
GB9914258D0
(en)
|
1999-06-18 |
1999-08-18 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
TR200909479T2
(tr)
|
1999-08-21 |
2012-02-21 |
Nycomed Gmbh |
Sinerjistik kombinasyon.
|
|
KR100399361B1
(ko)
|
1999-11-04 |
2003-09-26 |
주식회사 엘지생명과학 |
캐스파제 억제제 함유 치료제 조성물
|
|
DE60013147T2
(de)
*
|
1999-09-17 |
2005-08-11 |
Lg Chem Investment, Ltd. |
Caspase-hemmer
|
|
GB9924862D0
(en)
*
|
1999-10-20 |
1999-12-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
DE19953024A1
(de)
|
1999-11-04 |
2001-05-10 |
Merck Patent Gmbh |
Isoxazolderivate als Phosphodiesterase VII-Hemmer
|
|
GB2362101A
(en)
*
|
2000-05-12 |
2001-11-14 |
Astrazeneca Ab |
Treatment of chronic obstructive pulmonary disease
|
|
KR20040007596A
(ko)
*
|
2001-05-23 |
2004-01-24 |
다나베 세이야꾸 가부시키가이샤 |
골절 치료 촉진용 조성물
|
|
MXPA03010672A
(es)
|
2001-05-23 |
2004-03-02 |
Tanabe Seiyaku Co |
Composicion para el tratamiento regenerativo de enfermedades del cartilago.
|
|
HRP20031081A2
(en)
*
|
2001-05-29 |
2005-10-31 |
Schering Aktiengesellschaft |
Cdk inhibiting pyrimidines, production thereof and their use as medicaments
|
|
CA2450589C
(en)
*
|
2001-06-08 |
2011-12-20 |
Cytokine Pharmasciences, Inc. |
Isoxazoline compounds having mif antagonist activity
|
|
US20030129186A1
(en)
|
2001-07-25 |
2003-07-10 |
Biomarin Pharmaceutical Inc. |
Compositions and methods for modulating blood-brain barrier transport
|
|
AR039385A1
(es)
*
|
2002-04-19 |
2005-02-16 |
Astrazeneca Ab |
Derivados de tioxantina como inhibidores de la mieloperoxidasa
|
|
WO2004043349A2
(en)
*
|
2002-11-06 |
2004-05-27 |
Bristol-Myers Squibb Company |
Isoxazoline derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme
|
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
MXPA05010373A
(es)
|
2003-04-01 |
2005-12-05 |
Applied Research Systems |
Inhibidores de fosfodiesterasas en infertilidad.
|
|
KR100594544B1
(ko)
*
|
2003-08-27 |
2006-06-30 |
주식회사 엘지생명과학 |
이소옥사졸린 구조를 갖는 캐스파제 저해제
|
|
BRPI0413330A
(pt)
|
2003-08-29 |
2006-10-10 |
Ranbaxy Lab Ltd |
inibidores de fosfodiesterase do tipo iv, composição farmacêutica contendo os mesmos e processo para sua preparação
|
|
SE0302756D0
(sv)
*
|
2003-10-17 |
2003-10-17 |
Astrazeneca Ab |
Novel Compounds
|
|
US20070259874A1
(en)
*
|
2003-11-26 |
2007-11-08 |
Palle Venkata P |
Phosphodiesterase Inhibitors
|
|
BRPI0508140B1
(pt)
|
2004-03-05 |
2015-03-17 |
Nissan Chemical Ind Ltd |
Composto benzamida substituída por isoxazolina da fórmula (1); da fórmula (2) substituído por 3,5-bis (aril substituído); da fórmula (4) substituída por alquinibenzeno ou um sal do mesmo; "pesticida, agroquímico, inseticida, parasiticida contendo como ingrediente ativo um ou mais composto benzamida substituída por isoxazolina e sal do mesmo"
|
|
EP1727542A4
(en)
*
|
2004-03-26 |
2009-08-05 |
Cytokine Pharmasciences Inc |
COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE, AND METHODS OF USE FOR INHIBITING MACROPHAGE MIGRATION INHIBITION FACTOR
|
|
US20080009535A1
(en)
*
|
2004-08-30 |
2008-01-10 |
Sarala Balachandran |
Inhibitors of phosphodiesterase type-IV
|
|
SE0402591D0
(sv)
*
|
2004-10-25 |
2004-10-25 |
Astrazeneca Ab |
Novel use
|
|
MY140748A
(en)
*
|
2004-12-06 |
2010-01-15 |
Astrazeneca Ab |
Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
|
|
ES2370788T3
(es)
*
|
2005-02-07 |
2011-12-22 |
Aerocrine Ab |
Controlar flujo de aliento exhalado durante análisis.
|
|
KR101324451B1
(ko)
*
|
2005-03-15 |
2013-10-31 |
가니얼 이뮤노테라퓨틱스 인코포레이티드 |
면역 조절제 활성을 갖는 화합물
|
|
CN101287411B
(zh)
|
2005-04-28 |
2013-03-06 |
普罗秋斯生物医学公司 |
药物信息系统及其用途
|
|
WO2006117653A1
(en)
*
|
2005-05-03 |
2006-11-09 |
Ranbaxy Laboratories Limited |
Azole-based phosphodiesterase inhibitors
|
|
EP2275095A3
(en)
|
2005-08-26 |
2011-08-17 |
Braincells, Inc. |
Neurogenesis by muscarinic receptor modulation
|
|
EP2258359A3
(en)
|
2005-08-26 |
2011-04-06 |
Braincells, Inc. |
Neurogenesis by muscarinic receptor modulation with sabcomelin
|
|
CA2625153A1
(en)
|
2005-10-21 |
2007-04-26 |
Braincells, Inc. |
Modulation of neurogenesis by pde inhibition
|
|
CA2625210A1
(en)
|
2005-10-31 |
2007-05-10 |
Braincells, Inc. |
Gaba receptor mediated modulation of neurogenesis
|
|
CA2643199A1
(en)
*
|
2006-03-08 |
2007-09-13 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
|
US20100216734A1
(en)
*
|
2006-03-08 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
|
JP2009536669A
(ja)
|
2006-05-09 |
2009-10-15 |
ブレインセルス,インコーポレイティド |
アンジオテンシン調節による神経新生
|
|
US7678808B2
(en)
|
2006-05-09 |
2010-03-16 |
Braincells, Inc. |
5 HT receptor mediated neurogenesis
|
|
US20100009983A1
(en)
*
|
2006-05-09 |
2010-01-14 |
Braincells, Inc. |
5 ht receptor mediated neurogenesis
|
|
TW200804383A
(en)
*
|
2006-06-05 |
2008-01-16 |
Astrazeneca Ab |
New compounds
|
|
AU2007292848A1
(en)
*
|
2006-09-08 |
2008-03-13 |
Braincells, Inc. |
Combinations containing a 4-acylaminopyridine derivative
|
|
WO2008036682A2
(en)
|
2006-09-18 |
2008-03-27 |
Raptor Pharmaceutical Inc. |
Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
|
|
AU2007299920A1
(en)
*
|
2006-09-19 |
2008-03-27 |
Braincells, Inc. |
PPAR Mediated Modulation of Neurogenesis
|
|
US20100184806A1
(en)
|
2006-09-19 |
2010-07-22 |
Braincells, Inc. |
Modulation of neurogenesis by ppar agents
|
|
EP2066661A2
(en)
*
|
2006-09-22 |
2009-06-10 |
Ranbaxy Laboratories Limited |
Phosphodiesterase inhibitors
|
|
CN103601792B
(zh)
|
2007-06-04 |
2016-06-29 |
协同医药品公司 |
有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
|
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
|
AU2009256157B2
(en)
|
2008-06-04 |
2014-12-18 |
Bausch Health Ireland Limited |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
ES2624828T3
(es)
|
2008-07-16 |
2017-07-17 |
Synergy Pharmaceuticals Inc. |
Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
|
|
DK3395372T3
(da)
|
2009-02-20 |
2022-04-19 |
Enhanx Biopharm Inc |
System til afgivelse af glutathion-baseret medikament
|
|
WO2010099217A1
(en)
|
2009-02-25 |
2010-09-02 |
Braincells, Inc. |
Modulation of neurogenesis using d-cycloserine combinations
|
|
EP2427178B1
(en)
|
2009-05-06 |
2023-01-04 |
Laboratory Skin Care, Inc. |
Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
|
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
|
US20120077778A1
(en)
|
2010-09-29 |
2012-03-29 |
Andrea Bourdelais |
Ladder-Frame Polyether Conjugates
|
|
MX357121B
(es)
|
2011-03-01 |
2018-06-27 |
Synergy Pharmaceuticals Inc Star |
Proceso de preparacion de agonistas c de guanilato ciclasa.
|
|
PL2691379T3
(pl)
|
2011-03-31 |
2017-05-31 |
Bayer Intellectual Property Gmbh |
Skuteczne chwastobójczo i grzybobójczo 3-fenyloizoksazolino-5-karboksamidy i 3-fenyloizoksazolino-5-tioamidy
|
|
WO2013106547A1
(en)
|
2012-01-10 |
2013-07-18 |
President And Fellows Of Harvard College |
Beta-cell replication promoting compounds and methods of their use
|
|
WO2013158792A1
(en)
|
2012-04-17 |
2013-10-24 |
Inovio Pharmaceuticals, Inc. |
Compounds having immunomodulator activity
|
|
CN104812739B
(zh)
*
|
2012-09-25 |
2017-12-12 |
拜尔农作物科学股份公司 |
具有除草作用的3‑苯基异噁唑啉衍生物
|
|
US9850206B2
(en)
|
2012-11-20 |
2017-12-26 |
Biogen Ma Inc. |
S1P and/or ATX modulating agents
|
|
US9545446B2
(en)
|
2013-02-25 |
2017-01-17 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase and their uses
|
|
US9486494B2
(en)
|
2013-03-15 |
2016-11-08 |
Synergy Pharmaceuticals, Inc. |
Compositions useful for the treatment of gastrointestinal disorders
|
|
WO2014151206A1
(en)
|
2013-03-15 |
2014-09-25 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase and their uses
|
|
EP4424697A3
(en)
|
2013-06-05 |
2024-12-25 |
Bausch Health Ireland Limited |
Ultra-pure agonists of guanylate cyclase c, method of making and using same
|
|
CN103381157A
(zh)
*
|
2013-07-04 |
2013-11-06 |
丁圣雨 |
Chukrasone B在治疗慢性阻塞性肺疾病的药物中的应用
|
|
JP6694385B2
(ja)
|
2013-08-09 |
2020-05-13 |
アーデリクス,インコーポレーテッド |
リン酸塩輸送阻害のための化合物及び方法
|
|
JP6514716B2
(ja)
*
|
2014-04-22 |
2019-05-15 |
ノバルティス アーゲー |
LpxC阻害剤としてのイソオキサゾリンヒドロキサム酸誘導体
|
|
CN110799511B
(zh)
|
2017-06-13 |
2023-09-01 |
拜耳公司 |
除草活性的四氢和二氢呋喃甲酰胺的3-苯基异噁唑啉-5-甲酰胺
|
|
PT3638665T
(pt)
|
2017-06-13 |
2021-10-19 |
Bayer Cropscience Ag |
3-fenilisoxazolino-5-carboxamidas de ácidos tetrahidrofuranocarboxílicos e de ácidos dihidrofuranocarboxílicos e dos seus ésteres com eficácia herbicida
|
|
EP3668845B1
(de)
|
2017-08-17 |
2024-06-26 |
Bayer Aktiengesellschaft |
Herbizid wirksame 3-phenyl-5-trifluormethylisoxazolin-5-carboxamide von cyclopentylcarbonsäuren und -estern
|
|
DK3743411T3
(da)
|
2018-01-25 |
2023-02-13 |
Bayer Ag |
Herbicidt virksomt 3-phenylisoxazolin-5-carboxamider af cyclopentenylcarbonsyrederivater
|
|
DK3937637T3
(da)
|
2019-03-12 |
2023-07-24 |
Bayer Ag |
Herbicidt virksomme 3-phenylisoxazolin-5-carboxamider af s-holdige cyclopentenylcarbonsyreestere
|
|
JP2022533251A
(ja)
|
2019-05-21 |
2022-07-21 |
アルデリックス, インコーポレイテッド |
患者において血清リン酸塩を低下させるための組み合わせ
|