FI810961A7 - Menetelmä uusien pyrimidonijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia histamiini-H2-vasta-ainein - Google Patents

Menetelmä uusien pyrimidonijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia histamiini-H2-vasta-ainein Download PDF

Info

Publication number: FI810961A7
Authority: FI; Finland
Prior art keywords: histamine; antagonists; derivatives useful; preparing novel; pyrimidone derivatives
Prior art date: 1980-03-29

Application number

FI810961A

Other languages

English (en)

Swedish (sv)

Other versions

FI810961L (fi

Inventor

Thomas Henry Brown

Original Assignee

Smith Kline & French Laboratories

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-03-29

Filing date

1981-03-27

Publication date

1981-09-30

1981-03-27 Application filed by Smith Kline & French Laboratories filed Critical Smith Kline & French Laboratories

1981-09-30 Publication of FI810961A7 publication Critical patent/FI810961A7/fi

1981-09-30 Publication of FI810961L publication Critical patent/FI810961L/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

FI810961A 1980-03-29 1981-03-27 Foerfarande foer framstaellning av nya pyrimidonderivat vilka aer anvaendbara som histamin-h2-antagonister FI810961L (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8010663		1980-03-29
GB8101705		1981-01-21

Publications (2)

Publication Number	Publication Date
FI810961A7 true FI810961A7 (fi)	1981-09-30
FI810961L FI810961L (fi)	1981-09-30

Family

ID=26275023

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI810961A FI810961L (fi)	1980-03-29	1981-03-27	Foerfarande foer framstaellning av nya pyrimidonderivat vilka aer anvaendbara som histamin-h2-antagonister

Country Status (20)

Country	Link
US (1)	US4388317A (fi)
EP (1)	EP0039989B1 (fi)
AR (1)	AR225955A1 (fi)
AU (1)	AU541724B2 (fi)
CA (1)	CA1155842A (fi)
DD (1)	DD157703A5 (fi)
DE (1)	DE3165733D1 (fi)
DK (1)	DK140281A (fi)
ES (1)	ES500796A0 (fi)
FI (1)	FI810961L (fi)
GR (1)	GR74841B (fi)
JO (1)	JO1164B1 (fi)
NO (1)	NO811065L (fi)
NZ (1)	NZ196640A (fi)
PL (1)	PL230363A1 (fi)
PT (1)	PT72752B (fi)
RO (1)	RO81930A (fi)
SU (1)	SU1033003A3 (fi)
YU (1)	YU81181A (fi)
ZW (1)	ZW6581A1 (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4808589A (en) *	1982-02-20	1989-02-28	Smith Kline & French Laboratories Limited	Pyrimidone derivatives
JO1274B1 (en) *	1982-12-03	1985-04-20	سيدني ساخ جورج	Pyridine derivatives
GB8332091D0 (en) *	1983-12-01	1984-01-11	Smith Kline French Lab	Chemical compounds
GB8421427D0 (en) *	1984-08-23	1984-09-26	Smith Kline French Lab	Chemical compounds
CA1275097A (en) *	1984-10-02	1990-10-09	Fujio Nohara	Pyridyloxy derivatives
AU2007281212B8 (en)	2006-08-03	2013-02-28	Trustees Of Tufts College	Non-flushing niacin analogues, and methods of use thereof
US20100137388A1 (en) *	2007-04-19	2010-06-03	Barden Christopher J	Therapeutic Pro-Antibiotic Agents and Methods of Use Thereof
WO2022034121A1 (en)	2020-08-11	2022-02-17	Université De Strasbourg	H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4181730A (en) *	1973-05-03	1980-01-01	Smith Kline & French Laboratories Limited	Pharmacologically active compounds as inhibitors of H-2 histamine receptors
IN146736B (fi) *	1975-10-02	1979-08-25	Smith Kline French Lab
US4218452A (en) *	1975-10-02	1980-08-19	Smith Kline & French Laboratories Limited	Substituted 4-pyrimidone compounds, compositions and methods of use
US4154834A (en) *	1975-12-29	1979-05-15	Smith Kline & French Laboratories Limited	Substituted isocytosines having histamine H2 -antagonist activity
MW5076A1 (en) *	1975-12-29	1978-02-08	Smith Kline French Lab	Pharmacologicalle active compounds
GB1565966A (en) *	1976-08-04	1980-04-23	Allen & Hanburys Ltd	Aminoalkyl furan derivatives
IN151188B (fi) *	1978-02-13	1983-03-05	Smith Kline French Lab
IL57005A (en) *	1978-04-11	1983-11-30	Smith Kline French Lab	Process for the preparation of 2-amino pyrimid-4-one derivatives and novel 2-nitroaminopyrimid-4-ones as intermediates therefor
ZA793443B (en) *	1978-07-26	1980-12-31	Glaxo Group Ltd	Heterocyclic derivatives

1981
- 1981-03-20 CA CA000373475A patent/CA1155842A/en not_active Expired
- 1981-03-25 RO RO81103816A patent/RO81930A/ro unknown
- 1981-03-25 JO JO19811164A patent/JO1164B1/en active
- 1981-03-26 GR GR64493A patent/GR74841B/el unknown
- 1981-03-27 PL PL23036381A patent/PL230363A1/xx unknown
- 1981-03-27 EP EP81301324A patent/EP0039989B1/en not_active Expired
- 1981-03-27 ES ES500796A patent/ES500796A0/es active Granted
- 1981-03-27 PT PT72752A patent/PT72752B/pt unknown
- 1981-03-27 SU SU813261944A patent/SU1033003A3/ru active
- 1981-03-27 NO NO811065A patent/NO811065L/no unknown
- 1981-03-27 ZW ZW65/81A patent/ZW6581A1/xx unknown
- 1981-03-27 YU YU00811/81A patent/YU81181A/xx unknown
- 1981-03-27 FI FI810961A patent/FI810961L/fi not_active Application Discontinuation
- 1981-03-27 AR AR284775A patent/AR225955A1/es active
- 1981-03-27 DE DE8181301324T patent/DE3165733D1/de not_active Expired
- 1981-03-27 NZ NZ196640A patent/NZ196640A/xx unknown
- 1981-03-27 DK DK140281A patent/DK140281A/da not_active Application Discontinuation
- 1981-03-27 AU AU68858/81A patent/AU541724B2/en not_active Ceased
- 1981-03-27 US US06/248,096 patent/US4388317A/en not_active Expired - Fee Related
- 1981-03-27 DD DD81228661A patent/DD157703A5/de unknown

Also Published As

Publication number	Publication date
ZW6581A1 (en)	1981-07-01
NZ196640A (en)	1983-11-18
RO81930B (ro)	1983-05-30
AU541724B2 (en)	1985-01-17
DK140281A (da)	1981-09-30
YU81181A (en)	1983-12-31
EP0039989B1 (en)	1984-08-29
NO811065L (no)	1981-09-30
PT72752B (en)	1982-03-23
FI810961L (fi)	1981-09-30
AU6885881A (en)	1981-10-08
EP0039989A1 (en)	1981-11-18
GR74841B (fi)	1984-07-12
PT72752A (en)	1981-04-01
DD157703A5 (de)	1982-12-01
AR225955A1 (es)	1982-05-14
ES8201982A1 (es)	1982-01-01
CA1155842A (en)	1983-10-25
US4388317A (en)	1983-06-14
SU1033003A3 (ru)	1983-07-30
ES500796A0 (es)	1982-01-01
DE3165733D1 (en)	1984-10-04
JO1164B1 (en)	1983-11-30
PL230363A1 (fi)	1981-11-27
RO81930A (ro)	1983-06-01

Publication	Publication Date	Title
DK138281A (da)	1981-09-29	Fremgangsmaade til fremstilling af 3-(1-piperidinylalkyl)-4h-pyrido (1,2-a) pyrimidin-4-on-derivater
FI841759A7 (fi)	1984-11-04	Menetelmä uusien fluorialkoksiyhdisteiden valmistamiseksi.
PL234523A1 (en)	1983-12-19	Process for preparing novel derivatives of 4-amino-6,7-dimethoxy-2-piperazinequinazoline
PT77082B (en)	1986-04-11	Process for preparing 2-substituted 4-amino-6,7-dimethoxyquinolines
FI813054A7 (fi)	1982-04-02	Menetelmä amiinijohdannaisten valmistamiseksi.
FI814003A7 (fi)	1982-06-16	Menetelmä terapeuttisesti käytettävien indolijohdannaisten valmistamiseksi.
FI822281A7 (fi)	1982-12-28	Menetelmä pyrimidonijohdannaisten valmistamiseksi.
DK370781A (da)	1982-02-23	Fremgangsmaade til fremstilling af 3,4-bis-phenyl-1,2,4-triazoler
FI791143A7 (fi)	1981-01-01	Menetelmä histamiini-vasta-aineiden valmistamiseksi.
FI810961A7 (fi)	1981-09-30	Menetelmä uusien pyrimidonijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia histamiini-H2-vasta-ainein
FI821397A7 (fi)	1982-10-25	Menetelmä uusien bentsodioksolijohdannaisten valmistamiseksi.
DK154963C (da)	1989-06-26	Fremgangsmaade til fremstilling af pulverformet, fritflydende tocoferylsuccinat
FI882303A7 (fi)	1988-11-23	Menetelmä pyrimidiinijohdannaisten valmistamiseksi.
FI792220A7 (fi)	1981-01-01	Menetelmä pyrimidiiniyhdisteiden valmistamiseksi.
FI834410A7 (fi)	1984-06-04	Menetelmä pyrimidinonijohdannaisten valmistamiseksi.
DK314682A (da)	1983-01-16	Fremgangsmaade til fremstilling af substituerede thiazolo-(3,2-a)pyrimidiner
FI842907A7 (fi)	1985-01-24	Menetelmä pyrimidonijohdannaisten valmistamiseksi.
FI845095A7 (fi)	1984-12-21	Aminoimidatsolonijohdannaiset histamiini-H2-antagonisteina.
DK113483A (da)	1983-03-08	Fremgangsmaade til fremstilling af 3,4-diphenyl-5-methylpyrazolderivater
FI873051A7 (fi)	1988-01-11	Menetelmä pyrimidiinijohdannaisten valmistamiseksi
FI810935A7 (fi)	1981-10-03	Menetelmä substituoitujen triaryylitiatsoliyhdisteiden valmistamiseksi.
FI865028A7 (fi)	1987-06-12	Menetelmä verenpainetta alentavina aineina käytettävien heteroaromaattisten asetyleenien valmistamiseksi.
FI850994A7 (fi)	1985-09-17	Menetelmä uusien 1,2,4 -triatsasykloalkadieenijohdannaisten valmistamiseksi.
FI811610A7 (fi)	1981-12-14	Menetelmä 4-(3- jodipropargyylioksi)pyrimidiinijohdannaisten valmistamiseksi.
DE3464910D1 (de)	1987-08-27	Process for preparing pyrimidinetrione derivatives

Legal Events

Date	Code	Title	Description
2004-08-31	FD	Application lapsed	Owner name: SMITH KLINE & FRENCH LABORATORIES