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FI20155412A7 - Sokerien suora konversio glykolihapoksi - Google Patents

Sokerien suora konversio glykolihapoksi Download PDF

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Publication number
FI20155412A7
FI20155412A7 FI20155412A FI20155412A FI20155412A7 FI 20155412 A7 FI20155412 A7 FI 20155412A7 FI 20155412 A FI20155412 A FI 20155412A FI 20155412 A FI20155412 A FI 20155412A FI 20155412 A7 FI20155412 A7 FI 20155412A7
Authority
FI
Finland
Prior art keywords
glycolic acid
sugars
direct conversion
host
cytosol
Prior art date
Application number
FI20155412A
Other languages
English (en)
Swedish (sv)
Other versions
FI20155412A (fi
Inventor
Outi Koivistoinen
Joosu Kuivanen
Juha-Pekka Pitkänen
Peter Richard
Merja Penttilä
Original Assignee
Teknologian Tutkimuskeskus Vtt Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teknologian Tutkimuskeskus Vtt Oy filed Critical Teknologian Tutkimuskeskus Vtt Oy
Priority to FI20155412A priority Critical patent/FI20155412A/fi
Priority to PCT/FI2016/050373 priority patent/WO2016193540A1/en
Publication of FI20155412A7 publication Critical patent/FI20155412A7/fi
Publication of FI20155412A publication Critical patent/FI20155412A/fi

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01026—Glyoxylate reductase (1.1.1.26)

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Tämän keksinnön esimerkkiaspekti esittää eukaryoottisen isännän, jota on modifioitu niin, että se konvertoi sokereita suoraan glykolihapoksi. Koko glykolihapon tuotantoreitti on viety sytosoliin. Esitetään myös menetelmä glykolihapon valmistamiseksi tällaista isäntää käyttämällä.
FI20155412A 2015-05-29 2015-05-29 Sokerien suora konversio glykolihapoksi FI20155412A (fi)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI20155412A FI20155412A (fi) 2015-05-29 2015-05-29 Sokerien suora konversio glykolihapoksi
PCT/FI2016/050373 WO2016193540A1 (en) 2015-05-29 2016-05-30 Direct conversion of sugars to glycolic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI20155412A FI20155412A (fi) 2015-05-29 2015-05-29 Sokerien suora konversio glykolihapoksi

Publications (2)

Publication Number Publication Date
FI20155412A7 true FI20155412A7 (fi) 2016-11-30
FI20155412A FI20155412A (fi) 2016-11-30

Family

ID=57440220

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20155412A FI20155412A (fi) 2015-05-29 2015-05-29 Sokerien suora konversio glykolihapoksi

Country Status (2)

Country Link
FI (1) FI20155412A (fi)
WO (1) WO2016193540A1 (fi)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3354742A1 (en) 2017-01-26 2018-08-01 Metabolic Explorer Methods and microorganisms for the production of glycolic acid and/or glyoxylic acid
US11124810B2 (en) 2017-07-28 2021-09-21 Teknologian Tutkimuskeskus Vtt Oy Production of oxalyl-CoA, glyoxylate and/or glycolic acid
CN118956710A (zh) 2017-09-07 2024-11-15 多伦多大学管理委员会 从乙二醇生产乙醇酸盐以及相关微生物工程改造
WO2020180411A2 (en) * 2019-01-23 2020-09-10 Integrated Lipid Biofuels Llc Genetically engineered yeast yarrowia lipolytica and methods for producing bio-based glycolic acid
WO2020152342A1 (en) 2019-01-24 2020-07-30 Photanol B.V. A process for the bioproduction of glycolate
WO2020163935A1 (en) 2019-02-15 2020-08-20 Braskem S.A. Microorganisms and methods for the production of glycolic acid and glycine via reverse glyoxylate shunt
EP4631928A1 (en) 2024-04-10 2025-10-15 Metabolic Explorer Method of purification of glycolic acid, composition and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007140816A1 (en) * 2006-06-09 2007-12-13 Metabolic Explorer Glycolic acid production by fermentation from renewable resources
EP2233562A1 (en) * 2009-03-24 2010-09-29 Metabolic Explorer Method for producing high amount of glycolic acid by fermentation
FI125136B (fi) * 2011-10-04 2015-06-15 Teknologian Tutkimuskeskus Vtt Oy Eukaryottiset solut ja menetelmä glykolihapon valmistamiseksi
WO2014057008A1 (en) * 2012-10-09 2014-04-17 Chalmers Intellectual Property Rights Ab Engineering of acetyl-coenzyme a metabolism in yeast
FR3028529B1 (fr) * 2014-11-19 2016-12-30 Inst Nat De La Rech Agronomique Inra Procede de production d'au moins un metabolite d'interet par transformation d'un pentose dans un microorganisme

Also Published As

Publication number Publication date
WO2016193540A1 (en) 2016-12-08
FI20155412A (fi) 2016-11-30

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