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FI20145217A7 - Composition for binding aldehydes and free radicals in the gastrointestinal tract - Google Patents

Composition for binding aldehydes and free radicals in the gastrointestinal tract Download PDF

Info

Publication number
FI20145217A7
FI20145217A7 FI20145217A FI20145217A FI20145217A7 FI 20145217 A7 FI20145217 A7 FI 20145217A7 FI 20145217 A FI20145217 A FI 20145217A FI 20145217 A FI20145217 A FI 20145217A FI 20145217 A7 FI20145217 A7 FI 20145217A7
Authority
FI
Finland
Prior art keywords
composition
gastrointestinal tract
cysteine
free radicals
stomach
Prior art date
Application number
FI20145217A
Other languages
Finnish (fi)
Swedish (sv)
Inventor
Osmo Suovaniemi
Mårten Wikström
Original Assignee
Biohit Oyj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biohit Oyj filed Critical Biohit Oyj
Priority to FI20145217A priority Critical patent/FI20145217A7/en
Priority to PCT/FI2015/050143 priority patent/WO2015132472A1/en
Publication of FI20145217A7 publication Critical patent/FI20145217A7/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to a non-toxic composition containing one or more cysteine compounds selected from L- or D-cysteine, N-acetyl cysteine for decreasing the risk of a subject contracting cancer of the mouth and of the stomach, by locally binding both oxygen radicals and aldehydes present in the mouth and in the stomach, the composition being formulated with the help of two or more additives into a layered mixture, added into capsules or tablets, whereby these units contain one or more inner controlled release layers as well as an outer quick-release layer.
FI20145217A 2014-03-06 2014-03-06 Composition for binding aldehydes and free radicals in the gastrointestinal tract FI20145217A7 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI20145217A FI20145217A7 (en) 2014-03-06 2014-03-06 Composition for binding aldehydes and free radicals in the gastrointestinal tract
PCT/FI2015/050143 WO2015132472A1 (en) 2014-03-06 2015-03-06 Composition for binding aldehydes and free radicals in the gastrointestinal tract

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI20145217A FI20145217A7 (en) 2014-03-06 2014-03-06 Composition for binding aldehydes and free radicals in the gastrointestinal tract

Publications (1)

Publication Number Publication Date
FI20145217A7 true FI20145217A7 (en) 2015-09-07

Family

ID=52686394

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20145217A FI20145217A7 (en) 2014-03-06 2014-03-06 Composition for binding aldehydes and free radicals in the gastrointestinal tract

Country Status (2)

Country Link
FI (1) FI20145217A7 (en)
WO (1) WO2015132472A1 (en)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496548A (en) 1983-02-04 1985-01-29 Moldowan Mervin J Composition and method for reducing hangover
US4528295A (en) 1983-08-15 1985-07-09 Boris Tabakoff Composition and method for reducing blood acetaldehyde levels
US5202354A (en) 1986-02-18 1993-04-13 Takeda Chemical Industries, Ltd. Composition and method for reducing acetaldehyde toxicity
US5922346A (en) 1997-12-01 1999-07-13 Thione International, Inc. Antioxidant preparation
FI121528B (en) 2000-10-30 2010-12-31 Biohit Oyj A pharmaceutical composition for reducing the risk of cancer by topically binding acetaldehyde in saliva, stomach or colon
JP5654726B2 (en) 2004-10-08 2015-01-14 ビオヒット・ユルキネン・オサケユキテュアＢｉｏｈｉｔ Ｏｙｊ Methods and formulations for binding aldehydes in saliva
US20070098790A1 (en) 2005-10-31 2007-05-03 David Jiang Nutritional supplement for the enhancement of the health of the liver
FI20060501L (en) * 2006-05-22 2007-11-23 Biohit Oyj Composition and method for binding acetaldehyde in the stomach
WO2009137827A2 (en) 2008-05-09 2009-11-12 Tiara Pharmaceuticals, Inc. Controlled release of n-acetylcysteine (nac) for reduction of systemic and/or vascular inflammation
FI20115377A (en) * 2011-04-18 2012-10-19 Biohit Oyj Medical products for use in conditions related to microbial infections of upper respiratory and digestive organs

Also Published As

Publication number Publication date
WO2015132472A1 (en) 2015-09-11

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