FI20106067A0 - Noroviruksen kapsidi ja rotaviruksen VP6-proteiini käytettäväksi yhdistelmärokotteena - Google Patents
Noroviruksen kapsidi ja rotaviruksen VP6-proteiini käytettäväksi yhdistelmärokotteenaInfo
- Publication number
- FI20106067A0 FI20106067A0 FI20106067A FI20106067A FI20106067A0 FI 20106067 A0 FI20106067 A0 FI 20106067A0 FI 20106067 A FI20106067 A FI 20106067A FI 20106067 A FI20106067 A FI 20106067A FI 20106067 A0 FI20106067 A0 FI 20106067A0
- Authority
- FI
- Finland
- Prior art keywords
- rotavirus
- protein
- combination vaccine
- norovirus capsid
- norovirus
- Prior art date
Links
- 108090000565 Capsid Proteins Proteins 0.000 title 1
- 241001263478 Norovirus Species 0.000 title 1
- 108700031314 Rotavirus VP6 Proteins 0.000 title 1
- 210000000234 capsid Anatomy 0.000 title 1
- 229940001442 combination vaccine Drugs 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/125—Picornaviridae, e.g. calicivirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/15—Reoviridae, e.g. calf diarrhea virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12323—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/16011—Caliciviridae
- C12N2770/16023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/16011—Caliciviridae
- C12N2770/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20106067A FI122520B (fi) | 2010-10-15 | 2010-10-15 | Noroviruksen kapsidi ja rotaviruksen VP6-proteiini käytettäväksi yhdistelmärokotteena |
| US13/269,326 US8895015B2 (en) | 2010-10-14 | 2011-10-07 | Norovirus capsid and rotavirus VP6 protein for use as combined vaccine |
| JP2013533249A JP5902181B2 (ja) | 2010-10-14 | 2011-10-12 | 混合ワクチンとして使用するためのノロウイルスカプシド及びロタウイルスｖｐ６タンパク質 |
| EP11832191.8A EP2627353B1 (en) | 2010-10-14 | 2011-10-12 | Norovirus capsid and rotavirus vp6 protein for use as combined vaccine |
| SG2013027974A SG189398A1 (en) | 2010-10-14 | 2011-10-12 | Norovirus capsid and rotavirus vp6 protein for use as combined vaccine |
| CN201180049612.4A CN103260645B (zh) | 2010-10-14 | 2011-10-12 | 用作联合疫苗的诺罗病毒壳体和轮状病毒vp6蛋白 |
| CA2814175A CA2814175C (en) | 2010-10-14 | 2011-10-12 | Norovirus capsid and rotavirus vp6 protein for use as combined vaccine |
| RU2013121815/10A RU2013121815A (ru) | 2010-10-14 | 2011-10-12 | Капсид норовируса и белок vp6 ротавируса для использования в качестве комбинированной вакцины |
| KR1020137012218A KR101847472B1 (ko) | 2010-10-14 | 2011-10-12 | 혼합 백신으로 사용하기 위한 노로바이러스 캡시드 및 로타바이러스 ｖｐ6 단백질 |
| PCT/FI2011/050880 WO2012049366A1 (en) | 2010-10-14 | 2011-10-12 | Norovirus capsid and rotavirus vp6 protein for use as combined vaccine |
| AU2011315405A AU2011315405B2 (en) | 2010-10-14 | 2011-10-12 | Norovirus capsid and rotavirus VP6 protein for use as combined vaccine |
| BR112013009164A BR112013009164A2 (pt) | 2010-10-14 | 2011-10-12 | capsídeo de norovírus e proteína vp6 de rotavírus para uso como vacina combinada. |
| MX2013004159A MX352478B (es) | 2010-10-14 | 2011-10-12 | Proteina vp6 de la capside de norovirus y rotavirus para el uso como vacuna combinada. |
| TW100137092A TWI479022B (zh) | 2010-10-14 | 2011-10-13 | 諾羅病毒衣殼與輪狀病毒ｖｐ６蛋白質做為組合疫苗的用途 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20106067 | 2010-10-15 | ||
| FI20106067A FI122520B (fi) | 2010-10-15 | 2010-10-15 | Noroviruksen kapsidi ja rotaviruksen VP6-proteiini käytettäväksi yhdistelmärokotteena |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI20106067A0 true FI20106067A0 (fi) | 2010-10-15 |
| FI122520B FI122520B (fi) | 2012-03-15 |
Family
ID=43064225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI20106067A FI122520B (fi) | 2010-10-14 | 2010-10-15 | Noroviruksen kapsidi ja rotaviruksen VP6-proteiini käytettäväksi yhdistelmärokotteena |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8895015B2 (fi) |
| EP (1) | EP2627353B1 (fi) |
| JP (1) | JP5902181B2 (fi) |
| KR (1) | KR101847472B1 (fi) |
| CN (1) | CN103260645B (fi) |
| AU (1) | AU2011315405B2 (fi) |
| BR (1) | BR112013009164A2 (fi) |
| CA (1) | CA2814175C (fi) |
| FI (1) | FI122520B (fi) |
| MX (1) | MX352478B (fi) |
| RU (1) | RU2013121815A (fi) |
| SG (1) | SG189398A1 (fi) |
| TW (1) | TWI479022B (fi) |
| WO (1) | WO2012049366A1 (fi) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101576219B1 (ko) | 2007-03-14 | 2015-12-10 | 다케다 백신즈 인코포레이티드 | 바이러스 유사 입자 정제 |
| WO2013061941A1 (ja) | 2011-10-24 | 2013-05-02 | トヨタ自動車株式会社 | 組換え酵母を用いたエタノールの製造方法 |
| JOP20130186B1 (ar) | 2012-06-22 | 2021-08-17 | Takeda Vaccines Montana Inc | تنقية الجزيئات الشبيهة بالفيروسات |
| CN103667199B (zh) | 2012-09-20 | 2019-01-22 | 厦门大学 | 体外制备轮状病毒双层类病毒颗粒的方法 |
| WO2014152211A1 (en) | 2013-03-14 | 2014-09-25 | Moderna Therapeutics, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| ES2762631T3 (es) | 2013-03-14 | 2020-05-25 | Harvard College | Composiciones a base de nanopartículas |
| JP2015015931A (ja) * | 2013-07-12 | 2015-01-29 | 株式会社Ｕｍｎファーマ | ウイルス様粒子を含む培養物の製造方法 |
| WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| US20160194625A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| WO2015051214A1 (en) | 2013-10-03 | 2015-04-09 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| JP2018078806A (ja) * | 2016-11-14 | 2018-05-24 | 東ソー株式会社 | ノロウイルスｒｎａの検出方法 |
| WO2018182983A1 (en) * | 2017-03-28 | 2018-10-04 | Children's Hospital Medical Center | Norovirus s particle based vaccines and methods of making and using same |
| AU2018270111B2 (en) | 2017-05-18 | 2022-07-14 | Modernatx, Inc. | Polynucleotides encoding tethered interleukin-12 (IL12) polypeptides and uses thereof |
| JP6879111B2 (ja) | 2017-08-02 | 2021-06-02 | トヨタ自動車株式会社 | 組換え酵母及びこれを用いたエタノールの製造方法 |
| KR102038364B1 (ko) | 2018-03-15 | 2019-10-30 | 전남대학교 산학협력단 | 소 로타바이러스 감염증 예방용 약독화 혼합생백신 조성물 |
| EP4087604A4 (en) * | 2020-01-08 | 2023-11-01 | Bharat Biotech International Limited | COMPOSITIONS OF VIRAL VACCINES AND THEIR PREPARATION METHODS |
| CN111265660B (zh) * | 2020-01-19 | 2022-11-15 | 青岛明勤生物科技有限公司 | 一种通用型疫苗免疫增强剂 |
| CN114316009B (zh) * | 2020-09-29 | 2023-04-25 | 上海交通大学 | 一种能够结合多种病毒的蛋白及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5298244A (en) * | 1990-10-25 | 1994-03-29 | University Of Saskatchewan | Assembled viral particles and their use in a vaccine to rotaviral disease |
| IE920366A1 (en) | 1991-02-04 | 1992-08-12 | Univ Saskatchewan | Vp6 encapsulated drug delivery |
| US6673355B1 (en) | 1995-06-14 | 2004-01-06 | Baylor College Of Medicine | Rotavirus enterotoxin NSP4 and methods of using same |
| JP2000139473A (ja) * | 1998-11-16 | 2000-05-23 | Hokkaido Green Bio Kenkyusho:Kk | ロタウイルス遺伝子を導入した遺伝子組換え植物、この遺伝子組換え植物に由来するロタウイルスのタンパク質及びこのロタウイルスのタンパク質に対する抗体 |
| US20030166139A1 (en) | 2001-07-20 | 2003-09-04 | Choi Anthony H. | Rotavirus VP6 subunit |
| US8277819B2 (en) * | 2005-06-16 | 2012-10-02 | Children's Hospital Medical Center | Norovirus particle for use as an antiviral or vaccine |
| WO2007009081A2 (en) * | 2005-07-07 | 2007-01-18 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | A hexavalent bovine rotavirus reassortant composition designed for use in developing countries |
| CA2630220C (en) * | 2005-11-22 | 2020-10-13 | Doris Coit | Norovirus and sapovirus antigens |
| KR101576219B1 (ko) * | 2007-03-14 | 2015-12-10 | 다케다 백신즈 인코포레이티드 | 바이러스 유사 입자 정제 |
| SG184733A1 (en) * | 2007-09-18 | 2012-10-30 | Ligocyte Pharmaceuticals Inc | Method of conferring a protective immune response to norovirus |
| AU2009237767A1 (en) * | 2008-04-18 | 2009-10-22 | Unilever Plc | Compositions comprising antibodies or antibody fragments |
| WO2010006326A2 (en) * | 2008-07-11 | 2010-01-14 | Tufts University | Methods and compositions for spore-based vaccines |
| CN107043408B (zh) | 2009-06-09 | 2021-02-09 | 儿童医院医疗中心 | 抗原-诺罗病毒p-结构域单体和二聚体，抗原-诺罗病毒p-粒子分子，及其制备和应用方法 |
-
2010
- 2010-10-15 FI FI20106067A patent/FI122520B/fi active IP Right Grant
-
2011
- 2011-10-07 US US13/269,326 patent/US8895015B2/en active Active
- 2011-10-12 EP EP11832191.8A patent/EP2627353B1/en active Active
- 2011-10-12 BR BR112013009164A patent/BR112013009164A2/pt not_active IP Right Cessation
- 2011-10-12 RU RU2013121815/10A patent/RU2013121815A/ru not_active Application Discontinuation
- 2011-10-12 WO PCT/FI2011/050880 patent/WO2012049366A1/en not_active Ceased
- 2011-10-12 CA CA2814175A patent/CA2814175C/en active Active
- 2011-10-12 AU AU2011315405A patent/AU2011315405B2/en not_active Ceased
- 2011-10-12 JP JP2013533249A patent/JP5902181B2/ja active Active
- 2011-10-12 MX MX2013004159A patent/MX352478B/es active IP Right Grant
- 2011-10-12 SG SG2013027974A patent/SG189398A1/en unknown
- 2011-10-12 CN CN201180049612.4A patent/CN103260645B/zh active Active
- 2011-10-12 KR KR1020137012218A patent/KR101847472B1/ko active Active
- 2011-10-13 TW TW100137092A patent/TWI479022B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011315405A1 (en) | 2013-05-23 |
| FI122520B (fi) | 2012-03-15 |
| MX352478B (es) | 2017-11-27 |
| AU2011315405B2 (en) | 2016-09-22 |
| SG189398A1 (en) | 2013-05-31 |
| EP2627353A4 (en) | 2014-06-18 |
| JP2013540773A (ja) | 2013-11-07 |
| TWI479022B (zh) | 2015-04-01 |
| KR20140030100A (ko) | 2014-03-11 |
| MX2013004159A (es) | 2013-11-04 |
| EP2627353B1 (en) | 2017-11-29 |
| RU2013121815A (ru) | 2014-11-20 |
| WO2012049366A1 (en) | 2012-04-19 |
| US8895015B2 (en) | 2014-11-25 |
| KR101847472B1 (ko) | 2018-04-11 |
| CA2814175C (en) | 2019-11-05 |
| EP2627353A1 (en) | 2013-08-21 |
| CN103260645A (zh) | 2013-08-21 |
| US20120093884A1 (en) | 2012-04-19 |
| CN103260645B (zh) | 2016-03-16 |
| BR112013009164A2 (pt) | 2019-09-24 |
| JP5902181B2 (ja) | 2016-04-13 |
| CA2814175A1 (en) | 2012-04-19 |
| TW201217530A (en) | 2012-05-01 |
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