FI20041489L - Menetelmä atorvastatiini kalsiumin valmistamiseksi amorfisessa muodossa - Google Patents
Menetelmä atorvastatiini kalsiumin valmistamiseksi amorfisessa muodossa Download PDFInfo
- Publication number
- FI20041489L FI20041489L FI20041489A FI20041489A FI20041489L FI 20041489 L FI20041489 L FI 20041489L FI 20041489 A FI20041489 A FI 20041489A FI 20041489 A FI20041489 A FI 20041489A FI 20041489 L FI20041489 L FI 20041489L
- Authority
- FI
- Finland
- Prior art keywords
- amorphous form
- atorvastatin calcium
- preparing atorvastatin
- preparing
- calcium
- Prior art date
Links
- OJRHUICOVVSGSY-RXMQYKEDSA-N (2s)-2-chloro-3-methylbutan-1-ol Chemical compound CC(C)[C@H](Cl)CO OJRHUICOVVSGSY-RXMQYKEDSA-N 0.000 title 1
- 229960001770 atorvastatin calcium Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05077109A EP1659110A1 (en) | 2004-03-17 | 2005-09-16 | Process for the production of atorvastatin calcium un amorphous form |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN491DE2004 | 2004-03-17 | ||
| IN491DE2004 | 2004-03-17 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI20041489A0 FI20041489A0 (fi) | 2004-11-19 |
| FI20041489L true FI20041489L (fi) | 2006-07-20 |
| FI120344B FI120344B (fi) | 2009-09-30 |
Family
ID=33516010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI20041489A FI120344B (fi) | 2004-03-17 | 2004-11-19 | Menetelmä amorfisessa muodossa olevan atorvastatiinikalsiumin valmistamiseksi |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7994343B2 (fi) |
| EP (3) | EP1727795B1 (fi) |
| CN (2) | CN1942439B (fi) |
| AR (1) | AR048271A1 (fi) |
| AT (1) | ATE545629T1 (fi) |
| AU (2) | AU2004317570B2 (fi) |
| CA (3) | CA2666359A1 (fi) |
| CY (1) | CY1112583T1 (fi) |
| DK (1) | DK1727795T3 (fi) |
| ES (1) | ES2381473T3 (fi) |
| FI (1) | FI120344B (fi) |
| MY (1) | MY147435A (fi) |
| NO (1) | NO330092B1 (fi) |
| PL (1) | PL1727795T3 (fi) |
| PT (1) | PT1727795E (fi) |
| SI (1) | SI1727795T1 (fi) |
| WO (1) | WO2005092852A1 (fi) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1727795T3 (pl) * | 2004-03-17 | 2012-06-29 | Ranbaxy Laboratories Ltd | Sposób wytwarzania soli wapniowej atorwastatyny w formie bezpostaciowej |
| CA2833770A1 (en) * | 2004-07-16 | 2006-01-26 | Lek Pharmaceuticals D.D | Oxidative degradation products of atorvastatin calcium |
| US7645888B2 (en) * | 2004-08-27 | 2010-01-12 | Biocon Limited | Process for the production of amorphous atorvastatin calcium |
| GB2424880A (en) * | 2005-04-06 | 2006-10-11 | Generics | Crystalline forms of atorvastatin sodium, processes for their preparation and their use in inhibiting HMG-CoA reductase |
| CN101268047B (zh) | 2005-08-15 | 2012-11-07 | 箭锋国际有限公司 | 结晶和无定形阿托伐他汀钠 |
| GB0613567D0 (en) * | 2006-07-07 | 2006-08-16 | Arrow Int Ltd | Crystalline sodium atorvastatin |
| GB0613566D0 (en) * | 2006-07-07 | 2006-08-16 | Arrow Int Ltd | Crystalline sodium atorvastatin |
| BRPI0614279A2 (pt) | 2005-08-15 | 2012-11-06 | Arrow Int Ltd | atorvastatina sódica cristalina e amorfa |
| ES2270722B1 (es) * | 2005-09-15 | 2008-03-01 | Ercros Industrial, S.A. | Procedimiento para la obtencion de atorvastatina calcica amorfa. |
| GB0523637D0 (en) * | 2005-11-21 | 2005-12-28 | Avecia Pharmaceuticals Ltd | Process and compounds |
| WO2007099552A2 (en) * | 2006-03-02 | 2007-09-07 | Matrix Labaratories Ltd | Novel crystalline form of atovastatin hemi-magnesium |
| SI22255A (sl) * | 2006-04-14 | 2007-10-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Novi polimorfi statinovih soli in njihova uporabav farmacevtskih formulacijah |
| CN101205209B (zh) * | 2007-12-25 | 2010-06-02 | 浙江新东港药业股份有限公司 | 一种阿伐他汀中间体的精制方法 |
| EP2075246A1 (en) * | 2007-12-27 | 2009-07-01 | M. J. Institute of Research | A process for preparation of amorphous form of atorvastatin hemi-calcium salt |
| CN101468963B (zh) * | 2007-12-28 | 2012-09-19 | 石药集团中奇制药技术(石家庄)有限公司 | 一种无定形阿伐他汀钙的制备方法 |
| KR100850558B1 (ko) * | 2008-01-02 | 2008-08-06 | 조동옥 | 아토르바스타틴의 효율적인 제조방법 |
| CN101560177B (zh) * | 2008-04-16 | 2012-10-03 | 北京万全阳光医学技术有限公司 | 一种阿托伐他汀钙的制备方法 |
| CN101429195B (zh) * | 2008-11-03 | 2010-12-15 | 华东师范大学 | 一种高纯度阿托伐他汀重要合成中间体的制备方法 |
| US8115015B2 (en) | 2009-01-26 | 2012-02-14 | Cadila Healthcare Limited | Process for the preparation of amorphous atorvastatin calcium |
| SI2560951T1 (sl) * | 2010-04-19 | 2016-10-28 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Proizvodnja atorvastanina z nizko vsebnostjo etrskih nečistoč |
| CN102127060B (zh) * | 2010-12-17 | 2013-12-04 | 蚌埠丰原医药科技发展有限公司 | 一种阿托伐他汀钙中间体的制备方法 |
| CN102070504A (zh) * | 2010-12-23 | 2011-05-25 | 蚌埠丰原医药科技发展有限公司 | 阿托伐他汀钠的制备方法 |
| CN102070505B (zh) * | 2011-01-28 | 2012-01-11 | 海南美大制药有限公司 | 阿托伐他汀钙化合物及其新制法 |
| CN103483238B (zh) * | 2013-08-20 | 2014-12-31 | 蚌埠丰原医药科技发展有限公司 | 阿托伐他汀钙三水合物的制备方法 |
| CN104945300B (zh) * | 2015-06-17 | 2017-05-10 | 北京嘉林药业股份有限公司 | 一种ⅰ型阿托伐他汀钙的纯化方法 |
| WO2017060885A1 (en) * | 2015-10-09 | 2017-04-13 | Laurus Labs Private Limited | An improved process for preparation of atorvastatin or pharmaceutically acceptable salts thereof |
| CN106478591B (zh) * | 2016-09-30 | 2018-11-13 | 北京嘉林药业股份有限公司 | 一种阿托伐他汀缩合物中间体的拆分方法 |
| CN106432033B (zh) * | 2016-10-21 | 2018-07-27 | 江苏阿尔法药业有限公司 | 一种无定形阿托伐他汀钙的制备方法 |
| CN108033899B (zh) * | 2017-12-06 | 2020-04-10 | 浙江科技学院 | 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法 |
| CN109280024A (zh) * | 2018-10-09 | 2019-01-29 | 河南师范大学 | 一种高纯度阿托伐他汀叔丁酯的制备方法 |
| CN109232355A (zh) * | 2018-10-09 | 2019-01-18 | 河南师范大学 | 一种有效去除阿托伐他汀钙粗品中杂质阿托伐他汀缩合物的方法 |
| CN110563628B (zh) * | 2019-08-26 | 2022-04-05 | 北京嘉林药业股份有限公司 | 一种双釜制备高纯度和单分散i晶型阿托伐他汀钙的结晶方法 |
| CN110776451B (zh) * | 2020-01-02 | 2020-05-22 | 湖南迪诺制药股份有限公司 | 一种i晶型阿托伐他汀钙的制备方法 |
| CN113695307B (zh) * | 2020-05-20 | 2022-12-02 | 天津嘉林科医有限公司 | 一种盛放阿托伐他汀钙的玻璃器皿的清洗方法 |
| WO2025147589A1 (en) | 2024-01-05 | 2025-07-10 | Osanni Bio, Inc. | Implants, compositions, and methods for treating retinal diseases and disorders |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5216174A (en) | 1988-02-22 | 1993-06-01 | Warner-Lambert Co. | Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5003080A (en) | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
| US5149837A (en) | 1988-02-22 | 1992-09-22 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5097045A (en) | 1989-02-01 | 1992-03-17 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5124482A (en) | 1988-02-22 | 1992-06-23 | Warner-Lambert Company | Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis |
| US5245047A (en) | 1988-02-22 | 1993-09-14 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5103024A (en) | 1990-10-17 | 1992-04-07 | Warner-Lambert Company | Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
| US5248793A (en) | 1990-10-17 | 1993-09-28 | Warner-Lambert Company | Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
| US5155251A (en) | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
| DE69324504T2 (de) | 1993-01-19 | 1999-08-26 | Warner-Lambert Co. | Stabilisierte, oral anzuwendende zusammensetzung enthaltend die verbindung ci-981 und verfahren |
| US5298627A (en) | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| HU223599B1 (hu) | 1995-07-17 | 2004-10-28 | Warner-Lambert Company | I,II és IV kristályformájú [R-(R*,R*)]-2(4-fluor-fenil)-béta,delta-dihidroxi-5-(1-metil-etil)-3-fenil-4-[(fenil-amino)-karbonil]-1H-pirrol-1-heptánkarbonsav-hemikalciumsó-hidrát (atorvasztatin-hidrát) és a vegyületeket tartalmazó gyógyászati készítmények |
| HRP960312B1 (en) | 1995-07-17 | 2001-10-31 | Warner Lambert Co | NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1) |
| IN191236B (fi) | 1999-05-25 | 2003-10-11 | Ranbaxy Lab Ltd | |
| HU226640B1 (en) | 1999-10-18 | 2009-05-28 | Egis Gyogyszergyar Nyilvanosan | Process for producing amorphous atorvastatin calcium salt |
| US6646133B1 (en) * | 2000-10-17 | 2003-11-11 | Egis Gyogyszergyar Rt. | Process for the preparation of amorphous atorvastatin calcium |
| SI20425A (sl) * | 1999-12-10 | 2001-06-30 | LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. | Priprava amorfnega atorvastatina |
| HRP20020950A2 (en) | 2000-06-09 | 2004-12-31 | Lek Tovarna Farmacevtskih | Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same |
| PL362472A1 (en) | 2000-11-03 | 2004-11-02 | Teva Pharma | Atorvastatin hemi-calcium form vii |
| IL156055A0 (en) | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
| WO2002057225A2 (en) | 2000-12-18 | 2002-07-25 | Merck & Co., Inc. | Thrombin inhibitors |
| SK9532003A3 (en) | 2000-12-27 | 2004-04-06 | Ciba Sc Holding Ag | Crystalline forms of atorvastatin calcium |
| WO2002057228A1 (en) | 2001-01-17 | 2002-07-25 | Biocon India Limited | Atorvastatin calcium |
| SI20814A (sl) | 2001-01-23 | 2002-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Priprava amorfnega atorvastatina |
| IN190564B (fi) | 2001-04-11 | 2003-08-09 | Cadila Heathcare Ltd | |
| JP3965155B2 (ja) | 2001-06-29 | 2007-08-29 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 結晶型[R−(R*,R*)]−2−(4−フルオロフェニル)−β,δ−ジヒドロキシ−5−(1−メチルエチル)−3−フェニル−4−[(フェニルアミノ)カルボニル]−1H−ピロール−1−ヘプタン酸カルシウム塩(2:1)(アトロバスタチン) |
| JP2005500351A (ja) | 2001-07-30 | 2005-01-06 | ドクター・レディーズ・ラボラトリーズ・リミテッド | 結晶形態viおよびviiのアトルバスタチンカルシウム |
| AU2001284385A1 (en) | 2001-08-31 | 2003-03-10 | Morepen Laboratories Ltd. | An improved process for the preparation of amorphous atorvastatin calcium salt (2:1) |
| CZ296967B6 (cs) * | 2002-02-01 | 2006-08-16 | Zentiva, A.S. | Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu) |
| HUP0500074A3 (en) | 2002-03-18 | 2005-07-28 | Biocon Ltd Bangalore | Amorphous hmg-coa reductase inhibitors of desired particle size and process for producing them |
| WO2003099785A1 (en) | 2002-05-28 | 2003-12-04 | Cadila Healthcare Limited | Process for the preparation of amorphous atorvastatin calcium |
| SI21302A (sl) | 2002-10-11 | 2004-04-30 | LEK farmacevtska dru�ba d.d. | Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino |
| HU227041B1 (en) | 2003-03-24 | 2010-05-28 | Richter Gedeon Nyrt | Process for the synthesis of amorphous atorvastatin calcium |
| PL1727795T3 (pl) * | 2004-03-17 | 2012-06-29 | Ranbaxy Laboratories Ltd | Sposób wytwarzania soli wapniowej atorwastatyny w formie bezpostaciowej |
| CN101124230A (zh) | 2004-09-28 | 2008-02-13 | 特瓦制药工业有限公司 | 制备基本无杂质的阿托伐他汀钙形式的方法 |
-
2004
- 2004-11-19 PL PL04798913T patent/PL1727795T3/pl unknown
- 2004-11-19 AU AU2004317570A patent/AU2004317570B2/en not_active Ceased
- 2004-11-19 CA CA002666359A patent/CA2666359A1/en not_active Abandoned
- 2004-11-19 FI FI20041489A patent/FI120344B/fi not_active IP Right Cessation
- 2004-11-19 CA CA002627940A patent/CA2627940A1/en not_active Abandoned
- 2004-11-19 US US10/549,890 patent/US7994343B2/en not_active Expired - Fee Related
- 2004-11-19 PT PT04798913T patent/PT1727795E/pt unknown
- 2004-11-19 CA CA002560252A patent/CA2560252C/en not_active Expired - Fee Related
- 2004-11-19 WO PCT/IB2004/003789 patent/WO2005092852A1/en not_active Ceased
- 2004-11-19 ES ES04798913T patent/ES2381473T3/es not_active Expired - Lifetime
- 2004-11-19 SI SI200431843T patent/SI1727795T1/sl unknown
- 2004-11-19 CN CN2004800428343A patent/CN1942439B/zh not_active Expired - Fee Related
- 2004-11-19 AT AT04798913T patent/ATE545629T1/de active
- 2004-11-19 EP EP04798913A patent/EP1727795B1/en not_active Expired - Lifetime
- 2004-11-19 EP EP04027584A patent/EP1577297A1/en not_active Withdrawn
- 2004-11-19 DK DK04798913.2T patent/DK1727795T3/da active
- 2004-11-19 NO NO20045037A patent/NO330092B1/no not_active IP Right Cessation
-
2005
- 2005-03-16 AR ARP050101018A patent/AR048271A1/es unknown
- 2005-03-17 CN CNA200580012704XA patent/CN1946688A/zh active Pending
- 2005-03-17 MY MYPI20051161A patent/MY147435A/en unknown
- 2005-09-16 EP EP05077109A patent/EP1659110A1/en not_active Ceased
-
2010
- 2010-12-03 AU AU2010249166A patent/AU2010249166B2/en not_active Ceased
-
2012
- 2012-04-04 CY CY20121100335T patent/CY1112583T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR048271A1 (es) | 2006-04-12 |
| CN1942439B (zh) | 2011-12-21 |
| AU2004317570A1 (en) | 2005-10-06 |
| EP1577297A1 (en) | 2005-09-21 |
| US7994343B2 (en) | 2011-08-09 |
| CA2666359A1 (en) | 2005-10-06 |
| ATE545629T1 (de) | 2012-03-15 |
| NO330092B1 (no) | 2011-02-14 |
| AU2004317570B2 (en) | 2011-01-06 |
| CA2560252C (en) | 2009-08-04 |
| EP1659110A1 (en) | 2006-05-24 |
| SI1727795T1 (sl) | 2012-05-31 |
| NO20045037D0 (no) | 2004-11-19 |
| CN1946688A (zh) | 2007-04-11 |
| AU2010249166A1 (en) | 2010-12-23 |
| FI120344B (fi) | 2009-09-30 |
| ES2381473T3 (es) | 2012-05-28 |
| EP1727795B1 (en) | 2012-02-15 |
| DK1727795T3 (da) | 2012-04-16 |
| PL1727795T3 (pl) | 2012-06-29 |
| FI20041489A0 (fi) | 2004-11-19 |
| CA2560252A1 (en) | 2005-10-06 |
| CN1942439A (zh) | 2007-04-04 |
| EP1727795A1 (en) | 2006-12-06 |
| US20100197941A1 (en) | 2010-08-05 |
| CA2627940A1 (en) | 2005-10-06 |
| CY1112583T1 (el) | 2016-02-10 |
| PT1727795E (pt) | 2012-04-11 |
| AU2010249166B2 (en) | 2012-02-09 |
| WO2005092852A1 (en) | 2005-10-06 |
| NO20045037L (no) | 2005-09-19 |
| MY147435A (en) | 2012-12-14 |
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