[go: up one dir, main page]

ES8801624A1 - Procedimiento para preparar disulfuros heterociclicos - Google Patents

Procedimiento para preparar disulfuros heterociclicos

Info

Publication number
ES8801624A1
ES8801624A1 ES557614A ES557614A ES8801624A1 ES 8801624 A1 ES8801624 A1 ES 8801624A1 ES 557614 A ES557614 A ES 557614A ES 557614 A ES557614 A ES 557614A ES 8801624 A1 ES8801624 A1 ES 8801624A1
Authority
ES
Spain
Prior art keywords
disulphes
cyclic
procedure
preparing hetero
hetero
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557614A
Other languages
English (en)
Other versions
ES557614A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8801624A1 publication Critical patent/ES8801624A1/es
Publication of ES557614A0 publication Critical patent/ES557614A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DISULFUROS HETEROCICLICOS, DE FORMULA GENERAL (I). CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE HETK REPRESENTA UN HETEROCICLO DE 5 MIEMBROS, EVENTUALMENTE SUSTITUIDO, CON UN ATOMO DE AZUFRE Y CON 1 A 2 ATOMOS DE NITROGENO O CON 1 A 3 ATOMOS DE NITROGENO, PUDIENDO ESTOS HETEROCICLOS TAMBIEN ESTAR CONDENSADOS CON BENZO; Y X REPRESENTA UN GRUPO REACTIVO, FACILMENTE SEPARABLE, CON ME2S2, REPRESENTANDO ME UN METAL ALCALINO. DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA DE INMUNIDAD.
ES557614A 1985-03-12 1987-07-07 Procedimiento para preparar disulfuros heterociclicos Expired ES8801624A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853508666 DE3508666A1 (de) 1985-03-12 1985-03-12 Heterocyclische disulfide und ihre anwendung als immunmodulatoren

Publications (2)

Publication Number Publication Date
ES8801624A1 true ES8801624A1 (es) 1988-02-16
ES557614A0 ES557614A0 (es) 1988-02-16

Family

ID=6264871

Family Applications (3)

Application Number Title Priority Date Filing Date
ES552840A Expired ES8801506A1 (es) 1985-03-12 1986-03-10 Procedimiento para preparar disulfuros heterociclicos
ES557615A Expired ES8801625A1 (es) 1985-03-12 1987-07-07 Procedimiento para preparar disulfuros heterociclicos
ES557614A Expired ES8801624A1 (es) 1985-03-12 1987-07-07 Procedimiento para preparar disulfuros heterociclicos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES552840A Expired ES8801506A1 (es) 1985-03-12 1986-03-10 Procedimiento para preparar disulfuros heterociclicos
ES557615A Expired ES8801625A1 (es) 1985-03-12 1987-07-07 Procedimiento para preparar disulfuros heterociclicos

Country Status (19)

Country Link
EP (1) EP0194571B1 (es)
JP (1) JPH0751572B2 (es)
KR (1) KR940001773B1 (es)
AR (1) AR245113A1 (es)
AT (1) ATE58293T1 (es)
AU (1) AU594943B2 (es)
DE (2) DE3508666A1 (es)
DK (1) DK165181C (es)
ES (3) ES8801506A1 (es)
FI (1) FI860980A7 (es)
GR (1) GR860649B (es)
HU (1) HU201742B (es)
IE (1) IE58729B1 (es)
IL (1) IL78091A (es)
NO (1) NO168357C (es)
NZ (1) NZ215424A (es)
PH (1) PH22275A (es)
PT (1) PT82166B (es)
ZA (1) ZA861780B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3915094A1 (de) 1989-05-09 1991-01-10 Hoechst Ag Verfahren zur herstellung von 2-mercapto-4-methyl-1,3-thiazol-5-yl-essigsaeure und deren ester
TW252112B (es) * 1993-08-19 1995-07-21 Pfizer
DE10055219A1 (de) * 2000-11-08 2002-05-29 Bayer Ag Verfahren zur Herstellung von Dithiazolyldisulfiden
AU2002239879A1 (en) 2001-01-10 2002-07-24 Davide R. Grassetti Method of immunomodulation using thione-forming disulfides
DE102005004472A1 (de) * 2005-01-31 2006-08-10 Rhein Chemie Rheinau Gmbh Verfahren zur Herstellung von Bis-DMTD

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5680M (es) * 1966-08-19 1968-01-08
IL36587A (en) * 1970-05-05 1977-10-31 Grassetti D Compositions containing pyridine derivatives and their use in a method of modifying cellular surface reactions
US4378364A (en) * 1970-05-05 1983-03-29 Grassetti Davide R Postoperative treatment of carcinoma patients
GB1365943A (en) * 1970-09-16 1974-09-04 Gaf Corp Metalworking additive and composition and process for making the same
GB1327467A (en) * 1970-10-12 1973-08-22 Merck & Co Inc Pharmaceutical compositions for inhibiting indoleamine- n-methyl transferase
FR2403798A1 (fr) * 1977-09-22 1979-04-20 Rorer Inc William H Compositions synergiques a base de disulfure de bis(2-pyridyl-1-oxyde et leur utilisation pour leur activite anti-inflammatoire
US4152439A (en) * 1978-01-12 1979-05-01 Davide R. Grassetti Stimulant and antidepressant agents
DE2944225A1 (de) * 1979-11-02 1981-05-07 Akzo Gmbh, 5600 Wuppertal Verfahren zur herstellung von dithiazoldisulfiden
US4451471A (en) * 1981-03-18 1984-05-29 Ciba-Geigy Corporation Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same
DE3118128A1 (de) * 1981-05-07 1982-12-02 Bayer Ag, 5090 Leverkusen Verwendung von disulfiden als lipoxygenasehemmer und diese enthaltende arzneimittel
DE3263149D1 (en) * 1981-10-21 1985-05-23 Beecham Group Plc Topical antimicrobial compositions
HU193951B (en) * 1985-03-11 1987-12-28 Richter Gedeon Vegyeszet Process for producing new sulfur-containing 5-substituted benzimidazol derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
JPH0751572B2 (ja) 1995-06-05
FI860980L (fi) 1986-09-13
ZA861780B (en) 1986-10-29
KR860007246A (ko) 1986-10-10
DE3508666A1 (de) 1986-09-18
PT82166A (de) 1986-04-01
DK165181B (da) 1992-10-19
EP0194571A1 (de) 1986-09-17
IL78091A (en) 1990-04-29
FI860980A0 (fi) 1986-03-10
FI860980A7 (fi) 1986-09-13
ES8801625A1 (es) 1988-02-16
IE58729B1 (en) 1993-11-03
ATE58293T1 (de) 1990-11-15
DK108786D0 (da) 1986-03-10
NO860908L (no) 1986-09-15
PH22275A (en) 1988-07-14
NO168357C (no) 1992-02-12
ES8801506A1 (es) 1988-01-16
NZ215424A (en) 1989-04-26
GR860649B (en) 1986-07-11
AR245113A1 (es) 1993-12-30
IL78091A0 (en) 1986-07-31
KR940001773B1 (ko) 1994-03-05
ES552840A0 (es) 1988-01-16
AU594943B2 (en) 1990-03-22
ES557614A0 (es) 1988-02-16
EP0194571B1 (de) 1990-11-14
JPS61207331A (ja) 1986-09-13
ES557615A0 (es) 1988-02-16
IE860630L (en) 1986-09-12
HU201742B (en) 1990-12-28
DE3675561D1 (de) 1990-12-20
DK165181C (da) 1993-03-01
AU5460586A (en) 1986-10-16
NO168357B (no) 1991-11-04
DK108786A (da) 1986-09-13
PT82166B (pt) 1988-07-29

Similar Documents

Publication Publication Date Title
NO873244D0 (no) Legemiddel.
FI952607A0 (fi) Farmakologisesti aktiiviset pyridiinijohdannaiset ja menetelmät niiden valmistamiseksi
IS1565B (is) Aðferð við framleiðslu á N1-súbstitúeruðum bensimidasólafleiðum til að nota við lækningar
BG103219A (bg) Бензамидинови производни и използването им като лекарствени средства с ltb4-антагонистично действие
ES468525A1 (es) Procedimiento para la obtencion de nuevas 2-alquilenaminodi-hidropiridinas
FI972308A0 (fi) 2-substituoituja 1,2,5-tiadiatsolidin-3-oni-1,1-dioksideja ja niitä sisältäviä koostumuksia ja menetelmiä niiden käyttämiseksi
DK0556322T3 (da) Aminosulfonylurinstof-ACAT-inhibitorer
NO890046D0 (no) Disubstituerte pyridiner.
BG50159A3 (bg) Метод за получаване на производни на пиранобензоксадиазол
ES2095208T3 (es) Compuestos de tienotriazolodiazepina y usos farmaceuticos de los mismos.
ATE64300T1 (de) Wirkstoffe zur anwendung bei der behandlung von tumoren.
ES8801624A1 (es) Procedimiento para preparar disulfuros heterociclicos
ES8801505A1 (es) Procedimiento para preparar sulfuros heterociclicos
ATE28188T1 (de) Antikonvulsive mittel.
ES2118248T3 (es) Esteres y amidas de 9-cloro-prostaglandina y su empleo para preparar medicamentos.
ATE25969T1 (de) 1,7-diphenyl-3-methylaza-7-cyan-8-methyl-nonan zur verwendung bei der bekaempfung von krankheiten.
DK131586A (da) Transdermalt, antiallergisk, farmaceutisk praeparat
PT86771A (pt) Process for preparing 4-substituted benzamide derivatives with anticonvulsant activity
ES2031959T3 (es) Procedimiento para preparar acidos 3,5-dihidroxicarboxilicos y sus derivados.
IT8219409A0 (it) Derivati, tiolici dell'eritromicina ad attivita' terapeutica, relativo procedimento di preparazione e composizioni farmaceutiche che licontengono.
ES2037807T3 (es) Medicamentos que contienen en combinacion interferon y 1-desoxi-piperidinosas, procedimiento para su fabricacion y su aplicacion.
ATE57526T1 (de) P-acylaminobenzamide.
ATE75938T1 (de) Enantiomere des propafenons enthaltende therapeutische mittel.
ES548790A0 (es) Un procedimiento para preparar diazohidroxidos de pirazina.
DE3879709D1 (de) Platin-arzneimittel.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010301