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ES8801674A1 - Un procedimiento para la preparacion de una proteina que presenta actividad procoagulante. - Google Patents

Un procedimiento para la preparacion de una proteina que presenta actividad procoagulante.

Info

Publication number
ES8801674A1
ES8801674A1 ES553935A ES553935A ES8801674A1 ES 8801674 A1 ES8801674 A1 ES 8801674A1 ES 553935 A ES553935 A ES 553935A ES 553935 A ES553935 A ES 553935A ES 8801674 A1 ES8801674 A1 ES 8801674A1
Authority
ES
Spain
Prior art keywords
region
polypeptide sequence
proteins
amino
terminus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553935A
Other languages
English (en)
Other versions
ES553935A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24914180&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8801674(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Publication of ES8801674A1 publication Critical patent/ES8801674A1/es
Publication of ES553935A0 publication Critical patent/ES553935A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/10—Factor VIII, AHF; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/30—Signal or leader sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UNA PROTEINA CON LA SECUENCIA DE AMINOACIDOS DE FORMULA GENERAL (I), EN LA QUE A, X Y B SON SECUENCIAS POLIPEPTIDAS. CONSISTE EN CULTIVAR UNA CELULA HUESPED QUE CONTIENE Y ES CAPAZ DE EXPRESAR UNA MOLECULA DE ADN CODIFICANTE DE LA PROTEINA A UNA TEMPERATURA COMPRENDIDA ENTRE 32 Y 42 GRADOS APROXIMADAMENTE, DENTRO DE UN INTERVALO DE PH COMPRENDIDO ENTRE 7,0 Y 7,6 APROXIMADAMENTE, EN UN MEDIO DE CULTIVO DE TEJIDOS TAL COMO DMA SUPLEMENTADO CON HASTA UN 10% DE SUERO DE MAMIFERO, PARA PRODUCIR LA PROTEINA. EL CULTIVO ES DE TIPO AEROBICO. DE APLICACION EN MEDICINA POR SU ACTIVIDAD PROCOAGULANTE.
ES553935A 1985-04-12 1986-04-11 Un procedimiento para la preparacion de una proteina que presenta actividad procoagulante. Expired ES8801674A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72535085A 1985-04-12 1985-04-12

Publications (2)

Publication Number Publication Date
ES8801674A1 true ES8801674A1 (es) 1988-02-16
ES553935A0 ES553935A0 (es) 1988-02-16

Family

ID=24914180

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553935A Expired ES8801674A1 (es) 1985-04-12 1986-04-11 Un procedimiento para la preparacion de una proteina que presenta actividad procoagulante.

Country Status (12)

Country Link
US (1) US4868112A (es)
EP (1) EP0218712B1 (es)
JP (1) JPH0788399B2 (es)
AT (1) ATE72838T1 (es)
AU (2) AU5772886A (es)
CA (1) CA1341174C (es)
DE (1) DE3683980D1 (es)
DK (1) DK166457B1 (es)
ES (1) ES8801674A1 (es)
LU (1) LU90458I2 (es)
MX (1) MX9203440A (es)
WO (1) WO1986006101A1 (es)

Families Citing this family (146)

* Cited by examiner, † Cited by third party
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EP0218712A4 (en) 1987-10-27
MX9203440A (es) 1992-07-01
EP0218712B1 (en) 1992-02-26
JPH0788399B2 (ja) 1995-09-27
DK601786D0 (da) 1986-12-12
DE3683980D1 (de) 1992-04-02
AU5772886A (en) 1986-11-05
DK601786A (da) 1986-12-12
DK166457B1 (da) 1993-05-24
LU90458I2 (fr) 2001-04-13
AU629649B2 (en) 1992-10-08
CA1341174C (en) 2001-01-30
US4868112A (en) 1989-09-19
JPS62502941A (ja) 1987-11-26
ATE72838T1 (de) 1992-03-15
EP0218712A1 (en) 1987-04-22
WO1986006101A1 (en) 1986-10-23
AU5753490A (en) 1991-02-07
ES553935A0 (es) 1988-02-16

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