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ES8801545A1 - Un procedimiento para la preparacion de compuestos aminoheterociclicos - Google Patents

Un procedimiento para la preparacion de compuestos aminoheterociclicos

Info

Publication number
ES8801545A1
ES8801545A1 ES551509A ES551509A ES8801545A1 ES 8801545 A1 ES8801545 A1 ES 8801545A1 ES 551509 A ES551509 A ES 551509A ES 551509 A ES551509 A ES 551509A ES 8801545 A1 ES8801545 A1 ES 8801545A1
Authority
ES
Spain
Prior art keywords
amino compounds
heterocyclic amino
compounds
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551509A
Other languages
English (en)
Other versions
ES551509A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848410456A external-priority patent/GB8410456D0/en
Priority claimed from GB858503975A external-priority patent/GB8503975D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8801545A1 publication Critical patent/ES8801545A1/es
Publication of ES551509A0 publication Critical patent/ES551509A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Light Receiving Elements (AREA)
  • Pyrrole Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR COMPUESTOS AMINOS-HETEROCICLICOS. CONSISTE EN TRATAR A UN COMPUESTO DE FORMULA (II) CON HIDROGENO, EN PRESENCIA DE PLATINO SOBRE UN SOPORTE ACTIVO Y EN ALCOHOL, PARA DESPROTEGER A (II) (R, UN GRUPO PROTECTOR COMO ARILMETILO O ACILO) Y OBTENER UN COMPUESTO DE FORMULA (I) (R-H) O SUS SALES FISIOLOGICAMENTE ACEPTABLES. SIENDO: R1, HAL O UN GRUPO ELEGIDO ENTRE ALQUILO DE C 1 A 4, HIDROXILO, CIANO Y OTROS; R2, H, HAL O UN GRUPO ELEGIDO ENTRE ALQUILO DE C 1 A 4 Y CIANO. SE UTILIZA PARA EL TRATAMIENTO Y LA PREVENCION DE JAQUECA, TROMBOSIS, DIABETES E HIPERTENSION.
ES551509A 1984-04-24 1986-01-31 Un procedimiento para la preparacion de compuestos aminoheterociclicos Expired ES8801545A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848410456A GB8410456D0 (en) 1984-04-24 1984-04-24 Chemical compounds
GB858503975A GB8503975D0 (en) 1985-02-15 1985-02-15 Chemical compounds

Publications (2)

Publication Number Publication Date
ES8801545A1 true ES8801545A1 (es) 1988-02-01
ES551509A0 ES551509A0 (es) 1988-02-01

Family

ID=26287645

Family Applications (2)

Application Number Title Priority Date Filing Date
ES542516A Expired ES8607311A1 (es) 1984-04-24 1985-04-24 Un procedimiento para la preparacion de compuestos aminoheterociclicos.
ES551509A Expired ES8801545A1 (es) 1984-04-24 1986-01-31 Un procedimiento para la preparacion de compuestos aminoheterociclicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES542516A Expired ES8607311A1 (es) 1984-04-24 1985-04-24 Un procedimiento para la preparacion de compuestos aminoheterociclicos.

Country Status (21)

Country Link
US (1) US4880801A (es)
EP (2) EP0359290B1 (es)
JP (2) JPH02270878A (es)
KR (1) KR920003065B1 (es)
AT (1) ATE55605T1 (es)
AU (1) AU577367B2 (es)
CA (1) CA1256111A (es)
CS (1) CS402491A3 (es)
CY (2) CY1532A (es)
DE (2) DE3587511T2 (es)
DK (2) DK160556C (es)
ES (2) ES8607311A1 (es)
FI (1) FI84069C (es)
GB (3) GB2201414B (es)
GR (1) GR850993B (es)
HK (2) HK42890A (es)
IL (1) IL75011A (es)
MX (1) MX9203233A (es)
NZ (1) NZ211885A (es)
PT (1) PT80344B (es)
SG (2) SG23590G (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8526210D0 (en) * 1985-10-23 1985-11-27 Glaxo Group Ltd Chemical compounds
GB8526209D0 (en) * 1985-10-23 1985-11-27 Glaxo Group Ltd Chemical process
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8828032D0 (en) * 1988-12-01 1989-01-05 Glaxo Group Ltd Medicaments
GB9012469D0 (en) * 1990-06-05 1990-07-25 Glaxo Group Ltd Medicaments
GB9119466D0 (en) * 1991-09-12 1991-10-23 Glaxo Group Ltd Chemical compounds
US6451806B2 (en) 1999-09-29 2002-09-17 Adolor Corporation Methods and compositions involving opioids and antagonists thereof
US6469030B2 (en) 1999-11-29 2002-10-22 Adolor Corporation Methods for the treatment and prevention of ileus
JP2006523674A (ja) * 2003-04-18 2006-10-19 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 慢性閉塞性肺疾患（ｃｏｐｄ）のための組合せ治療法
GB2503187A (en) * 2011-09-15 2013-12-25 Univ Sussex Composition for use in the treatment of neurodevelopmental disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2485539A1 (fr) * 1980-06-26 1981-12-31 Sori Soc Rech Ind Nouveau derive de pyranno-indole, son procede de preparation et son application en therapeutique
IL70034A0 (en) * 1982-10-25 1984-01-31 Glaxo Group Ltd Heterocyclic amino compounds,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
NZ211885A (en) 1988-09-29
DK160824C (da) 1991-10-07
KR850007259A (ko) 1985-12-02
IL75011A (en) 1990-02-09
DK160556B (da) 1991-03-25
JPH02270878A (ja) 1990-11-05
EP0359290A1 (en) 1990-03-21
ES551509A0 (es) 1988-02-01
KR920003065B1 (ko) 1992-04-13
EP0162593A1 (en) 1985-11-27
US4880801A (en) 1989-11-14
DK141590D0 (da) 1990-06-08
DK160824B (da) 1991-04-22
FI851611L (fi) 1985-10-25
HK42890A (en) 1990-06-08
EP0359290B1 (en) 1993-08-04
MX9203233A (es) 1992-07-01
FI84069B (fi) 1991-06-28
ES542516A0 (es) 1986-06-16
CA1256111A (en) 1989-06-20
CY1695A (en) 1994-01-14
CY1532A (en) 1990-11-16
ATE55605T1 (de) 1990-09-15
DE3579189D1 (de) 1990-09-20
DK184085D0 (da) 1985-04-24
EP0162593B1 (en) 1990-08-16
SG23590G (en) 1990-07-13
DE3587511T2 (de) 1993-11-18
FI851611A0 (fi) 1985-04-24
GB8728949D0 (en) 1988-01-27
HK112093A (en) 1993-10-29
GB8510449D0 (en) 1985-05-30
JPH02270819A (ja) 1990-11-05
GB2157691B (en) 1989-07-05
ES8607311A1 (es) 1986-06-16
DK160556C (da) 1991-09-02
FI84069C (fi) 1991-10-10
GB2201414A (en) 1988-09-01
CS402491A3 (en) 1992-10-14
AU4166785A (en) 1985-10-31
DK141590A (da) 1990-06-08
PT80344A (en) 1985-05-01
GB8802949D0 (en) 1988-03-09
GR850993B (es) 1985-11-25
DK184085A (da) 1985-10-25
AU577367B2 (en) 1988-09-22
DE3587511D1 (de) 1993-09-09
PT80344B (pt) 1987-09-30
SG12293G (en) 1993-04-16
GB2201414B (en) 1988-12-29
GB2157691A (en) 1985-10-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519