ES8707204A1 - Procedimiento para preparar diazepinoindoles - Google Patents
Procedimiento para preparar diazepinoindolesInfo
- Publication number
- ES8707204A1 ES8707204A1 ES555042A ES555042A ES8707204A1 ES 8707204 A1 ES8707204 A1 ES 8707204A1 ES 555042 A ES555042 A ES 555042A ES 555042 A ES555042 A ES 555042A ES 8707204 A1 ES8707204 A1 ES 8707204A1
- Authority
- ES
- Spain
- Prior art keywords
- schizophrenia
- diazepinoindoles
- anxiety
- useful
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 201000000980 schizophrenia Diseases 0.000 title abstract 2
- 208000019901 Anxiety disease Diseases 0.000 title 1
- 206010041243 Social avoidant behaviour Diseases 0.000 title 1
- 230000036506 anxiety Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- BSYFXFLGOGQHFU-UHFFFAOYSA-N pyrrolo[2,3-g][1,2]benzodiazepine Chemical class N1=NC=CC=C2C3=NC=CC3=CC=C21 BSYFXFLGOGQHFU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical class CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 1
- ZOCHARZZJNPSEU-UHFFFAOYSA-N diboron Chemical compound B#B ZOCHARZZJNPSEU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DIAZEPINOINDOLES.COMPRENDE: A) REDUCIR UN COMPUESTO DE FORMULA (II) CON DIBORANO, PARA OBTENER UN COMPUESTO DE FORMULA (III); B) DIMETILAR A (III) CON ESTER ETILICO, PARA OBTENER UN COMPUESTO DE FORMULA (IV); Y C) ALQUILAR A (IV) CON DERIVADOS N-ACILO, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SALES DE ADICION DE LOS MISMOS. SIENDO: R1 Y R2, H, ALQUILO DE C 1 A 3,5, HAL Y OTROS; RK3, H, ALQUILO DE C 1 A 3 Y OTROS; RL3, CICLOALQUILO DE C 3 A 6, ALQUILO DE C 1 A 3 Y OTROS; R4, R5 Y R6, H O ALQUILO DE C 1 A 4. SE UTILIZA PARA TRATAR LA ESQUIZOFRENIA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH86384 | 1984-02-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8707204A1 true ES8707204A1 (es) | 1987-07-16 |
| ES555042A0 ES555042A0 (es) | 1987-07-16 |
Family
ID=4196936
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES540559A Expired ES8706681A1 (es) | 1984-02-22 | 1985-02-20 | Procedimiento para preparar diazepinoindoles. |
| ES555042A Expired ES8707204A1 (es) | 1984-02-22 | 1986-05-16 | Procedimiento para preparar diazepinoindoles |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES540559A Expired ES8706681A1 (es) | 1984-02-22 | 1985-02-20 | Procedimiento para preparar diazepinoindoles. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4673674A (es) |
| JP (1) | JPS60202887A (es) |
| AT (1) | AT388379B (es) |
| BE (1) | BE901725A (es) |
| CA (1) | CA1271193A (es) |
| DE (1) | DE3505017A1 (es) |
| DK (1) | DK78385A (es) |
| ES (2) | ES8706681A1 (es) |
| FI (1) | FI79316C (es) |
| FR (1) | FR2609715B1 (es) |
| GB (1) | GB2154584B (es) |
| GR (1) | GR850443B (es) |
| HU (1) | HU193083B (es) |
| IL (1) | IL74388A (es) |
| IT (1) | IT1199949B (es) |
| LU (1) | LU85778A1 (es) |
| MY (1) | MY100083A (es) |
| NL (1) | NL8500370A (es) |
| PH (1) | PH22247A (es) |
| PL (2) | PL144329B1 (es) |
| PT (1) | PT79990B (es) |
| SE (1) | SE8500822L (es) |
| ZA (1) | ZA851373B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3635071A1 (de) * | 1986-10-15 | 1988-04-28 | Autoflug Gmbh | Rueckenlehnenverriegelung fuer einen mit sicherheitsgurten ausgeruesteten fahrzeugsitz |
| CA2402472A1 (en) * | 2000-03-14 | 2001-10-04 | Michael Dalton Ennis | 2,3,4,5-tetrahydro-1h-¬1,4|diazepino¬1,7a|indole compounds |
| KR20130122810A (ko) * | 2005-06-27 | 2013-11-08 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 제조 방법 |
| HU230880B1 (hu) * | 2015-04-15 | 2018-11-29 | Richter Gedeon Nyrt | Indol származékok |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1593146A (en) * | 1976-11-05 | 1981-07-15 | Beecham Group Ltd | Octahydro-quinolizinyl benzamide derivatives |
| US4210590A (en) * | 1978-01-06 | 1980-07-01 | Mcneil Laboratories, Incorporated | Reduction of indole compounds to indoline compounds |
| CH649553A5 (de) * | 1982-05-06 | 1985-05-31 | Sandoz Ag | Azepinoindole und verfahren zu deren herstellung. |
-
1985
- 1985-02-11 HU HU85510A patent/HU193083B/hu not_active IP Right Cessation
- 1985-02-11 NL NL8500370A patent/NL8500370A/nl not_active Application Discontinuation
- 1985-02-13 BE BE1/11188A patent/BE901725A/fr unknown
- 1985-02-14 DE DE19853505017 patent/DE3505017A1/de not_active Withdrawn
- 1985-02-14 PH PH31856A patent/PH22247A/en unknown
- 1985-02-19 GB GB08504179A patent/GB2154584B/en not_active Expired
- 1985-02-20 IL IL74388A patent/IL74388A/xx unknown
- 1985-02-20 PT PT79990A patent/PT79990B/pt unknown
- 1985-02-20 SE SE8500822A patent/SE8500822L/xx not_active Application Discontinuation
- 1985-02-20 IT IT47704/85A patent/IT1199949B/it active
- 1985-02-20 FI FI850702A patent/FI79316C/fi not_active IP Right Cessation
- 1985-02-20 LU LU85778A patent/LU85778A1/fr unknown
- 1985-02-20 ES ES540559A patent/ES8706681A1/es not_active Expired
- 1985-02-20 DK DK78385A patent/DK78385A/da not_active Application Discontinuation
- 1985-02-20 GR GR850443A patent/GR850443B/el unknown
- 1985-02-21 JP JP60034261A patent/JPS60202887A/ja active Pending
- 1985-02-21 AT AT0052285A patent/AT388379B/de not_active IP Right Cessation
- 1985-02-21 PL PL1985252065A patent/PL144329B1/pl unknown
- 1985-02-21 US US06/704,040 patent/US4673674A/en not_active Expired - Fee Related
- 1985-02-21 CA CA000474852A patent/CA1271193A/en not_active Expired - Lifetime
- 1985-02-21 PL PL1985268394A patent/PL146274B1/pl unknown
- 1985-02-22 ZA ZA851373A patent/ZA851373B/xx unknown
-
1986
- 1986-05-16 ES ES555042A patent/ES8707204A1/es not_active Expired
-
1987
- 1987-09-25 MY MYPI87001944A patent/MY100083A/en unknown
- 1987-11-23 FR FR878716324A patent/FR2609715B1/fr not_active Expired
Also Published As
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