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ES8706164A1 - Un procedimiento para la preparacion de glicosidos de homo- nojirimicina - Google Patents

Un procedimiento para la preparacion de glicosidos de homo- nojirimicina

Info

Publication number
ES8706164A1
ES8706164A1 ES550060A ES550060A ES8706164A1 ES 8706164 A1 ES8706164 A1 ES 8706164A1 ES 550060 A ES550060 A ES 550060A ES 550060 A ES550060 A ES 550060A ES 8706164 A1 ES8706164 A1 ES 8706164A1
Authority
ES
Spain
Prior art keywords
glycosyl
homodisaccharide
benzyl
formula
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550060A
Other languages
English (en)
Other versions
ES550060A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of ES550060A0 publication Critical patent/ES550060A0/es
Publication of ES8706164A1 publication Critical patent/ES8706164A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Luminescent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

METODO DE PREPARAR GLICOSIDOS DE HOMONOKIRIMICINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN BROMURO O CLORURO DE GLICOSILO EN EL QUE LOS GRUPOS HIDROXI ESTAN PROTEGIDOS CON GRUPOS BENCILO O GRUPOS ALCANOILO QUE CONTIENEN HASTA 6 ATOMOS DE CARBONO, Y DESPUES SOMETER A HIDROGENACION CATALITICA Y SAPONIFICACION, PARA SEPARAR LOS GRUPOS PROTECTORES BENCILO O ESTER, PARA OBTENER GLICOSIDOS DE HOMONOJIRIMICINA DE FORMULA (I), DONDE R ES UN RADICAL GLICOSILO O GLICOSILO ACILADO QUE CONTIENE DE 1 A 3 UNIDADES DE HEXOSA O PENTOSA.TIENEN APLICACIONES FARMACEUTICAS COMO AGENTES ANTIDIABETICOS.
ES550060A 1984-12-18 1985-12-17 Un procedimiento para la preparacion de glicosidos de homo- nojirimicina Expired ES8706164A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/683,127 US4634765A (en) 1984-12-18 1984-12-18 Homodisaccharide hypoglycemic agents

Publications (2)

Publication Number Publication Date
ES550060A0 ES550060A0 (es) 1987-06-01
ES8706164A1 true ES8706164A1 (es) 1987-06-01

Family

ID=24742682

Family Applications (1)

Application Number Title Priority Date Filing Date
ES550060A Expired ES8706164A1 (es) 1984-12-18 1985-12-17 Un procedimiento para la preparacion de glicosidos de homo- nojirimicina

Country Status (20)

Country Link
US (1) US4634765A (es)
EP (1) EP0186103B1 (es)
JP (1) JPS61158994A (es)
KR (1) KR900005607B1 (es)
CN (1) CN1016784B (es)
AT (1) ATE62249T1 (es)
AU (1) AU574246B2 (es)
CA (1) CA1240989A (es)
DE (1) DE3582420D1 (es)
DK (1) DK587085A (es)
ES (1) ES8706164A1 (es)
FI (1) FI80707C (es)
GR (1) GR853032B (es)
HU (1) HU194263B (es)
IE (1) IE58186B1 (es)
NO (1) NO162387B (es)
NZ (1) NZ214570A (es)
PH (1) PH23660A (es)
PT (1) PT81689B (es)
ZA (1) ZA859573B (es)

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GB2181729B (en) * 1985-10-12 1990-04-04 Nippon Shinyaku Co Ltd Glucosylmoranoline derivatives and production thereof
JPS62242692A (ja) * 1986-04-15 1987-10-23 Nippon Shinyaku Co Ltd モラノリン誘導体の製造法
EP0344383A1 (en) * 1988-06-02 1989-12-06 Merrell Dow Pharmaceuticals Inc. Novel alpha-Glucosidase inhibitors
EP0345104B1 (en) * 1988-06-02 1995-11-02 Merrell Dow Pharmaceuticals Inc. Novel Alpha-glucosidase inhibitors
US4880917A (en) * 1988-07-01 1989-11-14 Merrell Dow Pharmaceuticals Inc. Process for hydrolyzing 2,6-dideoxy-2,6-iminoheptononitrile derivatives using trifluoroacetic acid and dinitrogen tetroxide
US4908439A (en) * 1988-09-16 1990-03-13 Merrell Dow Pharmaceuticals Inc. Synthesis of intermediate useful in the preparation of nojirimycin and related compounds
US5227479A (en) * 1989-12-20 1993-07-13 Merrell Dow Pharmaceuticals Inc. Process for the preparation of nojirimycin and related compounds
US5504078A (en) * 1990-06-08 1996-04-02 Merrell Dow Pharmaceuticals Inc. α-glucosidase inhibitors
EP0973534B1 (en) * 1997-04-15 2006-11-02 Csir Plant extracts having appetite suppressant activity
GB2396815B (en) * 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
AU2001247848A1 (en) 2000-03-31 2001-10-15 Michigan State University Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines
GB2363985B (en) * 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
DE602005016009D1 (de) * 2004-11-23 2009-09-24 Warner Lambert Co 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptansäure-derivate als hmg-co-a-reductase-inhibitoren zur behandlung von lipidemia
US20060293250A1 (en) * 2005-06-08 2006-12-28 Michael Major Crystalline sugar compositions and method of making
CN101228173A (zh) * 2005-06-08 2008-07-23 阿米库斯治疗学公司 三氟甲磺酸酯化的化合物的稳定化
PT2027137E (pt) 2005-06-08 2015-06-09 Amicus Therapeutics Inc Purificação de imino e amino-açúcares
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
ATE547394T1 (de) 2006-12-01 2012-03-15 Bristol Myers Squibb Co N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
CN101765433A (zh) 2007-03-12 2010-06-30 Zadec私人有限责任公司 一种抗糖尿病的红灌木提取物
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN103601792B (zh) 2007-06-04 2016-06-29 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
JP2013528172A (ja) 2010-05-21 2013-07-08 ファイザー・インク ２−フェニルベンゾイルアミド
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN102462726B (zh) * 2010-11-04 2016-03-09 中国医学科学院药物研究所 白树总生物碱及多羟基生物碱化合物的提取、分离及用途
CA2828343A1 (en) 2011-03-04 2012-09-13 The Scripps Research Institute Edn3-like peptides and uses thereof
CN103703012A (zh) * 2011-05-13 2014-04-02 格礼卡姆股份公司 乳糖-n-四糖的制造
MY188344A (en) 2012-03-09 2021-12-01 Biotropics Malaysia Berhad Extract formulations of rhodamnia cinerea and uses thereof
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2909442A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
EP4424697A3 (en) 2013-06-05 2024-12-25 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
JP6769963B2 (ja) 2014-08-29 2020-10-14 ティエエッセ ファルマ ソチエタ レスポンサビリタ リミタータ α−アミノ−β−カルボキシムコン酸セミアルデヒド脱炭酸酵素の阻害剤
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN104530150A (zh) * 2015-01-14 2015-04-22 佛山市赛维斯医药科技有限公司 含胺基苯和双葡萄糖苷结构化合物、其制备方法和用途
AU2017342083A1 (en) 2016-10-14 2019-04-11 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
IT201700078102A1 (it) 2017-07-11 2019-01-11 Dipharma Francis Srl Sintesi di un azazucchero e suoi intermedi
CN108828121B (zh) * 2018-06-14 2020-06-05 华润三九医药股份有限公司 一种白树药材中α-高野尻霉素的含量检测方法
CA3119509A1 (en) 2018-11-20 2020-05-28 Tes Pharma S.R.L Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxxylase
EP4470609A3 (en) 2019-01-18 2025-03-12 Astrazeneca AB Pcsk9 inhibitors and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065562A (en) * 1975-12-29 1977-12-27 Nippon Shinyaku Co., Ltd. Method and composition for reducing blood glucose levels
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2848117A1 (de) * 1978-11-06 1980-05-14 Bayer Ag Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels
DE2942365A1 (de) * 1979-10-19 1981-05-14 Bayer Ag, 5090 Leverkusen 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB2064527B (en) * 1979-12-08 1984-05-02 Nippon Shinyaku Co Ltd Moranoline derivatives and process for preparation thereof
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.

Also Published As

Publication number Publication date
EP0186103B1 (en) 1991-04-03
PT81689B (pt) 1987-11-30
ZA859573B (en) 1986-08-27
AU574246B2 (en) 1988-06-30
US4634765A (en) 1987-01-06
DK587085A (da) 1986-06-19
DE3582420D1 (de) 1991-05-08
KR900005607B1 (ko) 1990-07-31
GR853032B (es) 1986-04-18
IE853179L (en) 1986-06-18
PH23660A (en) 1989-09-27
FI80707C (fi) 1990-07-10
PT81689A (en) 1986-01-01
IE58186B1 (en) 1993-07-28
NO162387B (no) 1989-09-11
AU5081085A (en) 1986-06-26
HUT40137A (en) 1986-11-28
NZ214570A (en) 1988-03-30
DK587085D0 (da) 1985-12-17
FI854944L (fi) 1986-06-19
FI80707B (fi) 1990-03-30
ES550060A0 (es) 1987-06-01
NO855087L (no) 1986-06-19
CA1240989A (en) 1988-08-23
ATE62249T1 (de) 1991-04-15
JPS61158994A (ja) 1986-07-18
EP0186103A3 (en) 1988-02-03
KR860004921A (ko) 1986-07-16
JPH0565519B2 (es) 1993-09-17
HU194263B (en) 1988-01-28
EP0186103A2 (en) 1986-07-02
CN1016784B (zh) 1992-05-27
CN85109548A (zh) 1986-07-09
FI854944A0 (fi) 1985-12-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519