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ES8705837A1 - Un procedimiento para la preparacion de derivados de naftaleno. - Google Patents

Un procedimiento para la preparacion de derivados de naftaleno.

Info

Publication number
ES8705837A1
ES8705837A1 ES550578A ES550578A ES8705837A1 ES 8705837 A1 ES8705837 A1 ES 8705837A1 ES 550578 A ES550578 A ES 550578A ES 550578 A ES550578 A ES 550578A ES 8705837 A1 ES8705837 A1 ES 8705837A1
Authority
ES
Spain
Prior art keywords
naphthalene derivatives
preparation
pharmaceutical composition
composition containing
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550578A
Other languages
English (en)
Other versions
ES550578A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of ES8705837A1 publication Critical patent/ES8705837A1/es
Publication of ES550578A0 publication Critical patent/ES550578A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/337—Polycyclic acids with carboxyl groups bound to condensed ring systems
    • C07C63/34—Polycyclic acids with carboxyl groups bound to condensed ring systems containing two condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Fats And Perfumes (AREA)
  • Lubricants (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

METODO DE PREPARAR DERIVADOS DE NAFTALENO. CONSISTE EN CONDENSAR UN COMPUESTO DE FORMULA R1-FC-R2 CON UN ALDEHIDO DE FORMULA (II), EFECTUANDOSE LA CONDENSACION EN PRESENCIA DE UN ACIDO, CON O SIN DISOLVENTE A UNA TEMPERATURA ENTRE 0 Y 150JC, PARA OBTENER DERIVADOS DE NAFTALENO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE R1 ES UN ATOMO DE HIDROGENO O UN GRUPO (ALCOXI INFERIOR)CARBONILO; R2 ES UN ALCOXI INFERIOR CARBONILO; R3 Y R4 SON CADA UNO UN GRUPO ALCOXI INFERIOR O UNO ES UN ATOMO DE H Y EL OTRO ES UN GRUPO ALCOXI INFERIOR; Y A ES UN ANILLO BENCENICO SUSTITUIDO O NO SUSTITUIDO. TIENE APLICACIONES FARMACEUTICAS PARA TRATAR LA ARTERIOSCLEROSIS.
ES550578A 1985-01-10 1985-12-30 Un procedimiento para la preparacion de derivados de naftaleno. Expired ES8705837A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP309085 1985-01-10

Publications (2)

Publication Number Publication Date
ES8705837A1 true ES8705837A1 (es) 1987-05-16
ES550578A0 ES550578A0 (es) 1987-05-16

Family

ID=11547645

Family Applications (2)

Application Number Title Priority Date Filing Date
ES550578A Expired ES8705837A1 (es) 1985-01-10 1985-12-30 Un procedimiento para la preparacion de derivados de naftaleno.
ES557052A Expired ES8801239A1 (es) 1985-01-10 1986-09-03 Un procedimiento para la preparacion de derivados de naftaleno

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557052A Expired ES8801239A1 (es) 1985-01-10 1986-09-03 Un procedimiento para la preparacion de derivados de naftaleno

Country Status (18)

Country Link
US (2) US4771072A (es)
EP (1) EP0188248B1 (es)
JP (3) JPS61267541A (es)
KR (1) KR890001884B1 (es)
CN (1) CN1006464B (es)
AT (1) ATE54441T1 (es)
AU (1) AU584153B2 (es)
BG (2) BG45385A3 (es)
DD (1) DD270529A5 (es)
DE (1) DE3672501D1 (es)
ES (2) ES8705837A1 (es)
FI (1) FI87557C (es)
HU (1) HU196737B (es)
IL (1) IL91117A0 (es)
MY (1) MY101268A (es)
NO (1) NO170760C (es)
PH (1) PH22105A (es)
PT (1) PT81814B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US5011948A (en) * 1985-04-12 1991-04-30 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
JPS6310746A (ja) * 1986-07-01 1988-01-18 Tanabe Seiyaku Co Ltd ナフタレン誘導体
AT388372B (de) * 1987-10-08 1989-06-12 Tanabe Seiyaku Co Neue naphthalinderivate und sie enthaltende pharmazeutika
JPH01135766A (ja) * 1987-11-20 1989-05-29 Tanabe Seiyaku Co Ltd ビフェニル誘導体
PH26342A (en) * 1988-11-29 1992-04-29 Univ Texas Microbial cellulose modified during synthesis
MY105057A (en) * 1989-01-27 1994-07-30 Tanabe Seiyaku Co A process for preparing naphthalene derivatives
ZA9076B (en) * 1989-02-03 1990-10-31 Tanabe Seiyaku Co Limited A process for preparing a naphthalene derivative and a synthetic intermediate thereof
EP0501578A1 (en) * 1991-02-28 1992-09-02 Merck Frosst Canada Inc. Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis
EP0501579A1 (en) * 1991-02-28 1992-09-02 Merck Frosst Canada Inc. Naphthalene lactones as inhibitors of leukotriene biosynthesis
US5281720A (en) * 1991-02-28 1994-01-25 Merck Frosst Canada, Inc. Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis
US5227399A (en) * 1991-02-28 1993-07-13 Merck Frosst Canada, Inc. Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis
DE69228262D1 (de) * 1991-10-17 1999-03-04 Shionogi & Co Verfahren zum Herstellen von Lignin-Analoga und Ausgangsprodukte dafür
US5308852A (en) * 1992-06-29 1994-05-03 Merck Frosst Canada, Inc. Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis
US5426109A (en) * 1992-08-27 1995-06-20 Merck Frosst Canada, Inc. Phenylnaphthalene hydroxy acids
US5428060A (en) * 1992-08-27 1995-06-27 Merck Frosst Canada, Inc. Heteroarylnaphthalene lactones as inhibitors of leukotriene biosynthesis
US5350744A (en) * 1992-08-27 1994-09-27 Merck Frosst Canada, Inc. Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis
US5252599A (en) * 1992-08-27 1993-10-12 Merck Frosst Canada, Inc. Heteroarylnaphthalene hydroxy acids as inhibitors of leukotriene biosynthesis
CA2121060C (en) * 1993-04-16 2004-04-06 Sachio Mori Preparation of lignan analogues
ID18046A (id) * 1996-08-20 1998-02-19 Takeda Chemical Industries Ltd Senyawa siklik campuran, pembuatan dan penngunaannya.
BR9913333A (pt) 1998-08-25 2001-05-15 Univ Yale Inibição e tratamento do vìrus da hepatite b e flavivìrus com helioxatina e seus análogos
US6680344B1 (en) 1999-06-01 2004-01-20 The University Of Texas Southwestern Medical Center Method of treating hair loss using diphenylmethane derivatives
US6646005B1 (en) 1999-06-01 2003-11-11 The University Of Texas Southwestern Medical Center Method of treating hair loss using sulfonyl thyromimetic compounds
AU3507700A (en) 1999-06-01 2000-12-18 University Of Texas Southwestern Medical Center, The Method of treating hair loss using diphenylether derivatives
SE0102168D0 (sv) * 2001-06-19 2001-06-19 Karolinska Innovations Ab New use and new compounds
MXPA04001878A (es) * 2001-08-28 2004-06-15 Sankyo Co Composiciones medicinales que comprenden antagonista del receptor de angiotensina ii.
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
ES2552657T3 (es) 2010-05-26 2015-12-01 Satiogen Pharmaceuticals, Inc. Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias
SG11201401849QA (en) 2011-10-28 2014-05-29 Lumena Pharmaceuticals Inc Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
SG10201406155QA (en) 2011-10-28 2014-11-27 Lumena Pharmaceuticals Inc Bile Acid Recycling Inhibitors For Treatment Of Pediatric Cholestatic Liver Diseases
CN105228615A (zh) 2013-03-15 2016-01-06 鲁美纳医药公司 用于治疗巴雷特食管和胃食管返流疾病的胆汁酸再循环抑制剂
RU2015139731A (ru) 2013-03-15 2017-04-20 ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи Ингибиторы рециркуляции желчных кислот для лечения первичного склерозирующего холангита и воспалительного заболевания кишечника
WO2015153653A1 (en) * 2014-03-31 2015-10-08 Ohio State Innovation Foundation Arylnaphthalene lactone derivatives and methods of making and using thereof
WO2017147624A1 (en) 2016-02-26 2017-08-31 Ohio State Innovation Foundation Antitumor arylnaphthalene ligand glycosides
EP3923943B1 (en) 2019-02-12 2024-07-31 Mirum Pharmaceuticals, Inc. Genotype and dose-dependent response to an asbti in patients with bile salt export pump deficiency

Also Published As

Publication number Publication date
KR860005778A (ko) 1986-08-13
DE3672501D1 (de) 1990-08-16
NO170760C (no) 1992-12-02
NO855355L (no) 1986-07-11
US4771072A (en) 1988-09-13
JPS61267541A (ja) 1986-11-27
ES557052A0 (es) 1987-12-16
ES8801239A1 (es) 1987-12-16
JPH0272136A (ja) 1990-03-12
BG45385A3 (bg) 1989-05-15
AU584153B2 (en) 1989-05-18
CN1006464B (zh) 1990-01-17
FI87557B (fi) 1992-10-15
HU196737B (en) 1989-01-30
ATE54441T1 (de) 1990-07-15
PT81814A (en) 1986-02-01
CN86100090A (zh) 1986-08-20
BG45383A3 (bg) 1989-05-15
NO170760B (no) 1992-08-24
DD270529A5 (de) 1989-08-02
KR890001884B1 (ko) 1989-05-29
ES550578A0 (es) 1987-05-16
FI860089L (fi) 1986-07-11
JPH0549668B2 (es) 1993-07-26
US5070103A (en) 1991-12-03
HUT42428A (en) 1987-07-28
FI860089A0 (fi) 1986-01-09
FI87557C (fi) 1993-01-25
EP0188248A3 (en) 1986-12-17
IL91117A0 (en) 1990-03-19
PH22105A (en) 1988-06-01
AU5175185A (en) 1986-07-17
JPH0272170A (ja) 1990-03-12
MY101268A (en) 1991-08-17
PT81814B (pt) 1988-07-29
EP0188248B1 (en) 1990-07-11
EP0188248A2 (en) 1986-07-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401