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ES8701494A1 - Procedimiento para la preparacion de etofibrato o compuestossimilares que contienen microgranulos de liberacion constan-te - Google Patents

Procedimiento para la preparacion de etofibrato o compuestossimilares que contienen microgranulos de liberacion constan-te

Info

Publication number
ES8701494A1
ES8701494A1 ES544649A ES544649A ES8701494A1 ES 8701494 A1 ES8701494 A1 ES 8701494A1 ES 544649 A ES544649 A ES 544649A ES 544649 A ES544649 A ES 544649A ES 8701494 A1 ES8701494 A1 ES 8701494A1
Authority
ES
Spain
Prior art keywords
etofibrate
microgranules
preparing
sieving
sustained release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544649A
Other languages
English (en)
Other versions
ES544649A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of ES8701494A1 publication Critical patent/ES8701494A1/es
Publication of ES544649A0 publication Critical patent/ES544649A0/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ETOFIBRATO O COMPUESTOS SIMILARES QUE CONTIENEN MICROGRANULOS DE LIBERACION CONSTANTE. COMPRENDE LAS SIGUIENTES ETAPAS: PRIMERA, EN UN DEPOSITO GIRATORIO SE DISPONE ETOFIBRATO O UNA SUSTANCIA SIMILAR EN POLVO, AL QUE SE AÑADE UN DISOLVENTE; SEGUNDA, SE SOMETE EL COMPUESTO A UN PRIMER CRIBADO PARA OBTENER LOS PRIMEROS MICROGRANULOS; TERCERA, EL PRODUCTO QUE COMPRENDE LOS PRIMEROS MICROGRANULOS SE SECA HASTA QUE SE EVAPORA EL DISOLVENTE, CON LO QUE SE OBTIENEN UNOS SEGUNDOS MICROGRANULOS DE MENOR DIAMETRO QUE EL DE LOS PRIMEROS MICROGRANULOS; CUARTA, LOS SEGUNDOS MICROGRANULOS SE COLOCAN NUEVAMENTE EN EL DEPOSITO GIRATORIO; QUINTA, SE LLEVA A CABO UN ULTIMO CRIBADO AL OBJETO DE SEPARAR LOS TERCEROS MICROGRANULOS, CUYO TAMAÑO RESPONDE AL TAMAÑO REQUERIDO; Y POR ULTIMO, LOS TERCEROS MICROGRANULOS SE COLOCAN EN CAPSULAS.
ES544649A 1984-06-29 1985-06-27 Procedimiento para la preparacion de etofibrato o compuestossimilares que contienen microgranulos de liberacion constan-te Expired ES8701494A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03511/84A IT1180507B (it) 1984-06-29 1984-06-29 Procedimento per la preparazione di etofibrato o sostanze di pari o simili caratteristiche, in microgunuli-ritardo e prodotto ottenuto con tale procedimento

Publications (2)

Publication Number Publication Date
ES8701494A1 true ES8701494A1 (es) 1986-12-16
ES544649A0 ES544649A0 (es) 1986-12-16

Family

ID=11108749

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544649A Expired ES8701494A1 (es) 1984-06-29 1985-06-27 Procedimiento para la preparacion de etofibrato o compuestossimilares que contienen microgranulos de liberacion constan-te

Country Status (9)

Country Link
US (1) US4957746A (es)
EP (1) EP0168360B1 (es)
JP (1) JPS6133113A (es)
KR (1) KR870001959B1 (es)
AT (1) ATE77052T1 (es)
DE (1) DE3586185T2 (es)
ES (1) ES8701494A1 (es)
IT (1) IT1180507B (es)
RU (1) RU1829934C (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4021678C2 (de) * 1990-07-07 1994-07-07 Merz & Co Gmbh & Co Verfahren zur Herstellung klein dimensionierter Formkörper mit hohem Etofibrat-Gehalt und kontrollierter Wirkstoff-Freisetzung, deren Verwendung und daraus bestehende oral verabreichbare Applikationsformen
SE9003296L (sv) * 1990-10-16 1992-04-17 Kabi Pharmacia Ab Foerfarande foer att formulera laekemedel
DE4317127A1 (de) * 1993-05-19 1994-11-24 Merz & Co Gmbh & Co Verwendung von Etofibrat und pharmazeutische Zusammensetzungen, enthaltend Etofibrat, zur Behandlung der diabetischen Angio- und Retinopathie
FR2758459B1 (fr) * 1997-01-17 1999-05-07 Pharma Pass Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation
FR2758461A1 (fr) * 1997-01-17 1998-07-24 Pharma Pass Composition pharmaceutique presentant une biodisponibilite elevee et son procede de preparation
US7014864B1 (en) 1998-12-18 2006-03-21 Abbott Laboratories Formulations comprising lipid-regulating agents
US6838091B2 (en) * 1998-12-18 2005-01-04 Abbott Laboratories Formulations comprising lipid-regulating agents
US6814977B1 (en) 1998-12-18 2004-11-09 Abbott Laboratories Formulations comprising lipid-regulating agents
US6368622B2 (en) 1999-01-29 2002-04-09 Abbott Laboratories Process for preparing solid formulations of lipid regulating agents with enhanced dissolution and absorption
US6719999B2 (en) 1999-03-31 2004-04-13 Abbott Laboratories Formulations comprising lipid-regulating agents
WO2000072829A1 (en) * 1999-05-28 2000-12-07 Abbott Laboratories Novel formulations comprising lipid-regulating agents
US6372251B2 (en) 1999-06-11 2002-04-16 Abbott Laboratories Formulations comprising lipid-regulating agents
FR2816507B1 (fr) * 2000-11-16 2003-02-28 Ethypharm Lab Prod Ethiques Microgranules a base de principe actif, procede de fabrication et compositons pharmaceutiques integrant lesdits microgranules
CN101961324A (zh) * 2010-09-10 2011-02-02 武汉药谷生物工程有限公司 一种依托贝特缓释胶囊的处方及制备方法
CN102579366A (zh) * 2012-03-23 2012-07-18 南京泽恒医药技术开发有限公司 一种依托贝特缓释微丸的制备方法
CN105769767A (zh) * 2016-04-12 2016-07-20 武汉理工大学 依托贝特自乳化制剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4064230A (en) * 1966-04-25 1977-12-20 Schmid Laboratories, Inc. Polyenic macrolide compositions
US4000254A (en) * 1966-04-25 1976-12-28 Schmid Laboratories, Inc. Fungimycin compositions
US4321263A (en) * 1980-09-30 1982-03-23 Rowell Laboratories, Inc. Psyllium compositions
FR2494112B1 (es) * 1980-11-19 1986-01-10 Laruelle Claude
GB2115409B (en) * 1982-02-24 1985-08-07 Zyma Sa Novel crystal modifications of (+)-catechin

Also Published As

Publication number Publication date
US4957746A (en) 1990-09-18
IT8403511A0 (it) 1984-06-29
IT1180507B (it) 1987-09-23
DE3586185D1 (de) 1992-07-16
EP0168360B1 (en) 1992-06-10
ATE77052T1 (de) 1992-06-15
DE3586185T2 (de) 1993-01-21
EP0168360A2 (en) 1986-01-15
KR870001959B1 (ko) 1987-10-23
ES544649A0 (es) 1986-12-16
JPS6133113A (ja) 1986-02-17
RU1829934C (ru) 1993-07-23
EP0168360A3 (en) 1987-01-07
KR860000069A (ko) 1986-01-25

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