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ES8701143A1 - Un procedimiento para la preparacion de nuevos aminas terciarias. - Google Patents

Un procedimiento para la preparacion de nuevos aminas terciarias.

Info

Publication number
ES8701143A1
ES8701143A1 ES545365A ES545365A ES8701143A1 ES 8701143 A1 ES8701143 A1 ES 8701143A1 ES 545365 A ES545365 A ES 545365A ES 545365 A ES545365 A ES 545365A ES 8701143 A1 ES8701143 A1 ES 8701143A1
Authority
ES
Spain
Prior art keywords
hydroxy
aryloxypropyl
substituted
hyperglycaemic
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545365A
Other languages
English (en)
Other versions
ES545365A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES545365A0 publication Critical patent/ES545365A0/es
Publication of ES8701143A1 publication Critical patent/ES8701143A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVAS AMINAS TERCIARIAS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA OBTENER AMINAS TERCIARIAS DE FORMULA (I) O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES; DONDE R1 ES UN GRUPO 2-HIDROXI-2-(BENZOFURAN-2-IL)ETILO Y OTROS; R2 ES UN GRUPO DE HIDROGENO O UN GRUPO METILO; D ES UN RADICAL BENZOFURAN-2-ILO Y OTROS; R4 ES UN RADICAL -(CH2)ACOOH, -O(CH2)BCOOH Y OTROS; R4K ES UN ATOMO DE HIDROGENO O DE HALOGENO O UN RADICAL ALQUILO INFERIOR O ALCOXI INFERIOR Y OTROS; N ES 1 O 2; M ES 0 O 1, CON LA CONDICION DE QUE NBM ES 1 O 2; Q1 ES UN ATOMO DE HIDROGENO; Y Q2 ES UN GRUPO HIDROXI O UN ESTER HIDROLIZABLE IN-VIVO. TIENEN APLICACION EN MEDICINA Y AGRICULTURA POR SU ACTIVIDAD ANTI-HIPERGLICEMICA Y/O ANTI-OBESIDAD.
ES545365A 1984-07-19 1985-07-18 Un procedimiento para la preparacion de nuevos aminas terciarias. Expired ES8701143A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848418472A GB8418472D0 (en) 1984-07-19 1984-07-19 Compounds

Publications (2)

Publication Number Publication Date
ES545365A0 ES545365A0 (es) 1986-11-16
ES8701143A1 true ES8701143A1 (es) 1986-11-16

Family

ID=10564149

Family Applications (2)

Application Number Title Priority Date Filing Date
ES545365A Expired ES8701143A1 (es) 1984-07-19 1985-07-18 Un procedimiento para la preparacion de nuevos aminas terciarias.
ES552860A Expired ES8705362A1 (es) 1984-07-19 1986-03-10 Un procedimiento para la preparacion de nuevas aminas terciarias

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES552860A Expired ES8705362A1 (es) 1984-07-19 1986-03-10 Un procedimiento para la preparacion de nuevas aminas terciarias

Country Status (11)

Country Link
EP (1) EP0170121B1 (es)
JP (1) JPS6176446A (es)
AT (1) ATE64590T1 (es)
AU (1) AU4517385A (es)
DE (1) DE3583261D1 (es)
DK (1) DK325385A (es)
ES (2) ES8701143A1 (es)
GB (1) GB8418472D0 (es)
GR (1) GR851779B (es)
PT (1) PT80835B (es)
ZA (1) ZA855400B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1262729A (en) * 1983-10-19 1989-11-07 Leo Alig Phenoxypropanolamines
US5166218A (en) * 1983-10-19 1992-11-24 Hoffmann-La Roche Inc. Phenoxypropanolamines and pharmaceutical compositions thereof
CA1337429C (en) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
GB8620951D0 (en) * 1986-08-29 1986-10-08 Beecham Group Plc Compounds
DE3866984D1 (en) * 1987-07-21 1992-01-30 Hoffmann La Roche Phenoxypropanolamine.
US5321036A (en) * 1993-02-10 1994-06-14 Bristol-Myers Squibb Company Thiazole and oxazole-based β3 adrenergic receptor agonists
US5578638A (en) * 1993-11-05 1996-11-26 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists
US5563171A (en) * 1993-11-05 1996-10-08 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists
AU4320297A (en) * 1996-09-26 1998-04-17 Kissei Pharmaceutical Co. Ltd. 2-amino-1-(4-hydroxy-2-methylphenyl)propanol derivatives
MY126489A (en) * 1998-07-08 2006-10-31 Kissei Pharmaceutical Phenoxyacetic acid derivatives and medicinal compositions containing the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146638A (en) * 1976-02-17 1979-03-27 Boehringer Ingelheim Gmbh N-(3-phenoxy-2-hydroxy-propyl)-n-(2-phenyl-2-hydroxy-ethyl)-amines
DE3368258D1 (en) * 1982-07-16 1987-01-22 Beecham Group Plc 2-aminoethyl ether derivatives, processes for their preparation and pharmaceutical compositions containing them
CA1258454A (en) * 1982-08-10 1989-08-15 Leo Alig Phenethanolamines
CA1262729A (en) * 1983-10-19 1989-11-07 Leo Alig Phenoxypropanolamines

Also Published As

Publication number Publication date
DE3583261D1 (de) 1991-07-25
JPS6176446A (ja) 1986-04-18
EP0170121B1 (en) 1991-06-19
ES545365A0 (es) 1986-11-16
GB8418472D0 (en) 1984-08-22
ZA855400B (en) 1986-05-28
PT80835B (en) 1987-03-23
GR851779B (es) 1985-11-26
PT80835A (en) 1985-08-01
ATE64590T1 (de) 1991-07-15
AU4517385A (en) 1986-01-23
EP0170121A1 (en) 1986-02-05
ES8705362A1 (es) 1987-05-01
DK325385A (da) 1986-01-20
DK325385D0 (da) 1985-07-17
ES552860A0 (es) 1987-05-01

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