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ES8700267A1 - Un procedimiento para la preparacion del complejo antibiotico y antitumoral bbm-1675. - Google Patents

Un procedimiento para la preparacion del complejo antibiotico y antitumoral bbm-1675.

Info

Publication number
ES8700267A1
ES8700267A1 ES532476A ES532476A ES8700267A1 ES 8700267 A1 ES8700267 A1 ES 8700267A1 ES 532476 A ES532476 A ES 532476A ES 532476 A ES532476 A ES 532476A ES 8700267 A1 ES8700267 A1 ES 8700267A1
Authority
ES
Spain
Prior art keywords
bbm
antibiotic
complex
preparation
antitumoral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532476A
Other languages
English (en)
Other versions
ES532476A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8700267A1 publication Critical patent/ES8700267A1/es
Publication of ES532476A0 publication Critical patent/ES532476A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PREPARACION DE UN NUEVO COMPLEJO ANTIBIOTICO ANTITUMORAL, DE ESTRUCTURA TODAVIA DESCONOCIDA Y DENOMINADO AQUI BBM-1675, Y RECUPERACION DE DICHO COMPLEJO. EL ANTIBIOTICO SE PRODUCE POR FERMENTACION DE CIERTAS CAPAS NUEVAS DE ACTINOMADURA VERRUCOSOSPORA, O UN MUTANTE DE LAS MISMAS, EN UN MEDIO NUTRITIVO ACUOSO QUE CONTIENE FUENTES ASIMILABLES DE CARBONO Y NITROGENO, BAJO CONDICIONES AEROBIAS SUMERGIDAS. ESTA INVENCION SUMINISTRA DOS COMPONENTES PRINCIPALES BBM-1675 A1 Y A2 Y CUATRO COMPONENTES MINORITARIAS, BBM-1675 A3, A4, B1 Y B2 QUE PUEDEN SEPARARSE Y PURIFICARSE POR MEDIOS CROMATOGRAFICOS CONVENCIONALES. AUNQUE LOS ANTIBIOTICOS ANTITUMORALES BBM-1675, ARRIBA CITADOS, NO HAN SIDO IDENTIFICADOS EN CUANTO A SU ESTRUCTURA, DADAS SUS PROPIEDADES FISICAS, QUIMICAS Y BIOLOGICAS UNICAS, SE CREE MUY FUNDADAMENTE QUE SON SUSTANCIAS NUEVAS.
ES532476A 1983-05-16 1984-05-14 Un procedimiento para la preparacion del complejo antibiotico y antitumoral bbm-1675. Expired ES8700267A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49523183A 1983-05-16 1983-05-16

Publications (2)

Publication Number Publication Date
ES8700267A1 true ES8700267A1 (es) 1986-09-16
ES532476A0 ES532476A0 (es) 1986-09-16

Family

ID=23967812

Family Applications (1)

Application Number Title Priority Date Filing Date
ES532476A Expired ES8700267A1 (es) 1983-05-16 1984-05-14 Un procedimiento para la preparacion del complejo antibiotico y antitumoral bbm-1675.

Country Status (28)

Country Link
JP (2) JPS59232094A (es)
KR (2) KR840008817A (es)
AT (1) AT393691B (es)
AU (1) AU569294B2 (es)
BE (1) BE899667A (es)
CA (1) CA1241282A (es)
CY (1) CY1465A (es)
DE (1) DE3418023A1 (es)
DK (1) DK163127C (es)
ES (1) ES8700267A1 (es)
FI (1) FI81114C (es)
FR (1) FR2547594B1 (es)
GB (1) GB2141425B (es)
GR (1) GR81581B (es)
HK (1) HK9889A (es)
HU (1) HU193928B (es)
IE (1) IE57444B1 (es)
IL (1) IL71824A (es)
IT (1) IT1175498B (es)
KE (1) KE3846A (es)
LU (1) LU85362A1 (es)
NL (1) NL8401572A (es)
NZ (1) NZ208013A (es)
PT (1) PT78590A (es)
SE (1) SE460364B (es)
SU (1) SU1344249A3 (es)
YU (1) YU43846B (es)
ZA (1) ZA843591B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR78648B (es) * 1982-07-26 1984-09-27 Bristol Myers Co
IL79519A0 (en) * 1985-08-27 1986-10-31 Bristol Myers Co Bbm-1675c and d antitumor antibiotics
US4837206A (en) * 1987-04-29 1989-06-06 Bristol-Myers Company Esperamicin derivatives
US4996305A (en) * 1988-02-29 1991-02-26 American Cyanamid Company Process for producing the antibiotic and antitumor agents LL-E33288.epsilon.ε-Br
CA2027601A1 (en) * 1989-11-06 1991-05-07 Koko Sugawara Antitumor antibiotic bu-3983t
GB0016020D0 (en) * 2000-06-29 2000-08-23 Inst Biomar Sa New polyciclic xanthones and their use
US12194393B2 (en) * 2021-03-17 2025-01-14 Nissui Corporation Method of purification and purified products

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195079A (en) * 1979-01-31 1980-03-25 Pfizer Inc. New polycyclic ether antibiotic
JPS56113791A (en) * 1980-02-15 1981-09-07 Kaken Pharmaceut Co Ltd Novel antibiotic and its preparation
GR78648B (es) * 1982-07-26 1984-09-27 Bristol Myers Co
US4539203A (en) * 1984-11-13 1985-09-03 Warner-Lambert Company CL-1577D And CL-1577E antibiotic/antitumor compounds, their production and use

Also Published As

Publication number Publication date
YU84984A (en) 1988-04-30
HUT37168A (en) 1985-11-28
FI841906A0 (fi) 1984-05-11
DK239784D0 (da) 1984-05-15
ATA160984A (de) 1991-05-15
CA1241282A (en) 1988-08-30
CY1465A (en) 1989-07-21
IT8420928A0 (it) 1984-05-15
GB2141425A (en) 1984-12-19
FR2547594B1 (fr) 1988-03-25
HK9889A (en) 1989-02-10
IL71824A0 (en) 1984-09-30
KE3846A (en) 1989-04-07
DK163127C (da) 1992-06-09
SE8402619D0 (sv) 1984-05-15
BE899667A (fr) 1984-11-16
GR81581B (es) 1984-12-11
FI81114B (fi) 1990-05-31
FI81114C (fi) 1990-09-10
NZ208013A (en) 1987-07-31
JPS59232094A (ja) 1984-12-26
DE3418023C2 (es) 1988-08-18
IL71824A (en) 1988-09-30
ZA843591B (en) 1985-02-27
GB2141425B (en) 1986-12-03
AU2779184A (en) 1984-11-22
FR2547594A1 (fr) 1984-12-21
HU193928B (en) 1987-12-28
FI841906L (fi) 1984-11-17
KR900019562A (ko) 1990-12-24
GB8412368D0 (en) 1984-06-20
LU85362A1 (fr) 1985-03-21
NL8401572A (nl) 1984-12-17
SE8402619L (sv) 1984-11-17
AT393691B (de) 1991-11-25
ES532476A0 (es) 1986-09-16
YU43846B (en) 1989-12-31
AU569294B2 (en) 1988-01-28
JPH02128693A (ja) 1990-05-17
KR920001366B1 (ko) 1992-02-11
DK239784A (da) 1984-11-17
PT78590A (en) 1984-06-01
JPH0229079B2 (es) 1990-06-27
KR840008817A (ko) 1984-12-19
JPH0555111B2 (es) 1993-08-16
IT1175498B (it) 1987-07-01
DK163127B (da) 1992-01-20
IE841200L (en) 1984-11-16
DE3418023A1 (de) 1984-11-22
SE460364B (sv) 1989-10-02
IT8420928A1 (it) 1985-11-15
SU1344249A3 (ru) 1987-10-07
IE57444B1 (en) 1992-09-09

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612