ES8608871A1 - Derivados del hidroxietil-azol - Google Patents
Derivados del hidroxietil-azolInfo
- Publication number
- ES8608871A1 ES8608871A1 ES547530A ES547530A ES8608871A1 ES 8608871 A1 ES8608871 A1 ES 8608871A1 ES 547530 A ES547530 A ES 547530A ES 547530 A ES547530 A ES 547530A ES 8608871 A1 ES8608871 A1 ES 8608871A1
- Authority
- ES
- Spain
- Prior art keywords
- optionally substituted
- group
- alkyl
- antimycotic agent
- nor2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003429 antifungal agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- TWHMHPRBRHRBOC-UHFFFAOYSA-N 2-ethyl-1h-pyrrol-3-ol Chemical compound CCC=1NC=CC=1O TWHMHPRBRHRBOC-UHFFFAOYSA-N 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000006193 alkinyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEL HIDROXIETIL-AZOL, DE FORMULA (I), Y DE SUS SALES DE ADICION DE ACIDO. CONSISTE EN LA REACCION DE UN DERIVADO DEL HIDROXIETILAZOLILACETAL DE FORMULA (II), POR CALENTAMIENTO A UNA TEMPERATURA COMPRENDIDA ENTRE 30JC Y 120JC EN UNA MEZCLA DE AGUA Y UN ALCOHOL Y EN PRESENCIA DE ACIDO CLORHIDRICO, PARA FORMAR EL COMPUESTO DE FORMULA (I), EN LAS QUE Z ES OXIGENO, X ES NITROGENO O EL GRUPO CH, R1 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES Y Z1 Y Z2 SON ALQUILO, O UNIDOS AL OXIGENO FORMAN OXOLANO; SEGUIDA DE LA REACCION CON UN COMPUESTO DE FORMULA H2NOR2, DONDE R2 ES UN RADICAL HIDROCARBONADO, EN AGUA Y UN ALCOHOL, A TEMPERATURA ENTRE 50JC Y 100JC, PARA FORMAR UN COMPUESTO DE FORMULA (I), DONDE Z ES NOH. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIMICOTICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843436452 DE3436452A1 (de) | 1984-10-05 | 1984-10-05 | Antimykotisches mittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8608871A1 true ES8608871A1 (es) | 1986-09-01 |
| ES547530A0 ES547530A0 (es) | 1986-09-01 |
Family
ID=6247106
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES547530A Expired ES8608871A1 (es) | 1984-10-05 | 1985-10-03 | Derivados del hidroxietil-azol |
| ES554632A Expired ES8704729A1 (es) | 1984-10-05 | 1986-04-30 | Procedimiento de obtencion de agentes antimicoticos, derivados del hidroxietil-azol |
| ES554631A Expired ES8704728A1 (es) | 1984-10-05 | 1986-04-30 | Procedimiento de obtencion de agentes antimicoticos, derivados del hidroxietil-azol |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES554632A Expired ES8704729A1 (es) | 1984-10-05 | 1986-04-30 | Procedimiento de obtencion de agentes antimicoticos, derivados del hidroxietil-azol |
| ES554631A Expired ES8704728A1 (es) | 1984-10-05 | 1986-04-30 | Procedimiento de obtencion de agentes antimicoticos, derivados del hidroxietil-azol |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4843089A (es) |
| EP (1) | EP0176998B1 (es) |
| JP (1) | JPS6191175A (es) |
| AT (1) | ATE47842T1 (es) |
| CA (1) | CA1285228C (es) |
| DE (2) | DE3436452A1 (es) |
| DK (1) | DK163663C (es) |
| ES (3) | ES8608871A1 (es) |
| ZA (1) | ZA857668B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3725396A1 (de) * | 1987-07-31 | 1989-02-09 | Bayer Ag | Hydroxyethyl-azolyl-oximether |
| JPH07215951A (ja) * | 1994-02-04 | 1995-08-15 | Mochida Pharmaceut Co Ltd | 抗真菌作用を有する新規なトリアゾール誘導体 |
| US6242019B1 (en) | 1997-08-14 | 2001-06-05 | Warner-Lambert Company | Taste modified hard confectionery compositions containing functional ingredients |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2247186A1 (de) * | 1972-09-26 | 1974-03-28 | Bayer Ag | Antimykotisches mittel |
| DE2347057A1 (de) * | 1973-09-19 | 1975-04-03 | Bayer Ag | Antimikrobielle mittel |
| DE3021551A1 (de) * | 1980-06-07 | 1981-12-24 | Bayer Ag, 5090 Leverkusen | 4-substituierte 1-azolyl-1-phenoxy-3,3-dimethyl-butan-2-one und -ole, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
| DE3032326A1 (de) * | 1980-08-27 | 1982-04-08 | Bayer Ag, 5090 Leverkusen | Azolylalkyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
| GB2114120B (en) * | 1982-02-02 | 1986-01-22 | Ici Plc | Heterocyclic compounds useful as pesticides and processes for making them |
| DE3224129A1 (de) * | 1982-06-29 | 1983-12-29 | Bayer Ag, 5090 Leverkusen | Substituierte azolyl-ketone und -alkohole |
| DE3233173A1 (de) * | 1982-09-07 | 1984-03-08 | Bayer Ag, 5090 Leverkusen | Substituierte azolylether-ketone und -carbinole |
| DE3242252A1 (de) * | 1982-11-15 | 1984-05-17 | Bayer Ag, 5090 Leverkusen | Heterocyclisch substituierte hydroxyalkyl-azolyl-derivate |
| DE3242236A1 (de) * | 1982-11-15 | 1984-05-17 | Bayer Ag, 5090 Leverkusen | "antimykotische mittel" |
| GB8301678D0 (en) * | 1983-01-21 | 1983-02-23 | Ici Plc | Heterocyclic compounds |
| DE3334779A1 (de) * | 1983-09-26 | 1985-04-11 | Bayer Ag, 5090 Leverkusen | Hydroxyethyl-azol-derivate |
-
1984
- 1984-10-05 DE DE19843436452 patent/DE3436452A1/de not_active Withdrawn
-
1985
- 1985-09-30 DE DE8585112351T patent/DE3574134D1/de not_active Expired
- 1985-09-30 AT AT85112351T patent/ATE47842T1/de not_active IP Right Cessation
- 1985-09-30 EP EP85112351A patent/EP0176998B1/de not_active Expired
- 1985-10-03 ES ES547530A patent/ES8608871A1/es not_active Expired
- 1985-10-03 CA CA000492209A patent/CA1285228C/en not_active Expired - Lifetime
- 1985-10-04 JP JP60220475A patent/JPS6191175A/ja active Pending
- 1985-10-04 ZA ZA857668A patent/ZA857668B/xx unknown
- 1985-10-04 DK DK453885A patent/DK163663C/da not_active IP Right Cessation
-
1986
- 1986-04-30 ES ES554632A patent/ES8704729A1/es not_active Expired
- 1986-04-30 ES ES554631A patent/ES8704728A1/es not_active Expired
-
1987
- 1987-05-29 US US07/055,818 patent/US4843089A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES554631A0 (es) | 1987-04-16 |
| DE3574134D1 (en) | 1989-12-14 |
| ES8704729A1 (es) | 1987-04-16 |
| DK453885D0 (da) | 1985-10-04 |
| DE3436452A1 (de) | 1986-04-10 |
| EP0176998A3 (en) | 1986-11-26 |
| ATE47842T1 (de) | 1989-11-15 |
| ZA857668B (en) | 1986-05-28 |
| CA1285228C (en) | 1991-06-25 |
| EP0176998B1 (de) | 1989-11-08 |
| DK163663B (da) | 1992-03-23 |
| ES8704728A1 (es) | 1987-04-16 |
| ES547530A0 (es) | 1986-09-01 |
| US4843089A (en) | 1989-06-27 |
| DK163663C (da) | 1992-08-17 |
| EP0176998A2 (de) | 1986-04-09 |
| JPS6191175A (ja) | 1986-05-09 |
| ES554632A0 (es) | 1987-04-16 |
| DK453885A (da) | 1986-04-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970519 |