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ES8606841A1 - Procedimiento para la preparacion de derivados de carboci- clina - Google Patents

Procedimiento para la preparacion de derivados de carboci- clina

Info

Publication number
ES8606841A1
ES8606841A1 ES545617A ES545617A ES8606841A1 ES 8606841 A1 ES8606841 A1 ES 8606841A1 ES 545617 A ES545617 A ES 545617A ES 545617 A ES545617 A ES 545617A ES 8606841 A1 ES8606841 A1 ES 8606841A1
Authority
ES
Spain
Prior art keywords
rest
atoms
hydrogen
carbon
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545617A
Other languages
English (en)
Other versions
ES545617A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES545617A0 publication Critical patent/ES545617A0/es
Publication of ES8606841A1 publication Critical patent/ES8606841A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/62—Unsaturated compounds containing ether groups, groups, groups, or groups containing rings other than six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CARBACICLINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN DERIVADO DE ACIDO HALOGENOALCANOICO DE FORMULA (III), EN PRESENCIA DE UNA BASE, EN UN DISOLVENTE O MEZCLA DE DISOLVENTES APROTICOS, POR EJEMPLO DIMETILSULFOXIDO, A UNA TEMPERATURA ENTRE 0 HASTA 100JC PARA OBTENER DERIVADOS DE CARBACICLINA DE FORMULA (I). SIENDO: A, GRUPO -CH2-CH2, TRANS -CHFCH- O -CFC; D, GRUPO DE FORMULA (IV), GRUPO ALQUILENO DE C 1 A 5, ETC.; E, ENLACE DIRECTO, GRUPO -CFC O GRUPO -CHFCR7; N, 1 O 3; HAL, CL O BR; O, 1, 2 O 3; M, 1 A 16; R1, RADICAL DE FORMULA (V), (VI), -COCH3, COOR2, CONHR3; R2, H O ALQUILO DE C 1 A 10, ETC.; R3, H O RADICAL ALCANOILO DE C 1 A 10; R4, GRUPO ALQUILO DE C 1 A 10, ETC.; R5, GRUPO HIDROXI LIBRE O FUNCIONALMENTE MODIFICADO; R6, H, HIDROXI, AMINO O TRIMETILSILILO; R7, H, GRUPO ALQUILO DE C 1 A 5; R8, RADICAL ALQUILO DE C 1 A 4; R9, GRUPO ALQUILO DE C 5 A 10, GRUPO METILENO; X, O; E Y, H O FLUORO. SE UTILIZA COMO ANTITROMBOTICOS, ANTISECRETORES Y BRONQUIODILATADORES.
ES545617A 1984-07-27 1985-07-26 Procedimiento para la preparacion de derivados de carboci- clina Expired ES8606841A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3428266A DE3428266A1 (de) 1984-07-27 1984-07-27 Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES545617A0 ES545617A0 (es) 1986-05-16
ES8606841A1 true ES8606841A1 (es) 1986-05-16

Family

ID=6242048

Family Applications (1)

Application Number Title Priority Date Filing Date
ES545617A Expired ES8606841A1 (es) 1984-07-27 1985-07-26 Procedimiento para la preparacion de derivados de carboci- clina

Country Status (11)

Country Link
EP (1) EP0190233B1 (es)
JP (1) JPS61502823A (es)
AT (1) ATE83232T1 (es)
AU (1) AU588543B2 (es)
CA (1) CA1275093A (es)
DE (2) DE3428266A1 (es)
DK (1) DK119886A (es)
ES (1) ES8606841A1 (es)
GR (1) GR851843B (es)
HU (1) HU196175B (es)
WO (1) WO1986000895A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3542745A1 (de) * 1985-11-29 1987-08-06 Schering Ag Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4735966A (en) * 1986-08-25 1988-04-05 Syntex (U.S.A.) Inc. Novel substituted (4.2.0)bicyclooctane derivatives with valuable therapeutic properties
DE3725031A1 (de) * 1987-07-24 1989-02-02 Schering Ag Neue 9-substituierte carbacyclinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US5374654A (en) * 1987-07-24 1994-12-20 Schering Aktiengesellschaft 9-substituted carbacyclin derivatives, processes for their preparation, and their use as medicinal agents
DE4134156A1 (de) * 1991-10-11 1993-04-15 Schering Ag 9-substituierte bicyclo(3.3.0)octan-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2038333B (en) * 1978-01-26 1982-10-06 Erba Farmitalia 12 -formyl- (20 12)octanor-9-deoxy-9 -methylene pgi derivatives
DE2845770A1 (de) * 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
CA1201712A (en) * 1980-02-28 1986-03-11 Paul A. Aristoff Carbacyclin analogs
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4533749A (en) * 1982-02-16 1985-08-06 The Upjohn Company 9-Substituted carbacyclin analogs
US4487961A (en) * 1982-02-16 1984-12-11 The Upjohn Company 9-Substituted carbacyclin analogs
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
JPS59141536A (ja) * 1983-02-01 1984-08-14 Sumitomo Chem Co Ltd 新規ビシクロオクタン誘導体
DE3408699A1 (de) * 1984-03-08 1985-09-12 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
GR851843B (es) 1985-11-26
DK119886D0 (da) 1986-03-14
EP0190233A1 (de) 1986-08-13
DK119886A (da) 1986-03-14
WO1986000895A1 (fr) 1986-02-13
DE3586891D1 (de) 1993-01-21
HUT39158A (en) 1986-08-28
EP0190233B1 (de) 1992-12-09
DE3428266A1 (de) 1986-01-30
ATE83232T1 (de) 1992-12-15
ES545617A0 (es) 1986-05-16
HU196175B (en) 1988-10-28
AU4676785A (en) 1986-02-25
CA1275093A (en) 1990-10-09
JPS61502823A (ja) 1986-12-04
AU588543B2 (en) 1989-09-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612