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ES8606368A1 - Un procedimiento para producir un derivado de bencil-fosfi- nato etilico - Google Patents

Un procedimiento para producir un derivado de bencil-fosfi- nato etilico

Info

Publication number
ES8606368A1
ES8606368A1 ES543607A ES543607A ES8606368A1 ES 8606368 A1 ES8606368 A1 ES 8606368A1 ES 543607 A ES543607 A ES 543607A ES 543607 A ES543607 A ES 543607A ES 8606368 A1 ES8606368 A1 ES 8606368A1
Authority
ES
Spain
Prior art keywords
calcium antagonist
derivatives
production
image
benzylphosphinate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543607A
Other languages
English (en)
Other versions
ES543607A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP26343884A external-priority patent/JPS61140593A/ja
Priority claimed from JP7909385A external-priority patent/JPS61236789A/ja
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Publication of ES8606368A1 publication Critical patent/ES8606368A1/es
Publication of ES543607A0 publication Critical patent/ES543607A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE BENCILFOSFINATO DE ETILO. COMPRENDE: A) TRATAR A UN COMPUESTO DE FORMULA (V) CON N-BROMOSUCCINIMIDA O N-CLOROSUCCINIMIDA, PARA REALIZAR UN COMPUESTO DE FORMULA (VI); B) HACER REACCIONAR A (V) CON FOSFINA DE TRIETILO, PARA OBTENER UN COMPUESTO DE FORMULA (IV); C) CALENTAR A (IV) CON CLORURO DE TIONILO, EN PRESENCIA DE DIMETILFORMAMIDA, BAJO REFLUJO DURANTE 2 A 4 HORAS, PARA PRODUCIR UN COMPUESTO DE FORMULA (II); Y D) HACER REACCIONAR A UN COMPUESTO DE FORMULA (III) CON (II), EN TOLUENO O TETRAHIDROFURANO, ENTRE 0JC Y LA TEMPERATURA AMBIENTE DURANTE 1 A 24 HORAS, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: X, UN GRUPO METILENO U O; Y, F; Y N, 2, 3 O 4; Y M UN METAL ALCALINO. SE UTILIZAN PARA EL TRATAMIENTO DE ENFERMEDADES DEL CORAZON ISQUEMICAS COMO ANGINA DE PECHO, ARRITMIA O INFARTO DE MIOCARDIO.
ES543607A 1984-12-12 1985-05-29 Un procedimiento para producir un derivado de bencil-fosfi- nato etilico Expired ES8606368A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP26343884A JPS61140593A (ja) 1984-12-12 1984-12-12 新規ベンジルホスフイン酸エステル誘導体、その製造法およびそれを有効成分とする医薬組成物
JP7909385A JPS61236789A (ja) 1985-04-13 1985-04-13 新規ベンジルホスフイン酸エステル誘導体、その製造法およびそれを有効成分とする医薬組成物

Publications (2)

Publication Number Publication Date
ES8606368A1 true ES8606368A1 (es) 1986-04-01
ES543607A0 ES543607A0 (es) 1986-04-01

Family

ID=26420162

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543607A Expired ES8606368A1 (es) 1984-12-12 1985-05-29 Un procedimiento para producir un derivado de bencil-fosfi- nato etilico

Country Status (4)

Country Link
US (1) US4607031A (es)
EP (1) EP0185132B1 (es)
DE (1) DE3564274D1 (es)
ES (1) ES8606368A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0651625B2 (ja) * 1986-12-29 1994-07-06 株式会社大塚製薬工場 高脂質血症治療剤
JPH0739430B2 (ja) * 1990-07-06 1995-05-01 アグロカネショウ株式会社 有機リン化合物、その製造法および該化合物を含有する殺虫、殺ダニ、殺線虫剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU523040B2 (en) * 1978-05-15 1982-07-08 Kanebo Limited Calcium -antagonistic composition
US4434162A (en) * 1981-02-17 1984-02-28 Kanebo, Ltd. Phosphonic acid ester, pharmaceutical compositions containing the same and method of using the same

Also Published As

Publication number Publication date
US4607031A (en) 1986-08-19
EP0185132A1 (en) 1986-06-25
ES543607A0 (es) 1986-04-01
DE3564274D1 (en) 1988-09-15
EP0185132B1 (en) 1988-08-10

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