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ES8604957A1 - Preparation of (+/-)14, 15-dihydro-(3 beta, 14 alpha, 16 alpha)-20, 21-dinoreburunamenine-14-ol - Google Patents

Preparation of (+/-)14, 15-dihydro-(3 beta, 14 alpha, 16 alpha)-20, 21-dinoreburunamenine-14-ol

Info

Publication number
ES8604957A1
ES8604957A1 ES549399A ES549399A ES8604957A1 ES 8604957 A1 ES8604957 A1 ES 8604957A1 ES 549399 A ES549399 A ES 549399A ES 549399 A ES549399 A ES 549399A ES 8604957 A1 ES8604957 A1 ES 8604957A1
Authority
ES
Spain
Prior art keywords
alpha
reaction
dihydro
dinoreburunamenine
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549399A
Other languages
Spanish (es)
Other versions
ES549399A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covex SA
Original Assignee
Covex SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Covex SA filed Critical Covex SA
Priority to ES549399A priority Critical patent/ES8604957A1/en
Publication of ES8604957A1 publication Critical patent/ES8604957A1/en
Publication of ES549399A0 publication Critical patent/ES549399A0/en
Priority to JP61283026A priority patent/JPH0662617B2/en
Priority to FR868616623A priority patent/FR2590572B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

(+-)14,15-Dihydro (3beta,14alpha,16alpha) 20,21-dinoreburnamenine-14 -ol (I) is prepd. by treating (+-)3beta, 16alpha-eburnamenine (II) to a heterogeneous phase oxidn-redn. reaction using hydrogen peroxide and a quat. ammonium reducing salt, such as tetrabutyl ammonium borohydride, in the presence of ethyl bromide. The solvent is a mixt. of dichloromethane and 20% aqs. sodium hydroxide, and the reaction is effected at 20 deg. C for 24 hrs. with vigorous stirring. The reaction is hydrolysed progressively and purified by chromatography.
ES549399A 1985-11-28 1985-11-28 Preparation of (+/-)14, 15-dihydro-(3 beta, 14 alpha, 16 alpha)-20, 21-dinoreburunamenine-14-ol Expired ES8604957A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES549399A ES8604957A1 (en) 1985-11-28 1985-11-28 Preparation of (+/-)14, 15-dihydro-(3 beta, 14 alpha, 16 alpha)-20, 21-dinoreburunamenine-14-ol
JP61283026A JPH0662617B2 (en) 1985-11-28 1986-11-26 Method for preparing (+/-) 14,15-dihydro- (3β, 14α, 16α) -20,21-dinorebulenamenin-14-ol
FR868616623A FR2590572B1 (en) 1985-11-28 1986-11-28 PROCESS FOR THE PREPARATION OF (+/-) 14, 15-DIHYDRO- (3 B, 14 A, 16 A) -20.21, DINOREBURNAMENINE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES549399A ES8604957A1 (en) 1985-11-28 1985-11-28 Preparation of (+/-)14, 15-dihydro-(3 beta, 14 alpha, 16 alpha)-20, 21-dinoreburunamenine-14-ol

Publications (2)

Publication Number Publication Date
ES8604957A1 true ES8604957A1 (en) 1986-03-16
ES549399A0 ES549399A0 (en) 1986-03-16

Family

ID=8490315

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549399A Expired ES8604957A1 (en) 1985-11-28 1985-11-28 Preparation of (+/-)14, 15-dihydro-(3 beta, 14 alpha, 16 alpha)-20, 21-dinoreburunamenine-14-ol

Country Status (3)

Country Link
JP (1) JPH0662617B2 (en)
ES (1) ES8604957A1 (en)
FR (1) FR2590572B1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623501B1 (en) * 1987-11-19 1990-03-16 Roussel Uclaf NOVEL SUBSTITUTED DERIVATIVES OF 20.21-DINOREBURNAMENINE, THEIR PREPARATION PROCESS AND THE NOVEL INTERMEDIATES THUS OBTAINED, THEIR APPLICATION AS DRUGS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2623503B1 (en) * 1987-11-19 1991-04-05 Roussel Uclaf
FR2865649A1 (en) * 2004-01-30 2005-08-05 Biocortech Use of 14,15-dihydro-20,21-dinor-14-eburnameninol to prepare a pharmaceutical composition for treating or preventing major depression
FR2865650B1 (en) * 2004-01-30 2008-06-13 Biocortech USE OF 14,15 DIHYDRO 20,21-DINOREBURNAMENIN14-OL FOR THE TREATMENT AND / OR PREVENTION OF MAJOR LOWERS AND SLEEP-RELIEF CYCLE DISORDERS

Also Published As

Publication number Publication date
FR2590572A1 (en) 1987-05-29
FR2590572B1 (en) 1990-05-25
ES549399A0 (en) 1986-03-16
JPS62145082A (en) 1987-06-29
JPH0662617B2 (en) 1994-08-17

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