[go: up one dir, main page]

ES8506302A1 - Un procedimiento para la preparacion de un derivado de carbostirilo - Google Patents

Un procedimiento para la preparacion de un derivado de carbostirilo

Info

Publication number
ES8506302A1
ES8506302A1 ES536982A ES536982A ES8506302A1 ES 8506302 A1 ES8506302 A1 ES 8506302A1 ES 536982 A ES536982 A ES 536982A ES 536982 A ES536982 A ES 536982A ES 8506302 A1 ES8506302 A1 ES 8506302A1
Authority
ES
Spain
Prior art keywords
carbostirile
derivative
almothe
formula
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536982A
Other languages
English (en)
Other versions
ES536982A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56137984A external-priority patent/JPS5838258A/ja
Priority claimed from JP56210368A external-priority patent/JPS58110568A/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES8506302A1 publication Critical patent/ES8506302A1/es
Publication of ES536982A0 publication Critical patent/ES536982A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO DE CARBOSTIRILO.COMPRENDE HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA X-R2 PARA PREPARAR UN DERIVADO CARBOSTIRILO DE FORMULA (I) DONDE R ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO INFERIOR, ALQUENILO INFERIOR Y OTROS; R2 ES ALACANOSULFONILO INFERIOR, UN GRUPO FENOXI-ALQUILO INFERIOR O UN GRUPO FENIL-SULFONILO Y A ES UN GRUPO ALQUILENO INFERIOR.EJERCEN ACTIVIDAD INOTROPICA POSITIVA, POTENCIADORA DEL FLUJO SANGUINEO CORONARIO E HIPOTENSIVA AL MISMO TIEMPO QUE SON MENOS TOXICOS PARA EL CORAZON.
ES536982A 1981-09-01 1984-10-22 Un procedimiento para la preparacion de un derivado de carbostirilo Granted ES536982A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56137984A JPS5838258A (ja) 1981-09-01 1981-09-01 カルボスチリル誘導体
JP56210368A JPS58110568A (ja) 1981-12-25 1981-12-25 カルボスチリル誘導体

Publications (2)

Publication Number Publication Date
ES8506302A1 true ES8506302A1 (es) 1985-07-01
ES536982A0 ES536982A0 (es) 1985-07-01

Family

ID=26471144

Family Applications (5)

Application Number Title Priority Date Filing Date
ES514992A Expired ES8401058A1 (es) 1981-09-01 1982-08-13 Un procedimiento para la preparacion de un derivado carbostirilo.
ES521471A Granted ES521471A0 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.
ES521472A Expired ES8405000A1 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.
ES521473A Granted ES521473A0 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.
ES536982A Granted ES536982A0 (es) 1981-09-01 1984-10-22 Un procedimiento para la preparacion de un derivado de carbostirilo

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES514992A Expired ES8401058A1 (es) 1981-09-01 1982-08-13 Un procedimiento para la preparacion de un derivado carbostirilo.
ES521471A Granted ES521471A0 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.
ES521472A Expired ES8405000A1 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.
ES521473A Granted ES521473A0 (es) 1981-09-01 1983-04-14 Un procedimiento para la preparacion de un derivado de carbostirilo.

Country Status (21)

Country Link
US (1) US4514401A (es)
KR (1) KR860000135B1 (es)
AR (2) AR241905A1 (es)
AT (1) AT383592B (es)
AU (1) AU532361B2 (es)
BE (1) BE894105A (es)
CA (1) CA1205807A (es)
CH (1) CH650783A5 (es)
DE (1) DE3230209C2 (es)
DK (1) DK166877B1 (es)
ES (5) ES8401058A1 (es)
FI (1) FI78688C (es)
FR (1) FR2512019B1 (es)
GB (1) GB2108109B (es)
IT (1) IT1156490B (es)
NL (1) NL8203225A (es)
NO (1) NO159591C (es)
PH (1) PH18055A (es)
PT (1) PT75424B (es)
SE (1) SE452984B (es)
SU (1) SU1356962A3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FR2557570B1 (fr) * 1984-01-04 1986-04-18 Adir Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant
DE3423003A1 (de) * 1984-06-22 1986-01-02 Beiersdorf Ag, 2000 Hamburg Benzo(c)(1,8)naphthyridine, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
DE3431303A1 (de) * 1984-08-25 1986-02-27 Goedecke Ag 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
JPH0696555B2 (ja) * 1986-07-31 1994-11-30 大塚製薬株式会社 カルボスチリル誘導体
US4886809A (en) * 1986-07-31 1989-12-12 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof
US5098477A (en) * 1988-12-14 1992-03-24 Ciba-Geigy Corporation Inks, particularly for ink printing
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
UA91007C2 (ru) * 2003-12-10 2010-06-25 Янссен Фармацевтика Н.В. Замещенные 6-циклогексилалкилом замещенные 2-хинолиноны и 2-хиноксалиноны как ингибиторы поли-(адф-рибоза)полимеразы
EP2445502B2 (en) 2009-06-25 2022-09-28 Alkermes Pharma Ireland Limited Heterocyclic compounds for the treatment of neurological and psychological disorders
CA2797708C (en) 2010-05-04 2016-08-16 Alkermes Pharma Ireland Limited Process for synthesizing oxidized lactam compounds
RU2448698C2 (ru) * 2010-06-21 2012-04-27 Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО НижГМА Росздрава) Способ восстановления синусового ритма при трепетании предсердий i типа
CA2802733C (en) 2010-06-24 2017-11-21 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5118771A (ja) * 1974-08-07 1976-02-14 Akimitsu Takeya Bantaioshigatanitaisuru keshoshiitotenchakuho
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
JPS597707B2 (ja) * 1975-06-23 1984-02-20 オオツカセイヤク カブシキガイシヤ カルボスチリルユウドウタイノ セイゾウホウ
JPS52283A (en) * 1975-06-23 1977-01-05 Otsuka Pharmaceut Co Ltd Process for preparation of carbostyril derivatives
GB1589871A (en) * 1976-07-19 1981-05-20 Conder Group Serv Ltd Tank construction
JPS5416478A (en) * 1977-07-08 1979-02-07 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril herivative
DE2853996A1 (de) * 1978-12-14 1980-07-03 Hoechst Ag Neue substituierte phenylpiperazinderivate und verfahren zu deren herstellung
JPS5585520A (en) * 1978-12-22 1980-06-27 Otsuka Pharmaceut Co Ltd Remedy for peptic ulcer
DE2928583A1 (de) * 1979-07-14 1981-01-29 Thomae Gmbh Dr K Verfahren zur herstellung von carbostyrilderivaten
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.

Also Published As

Publication number Publication date
PT75424B (en) 1985-01-04
FR2512019B1 (fr) 1986-01-03
IT8268020A1 (it) 1984-02-16
ES521472A0 (es) 1984-05-16
ES514992A0 (es) 1983-11-16
AU532361B2 (en) 1983-09-29
IT8268020A0 (it) 1982-08-16
NL8203225A (nl) 1983-04-05
BE894105A (fr) 1983-02-14
FI78688B (fi) 1989-05-31
PH18055A (en) 1985-03-18
US4514401A (en) 1985-04-30
CH650783A5 (de) 1985-08-15
AR240918A1 (es) 1991-03-27
AT383592B (de) 1987-07-27
DK166877B1 (da) 1993-07-26
NO822749L (no) 1983-03-02
AR241905A1 (es) 1993-01-29
SE8204677D0 (sv) 1982-08-13
ES8401058A1 (es) 1983-11-16
AU8698082A (en) 1983-04-14
DK361982A (da) 1983-03-02
GB2108109A (en) 1983-05-11
SU1356962A3 (ru) 1987-11-30
SE452984B (sv) 1988-01-04
AR240918A2 (es) 1991-03-27
KR840001157A (ko) 1984-03-28
DE3230209C2 (de) 1985-08-22
FI78688C (fi) 1989-09-11
FI822803A0 (fi) 1982-08-11
KR860000135B1 (ko) 1986-02-26
PT75424A (en) 1982-09-01
FR2512019A1 (fr) 1983-03-04
SE8204677L (sv) 1983-03-02
ES8500933A1 (es) 1984-11-01
FI822803L (fi) 1983-03-02
GB2108109B (en) 1985-05-09
ATA310682A (de) 1986-12-15
ES8405001A1 (es) 1984-05-16
ES521471A0 (es) 1984-11-01
ES536982A0 (es) 1985-07-01
ES521473A0 (es) 1984-05-16
CA1205807A (en) 1986-06-10
NO159591C (no) 1989-01-18
ES8405000A1 (es) 1984-05-16
IT1156490B (it) 1987-02-04
NO159591B (no) 1988-10-10
DE3230209A1 (de) 1983-03-10

Similar Documents

Publication Publication Date Title
ES8506302A1 (es) Un procedimiento para la preparacion de un derivado de carbostirilo
AR246275A1 (es) Composiciones de catalizador, procedimiento para la preparacion de polimeros de monoxido de carbono, y eteno y nuevo compuesto.
AR241018A2 (es) "n-(ciclopropil-triazinil-y-pirimidinil)-n'- (bencensulfonil) ureas con accion herbicida, procedimiento para su preparacion, intermediarios y composiciones que las contienen"
ES8702787A1 (es) Procedimiento para preparar nuevos tetrahidro-benzotiazoles.
GB1513704A (en) Dyeing compositions containing dihydroxy coupling agents
ES2076943T3 (es) Componente catalitico liquido, sistema catalitico que contiene dicho componente y procedimiento para producir copolimeros de etileno-alfa-olefina utilizando dicho sistema catalitico.
KR870006039A (ko) 신규 티아졸 화합물, 그 제조방법 및 이 화합물을 함유하는 약학적 조성물
FI88717C (fi) Foerfarande foer framstaellning av som laekemedel anvaendbara cyklopenta/d/pyrimidinderivat
FR2363330A1 (fr) Medicament destine a reduire la fertilite chez les mammiferes
DE3477488D1 (en) Polymethoxybenzyl piperazine derivatives, processes for their preparation and pharmaceutical compositions containing said derivatives
KR870700626A (ko) 치환된 4-벤질피페라지닐 화합물
KR830005865A (ko) 인체 황체형성 호르몬의 제조방법
ES420643A1 (es) Procedimiento para la obtencion de sulfuros organicos.
ATE87661T1 (de) Antidiabetikaverbindungen.
ES524363A0 (es) Procedimiento para la preparacion de 7 -aciltio-15,16-metilen-3-oxo-17 -pregna-1,4-dien-21,17-carbolactonas
BR8005948A (pt) Processo para hidroxilacao de mono-ou diolefinas alifaticas de cadeia curta
ES2054186T3 (es) Composicion antihepatopatica.
ES509331A0 (es) Procedimiento para preparar bis- y poli-sulfuros.
KR850005830A (ko) 2-알콕시아미노설포닐벤젠-설포닐우레아의 제조방법
ES2058499T3 (es) Procedimiento para la preparacion de derivados de penicilina 2 beta-metil sustituidos.
ES418694A1 (es) Procedimiento para la preparacion de tiazolinas-(3) susti- tuidas en posiciones 2 y 5.
FR2429257A1 (fr) Procede de fermentation de la cellulose
GB1287084A (en) Benzimidazole derivatives, process for their preparation, and their fungicidal use
KR840005754A (ko) 탄 성 사
ES8600251A1 (es) Metodo de preparar nuevos 2-acilamino-5-feniletenilbencimidazoles

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020401