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ES8505942A1 - 2-hydroxypropylamine aryl ester derivatives. - Google Patents

2-hydroxypropylamine aryl ester derivatives.

Info

Publication number
ES8505942A1
ES8505942A1 ES530788A ES530788A ES8505942A1 ES 8505942 A1 ES8505942 A1 ES 8505942A1 ES 530788 A ES530788 A ES 530788A ES 530788 A ES530788 A ES 530788A ES 8505942 A1 ES8505942 A1 ES 8505942A1
Authority
ES
Spain
Prior art keywords
hydroxypropylamine
nr2coor1
nr2so2r1
ester derivatives
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530788A
Other languages
Spanish (es)
Other versions
ES530788A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American Hospital Supply Corp
Original Assignee
American Hospital Supply Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Hospital Supply Corp filed Critical American Hospital Supply Corp
Publication of ES530788A0 publication Critical patent/ES530788A0/en
Publication of ES8505942A1 publication Critical patent/ES8505942A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Novel compounds of the general formula < IMAGE > wherein Ar represents a substituted or unsubstituted aromatic or heterocyclic group W represents alkylene of from 1 to about 10 carbon atoms and B represents -NR2COR1, -NR2CONR1R3, -NR2SO2R1, -NR2SO2NR1R3, or -NR2COOR1 wherein R1, R2 and R3 may be the same or different and may be hydrogen, alkyl, alkoxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl, except that R1 is not hydrogen when B is -NR2SO2R1 or -NR2COOR1, or R1 and R3 may together with N form a 5 to 7 momoered heterocyclic group and the pharmaceutically acceptable salts thereof. These compounds exhibit beta -adrenergic blocking activity and are also useful in the treatment of glaucoma.
ES530788A 1981-11-12 1984-03-20 2-hydroxypropylamine aryl ester derivatives. Expired ES8505942A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/320,773 US4582855A (en) 1981-11-12 1981-11-12 Aromatic and esters of hydroxypropylamines

Publications (2)

Publication Number Publication Date
ES530788A0 ES530788A0 (en) 1985-06-01
ES8505942A1 true ES8505942A1 (en) 1985-06-01

Family

ID=23247815

Family Applications (4)

Application Number Title Priority Date Filing Date
ES517296A Granted ES517296A0 (en) 1981-11-12 1982-11-11 A PROCEDURE FOR THE PREPARATION OF NEW PROPANOLAMINE DERIVATIVES.
ES523804A Expired ES8500887A1 (en) 1981-11-12 1983-07-01 2-hydroxypropylamine aryl ester derivatives.
ES523805A Expired ES8500888A1 (en) 1981-11-12 1983-07-01 2-hydroxypropylamine aryl ester derivatives.
ES530788A Expired ES8505942A1 (en) 1981-11-12 1984-03-20 2-hydroxypropylamine aryl ester derivatives.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES517296A Granted ES517296A0 (en) 1981-11-12 1982-11-11 A PROCEDURE FOR THE PREPARATION OF NEW PROPANOLAMINE DERIVATIVES.
ES523804A Expired ES8500887A1 (en) 1981-11-12 1983-07-01 2-hydroxypropylamine aryl ester derivatives.
ES523805A Expired ES8500888A1 (en) 1981-11-12 1983-07-01 2-hydroxypropylamine aryl ester derivatives.

Country Status (14)

Country Link
US (1) US4582855A (en)
EP (1) EP0093765B1 (en)
JP (2) JPS6320424B1 (en)
AU (1) AU562862B2 (en)
CA (1) CA1201438A (en)
DE (1) DE3274640D1 (en)
EG (1) EG16198A (en)
ES (4) ES517296A0 (en)
GR (1) GR78306B (en)
IL (1) IL67243A0 (en)
IT (1) IT1149118B (en)
NZ (1) NZ202228A (en)
WO (1) WO1983001770A1 (en)
ZA (1) ZA827749B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007044A1 (en) * 1987-03-17 1988-09-22 Insite Vision, Inc. Timolol derivatives
JPH0662521B2 (en) * 1988-02-24 1994-08-17 日東紡績株式会社 Novel choline derivative and method for assaying serum cholinesterase activity using the same
US4935422A (en) * 1988-12-15 1990-06-19 E. I. Du Pont De Nemours And Company Acyloxypropanolamines
US4897417A (en) * 1988-12-15 1990-01-30 E. I. Du Pont De Nemours & Co. Prodrugs of 3,4-hydroxy benzoyloxypropanolamines
US5064827A (en) * 1988-12-15 1991-11-12 Du Pont Merck Pharmaceutical Company Polyhydroxybenzyloxpropanolamines
US4966914A (en) * 1988-12-15 1990-10-30 E. I. Du Pont De Nemours And Company Oculoselective beta-blockers as antiglaucoma agents
US5248808A (en) * 1989-11-01 1993-09-28 Avery Dennison Corporation Vinyl functional reactive tackifiers for pressure-sensitive adhesives
JPH04343212A (en) * 1991-05-20 1992-11-30 Hitachi Aic Inc Capacitor with fuse
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5543083A (en) * 1994-07-26 1996-08-06 The Procter & Gamble Company Fatty amine derivatives of butylated hydroxy toluene for the protection of surfaces from physical and chemical degradation
US5536749A (en) * 1994-10-13 1996-07-16 Sl Pharmaceuticals, Inc. Method for attenuation of sympathetic nervous system activity or onset of migraine by selectively metabolized beta-blocking agents
EP1071654B1 (en) * 1998-04-14 2003-10-22 Samsung Fine Chemicals Co., Ltd. A process for preparing chiral (s)-2,3-disubstituted-1-propylamine derivatives
CA2713394C (en) * 2007-11-09 2016-01-19 Charles Yates Anti-inflammatory quinic acid derivatives for oral administration
EP2096105A1 (en) * 2008-02-28 2009-09-02 Laboratorios Almirall, S.A. Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1476934A (en) * 1922-02-13 1923-12-11 Abbott Lab Anaesthetic compound
US3129201A (en) * 1959-10-30 1964-04-14 Monsanto Chemicals Alkyl 3-acyloxy-2-alkenoates and homopolymers thereof
NL301580A (en) * 1962-12-11
US4387103A (en) * 1980-11-28 1983-06-07 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
US4405642A (en) * 1980-11-28 1983-09-20 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders

Also Published As

Publication number Publication date
ES523805A0 (en) 1984-11-01
ZA827749B (en) 1983-08-31
ES523804A0 (en) 1984-11-01
ES530788A0 (en) 1985-06-01
US4582855A (en) 1986-04-15
IT8249477A0 (en) 1982-11-12
ES8401014A1 (en) 1983-12-01
JPS6320424B1 (en) 1988-04-27
NZ202228A (en) 1985-10-11
WO1983001770A1 (en) 1983-05-26
EG16198A (en) 1987-09-30
EP0093765A1 (en) 1983-11-16
IL67243A0 (en) 1983-03-31
IT1149118B (en) 1986-12-03
ES8500888A1 (en) 1984-11-01
JPS58501724A (en) 1983-10-13
CA1201438A (en) 1986-03-04
EP0093765B1 (en) 1986-12-10
GR78306B (en) 1984-09-26
AU562862B2 (en) 1987-06-18
ES8500887A1 (en) 1984-11-01
ES517296A0 (en) 1983-12-01
DE3274640D1 (en) 1987-01-22
EP0093765A4 (en) 1984-04-27

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960401