[go: up one dir, main page]

ES8501745A1 - 2-(Phenylmethylene)cycloalkylamines. - Google Patents

2-(Phenylmethylene)cycloalkylamines.

Info

Publication number
ES8501745A1
ES8501745A1 ES523066A ES523066A ES8501745A1 ES 8501745 A1 ES8501745 A1 ES 8501745A1 ES 523066 A ES523066 A ES 523066A ES 523066 A ES523066 A ES 523066A ES 8501745 A1 ES8501745 A1 ES 8501745A1
Authority
ES
Spain
Prior art keywords
compounds
phenylmethylene
analgesic
antidepressant
cycloalkylamines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523066A
Other languages
Spanish (es)
Other versions
ES523066A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ES523066A0 publication Critical patent/ES523066A0/en
Publication of ES8501745A1 publication Critical patent/ES8501745A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/683—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

2-(Phenylmethylene)cycloalkylamines and -azetidines of the formula < IMAGE > (I) and acid addition salts thereof, e.g., 1-[2-(phenylmethylene)cyclohexyl]azetidine, and related compounds, which have analgesic, antidepressant and mixed analgesic/antidepressant central nervous system (CNS) activities, and which are useful in treating pain and/or depression in mammals including humans. The invention provides processes for preparing the compounds as well as compositions containing the compounds and methods for using the compounds as analgesic and/or antidepressant drugs for humans and valuable mammalian animals.
ES523066A 1982-02-09 1983-06-07 2-(Phenylmethylene)cycloalkylamines. Expired ES8501745A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34712382A 1982-02-09 1982-02-09
US06/408,333 US4540690A (en) 1982-02-09 1982-08-16 2-(Phenylmethylene)cycloalkylamines and -azetidines

Publications (2)

Publication Number Publication Date
ES523066A0 ES523066A0 (en) 1984-12-16
ES8501745A1 true ES8501745A1 (en) 1984-12-16

Family

ID=26995138

Family Applications (6)

Application Number Title Priority Date Filing Date
ES519331A Granted ES519331A0 (en) 1982-02-09 1983-01-28 PROCEDURE FOR PREPARING A COMPOUND OF 2- (FENYLMETHYLENE) CYCLOALKYLAMINES AND -AZETIDINS.
ES523066A Expired ES8501745A1 (en) 1982-02-09 1983-06-07 2-(Phenylmethylene)cycloalkylamines.
ES523065A Expired ES8502673A1 (en) 1982-02-09 1983-06-07 2-(Phenylmethylene)cycloalkylamines.
ES523064A Granted ES523064A0 (en) 1982-02-09 1983-06-07 PROCEDURE FOR PREPARING AZETIDINS.
ES523067A Granted ES523067A0 (en) 1982-02-09 1983-06-07 PROCEDURE FOR PREPARING 1- (2- (FENILMETILEN) CICLOHEXIL) AZETIDINAS.
ES532058A Granted ES532058A0 (en) 1982-02-09 1984-04-30 PROCEDURE FOR PREPARING A COMPOUND OF 2- (FENYLMETHYLENE) CYCLOALKYLAMINES AND AZETIDINES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES519331A Granted ES519331A0 (en) 1982-02-09 1983-01-28 PROCEDURE FOR PREPARING A COMPOUND OF 2- (FENYLMETHYLENE) CYCLOALKYLAMINES AND -AZETIDINS.

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES523065A Expired ES8502673A1 (en) 1982-02-09 1983-06-07 2-(Phenylmethylene)cycloalkylamines.
ES523064A Granted ES523064A0 (en) 1982-02-09 1983-06-07 PROCEDURE FOR PREPARING AZETIDINS.
ES523067A Granted ES523067A0 (en) 1982-02-09 1983-06-07 PROCEDURE FOR PREPARING 1- (2- (FENILMETILEN) CICLOHEXIL) AZETIDINAS.
ES532058A Granted ES532058A0 (en) 1982-02-09 1984-04-30 PROCEDURE FOR PREPARING A COMPOUND OF 2- (FENYLMETHYLENE) CYCLOALKYLAMINES AND AZETIDINES

Country Status (11)

Country Link
US (1) US4540690A (en)
EP (1) EP0085811B1 (en)
AU (2) AU562051B2 (en)
DE (1) DE3271073D1 (en)
DK (1) DK53083A (en)
ES (6) ES519331A0 (en)
GR (1) GR78061B (en)
HU (1) HU190887B (en)
IL (1) IL67442A (en)
NZ (1) NZ202728A (en)
PH (1) PH17709A (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2634483B2 (en) * 1987-12-29 1994-03-04 Esteve Labor Dr DERIVATIVES OF ACIDS 7- (1-AZETIDINYL) -1,4-DIHYDRO-4-OXOQUINOLEINE-3-CARBOXYLIQUES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS
JP3739377B2 (en) * 2003-12-10 2006-01-25 シャープ株式会社 Washing and drying machine
EP1709004A2 (en) * 2003-12-29 2006-10-11 Sepracor Inc. Pyrrole and pyrazole daao inhibitors
MX2008000250A (en) 2005-07-06 2008-03-19 Sepracor Inc Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2, 3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive dis
CN101426372A (en) * 2006-01-06 2009-05-06 塞普拉柯公司 Tetralone-based monoamine reuptake inhibitors
AU2007205114B2 (en) 2006-01-06 2012-11-08 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
PT2816024T (en) 2006-03-31 2017-10-20 Sunovion Pharmaceuticals Inc Chiral amines
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
KR20090111322A (en) * 2007-01-18 2009-10-26 세프라코 아이엔시. Inhibitors of diamino oxidase
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
US8669291B2 (en) * 2007-05-31 2014-03-11 Sunovion Pharmaceuticals Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US20110034434A1 (en) * 2009-08-07 2011-02-10 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
AU2012311061B2 (en) * 2011-09-23 2016-08-18 Advinus Therapeutics Limited Amide compounds, compositions and applications thereof
RU2016150902A (en) * 2014-06-06 2018-07-17 Аллерган, Инк. NEW EP4 AGONISTS AS THERAPEUTIC COMPOUNDS
KR102270026B1 (en) * 2020-01-31 2021-06-28 현대약품 주식회사 Quality evaluation method of (3S)-3-(4-(3-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)benzyloxy)phenyl)hex-4-ynoic acid

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558599A (en) * 1966-06-13 1971-01-26 Upjohn Co 1-(2-(alpha-alkoxybenzyl and substituted benzyl)cycloalkyl)heterocyclic amines
US3668199A (en) * 1966-06-13 1972-06-06 Upjohn Co 1,3-aminoalcohols
US3705176A (en) * 1966-06-13 1972-12-05 Upjohn Co 1,3-aminoalcohols
US3595867A (en) * 1966-06-13 1971-07-27 Upjohn Co 2 - piperidino- and methyl-substituted piperidino-substituted-phentl cycloalkane-methanols and derivatives
US3632813A (en) * 1966-06-13 1972-01-04 Upjohn Co Substituted phenyl 2-piperidinocycloalkyl ketones
US3458523A (en) * 1966-08-15 1969-07-29 Upjohn Co 2-(2 - furoyl)cycloalkanones,2 - furyl-2-(heterocyclicamino) cycloalkyl ketones,and d-(2 - furyl)-2-heterocyclicamino-cyclohexanemethanols
US3468881A (en) * 1966-08-15 1969-09-23 Upjohn Co Allylic amines
US3506670A (en) * 1966-09-26 1970-04-14 Upjohn Co 2-hetero-amino-alpha,alpha-diaryl-cycloalkone-methanols and esters thereof
US3499033A (en) * 1967-01-06 1970-03-03 Upjohn Co Ethers of alpha-phenyl-2-aminocycloalkanemethanols
US3651232A (en) * 1968-09-10 1972-03-21 Upjohn Co Compositions and methods for lowering blood sugar levels
US4145435A (en) * 1976-11-12 1979-03-20 The Upjohn Company 2-aminocycloaliphatic amide compounds
US4098904A (en) * 1976-11-12 1978-07-04 The Upjohn Company Analgesic n-(2-aminocycloaliphatic)benzamides
US4242261A (en) * 1979-07-19 1980-12-30 A. H. Robins Company, Inc. Production of methylene-cycloamines
US4260606A (en) * 1979-07-19 1981-04-07 A. H. Robins Company, Inc. 3-Methyleneazetidine derivatives

Also Published As

Publication number Publication date
ES8501746A1 (en) 1984-12-16
ES523065A0 (en) 1985-02-01
ES523067A0 (en) 1984-12-16
ES8507483A1 (en) 1985-09-16
ES8502673A1 (en) 1985-02-01
PH17709A (en) 1984-11-19
ES8501744A1 (en) 1984-12-16
AU562051B2 (en) 1987-05-28
NZ202728A (en) 1985-12-13
ES523066A0 (en) 1984-12-16
EP0085811B1 (en) 1986-05-07
ES532058A0 (en) 1985-09-16
GR78061B (en) 1984-09-26
ES8502969A1 (en) 1984-10-01
AU6350486A (en) 1987-01-15
ES523064A0 (en) 1984-10-01
ES519331A0 (en) 1984-12-16
DK53083D0 (en) 1983-02-08
IL67442A (en) 1986-01-31
IL67442A0 (en) 1983-05-15
DE3271073D1 (en) 1986-06-12
DK53083A (en) 1983-08-10
AU9134382A (en) 1983-08-18
HU190887B (en) 1986-12-28
EP0085811A1 (en) 1983-08-17
US4540690A (en) 1985-09-10

Similar Documents

Publication Publication Date Title
ES8507483A1 (en) 2-(Phenylmethylene)cycloalkylamines.
UA48939C2 (en) Disubstituted furanons, methods for synthesis, pharmaceutical composition, method for treating inflammatory disease, intermediate substances
IL72120A (en) 2-pyrimidinyl-1-piperazine derivatives,their preparation and pharmaceutical compositions containing them
EA200400953A1 (en) SUBSTITUTED PYRIDINOES AS MAP-KINASE P38 MODULATORS
GR3017613T3 (en) Ceramides, method for their preparation and their application in cosmetics and dermopharmacy.
RU94046067A (en) Substituted 1,2,3,4-tetrahydroisoquinolines, intermediate compounds, pharmcomposition and method of treatment
ES8705038A1 (en) Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same.
ES2087038B1 (en) NEW PIPERIDINES WITH ANTAGONIST ACTIVITY OF THE PAF.
MX9707472A (en) Radiosensitizing diamines and their pharmaceutical preparations.
ES8401960A1 (en) Imidazolylphenyl-tetrahydropyridazines, process for their preparation and pharmaceutical compositions containing them.
DE3064835D1 (en) 2-hydroxyalkyl-3,4,5,trihydroxy piperidines, processes for their preparation and their use as medicaments
DE3667059D1 (en) Benzodipyrroles, processes for their preparation and pharmaceutical compositions containing these compounds
ES8106905A1 (en) Novel benzodiazepine compounds, their preparation, intermediates employed in their preparation, and pharmaceutical compositions containing them.
IL65802A (en) 1-(3-fluoro-2-pyridinyl)piperazine and salts thereof,their preparation and pharmaceutical compositions containing them
PL328225A1 (en) Diphenylstilbenes as pro-medications used to produce cox-2-inhibitors
GR3021303T3 (en) Benzimidazoles, pharmaceutical compositions containing them and process for their preparation
EP0758312A4 (en) Substituted fused and bridged bicyclic compounds as therapeutic agents
ES8609319A1 (en) Phenylnaphthyridines, process for their preparation, medicaments containing them, particularly as anti-ulcer agents.
HUT39147A (en) Process for preparing phenoxy-propanol-acethylene derivatives and pharmaceutical compositions containing such compounds
UA48962C2 (en) Bicyclic antagonists of tachykinins, pharmaceutical composition and method of treatment
MY118946A (en) Novel intermediates and their use to prepare n, n&#39;&#39;- bridged bisindolylmaleimides
DE59108433D1 (en) PHENYLETHANOLAMINE, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
PT78598B (en) Process for preparing spiro-&lt;indole&lt;1,7-ab&gt;&lt;1,5&gt;benzodiazephin-2,4&#39;-piperidines&gt; and the intermediates therefor and pharmaceutical compositions containing them
ES8602676A1 (en) Hexahydropyrrolo (2,1-a) isoquinoline derivatives.
US5095014A (en) 3-(2-chloro-4-(trifluoromethyl)phenoxy)-1-azetidine carboxamides having anticonvulsant activity