ES8405796A1 - Benzoazacycloalkyl-spiro- imidazolidines - Google Patents
Benzoazacycloalkyl-spiro- imidazolidinesInfo
- Publication number
- ES8405796A1 ES8405796A1 ES521895A ES521895A ES8405796A1 ES 8405796 A1 ES8405796 A1 ES 8405796A1 ES 521895 A ES521895 A ES 521895A ES 521895 A ES521895 A ES 521895A ES 8405796 A1 ES8405796 A1 ES 8405796A1
- Authority
- ES
- Spain
- Prior art keywords
- benzoazacycloalkyl
- imidazolidines
- spiro
- hydrogen atom
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- -1 p-toluenesulphonyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The present invention provides a compound of the general formula: < IMAGE > in which - R1 represents a halogen or a hydrogen atom, or a hydroxy or methoxy group, - R2 represents a hydrogen atom, a lower alkyl radical, a phenyl-lower alkyl radical, a lower alkanoyl radical or a p-toluenesulphonyl group, and - n represents 1 or 2, in the racemic form or as an optical isomer, or salts thereof and a process for their preparation. These compounds are useful in the treatment of diabetes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8207203A FR2525603A1 (en) | 1982-04-27 | 1982-04-27 | BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLININES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES521895A0 ES521895A0 (en) | 1984-06-16 |
| ES8405796A1 true ES8405796A1 (en) | 1984-06-16 |
Family
ID=9273425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES521895A Expired ES8405796A1 (en) | 1982-04-27 | 1983-04-27 | Benzoazacycloalkyl-spiro- imidazolidines |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS5910584A (en) |
| KR (1) | KR840004428A (en) |
| AT (1) | ATA125383A (en) |
| AU (1) | AU1395383A (en) |
| BE (1) | BE896572A (en) |
| DD (1) | DD209833A5 (en) |
| DE (1) | DE3315106A1 (en) |
| DK (1) | DK183583A (en) |
| ES (1) | ES8405796A1 (en) |
| FR (1) | FR2525603A1 (en) |
| GB (1) | GB2133401B (en) |
| GR (1) | GR78481B (en) |
| IL (1) | IL68497A0 (en) |
| IT (1) | IT1167123B (en) |
| LU (1) | LU84770A1 (en) |
| MA (1) | MA19783A1 (en) |
| NL (1) | NL8301476A (en) |
| NO (1) | NO831473L (en) |
| OA (1) | OA07412A (en) |
| PT (1) | PT76595B (en) |
| SE (1) | SE8302347L (en) |
| ZA (1) | ZA832927B (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4927831A (en) * | 1988-10-20 | 1990-05-22 | American Home Products | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
| AU617541B2 (en) * | 1988-10-20 | 1991-11-28 | Wyeth | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
| US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| EP2332921B1 (en) | 2003-06-17 | 2016-03-02 | Arena Pharmaceuticals, Inc. | 8-Chloro-1 -methyl-2,3,4,5-tetrahydro-1 H-3benzazapine Hydrochloride |
| CN1805938B (en) | 2003-06-17 | 2010-06-16 | 艾尼纳制药公司 | Benzazepine derivatives for the treatment of 5HT2C receptor-related diseases |
| NZ589756A (en) | 2004-12-21 | 2012-05-25 | Arena Pharm Inc | Method for the preparation of crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride |
| WO2006071740A2 (en) | 2004-12-23 | 2006-07-06 | Arena Pharmaceuticals, Inc. | 5ht2c receptor modulator compositions and methods of use |
| CN101466684B (en) | 2006-04-03 | 2012-06-20 | 艾尼纳制药公司 | Preparation process of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and related intermediates |
| CA2670285A1 (en) | 2006-12-05 | 2008-06-12 | Arena Pharmaceuticals, Inc. | Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof |
| EP2288585A1 (en) | 2008-03-04 | 2011-03-02 | Arena Pharmaceuticals, Inc. | Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine |
| EP2443080A2 (en) | 2009-06-18 | 2012-04-25 | Arena Pharmaceuticals, Inc. | Process for the preparation of 5-ht2c receptor agonists |
| US9045431B2 (en) | 2010-06-02 | 2015-06-02 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-HT2C receptor agonists |
| WO2012030939A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Administration of lorcaserin to individuals with renal impairment |
| KR20130138770A (en) | 2010-09-01 | 2013-12-19 | 아레나 파마슈티칼스, 인크. | Salts of lorcaserin with optically active acids |
| EP2611433A2 (en) | 2010-09-01 | 2013-07-10 | Arena Pharmaceuticals, Inc. | Non-hygroscopic salts of 5-ht2c agonists |
| EP3485878A1 (en) | 2010-09-01 | 2019-05-22 | Arena Pharmaceuticals, Inc. | Modified-release dosage forms of 5-ht2c agonists useful for weight management |
| JP2015534563A (en) | 2012-10-09 | 2015-12-03 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Weight management method |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4209630A (en) * | 1976-10-18 | 1980-06-24 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
| US4235911A (en) * | 1979-06-13 | 1980-11-25 | Pfizer Inc. | Hydantoin derivatives |
-
1982
- 1982-04-27 FR FR8207203A patent/FR2525603A1/en active Granted
-
1983
- 1983-04-08 AT AT0125383A patent/ATA125383A/en not_active IP Right Cessation
- 1983-04-25 DD DD83250187A patent/DD209833A5/en unknown
- 1983-04-25 LU LU84770A patent/LU84770A1/en unknown
- 1983-04-26 KR KR1019830001753A patent/KR840004428A/en not_active Withdrawn
- 1983-04-26 IL IL68497A patent/IL68497A0/en unknown
- 1983-04-26 DK DK183583A patent/DK183583A/en not_active Application Discontinuation
- 1983-04-26 JP JP58073687A patent/JPS5910584A/en active Pending
- 1983-04-26 AU AU13953/83A patent/AU1395383A/en not_active Abandoned
- 1983-04-26 IT IT48155/83A patent/IT1167123B/en active
- 1983-04-26 BE BE0/210633A patent/BE896572A/en not_active IP Right Cessation
- 1983-04-26 NO NO831473A patent/NO831473L/en unknown
- 1983-04-26 ZA ZA832927A patent/ZA832927B/en unknown
- 1983-04-26 GR GR71214A patent/GR78481B/el unknown
- 1983-04-26 PT PT76595A patent/PT76595B/en unknown
- 1983-04-26 SE SE8302347A patent/SE8302347L/en not_active Application Discontinuation
- 1983-04-26 NL NL8301476A patent/NL8301476A/en not_active Application Discontinuation
- 1983-04-27 DE DE19833315106 patent/DE3315106A1/en not_active Withdrawn
- 1983-04-27 GB GB08311508A patent/GB2133401B/en not_active Expired
- 1983-04-27 MA MA20003A patent/MA19783A1/en unknown
- 1983-04-27 ES ES521895A patent/ES8405796A1/en not_active Expired
- 1983-04-27 OA OA57984A patent/OA07412A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES521895A0 (en) | 1984-06-16 |
| ATA125383A (en) | 1986-05-15 |
| DK183583D0 (en) | 1983-04-26 |
| AU1395383A (en) | 1983-11-03 |
| FR2525603A1 (en) | 1983-10-28 |
| GB8311508D0 (en) | 1983-06-02 |
| PT76595B (en) | 1986-01-21 |
| GB2133401A (en) | 1984-07-25 |
| GB2133401B (en) | 1985-10-23 |
| SE8302347L (en) | 1983-10-28 |
| MA19783A1 (en) | 1983-12-31 |
| DE3315106A1 (en) | 1983-11-03 |
| IT8348155A0 (en) | 1983-04-26 |
| BE896572A (en) | 1983-10-26 |
| IL68497A0 (en) | 1983-07-31 |
| LU84770A1 (en) | 1984-11-28 |
| KR840004428A (en) | 1984-10-15 |
| ZA832927B (en) | 1984-06-27 |
| JPS5910584A (en) | 1984-01-20 |
| NO831473L (en) | 1983-10-28 |
| GR78481B (en) | 1984-09-27 |
| NL8301476A (en) | 1983-11-16 |
| PT76595A (en) | 1983-05-01 |
| SE8302347D0 (en) | 1983-04-26 |
| DK183583A (en) | 1983-10-28 |
| DD209833A5 (en) | 1984-05-23 |
| IT1167123B (en) | 1987-05-13 |
| FR2525603B1 (en) | 1984-09-14 |
| OA07412A (en) | 1984-11-30 |
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