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ES8403461A1 - Procedimiento de preparacion de derivados de imidazolidina. - Google Patents

Procedimiento de preparacion de derivados de imidazolidina.

Info

Publication number
ES8403461A1
ES8403461A1 ES519532A ES519532A ES8403461A1 ES 8403461 A1 ES8403461 A1 ES 8403461A1 ES 519532 A ES519532 A ES 519532A ES 519532 A ES519532 A ES 519532A ES 8403461 A1 ES8403461 A1 ES 8403461A1
Authority
ES
Spain
Prior art keywords
preparation
imidazoline derivatives
reaction
therapeutical application
imidazoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519532A
Other languages
English (en)
Other versions
ES519532A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of ES8403461A1 publication Critical patent/ES8403461A1/es
Publication of ES519532A0 publication Critical patent/ES519532A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Emergency Protection Circuit Devices (AREA)
  • Control Of Transmission Device (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE IMIDAZOLIDINA, DE FORMULA (I), EN LA QUE R2 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE P-HIDROXIANILINA CON METILTIO-2-IMIDAZOLINA, EN PIRIDINA; SEGUIDA DE LA NITRATACION DEL COMPUESTO FORMADO CON ACIDO NITRICO; HIDROGENACION EN PRESENCIA DE UN CATALIZADOR, TAL COMO CARBONO PALADIADO; Y REACCION CON ACIDO FORMICO EN PRESENCIA DE ANHIDRIDO ACETICO O CON CLORURO DE METILSULFONILO O CON EL COMPUESTO NANCO O RKNCO, SIENDO RK ALCOHILO C1-4.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS, PARA LADESCONGESTION NASAL, PARA EL TRATAMIENTO DE HIPOTENSION ORTOSTATICA, EL GLAUCOMA Y LA HIPERSECRECION GASTRICA.
ES519532A 1982-02-05 1983-02-04 Procedimiento de preparacion de derivados de imidazolidina. Granted ES519532A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8201877A FR2521140A1 (fr) 1982-02-05 1982-02-05 Derives d'imidazolidine, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
ES8403461A1 true ES8403461A1 (es) 1984-03-16
ES519532A0 ES519532A0 (es) 1984-03-16

Family

ID=9270708

Family Applications (1)

Application Number Title Priority Date Filing Date
ES519532A Granted ES519532A0 (es) 1982-02-05 1983-02-04 Procedimiento de preparacion de derivados de imidazolidina.

Country Status (19)

Country Link
US (1) US4492709A (es)
EP (1) EP0086126B1 (es)
JP (1) JPS58146569A (es)
AT (1) ATE14424T1 (es)
AU (1) AU553893B2 (es)
CA (1) CA1190933A (es)
DE (1) DE3360411D1 (es)
DK (1) DK47683A (es)
ES (1) ES519532A0 (es)
FI (1) FI830397L (es)
FR (1) FR2521140A1 (es)
GR (1) GR77414B (es)
HU (1) HU191284B (es)
IE (1) IE830225L (es)
IL (1) IL67835A0 (es)
NO (1) NO830388L (es)
NZ (1) NZ203185A (es)
PT (1) PT76196B (es)
ZA (1) ZA83763B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63113077A (ja) * 1986-06-13 1988-05-18 Konica Corp 分光吸収特性等に優れたジフエニルイミダゾ−ル系染料
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
CN1137755A (zh) * 1993-12-17 1996-12-11 普罗克特和甘保尔公司 用作α-2肾上腺素能受体兴奋剂的6-(2-咪唑啉基氨基)喹喔啉化合物
DE19514579A1 (de) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
KR20000069128A (ko) * 1996-11-25 2000-11-25 데이비드 엠 모이어 알파-2 아드레날린수용체 아고니스트로서 유용한 2-이미다졸리닐아미노벤즈옥사졸 화합물
WO1998023612A1 (en) * 1996-11-25 1998-06-04 The Procter & Gamble Company 2-imidazolinylaminobenzothiazole compounds useful as alpha-2 adrenoceptor agonists
SG72827A1 (en) * 1997-06-23 2000-05-23 Hoffmann La Roche Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives
FR2805159B1 (fr) 2000-02-23 2005-06-10 Oreal Compositions pour la teinture d'oxydation des fibres keratiniques comprenant un n-(2-hydroxybenzene)-carbamate ou un n-(2-hydroxybenzene)-uree a titre de coupleur, et procedes de teinture
AU2000252458A1 (en) * 2000-06-08 2001-12-17 Shizuoka Coffein Co., Ltd. Benzene derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3818094A (en) * 1969-08-28 1974-06-18 Boehringer Sohn Ingelheim Hypotensive pharmaceutical compositions containing certain 2-anilino-1,3-diazacyclopentenes-(2)
DE2756638A1 (de) * 1976-12-20 1978-06-22 Wellcome Found Imidazoline, verfahren zu ihrer herstellung und ihre verwendung in schaedlingsbekaempfungsmitteln
DE2806775A1 (de) * 1978-02-17 1979-08-30 Boehringer Sohn Ingelheim Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
US4262005A (en) * 1978-05-31 1981-04-14 The Boots Company Limited Compounds, compositions and methods for controlling pests
US4290971A (en) * 1979-01-19 1981-09-22 Dso "Pharmachim" Method of preparing 2-(phenylamino)-imidazolines-(2)
ZA801680B (en) * 1979-04-03 1981-03-25 Fujisawa Pharmaceutical Co 2-imidazoline derivatives,process for the preparation thereof and the pharmaceutical composition of the same

Also Published As

Publication number Publication date
ZA83763B (en) 1983-10-26
FR2521140B1 (es) 1984-03-16
FI830397A7 (fi) 1983-08-06
AU1115083A (en) 1983-08-11
ATE14424T1 (de) 1985-08-15
IE830225L (en) 1983-08-05
NO830388L (no) 1983-08-08
US4492709A (en) 1985-01-08
FR2521140A1 (fr) 1983-08-12
DE3360411D1 (en) 1985-08-29
GR77414B (es) 1984-09-13
HU191284B (en) 1987-02-27
IL67835A0 (en) 1983-06-15
ES519532A0 (es) 1984-03-16
FI830397L (fi) 1983-08-06
CA1190933A (en) 1985-07-23
AU553893B2 (en) 1986-07-31
EP0086126B1 (fr) 1985-07-24
DK47683D0 (da) 1983-02-04
EP0086126A1 (fr) 1983-08-17
PT76196B (fr) 1986-01-27
PT76196A (fr) 1983-03-01
NZ203185A (en) 1985-07-31
FI830397A0 (fi) 1983-02-04
JPS58146569A (ja) 1983-09-01
DK47683A (da) 1983-08-06

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