[go: up one dir, main page]

ES8308309A1 - Procedimiento para la preparacion de derivados de benzazepina. - Google Patents

Procedimiento para la preparacion de derivados de benzazepina.

Info

Publication number
ES8308309A1
ES8308309A1 ES517753A ES517753A ES8308309A1 ES 8308309 A1 ES8308309 A1 ES 8308309A1 ES 517753 A ES517753 A ES 517753A ES 517753 A ES517753 A ES 517753A ES 8308309 A1 ES8308309 A1 ES 8308309A1
Authority
ES
Spain
Prior art keywords
group
preparation
pharmaceutical preparations
application
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517753A
Other languages
English (en)
Other versions
ES517753A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8308309A1 publication Critical patent/ES8308309A1/es
Publication of ES517753A0 publication Critical patent/ES517753A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE BENZAZEPINA, DE FORMULA GENERAL (I), EN LA QUE A SIGNIFICA UN GRUPO -CH<2-CH<2-, -CH=CH O N<5H-CO-; B SIGNIFICA UN GRUPO METILENO O CARBONILO; E SIGNIFICA UN GRUPO ETILENO O N-PROPILENO; G SIGNIFICA UN GRUPO METILENO O ETILENO; R<1 Y R<2 SIGNIFICAN GRUPOS HIDROXI, ALCOXI O FENILALCOXI; R<3 Y R<4 SIGNIFICAN ATOMOS DE HALOGENO O HIDROGENO; R<5 SIGNIFICA UN ATOMO DE HIDROGENO O UN GRUPO ALCOHILO O HIDROXI; Y R<6 SIGNIFICA UN ATOMO DE HIDROGENO O UN GRUPO FENIL-ALCOHILO, Y SUS SALES DE ADICION DE ACIDO FARMACOLOGICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) Y EN SEPARAR EVENTUALMENTE UN RADICAL PROTECTOR EMPLEADO. DE APLICACION EN PREPARADOS FARMACEUTICOS CAPACES DE DISMINUIR LA FRECUENCIA DE PULSACIONES DE LARGA DURACION.
ES517753A 1981-05-19 1982-11-29 Procedimiento para la preparacion de derivados de benzazepina. Granted ES517753A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813119874 DE3119874A1 (de) 1981-05-19 1981-05-19 "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"

Publications (2)

Publication Number Publication Date
ES8308309A1 true ES8308309A1 (es) 1983-08-16
ES517753A0 ES517753A0 (es) 1983-08-16

Family

ID=6132690

Family Applications (5)

Application Number Title Priority Date Filing Date
ES512285A Expired ES8306726A1 (es) 1981-05-19 1982-05-18 "procedimiento para la preparacion de derivados de benzazepina".
ES517758A Expired ES8308312A1 (es) 1981-05-19 1982-11-29 Procedimiento para la preparacion de derivados de benzazepina.
ES517756A Expired ES8308310A1 (es) 1981-05-19 1982-11-29 Procedimiento para la preparacion de derivados de benzazepina.
ES517757A Granted ES517757A0 (es) 1981-05-19 1982-11-29 Procedimiento para la preparacion de derivados de benzazepina.
ES517753A Granted ES517753A0 (es) 1981-05-19 1982-11-29 Procedimiento para la preparacion de derivados de benzazepina.

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES512285A Expired ES8306726A1 (es) 1981-05-19 1982-05-18 "procedimiento para la preparacion de derivados de benzazepina".
ES517758A Expired ES8308312A1 (es) 1981-05-19 1982-11-29 Procedimiento para la preparacion de derivados de benzazepina.
ES517756A Expired ES8308310A1 (es) 1981-05-19 1982-11-29 Procedimiento para la preparacion de derivados de benzazepina.
ES517757A Granted ES517757A0 (es) 1981-05-19 1982-11-29 Procedimiento para la preparacion de derivados de benzazepina.

Country Status (29)

Country Link
EP (1) EP0065229B1 (es)
JP (1) JPS57193462A (es)
KR (3) KR890001545B1 (es)
AR (1) AR231130A1 (es)
AT (1) ATE14725T1 (es)
AU (1) AU551509B2 (es)
BG (1) BG60412B2 (es)
CA (1) CA1185239A (es)
CS (2) CS251760B2 (es)
DD (1) DD202872A5 (es)
DE (2) DE3119874A1 (es)
DK (1) DK156720C (es)
ES (5) ES8306726A1 (es)
FI (1) FI77856C (es)
GB (1) GB2099425B (es)
GR (1) GR76458B (es)
HK (1) HK43388A (es)
HU (1) HU186584B (es)
IE (1) IE53016B1 (es)
IL (1) IL65814A (es)
MX (1) MX9202743A (es)
NO (1) NO159166C (es)
NZ (1) NZ200659A (es)
PL (1) PL136914B1 (es)
PT (1) PT74919B (es)
SU (1) SU1160935A3 (es)
UA (1) UA8038A1 (es)
YU (1) YU44674B (es)
ZA (1) ZA823413B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3242599A1 (de) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3343801A1 (de) * 1983-12-03 1985-06-13 Dr. Karl Thomae Gmbh, 7950 Biberach Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418270A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418271A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) * 1985-06-01 1990-01-03 Dr. Karl Thomae GmbH Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3541811A1 (de) * 1985-11-27 1987-06-04 Thomae Gmbh Dr K Neue cyclische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3736866A1 (de) * 1987-10-30 1989-05-11 Thomae Gmbh Dr K Mittel zur behandlung des bluthochdrucks und der herzinsuffizienz
FR2624117B1 (fr) * 1987-12-08 1991-02-22 Synthelabo Derives de hydroxy-3 (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique
JP2699511B2 (ja) * 1988-01-29 1998-01-19 武田薬品工業株式会社 置換アミン類
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
JPH09501405A (ja) * 1993-05-27 1997-02-10 スミスクライン・ビーチャム・ラボラトワール・ファルマソーティク 抗不整脈用ｎ−置換３−ベンズアゼピンまたはイソキノリン
FR2705675B1 (fr) * 1993-05-27 1996-05-03 Smithkline Beecham Labo Pharma Nouveaux composés, leur procédé de préparation et leur utilisation en tant que médicaments.
SE9303274D0 (sv) * 1993-10-07 1993-10-07 Astra Ab Novel phenylethyl and phenylproplamines
DE10018401A1 (de) 2000-04-13 2001-10-25 Boehringer Ingelheim Pharma Verwendung von Bradycardica bei der Behandlung von mit Hypertrophie einhergehenden Myocarderkrankungen und neue Arzneimittelkombinationen
US7250410B2 (en) 2001-06-07 2007-07-31 Via Pharmaceuticals, Inc. Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
KR100878737B1 (ko) * 2003-08-29 2009-01-14 미쓰이 가가쿠 가부시키가이샤 농업용 또는 원예용 살충제 및 그의 이용 방법
FR2868775B1 (fr) * 2004-04-13 2008-04-11 Servier Lab Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882554B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882553B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882555B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882556B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
EP1762179A1 (en) 2005-09-07 2007-03-14 Boehringer Ingelheim Vetmedica Gmbh Method for improving diagnostic quality in echocardiography
FR2891827B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891826B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2920773B1 (fr) * 2007-09-11 2009-10-23 Servier Lab Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
FR2941695B1 (fr) * 2009-02-04 2011-02-18 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
ME00987B (me) * 2009-03-31 2012-06-20 Servier Lab Novi postupak sinteze ivabradina i njegovih soli sa farmaceutski prihvatljivom kiselinom
FR2943668B1 (fr) * 2009-03-31 2011-05-06 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2956401B1 (fr) * 2010-02-17 2012-02-03 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
AU2012296925A1 (en) 2011-08-12 2014-02-06 Boehringer Ingelheim Vetmedica Gmbh Taste masked pharmaceutical composition
EP2953612A1 (en) 2013-02-11 2015-12-16 Boehringer Ingelheim Vetmedica GmbH Kit-of-parts
FR3003859B1 (fr) * 2013-03-26 2015-03-13 Servier Lab "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"
HU230826B1 (hu) * 2014-11-19 2018-07-30 Richter Gedeon Nyrt. Eljárás benzazepin származékok előállítására

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474090A (en) * 1966-12-22 1969-10-21 American Cyanamid Co 3-aminoalkyl-1,3-benzodiazepin-2-ones
US3780023A (en) * 1972-06-30 1973-12-18 J Suh 2-aralkylamino-4,5-dihydro-3h-1,3-benzodiazepines
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
DE2639718C2 (de) 1976-09-03 1987-03-05 Dr. Karl Thomae Gmbh, 7950 Biberach 1-[6,7-Dimethoxy-3,4-dihydro-2H-isochinolin-1-on-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-äthyl)-amino]-propan, dessen physiologisch verträgliche Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel
ZA786230B (en) * 1977-12-21 1979-10-31 Smithkline Corp 8 and/or 9 substituted 2-benzazepine compounds
ZA792785B (en) 1978-07-07 1980-08-27 Smithkline Corp Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines
ES484553A1 (es) * 1978-10-05 1980-05-16 Hoechst Ag Un metodo para preparar 4-fenil-1,3-benzodiazepinas
DE2850078A1 (de) * 1978-11-18 1980-05-29 Basf Ag Aminopropanolderivate des 6-hydroxy-2,3,4,5-tetrahydro-1h-1- benzazepin-2-ons

Also Published As

Publication number Publication date
PT74919B (de) 1985-05-16
GB2099425B (en) 1985-02-06
HU186584B (en) 1985-08-28
ES517758A0 (es) 1983-08-16
CA1185239A (en) 1985-04-09
ES8308312A1 (es) 1983-08-16
YU44674B (en) 1990-12-31
DE3119874A1 (de) 1982-12-09
DD202872A5 (de) 1983-10-05
BG60412B2 (bg) 1995-02-28
AU8379482A (en) 1982-11-25
FI77856B (fi) 1989-01-31
NO159166C (no) 1988-12-07
KR830010077A (ko) 1983-12-26
PL136914B1 (en) 1986-04-30
ATE14725T1 (de) 1985-08-15
HK43388A (en) 1988-06-17
GB2099425A (en) 1982-12-08
MX9202743A (es) 1992-06-30
UA8038A1 (uk) 1995-12-26
IL65814A0 (en) 1982-08-31
ES517753A0 (es) 1983-08-16
JPS57193462A (en) 1982-11-27
NO159166B (no) 1988-08-29
EP0065229A1 (de) 1982-11-24
CS410291A3 (en) 1992-08-12
DE3265206D1 (en) 1985-09-12
DK156720C (da) 1990-02-19
IE53016B1 (en) 1988-05-11
ES8308311A1 (es) 1983-08-16
FI77856C (fi) 1989-05-10
GR76458B (es) 1984-08-10
AR231130A1 (es) 1984-09-28
ES512285A0 (es) 1983-06-01
NO821645L (no) 1982-11-22
NZ200659A (en) 1985-05-31
ES8306726A1 (es) 1983-06-01
ES517756A0 (es) 1983-08-16
DK156720B (da) 1989-09-25
IL65814A (en) 1986-02-28
ES8308310A1 (es) 1983-08-16
KR890001544B1 (ko) 1989-05-08
FI821724A0 (fi) 1982-05-17
KR890001545B1 (ko) 1989-05-08
KR890001550B1 (ko) 1989-05-08
ES517757A0 (es) 1983-08-16
YU105182A (en) 1986-12-31
AU551509B2 (en) 1986-05-01
DK222382A (da) 1982-11-20
PT74919A (de) 1982-06-01
EP0065229B1 (de) 1985-08-07
SU1160935A3 (ru) 1985-06-07
ZA823413B (en) 1984-01-25
JPH0136829B2 (es) 1989-08-02
CS251760B2 (en) 1987-08-13
PL236474A1 (en) 1983-06-20
IE821194L (en) 1982-11-19

Similar Documents

Publication Publication Date Title
ES8308309A1 (es) Procedimiento para la preparacion de derivados de benzazepina.
MX9300014A (es) Nuevos derivados de 1,2,4-triaminobenceno y procedimiento para su elaboracion.
Zanini Jr et al. Action of compounds from Mandevilla velutina on croton oil‐induced ear oedema in mice. A comparative study with steroidal and nonsteroidal antiinflammatory drugs
FR2369263A1 (fr) Nouveaux derives de la piperidine
ATE142198T1 (de) Vitamin-d-derivate und verfahren zur herstellung dieser verbindungen
YU24496A (sh) UPOTREBA DERIVATA IMIDAZOLINA I IMIDAZOLIDINA KAO α1L AGONISTA, POSTUPCI ZA NJIHOVO DOBIJANJE, KAO I FARMACEUTSKI PREPARATI KOJI IH SADRŽE
ATE36859T1 (de) 4&#39;-demethyl-4-epipodophyllotoxin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
AU6371590A (en) 24-homo vitamin d derivatives, process for their production and pharmaceutical preparations obtained therefrom
DE59206439D1 (de) 23-oxa-derivate in der vitamin-d-reihe, verfahren zu ihrer herstellung, diese derivate enthaltende pharmazeutische präparate sowie deren verwendung als arzneimittel
ES8606282A1 (es) Un procedimiento de preparar derivados de acidos quinolin- ynaftiridin-carboxilicos
FR2649110B1 (fr) Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DK0541594T3 (da) Cyklopentan-derivater, fremgangsmåde til fremstilling deraf samt farmaceutisk anvendelse af derivaterne
ATE8401T1 (de) Anthracyclin-glycoside, verfahren zu ihrer herstellung, zwischenprodukte und ihre herstellung und arzneimittel.
ES2148240T3 (es) Sintesis de derivados del acido n-acetil neuraminico.
ES8301200A1 (es) Procedimiento para la preparacion de derivados de ciclohexe-no
FR2446829A1 (fr) Derives de polymethylene disubstitues en alpha, omega, procede pour leur preparation et compositions pharmaceutiques les contenant
ES8703141A1 (es) Un procedimiento para la preparacion de nuevos derivados de pirazol.
HUP9802096A2 (hu) Piperidino-alkanol-vegyületeket tartalmazó orális adagolású oldat formájú gyógyszerkészítmény, és eljárás előállítására
ES8503348A1 (es) Procedimiento para la preparacion de 5-cianoprostaciclinas
ES2061564T3 (es) Nuevo procedimiento para la preparacion de derivados de 6,7-diacil-7-desacetilforscolina.
FR2371461A1 (fr) Analogues disaccharides d&#39;anthracycline antitumorale et procede pour les preparer
GB1434074A (en) Antiviral compositions comprising hydantoin derivatives
PL251145A1 (en) Method of obtaining derivatives of phenylaniline
FR2630111B1 (fr) Nouveaux derives trieniques de structure chromenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2370039A1 (fr) Procede de preparation d&#39;esters de 1-(a-(carboxy)-4-hydroxybenzyl protege)-3-acylaminoazetidin-2-one, intermediaires de synthese de l&#39;antibiotique nocardicine

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20030526