[go: up one dir, main page]

ES8307798A1 - A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF PIPERAZILMETIL-4-DIBENZOFURANONA, OR, DIBENZOFURANOL. - Google Patents

A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF PIPERAZILMETIL-4-DIBENZOFURANONA, OR, DIBENZOFURANOL.

Info

Publication number
ES8307798A1
ES8307798A1 ES513035A ES513035A ES8307798A1 ES 8307798 A1 ES8307798 A1 ES 8307798A1 ES 513035 A ES513035 A ES 513035A ES 513035 A ES513035 A ES 513035A ES 8307798 A1 ES8307798 A1 ES 8307798A1
Authority
ES
Spain
Prior art keywords
piperazilmetil
dibenzofuranona
dibenzofuranol
derivatives
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513035A
Other languages
Spanish (es)
Other versions
ES513035A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riom Lab C E R M S A
Original Assignee
Riom Lab C E R M S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riom Lab C E R M S A filed Critical Riom Lab C E R M S A
Publication of ES513035A0 publication Critical patent/ES513035A0/en
Publication of ES8307798A1 publication Critical patent/ES8307798A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention is dealing with compounds of the formula: < IMAGE > I and pharmaceutically acceptable salts thereof, in which R1, R2, R3 and R4 are identical or different and represent hydrogen, halogen, lower alkyl or alkoxy or trifluoromethyl R5 represents hydrogen or lower alkyl, X represents hydrogen and Y represents hydroxy, or X and Y together represent oxygen and Ar represents an optionally substituted aromatic moiety, having potent anti-bronchoconstrictor properties.
ES513035A 1981-06-12 1982-06-11 A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF PIPERAZILMETIL-4-DIBENZOFURANONA, OR, DIBENZOFURANOL. Expired ES8307798A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8111672A FR2507603A1 (en) 1981-06-12 1981-06-12 SUBSTITUTED 1, 2, 3, 4, 4A, 9B-HEXAHYDRO-4A-PIPERAZINYLMETHYL-4-DIBENZOFURANONES OR 4-DIBENZOFURANOLS, SYNTHESIS METHOD AND THERAPEUTIC APPLICATION

Publications (2)

Publication Number Publication Date
ES513035A0 ES513035A0 (en) 1983-08-01
ES8307798A1 true ES8307798A1 (en) 1983-08-01

Family

ID=9259490

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513035A Expired ES8307798A1 (en) 1981-06-12 1982-06-11 A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF PIPERAZILMETIL-4-DIBENZOFURANONA, OR, DIBENZOFURANOL.

Country Status (11)

Country Link
US (1) US4409221A (en)
EP (1) EP0067769A1 (en)
JP (1) JPS5813579A (en)
AU (1) AU8471582A (en)
DK (1) DK264082A (en)
ES (1) ES8307798A1 (en)
FI (1) FI822071A7 (en)
FR (1) FR2507603A1 (en)
GR (1) GR82310B (en)
PT (1) PT75026B (en)
ZA (1) ZA823838B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668690A (en) * 1985-12-30 1987-05-26 Hoechst Roussel Pharmaceuticals Inc. 1,2,3,4,4a,9b-hexahydro-4a-aminoalkyldibenzofurans useful as analgesics, anticonvulsants or antidepressants
US4978679A (en) * 1989-09-25 1990-12-18 Merck & Co., Inc. 6- and/or 7-substituted-1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzofuran-3-ols as inhibitors of leukotriene biosynthesis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3337563A (en) * 1964-09-04 1967-08-22 Upjohn Co 2-amino-2, 3-dihydro-3-substituted-naphtho[1, 2-b]furan-5-ols
US3317527A (en) * 1965-10-06 1967-05-02 Upjohn Co 3a and 5a tertiaryamino cycloalkylene of 5 to 7[alpha]benzofuranols
US3496181A (en) * 1966-10-24 1970-02-17 Upjohn Co 2 - aminocycloalkyl hydroquinones,esters,ethers and n-oxides thereof,and a process for preparing the same

Also Published As

Publication number Publication date
ES513035A0 (en) 1983-08-01
JPS5813579A (en) 1983-01-26
DK264082A (en) 1982-12-13
PT75026B (en) 1984-05-25
EP0067769A1 (en) 1982-12-22
FR2507603A1 (en) 1982-12-17
GR82310B (en) 1984-12-13
FR2507603B1 (en) 1983-09-23
PT75026A (en) 1982-07-01
FI822071A0 (en) 1982-06-10
US4409221A (en) 1983-10-11
ZA823838B (en) 1983-03-30
FI822071A7 (en) 1982-12-13
AU8471582A (en) 1982-12-16

Similar Documents

Publication Publication Date Title
IL71664A (en) Fluoroalkoxy compounds,process for their preparation and pharmaceutical compositions containing the same
SE7908481L (en) NEW 5H-2,3-BENZODIAZEPINE DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF
ES8103744A1 (en) A METHOD FOR THE PREPARATION OF PHTHALIMIDINE DERIVATIVES
ES512842A0 (en) &#34;PROCEDURE FOR PREPARING CARBOXAMIDIC DERIVATIVES&#34;.
ES526765A0 (en) PROCEDURE FOR PREPARING 2-AMINO-3-ACILAMINO-6-BENCILAMINO-PIRIDINE DERIVATIVES
ES519650A0 (en) A PROCEDURE FOR OBTAINING INDANILBENZAMIDE DERIVATIVES.
DE69105572D1 (en) 4-phenylphthalazine derivatives.
ES532337A0 (en) PROCEDURE FOR THE PREPARATION OF 6-ARYL-3 (2H) PYRIDAZINONES
ES8800122A1 (en) Indene and naphthalene derivatives.
ES8307798A1 (en) A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF PIPERAZILMETIL-4-DIBENZOFURANONA, OR, DIBENZOFURANOL.
MX9101948A (en) PHARMACEUTICAL COMPOSITION CONTAINING TIAZOLOISOINDOLINONE DERIVATIVES
ES509553A0 (en) &#34;PROCEDURE FOR THE PREPARATION OF NEW CEPHALOSPORINS&#34;.
ES510739A0 (en) &#34;PROCEDURE FOR THE PREPARATION OF 4-HYDROXY-1,2-BENZOISOTIAZOL-3 (2H) -ONE 1,1-DIOXIDES&#34;.
ES550817A0 (en) PROCEDURE FOR PREPARING DERIVATIVES OF N-CARBOXIALKYL-2 - OXO-3-DIARIL-5,6-TRIAZINES
ES515201A0 (en) &#34;PROCEDURE FOR THE MANUFACTURE OF N-SUBSTITUTED DERIVATIVES OF TETRAHYDROISFTALIMIDE&#34;.
ES500108A0 (en) PROCEDURE FOR PREPARING NEW BENZOTIOPYRAN (2,3-C) PI-RIDINAS
FI953246A7 (en) Intermediates for the preparation of quinoline-3-carboxylic acid derivatives

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202