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ES8206455A1 - Guanidine derivatives and pharmaceutical compositions containing them. - Google Patents

Guanidine derivatives and pharmaceutical compositions containing them.

Info

Publication number
ES8206455A1
ES8206455A1 ES506337A ES506337A ES8206455A1 ES 8206455 A1 ES8206455 A1 ES 8206455A1 ES 506337 A ES506337 A ES 506337A ES 506337 A ES506337 A ES 506337A ES 8206455 A1 ES8206455 A1 ES 8206455A1
Authority
ES
Spain
Prior art keywords
formula
guanidine derivatives
pharmaceutical compositions
compositions containing
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506337A
Other languages
Spanish (es)
Other versions
ES506337A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ES506337A0 publication Critical patent/ES506337A0/en
Publication of ES8206455A1 publication Critical patent/ES8206455A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Quick-Acting Or Multi-Walled Pipe Joints (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE GUANIDINA, DE SUS ISONMEROS EN EL GRUPO GUANIDINA Y SALES FISIOLOGIAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE UNO DE X E Y ES CR5 Y EL OTRO ES CH O N , Y R1-R6 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA RREACCION DE UNA ISOTIUREA DE FORMULA (II) CON UNA AMINA DE FORMULA R2NHR3, EN LAS QUE R1-R6, X E I TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO DISOLVIENDO LOS REACTIVOS EN UN DISOLVENTE INERTE, SI ES NECESARIO MEDIANTE CALENTAMIENTO, Y AGITANDO HASTA QUE SE COMPLETA LA REACCION A LA TEMPERATURA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES PARA EL TRATAMIENTO DE ANIMALES Y SERES HUMANOS CONTRA GUSANOS PARASITOS.PROCEDURE FOR OBTAINING GUANIDINE DERIVATIVES, ITS ISONMERS IN THE GUANIDINE GROUP AND PHYSIOLOGICALLY COMPATIBLE SALTS, OF FORMULA (I), IN WHICH ONE OF X AND Y IS CR5 AND THE OTHER IS CH O N , AND R1-R6 MAY BE VARIOUS TYPES OF RADICALS. IT CONSISTS OF THE RREACTION OF AN ISOTHIUREA OF FORMULA (II) WITH AN AMINE OF FORMULA R2NHR3, IN WHICH R1-R6, X AND I HAVE THE SAME MEANING AS IN FORMULA (I). THE REACTION IS CARRIED OUT BY DISSOLVING THE REAGENTS IN AN INERT SOLVENT, IF NECESSARY BY HEATING, AND STIRRING UNTIL THE REACTION IS COMPLETE AT ROOM TEMPERATURE. THESE COMPOUNDS HAVE APPLICATIONS FOR THE TREATMENT OF ANIMALS AND HUMANS AGAINST PARASITIC WORMS.

ES506337A 1980-10-20 1981-10-19 Guanidine derivatives and pharmaceutical compositions containing them. Expired ES8206455A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/198,424 US4348406A (en) 1980-10-20 1980-10-20 Novel guanidine derivatives

Publications (2)

Publication Number Publication Date
ES506337A0 ES506337A0 (en) 1982-08-16
ES8206455A1 true ES8206455A1 (en) 1982-08-16

Family

ID=22733331

Family Applications (1)

Application Number Title Priority Date Filing Date
ES506337A Expired ES8206455A1 (en) 1980-10-20 1981-10-19 Guanidine derivatives and pharmaceutical compositions containing them.

Country Status (20)

Country Link
US (3) US4348406A (en)
EP (2) EP0050286B1 (en)
JP (2) JPH0323540B2 (en)
AT (1) ATE13423T1 (en)
AU (1) AU548628B2 (en)
CA (1) CA1248949A (en)
CY (1) CY1424A (en)
DE (1) DE3170623D1 (en)
DK (1) DK255682A (en)
ES (1) ES8206455A1 (en)
HK (1) HK26788A (en)
HU (1) HU183749B (en)
IE (1) IE51871B1 (en)
IL (1) IL64081A (en)
MY (1) MY8700682A (en)
NZ (1) NZ198679A (en)
PT (1) PT73841B (en)
SG (1) SG112187G (en)
WO (1) WO1982001367A1 (en)
ZA (1) ZA817265B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0156889A1 (en) * 1983-09-23 1985-10-09 Schering Corporation Phenylguanidines
US4723029A (en) * 1983-09-23 1988-02-02 Schering Corporation Organic acid-substituted guanidine anthelmintics
US4701447A (en) * 1983-09-23 1987-10-20 Schering Corporation N-((2-nitro)phenyl)-N' (organic acid) guanidine anthelmintics
AT401086B (en) * 1985-11-28 1996-06-25 Gossler Ewald Method for compressing gases
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
HU205343B (en) * 1989-06-21 1992-04-28 Chinoin Gyogyszer Es Vegyeszet New process for producing guanidine derivatives
GB9915709D0 (en) 1999-07-05 1999-09-08 Guilden Ltd Vehicle suspension systems
PT1913009E (en) * 2005-07-28 2010-06-25 Intervet Int Bv Novel benzimidazole (thio) carbamates with antiparasitic activity and the synthesis thereof
AU2007345301A1 (en) * 2006-06-12 2008-07-31 Smith And Nephew Inc Systems, methods and devices for tibial resection
MX2008015764A (en) 2006-06-14 2009-01-07 Intervet Int Bv A suspension comprising benzimidazole carbamate and a polysorbate.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL38933A0 (en) * 1971-03-17 1972-05-30 Ciba Geigy Ag New carbamates,their manufacture and their use in plant protection
US4097673A (en) * 1974-11-01 1978-06-27 E. I. Du Pont De Nemours And Company Herbicidal carbamates and thiolcarbamates
US3941824A (en) * 1973-05-02 1976-03-02 E. I. Du Pont De Nemours & Co. Herbicidal carbamates and thiolcarbamates
AR213309A1 (en) * 1976-05-05 1979-01-15 Rohm & Haas PROCEDURE TO PREPARE SUBSTITUTE 2-AMINO-ISOTIOUREIDOBENZENES
DE2651467A1 (en) * 1976-11-11 1978-05-18 Bayer Ag SUBSTITUTED O-PHENYLENE DIAMINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
US4293569A (en) * 1978-05-12 1981-10-06 E. R. Squibb & Sons, Inc. Substituted phenylguanindines and method
DE2836385A1 (en) 1978-08-19 1980-03-06 Hoechst Ag MONOCARBOXYLATES OF PHENYLGUANIDINE SULPHONIC ACID ESTERS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
US4217358A (en) 1979-04-18 1980-08-12 E. R. Squibb & Sons, Inc. Substituted phenylguanidines and method

Also Published As

Publication number Publication date
IL64081A (en) 1985-12-31
MY8700682A (en) 1987-12-31
PT73841B (en) 1983-11-07
EP0063158A1 (en) 1982-10-27
JPH0432051B2 (en) 1992-05-28
ZA817265B (en) 1982-09-29
PT73841A (en) 1981-11-01
ATE13423T1 (en) 1985-06-15
EP0050286B1 (en) 1985-05-22
WO1982001367A1 (en) 1982-04-29
DK255682A (en) 1982-06-07
CA1248949A (en) 1989-01-17
DE3170623D1 (en) 1985-06-27
JPS57501850A (en) 1982-10-14
CY1424A (en) 1988-09-02
NZ198679A (en) 1985-02-28
SG112187G (en) 1988-05-20
US4406893A (en) 1983-09-27
ES506337A0 (en) 1982-08-16
EP0050286A3 (en) 1982-05-26
IE51871B1 (en) 1987-04-15
US4435398A (en) 1984-03-06
IL64081A0 (en) 1982-01-31
EP0050286A2 (en) 1982-04-28
US4348406A (en) 1982-09-07
HK26788A (en) 1988-04-22
IE812453L (en) 1982-04-20
AU548628B2 (en) 1985-12-19
JPH0323540B2 (en) 1991-03-29
JPH03264527A (en) 1991-11-25
HU183749B (en) 1984-05-28
AU7809281A (en) 1982-05-11

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