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ES8203962A1 - Un procedimiento para la preparacion de una macrolida - Google Patents

Un procedimiento para la preparacion de una macrolida

Info

Publication number
ES8203962A1
ES8203962A1 ES502980A ES502980A ES8203962A1 ES 8203962 A1 ES8203962 A1 ES 8203962A1 ES 502980 A ES502980 A ES 502980A ES 502980 A ES502980 A ES 502980A ES 8203962 A1 ES8203962 A1 ES 8203962A1
Authority
ES
Spain
Prior art keywords
macrolide
procedure
ch2oh
formula
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES502980A
Other languages
English (en)
Other versions
ES502980A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8203962A1 publication Critical patent/ES8203962A1/es
Publication of ES502980A0 publication Critical patent/ES502980A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/54—Streptomyces fradiae

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UNA MACROLIDA, ASI COMO DE SUS ESTERES Y SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE Q ES CH2OH O CHO, CON LA CONDICION DE QUE SI HAY UN O-ACETILO EN LA POSICION 3 NO PUEDE HABER UN O-ISOVALERILO EN 4''''. CONSISTE EN EL CULTIVO DE STREPTOMYCES FRADIAE NRRL 12170 EN CONDICIONES AEROBIAS SUMERGIDAS HASTA OBTENER UNA CANTIDAD SUSTANCIAL DE ACTIVIDAD ANTIBIOTICA PARA QUE SE PRODUZCA LA MACROLIDA. TAMBIEN SE PUEDE REDUCIR QUIMICAMENTE LA 23-DESMICINOSILTILOSINA PARA OBTENER LA MACROLIDA DE FORMULA (I), EN LA QUE Q ES CH2OH. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIBIOTICOS.
ES502980A 1980-06-12 1981-06-11 Un procedimiento para la preparacion de una macrolida Granted ES502980A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/156,855 US4321362A (en) 1980-06-12 1980-06-12 De(mycinosyloxy)tylosin and process for its production
US06/156,854 US4321361A (en) 1980-06-12 1980-06-12 Demycinosyltylosin and process for its production

Publications (2)

Publication Number Publication Date
ES8203962A1 true ES8203962A1 (es) 1982-04-16
ES502980A0 ES502980A0 (es) 1982-04-16

Family

ID=26853578

Family Applications (1)

Application Number Title Priority Date Filing Date
ES502980A Granted ES502980A0 (es) 1980-06-12 1981-06-11 Un procedimiento para la preparacion de una macrolida

Country Status (26)

Country Link
US (2) US4321362A (es)
EP (1) EP0042250B1 (es)
JP (1) JPS5731699A (es)
KR (1) KR840001956B1 (es)
AR (2) AR227316A1 (es)
AU (1) AU544988B2 (es)
CA (1) CA1172189A (es)
CS (1) CS225841B2 (es)
DD (1) DD159644A5 (es)
DE (1) DE3162500D1 (es)
DK (1) DK255681A (es)
ES (1) ES502980A0 (es)
FI (1) FI811826A7 (es)
GB (1) GB2077731B (es)
GR (1) GR75277B (es)
HU (1) HU189512B (es)
IE (1) IE51614B1 (es)
IL (1) IL63075A (es)
NZ (1) NZ197359A (es)
PH (1) PH16171A (es)
PL (2) PL131731B1 (es)
PT (1) PT73165B (es)
RO (1) RO81016A (es)
SU (1) SU1151218A3 (es)
YU (1) YU144381A (es)
ZA (1) ZA813579B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486584A (en) * 1980-07-15 1984-12-04 Eli Lilly And Company Demethylmacrocin compounds and derivatives thereof
US4419508A (en) * 1980-11-10 1983-12-06 Eli Lilly And Company 20-Dihydro-20-deoxy-23-demycinosyltylosin and process for its production
US4396613A (en) * 1981-12-14 1983-08-02 Eli Lilly And Company 23-Ester derivatives of DMT and method of using same
US4487923A (en) * 1981-12-14 1984-12-11 Eli Lilly And Company Method of preparing 23-monoesters of OMT and DMT
US4401660A (en) * 1981-12-14 1983-08-30 Eli Lilly And Company Ester derivatives of 5-O-mycaminosyl tylonolide and method of using same
US4436733A (en) 1982-03-03 1984-03-13 Eli Lilly And Company 4"- And 3-ester derivatives of DMT and DMOT
US4435388A (en) 1982-06-10 1984-03-06 Schering Corporation Tylosin 20-imino-20-deoxo-4"-acyl derivatives, pharmaceutical compositions and method of use
JPS58219197A (ja) * 1982-06-15 1983-12-20 Sanraku Inc マクロライド系抗生物質の誘導体
US4436729A (en) * 1982-06-30 1984-03-13 Schering Corporation 23-Demycinosyltylosin compounds, pharmaceutical compositions and method of use
US4528369A (en) * 1982-07-02 1985-07-09 Eli Lilly And Company 20-Dihydro-20-deoxy-23-de(mycinosyloxy)tylosin
US4459290A (en) * 1982-07-19 1984-07-10 Eli Lilly And Company C-23-Modified derivatives of OMT, pharmaceutical compositions and method of use
US4452784A (en) * 1982-07-19 1984-06-05 Eli Lilly And Company C-23-Modified derivatives of DMT
US4820695A (en) * 1982-09-13 1989-04-11 Eli Lilly And Company C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics
US4443436A (en) * 1982-09-13 1984-04-17 Eli Lilly And Company C-20-Modified macrolide derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, and lactenocin
US4629786A (en) * 1983-02-28 1986-12-16 Eli Lilly And Company C-20- and C-23 modified macrolide derivatives
IL71032A0 (en) * 1983-02-28 1984-05-31 Lilly Co Eli C-20 and c-23-modified macrolide derivatives
US4468511A (en) * 1983-02-28 1984-08-28 Eli Lilly And Company C-20- And C-23-Modified macrolide derivatives
JPS59181294A (ja) * 1983-03-30 1984-10-15 Satoshi Omura 抗生物質ｐｔｌ−４４８とその誘導体およびそれらの製造方法
US4851518A (en) * 1985-12-23 1989-07-25 Schering Corporation Di and tri-O-acetyl-"O-iso-valeryl-23-O-demycinosyl tylosins, hydrazone derivatives thereof and processes for their preparation
US4808575A (en) * 1986-06-23 1989-02-28 Schering Corporation 12,13-oxoderivatives of macrolides
US4962146A (en) * 1987-04-29 1990-10-09 Schering Corporation 3-O-glycosyl 16-membered macrolide antibacterials and related derivatives
JPH01230559A (ja) * 1988-03-11 1989-09-14 Sagami Chem Res Center ５−置換メチリデンヒダントイン誘導体
IL98599A (en) * 1990-06-28 1995-06-29 Merck & Co Inc Stable salts of 4"-deoxy-4"-epi-methylamino avermectin b1a/b1b and insecticidal compositions containing them
US7247617B2 (en) * 2004-07-13 2007-07-24 Kosan Biosciences Incorporated Sixteen-member macrolide antiinfective agents
US7378508B2 (en) * 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3178341A (en) * 1960-06-27 1965-04-13 Lilly Co Eli Antibiotics tylosin and desmycosin and derivatives thereof
US3326759A (en) * 1962-07-19 1967-06-20 Lilly Co Eli Antibiotics macrocin and lactenocin
US3344024A (en) * 1963-04-17 1967-09-26 American Cyanamid Co Antibiotic am-684 and method of production
BE667952A (es) * 1964-08-05
US4161523A (en) * 1972-11-15 1979-07-17 Schering Corporation Rosamicin esters, acid addition salts and methods for production thereof
US3923784A (en) * 1973-09-10 1975-12-02 Hoffmann La Roche Erythromycin a derivatives
YU35363B (en) * 1974-01-14 1980-12-31 Pliva Zagreb Process for obtaining n-(benzene-sulfonyl)-5-0desosaminyl-erythromycilamine derivatives
JPS52139088A (en) * 1976-05-15 1977-11-19 Sanraku Inc Antibiotics tyrocin derivatives and their preparation
US4056616A (en) * 1976-03-05 1977-11-01 Schering Corporation Rosamicin derivatives and method of using same
JPS5315160A (en) * 1976-07-27 1978-02-10 Nippon Steel Corp Sensitivity controller of self-scan image sensor in thermal radiating object measuring apparatus
GB1587685A (en) * 1977-03-09 1981-04-08 Microbial Chem Res Found Macrolactone derivatives and their production
US4205163A (en) * 1977-11-08 1980-05-27 Sanraku-Ocean Co., Ltd. Tylosin derivatives
JPS6016960B2 (ja) * 1978-09-20 1985-04-30 メルシャン株式会社 マクロライド系抗生物質ｎ−１及びその製造法

Also Published As

Publication number Publication date
GB2077731B (en) 1984-04-26
EP0042250A1 (en) 1981-12-23
PT73165B (en) 1982-07-16
IL63075A0 (en) 1981-09-13
GB2077731A (en) 1981-12-23
KR830006429A (ko) 1983-09-24
PT73165A (en) 1981-07-01
EP0042250B1 (en) 1984-03-07
DK255681A (da) 1981-12-13
AU544988B2 (en) 1985-06-27
IE51614B1 (en) 1987-01-21
YU144381A (en) 1983-09-30
NZ197359A (en) 1984-03-16
KR840001956B1 (ko) 1984-10-26
FI811826L (fi) 1981-12-13
GR75277B (es) 1984-07-13
AR226899A1 (es) 1982-08-31
RO81016A (ro) 1983-02-01
PH16171A (en) 1983-07-21
ZA813579B (en) 1983-01-26
ES502980A0 (es) 1982-04-16
JPS5731699A (en) 1982-02-20
CA1172189A (en) 1984-08-07
PL231594A1 (es) 1982-02-15
US4321361A (en) 1982-03-23
AR227316A1 (es) 1982-10-15
PL131731B1 (en) 1984-12-31
HU189512B (en) 1986-07-28
US4321362A (en) 1982-03-23
DE3162500D1 (en) 1984-04-12
PL231598A1 (es) 1982-02-15
AU7144681A (en) 1981-12-17
PL131733B1 (en) 1984-12-31
SU1151218A3 (ru) 1985-04-15
DD159644A5 (de) 1983-03-23
CS225841B2 (en) 1984-02-13
FI811826A7 (fi) 1981-12-13
IL63075A (en) 1984-07-31
IE811297L (en) 1981-12-12

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960401