ES8201536A1 - PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF AMINOBENZOIC ACIDS - Google Patents
PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF AMINOBENZOIC ACIDSInfo
- Publication number
- ES8201536A1 ES8201536A1 ES492843A ES492843A ES8201536A1 ES 8201536 A1 ES8201536 A1 ES 8201536A1 ES 492843 A ES492843 A ES 492843A ES 492843 A ES492843 A ES 492843A ES 8201536 A1 ES8201536 A1 ES 8201536A1
- Authority
- ES
- Spain
- Prior art keywords
- opt
- alkyl
- formula
- substd
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000005415 aminobenzoic acids Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- -1 pyrrolidino, piperidino, hexamethylenimino, morpholino Chemical group 0.000 abstract 2
- JPRPJUMQRZTTED-UHFFFAOYSA-N 1,3-dioxolanyl Chemical group [CH]1OCCO1 JPRPJUMQRZTTED-UHFFFAOYSA-N 0.000 abstract 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 229960004050 aminobenzoic acid Drugs 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000000466 oxiranyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Abstract
Aminobenzoic acid derivs. of formula (I) and their acid-addn. salts are new, where R1 is H, F, Cl or Br R2 and R3 are each opt. branched 1-6C alkyl (opt. substd. with Ph or di(1-3C)alkylamino), pyridyl or 5-7C cycloalkyl or R2 and R3, together with the N atom form pyrrolidino, piperidino, hexamethylenimino, morpholino, N-arylpiperazino, or N-(1-3C)alkylpiperazino or one of R2 and R3 may be H. A is 5-7C cycloalkylene or straight-chain 2-10C alkylene, opt. substd. with 1 or 2 1-3C alkyl or 2-4C carbalkoxy, 1-4 OH and/or one gp. of formula T (where Z is -CH2-O-) and is opt. interrupted by O, S, SO, SO2, NH or piperazino, the NH gp. opt. substd. with 1-6C alkyl, Ph or phenyl(1-3C)alkyl X is O or NH Y is OH, amino, Cl, Br, I or a gp. of formula T (where Z is O or NH, or, together with the alpha and beta-C atoms of A, providing this contains at least 3C forms oxiranyl or 1,3-dioxolanyl or formula (II)) R4 and R5 are each H 1-3C alkyl or Ph. (I) can esp. be used to treat ulcers and inhibit stomach juice secretion. (I) are also intermediates in the prepn. of antiinflammatories (see DE2926472).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792926471 DE2926471A1 (en) | 1979-06-30 | 1979-06-30 | Amino:methyl-benzoic acid derivs. - are secrolytics can treat coughs, and are intermediates for antiinflammatory amino:methyl benzoyl derivs. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8201536A1 true ES8201536A1 (en) | 1981-11-16 |
| ES492843A0 ES492843A0 (en) | 1981-11-16 |
Family
ID=6074590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES492843A Granted ES492843A0 (en) | 1979-06-30 | 1980-06-27 | PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF AMINOBENZOIC ACIDS |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS5610154A (en) |
| AT (1) | AT370085B (en) |
| CA (1) | CA1140934A (en) |
| DE (1) | DE2926471A1 (en) |
| DK (1) | DK279380A (en) |
| ES (1) | ES492843A0 (en) |
| FI (1) | FI802048A7 (en) |
| GR (1) | GR69273B (en) |
| NO (1) | NO801930L (en) |
| PT (1) | PT71452B (en) |
-
1979
- 1979-06-30 DE DE19792926471 patent/DE2926471A1/en not_active Withdrawn
-
1980
- 1980-06-03 GR GR62112A patent/GR69273B/el unknown
- 1980-06-10 JP JP7828080A patent/JPS5610154A/en active Pending
- 1980-06-11 AT AT0306380A patent/AT370085B/en not_active IP Right Cessation
- 1980-06-25 PT PT71452A patent/PT71452B/en unknown
- 1980-06-27 FI FI802048A patent/FI802048A7/en not_active Application Discontinuation
- 1980-06-27 DK DK279380A patent/DK279380A/en not_active Application Discontinuation
- 1980-06-27 ES ES492843A patent/ES492843A0/en active Granted
- 1980-06-27 NO NO801930A patent/NO801930L/en unknown
- 1980-06-30 CA CA000355165A patent/CA1140934A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2926471A1 (en) | 1981-01-15 |
| AT370085B (en) | 1983-02-25 |
| PT71452A (en) | 1980-07-01 |
| ATA306380A (en) | 1982-07-15 |
| FI802048A7 (en) | 1981-01-01 |
| CA1140934A (en) | 1983-02-08 |
| DK279380A (en) | 1980-12-31 |
| PT71452B (en) | 1981-10-23 |
| ES492843A0 (en) | 1981-11-16 |
| GR69273B (en) | 1982-05-13 |
| NO801930L (en) | 1981-01-02 |
| JPS5610154A (en) | 1981-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19981103 |