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ES8106283A1 - Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzimas. - Google Patents

Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzimas.

Info

Publication number
ES8106283A1
ES8106283A1 ES494303A ES494303A ES8106283A1 ES 8106283 A1 ES8106283 A1 ES 8106283A1 ES 494303 A ES494303 A ES 494303A ES 494303 A ES494303 A ES 494303A ES 8106283 A1 ES8106283 A1 ES 8106283A1
Authority
ES
Spain
Prior art keywords
formula
precursors
sulfoxide
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES494303A
Other languages
English (en)
Other versions
ES494303A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES494303A0 publication Critical patent/ES494303A0/es
Publication of ES8106283A1 publication Critical patent/ES8106283A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Polymerisation Methods In General (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE PRECURSORES DE ALILSUFOXIDOS INHIBIDORES DE ENZIMAS DE FORMULA ESTRUCTURAL (I), DONDE X ES HIDROGENO, FLUOR, CLORO, TOLUENSULFONILOXI, BENCENOSULFONILOXI O SIMILARES O UN RADICAL DE FORMULA (II); Y ES HIDROGENO O UN RADICAL DE FORMULA (III); Z ES FLUOR, CLORO, TOLUENSULFONILOXI, BENCENOSULFONILOXI O SIMILARES O UN RADICAL DE FORMULA (II); O BIEN Y Y Z UNIDOS FORMAN UN GRUPO = CH2; CON LA CONDICION DE QUE UNO Y SOLAMENTE UNO DE LOS GRUPOS X, Y, Z ES UN SULFOXIDO Y UNO SOLAMENTE UNO DE LOS GRUPOS X Y Z ES HALOGENO; R ES FENILO NO SUSTITUIDO O SUSTITUIDO, TRIHALOMETILO O HETEROARILO DE CINCO O SEIS MIEMBROS; R ELEVADO A 1 ES IMIDAZO-4-ILO, AMINOETILO, 4-HIDROXIFENILO O HIDROGENO. CONSISTE EN OXIDAR UN TIO-DERIVADO AROMATICO DE FORMULA ESTRUCTURAL (IV). EL AGENTE OXIDANTE SE SELECCIONA ENTRE 1-CLOROBENZOTRIAZOL, CL2, BR2, NALO4, CH3COONO2 O UN PERACIDO. *FORMULA* O
ES494303A 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzimas. Expired ES8106283A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6660379A 1979-08-15 1979-08-15

Publications (2)

Publication Number Publication Date
ES494303A0 ES494303A0 (es) 1981-08-01
ES8106283A1 true ES8106283A1 (es) 1981-08-01

Family

ID=22070551

Family Applications (4)

Application Number Title Priority Date Filing Date
ES494302A Granted ES494302A0 (es) 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas.
ES494303A Expired ES8106283A1 (es) 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzimas.
ES494305A Granted ES494305A0 (es) 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas.
ES494304A Granted ES494304A0 (es) 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES494302A Granted ES494302A0 (es) 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES494305A Granted ES494305A0 (es) 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas.
ES494304A Granted ES494304A0 (es) 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas.

Country Status (9)

Country Link
EP (4) EP0026307B1 (es)
JP (4) JPS5630961A (es)
AT (4) ATE4316T1 (es)
DE (4) DE3064411D1 (es)
DK (4) DK351280A (es)
ES (4) ES494302A0 (es)
GR (4) GR69834B (es)
IE (4) IE50150B1 (es)
PT (4) PT71654B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2457296A1 (fr) * 1979-05-23 1980-12-19 Rhone Poulenc Ind Nouveaux derives de vinyl-3 cephalosporines et leur preparation
US4553191A (en) * 1982-12-03 1985-11-12 Xerox Corporation Static eliminator
EP0123543B1 (en) * 1983-04-21 1988-02-03 Merck Frosst Canada Inc. Leukotriene antagonists, their production and use and compositions containing them
US4609744A (en) * 1983-04-21 1986-09-02 Merck Frosst Canada Inc. 4-oxo-benzopyran carboxylic acids
FR2661909B1 (fr) * 1990-05-09 1997-08-14 Inst Nat Sante Rech Med Nouveaux composes agonistes du recepteur h3 de l'histamine a usage therapeutique, compositions pharmaceutiques agissant comme agonistes dudit recepteur et procede de preparation.
US5744485A (en) * 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
CA2389229A1 (en) * 1999-10-29 2001-05-10 The Picower Institute For Medical Research Compounds having mif antagonist activity
US8883772B2 (en) 2007-10-09 2014-11-11 Sopharmia, Inc. Broad spectrum beta-lactamase inhibitors
ES2700575T3 (es) 2013-03-12 2019-02-18 Gladius Pharmaceuticals Corp 3-Estiril-cefalosporinas derivadas

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3419606A (en) * 1964-05-13 1968-12-31 Merck & Co Inc 4-(2-methylenealkanoyl)phenylsulfinyl alkanoic acids
CH496639A (fr) * 1968-01-05 1970-09-30 Pfizer & Co C Procédé de préparation des aryl halogénocarbonyl cétènes
CH568708A5 (es) * 1969-04-30 1975-11-14 Hoffmann La Roche
GB1357154A (en) * 1970-09-25 1974-06-19 Shell Int Research Alkylthio-nitro-aniline compounds and herbicidal 'ompositions containing them
GB1463077A (en) * 1973-04-19 1977-02-02 Glaxo Lab Ltd 7-substituted-ethyl-cephalosporin derivatives
US4049806A (en) * 1975-08-15 1977-09-20 Syntex (U.S.A.) Inc. Cephalosporin type antibacterials
JPS5253890A (en) * 1975-10-14 1977-04-30 Syntex Inc Production of cephalosporin type compound
US4155907A (en) * 1976-08-16 1979-05-22 The Dow Chemical Company Method for inhibiting ADP-induced platelet aggregation using phenylthioalkylamines
JPS5350326A (en) * 1976-10-18 1978-05-08 Kao Corp Herbicides
AU4091178A (en) * 1977-10-25 1980-04-24 Merck & Co Inc Substituted mercapto acid amides

Also Published As

Publication number Publication date
ES8106285A1 (es) 1981-08-01
PT71652B (en) 1982-01-21
GR69832B (es) 1982-07-19
ES494303A0 (es) 1981-08-01
EP0024639B1 (en) 1984-06-06
EP0025857B1 (en) 1983-07-27
PT71654A (en) 1980-09-01
IE801706L (en) 1981-02-15
PT71651A (en) 1980-09-01
DK351080A (da) 1981-02-16
EP0026307A1 (en) 1981-04-08
GR69833B (es) 1982-07-19
EP0024347B1 (en) 1983-05-25
PT71653B (en) 1982-01-21
ES8106284A1 (es) 1981-08-01
ATE5403T1 (de) 1983-12-15
ATE3545T1 (de) 1983-06-15
EP0026307B1 (en) 1983-11-23
IE50150B1 (en) 1986-02-19
IE50225B1 (en) 1986-03-05
PT71653A (en) 1980-09-01
DE3064411D1 (en) 1983-09-01
DK351280A (da) 1981-02-16
EP0024639A1 (en) 1981-03-11
DK351180A (da) 1981-02-16
JPS5630960A (en) 1981-03-28
ATE4316T1 (de) 1983-08-15
JPS5663989A (en) 1981-05-30
IE801707L (en) 1981-02-15
IE801705L (en) 1981-02-15
EP0024347A1 (en) 1981-03-04
DE3068110D1 (en) 1984-07-12
GR69805B (es) 1982-07-12
JPS5630961A (en) 1981-03-28
ES494305A0 (es) 1981-08-01
DE3063503D1 (en) 1983-07-07
PT71652A (en) 1980-09-01
ES8106282A1 (es) 1981-08-01
PT71651B (en) 1982-01-21
IE50152B1 (en) 1986-02-19
PT71654B (en) 1982-01-22
ES494302A0 (es) 1981-08-01
JPS5643260A (en) 1981-04-21
ATE7785T1 (de) 1984-06-15
IE50151B1 (en) 1986-02-19
GR69834B (es) 1982-07-19
DE3065684D1 (en) 1983-12-29
DK350980A (da) 1981-02-16
ES494304A0 (es) 1981-08-01
IE801708L (en) 1981-02-15
EP0025857A1 (en) 1981-04-01

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