ES8105309A1 - Un procedimiento para la preparacion de nuevos derivados de cromano. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de cromano.Info
- Publication number
- ES8105309A1 ES8105309A1 ES491577A ES491577A ES8105309A1 ES 8105309 A1 ES8105309 A1 ES 8105309A1 ES 491577 A ES491577 A ES 491577A ES 491577 A ES491577 A ES 491577A ES 8105309 A1 ES8105309 A1 ES 8105309A1
- Authority
- ES
- Spain
- Prior art keywords
- processes
- preparation
- pharmaceutical compositions
- compositions containing
- chroman derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical class C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000578 anorexic effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE CROMANO. CONSISTE EN REDUCIR UN COMPUESTO DE FORMULA GENERAL I, OBTENIENDOSE EL COMPUESTO II, QUE OPCIONALMENTE SE SOMETE A ALQUILACION. R1, R2, R3 Y R4 PUEDEN SER IGUALES O DIFERENTES, SIENDO UN ATOMO DE HIDROGENO O DE HALOGENO, O UN GRUPO TRIFLUOROMETILO, ALQUILO C1-4 ALCOXI, HIDROXILO, CARBOXILO, ALCOXICARBONILO, AMIDO O ACETAMIDO; R6 ES HIDROGENO O ALQUILO; X ES UN ALQUILENO LINEAL O RAMIFICADO; R7, R8, HIDROGENO O ALQUILO. *FORMULA*
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7917495 | 1979-05-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES491577A0 ES491577A0 (es) | 1981-05-16 |
| ES8105309A1 true ES8105309A1 (es) | 1981-05-16 |
Family
ID=10505283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES491577A Expired ES8105309A1 (es) | 1979-05-19 | 1980-05-16 | Un procedimiento para la preparacion de nuevos derivados de cromano. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4303656A (es) |
| EP (1) | EP0020018B1 (es) |
| JP (1) | JPS55154967A (es) |
| AU (1) | AU5850080A (es) |
| DE (1) | DE3063585D1 (es) |
| DK (1) | DK215780A (es) |
| ES (1) | ES8105309A1 (es) |
| GR (1) | GR68537B (es) |
| NZ (1) | NZ193557A (es) |
| ZA (1) | ZA802626B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4360532A (en) * | 1981-01-29 | 1982-11-23 | E. R. Squibb & Sons, Inc. | Substituted chromans |
| FR2642065B1 (fr) * | 1989-01-24 | 1991-05-24 | Lipha | Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant |
| WO1999001453A1 (en) * | 1997-07-02 | 1999-01-14 | F. Hoffmann-La Roche Ag | A process for the manufacture of optically active chromanylpyridine derivatives |
| KR101052816B1 (ko) | 2002-04-17 | 2011-07-29 | 스미스 클라인 비참 코포레이션 | 화합물, 조성물 및 방법 |
| US7476741B2 (en) * | 2002-05-16 | 2009-01-13 | Cytovia, Inc. | Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| JP2005531566A (ja) * | 2002-05-16 | 2005-10-20 | サイトビア インコーポレイティッド | カスパーゼ活性化剤およびアポトーシス誘導物質としての置換４−アリール−４ｈ−ピロロ［２，３−ｈ］クロメンおよび類似体ならびにそれらの使用 |
| US7671052B2 (en) | 2004-10-05 | 2010-03-02 | Adolor Corporation | Phenyl derivatives and methods of use |
| LT2817299T (lt) * | 2012-02-24 | 2019-09-25 | Lupin Limited | Pakeisti chromano junginiai, kaip kalciui jautraus receptoriaus moduliatoriai |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3743659A (en) * | 1971-08-25 | 1973-07-03 | Riker Laboratories Inc | Substituted isochromans and processes therefor |
| US3851062A (en) * | 1973-08-01 | 1974-11-26 | Minnesota Mining & Mfg | Method of suppressing weight gain |
| US4146539A (en) * | 1974-07-30 | 1979-03-27 | Beecham Group Limited | Anorexic chromans |
| GB1493998A (en) * | 1975-06-03 | 1977-12-07 | Beecham Group Ltd | Propanolamine derivatives |
-
1980
- 1980-04-24 DE DE8080301326T patent/DE3063585D1/de not_active Expired
- 1980-04-24 EP EP80301326A patent/EP0020018B1/en not_active Expired
- 1980-04-29 NZ NZ193557A patent/NZ193557A/xx unknown
- 1980-05-01 US US06/145,856 patent/US4303656A/en not_active Expired - Lifetime
- 1980-05-01 ZA ZA00802626A patent/ZA802626B/xx unknown
- 1980-05-02 GR GR61837A patent/GR68537B/el unknown
- 1980-05-16 ES ES491577A patent/ES8105309A1/es not_active Expired
- 1980-05-16 DK DK215780A patent/DK215780A/da unknown
- 1980-05-16 AU AU58500/80A patent/AU5850080A/en not_active Abandoned
- 1980-05-19 JP JP6633980A patent/JPS55154967A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK215780A (da) | 1980-11-20 |
| EP0020018A1 (en) | 1980-12-10 |
| EP0020018B1 (en) | 1983-06-01 |
| US4303656A (en) | 1981-12-01 |
| ZA802626B (en) | 1981-04-29 |
| NZ193557A (en) | 1982-03-09 |
| ES491577A0 (es) | 1981-05-16 |
| AU5850080A (en) | 1980-11-27 |
| DE3063585D1 (en) | 1983-07-07 |
| GR68537B (es) | 1982-01-18 |
| JPS55154967A (en) | 1980-12-02 |
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