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ES8104203A1 - Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol - Google Patents

Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol

Info

Publication number
ES8104203A1
ES8104203A1 ES80488154A ES488154A ES8104203A1 ES 8104203 A1 ES8104203 A1 ES 8104203A1 ES 80488154 A ES80488154 A ES 80488154A ES 488154 A ES488154 A ES 488154A ES 8104203 A1 ES8104203 A1 ES 8104203A1
Authority
ES
Spain
Prior art keywords
methods
acylamido
propanol
aryl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES80488154A
Other languages
English (en)
Other versions
ES488154A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/009,207 external-priority patent/US4235892A/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of ES488154A0 publication Critical patent/ES488154A0/es
Publication of ES8104203A1 publication Critical patent/ES8104203A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DERIVADOS DE D-(TREO)-1-ARIL-2-ACILAMIDO-3-FLUOR-1-PROPANOL DE FORMULA (I), Y DE SUS SALES FARMACOLOGICAMENTE ACEPTABLES, EN LA QUE R, X Y X'' PUEDEN SER DIVERSOS RADICALES Y Z ES HIDROGENO O UN RADICAL ACILO DE UN ACIDO CARBOXILICO DE HASTA 16 ATOMOS DE CARBONO. EL PROCEDIMIENTO CONSISTE EN LA N-ACILACION DE UNA AMINA DE FORMULA (II), EN LA QUE X, X'' Y Z TIENEN EL MISMO SIGNIFICADO DE LA FORMULA (I), CON UN ACIDO R-COOH, SIENDO R EL MISMO RADICAL QUE EN LA FORMULA (I), O CON UN DERIVADO REACTIVO DE TAL ACIDO. EN EL CASO DE OBTENCION DE SALES, Z ES UN RADICAL ACILO DE ACIDO DICARBOXILICO O UN AMINOACIDO. LOS COMPUESTOS DE FORMULA (I) TIENEN APLICACION FARMACOLOGICA COMO ANTIBIOTICOS DE AMPLIO ESPECTRO. -
ES80488154A 1979-02-05 1980-01-31 Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol Expired ES8104203A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/009,207 US4235892A (en) 1979-02-05 1979-02-05 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor
ZA00800478A ZA80478B (en) 1979-02-05 1980-01-28 Novel 1-aryl-2-acylamido-3-fluoro-1-propanols,their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
ES488154A0 ES488154A0 (es) 1981-04-16
ES8104203A1 true ES8104203A1 (es) 1981-04-16

Family

ID=26679196

Family Applications (3)

Application Number Title Priority Date Filing Date
ES80488154A Expired ES8104203A1 (es) 1979-02-05 1980-01-31 Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol
ES494633A Expired ES8107163A1 (es) 1979-02-05 1980-08-29 Un procedimiento para la preparacion de un compuesto d(treo)-1-aril-2-acilamido-3-fluor-1-propanol
ES494632A Expired ES8107162A1 (es) 1979-02-05 1980-08-29 Un procedimiento para la preparacion de un compuesto d- (treo)-1-aril-2-acilamido-3-fluor-1-propanol

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES494633A Expired ES8107163A1 (es) 1979-02-05 1980-08-29 Un procedimiento para la preparacion de un compuesto d(treo)-1-aril-2-acilamido-3-fluor-1-propanol
ES494632A Expired ES8107162A1 (es) 1979-02-05 1980-08-29 Un procedimiento para la preparacion de un compuesto d- (treo)-1-aril-2-acilamido-3-fluor-1-propanol

Country Status (2)

Country Link
US (1) US4311857A (es)
ES (3) ES8104203A1 (es)

Families Citing this family (39)

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GB8322983D0 (en) * 1983-08-26 1983-09-28 Pfizer Ltd Triazole antifungal agents
US4582918A (en) * 1984-09-19 1986-04-15 Schering Corporation Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
US4973750A (en) * 1984-09-19 1990-11-27 Schering Corporation Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
US4876352A (en) * 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
US5124525A (en) * 1991-08-27 1992-06-23 Esab Welding Products, Inc. Plasma arc torch having improved nozzle assembly
US5352832A (en) * 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
MY146351A (en) * 2003-05-29 2012-08-15 Schering Plough Ltd Compositions for treating infection in cattle and swine
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
US7126005B2 (en) 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
PL1776109T3 (pl) 2004-08-13 2009-06-30 Schering Plough Ltd Farmaceutyczna formulacja zawierająca antybiotyk, triazol i kortykosteroid
CN101065352A (zh) 2004-09-23 2007-10-31 先灵-普劳有限公司 使用新的三氟甲磺酰苯胺肟醚衍生物控制动物中的寄生虫
DE602005017419D1 (de) * 2004-11-19 2009-12-10 Schering Plough Ltd Kontrolle von parasiten bei tieren mittels verwendung von parasitiziden 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitril-derivaten
SI1830885T1 (sl) * 2004-12-21 2009-02-28 Intervet Int Bv Injekcijski veterinarski sestavek, ki obsega florfenikol
EP1844171B1 (en) * 2005-01-31 2014-03-26 Materials And Electrochemical Research Corporation Process for the manufacture of titanium alloy structures
US20060281695A1 (en) * 2005-06-09 2006-12-14 Schering-Plough Animal Health Corporation Control of parasites in animals by N-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and N-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
US8084643B2 (en) * 2006-12-13 2011-12-27 Intervet Inc. Water-soluble prodrugs of florfenicol and its analogs
MX2009006468A (es) * 2006-12-13 2009-08-20 Schering Plough Ltd Profarmacos de fenicol solubles en agua en un sistema de vehiculo lipofilico.
EP2102154A1 (en) * 2006-12-13 2009-09-23 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
CA2685264A1 (en) * 2007-04-27 2008-11-06 Schering-Plough Ltd. Compounds and methods for enhancing solubility of florfenicol and structurally-related antibiotics using cyclodextrins
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
KR20100085162A (ko) * 2007-11-09 2010-07-28 인터벳 인터내셔널 비.브이. 속방성 고체 제형, 제조 및 이의 용도
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
JP2011529895A (ja) * 2008-07-30 2011-12-15 インターベツト・インターナシヨナル・ベー・ベー フロルフェニコール中間体として有用なオキサゾリン保護アミノジオール化合物を調製する方法
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
CN102574815A (zh) 2009-08-05 2012-07-11 杜邦公司 介离子杀虫剂
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
KR20120050467A (ko) 2009-08-05 2012-05-18 이 아이 듀폰 디 네모아 앤드 캄파니 메소이온성 살충제
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
PH12012502333A1 (en) 2010-05-27 2015-02-04 Corteva Agriscience Llc Crystalline form of 4- [5 - [3 -chloro-5 - (trifluoromethyl) phenyl] -4, 5 - dihydro - 5 - (trifluoromethyl) -3 - isoxazolyl] -n- [2-0x0-2- [ ( 2, 2, 2 - trifluoroethyl) amino] ethyl] -1- naphthalenecarboxamide
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
CN103649097A (zh) 2011-05-02 2014-03-19 佐蒂斯有限责任公司 用作抗菌剂的新型头孢菌素类
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN110903257A (zh) * 2019-12-18 2020-03-24 厦门本素药业有限公司 一种苯基异丝氨酸盐酸盐及其中间体的合成方法
CN111393341A (zh) * 2020-05-07 2020-07-10 中国农业大学 一种水溶性氟苯尼考氨基酸盐的制备方法
CN115634202A (zh) * 2022-10-19 2023-01-24 湖南中科汇智信息服务有限公司 一种水溶性氟苯尼考粉及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3012073A (en) * 1960-04-11 1961-12-05 Du Pont Trifluoro methylthiophenyl-dichloro-acet-amides-1, 3-propanediol

Also Published As

Publication number Publication date
ES494633A0 (es) 1981-08-16
ES8107163A1 (es) 1981-08-16
US4311857A (en) 1982-01-19
ES488154A0 (es) 1981-04-16
ES494632A0 (es) 1981-08-16
ES8107162A1 (es) 1981-08-16

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