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ES8102125A1 - Procedimiento para la preparacion de derivados de pirimido-(6,1-a)-isoquinolein-4-onas - Google Patents

Procedimiento para la preparacion de derivados de pirimido-(6,1-a)-isoquinolein-4-onas

Info

Publication number
ES8102125A1
ES8102125A1 ES485489A ES485489A ES8102125A1 ES 8102125 A1 ES8102125 A1 ES 8102125A1 ES 485489 A ES485489 A ES 485489A ES 485489 A ES485489 A ES 485489A ES 8102125 A1 ES8102125 A1 ES 8102125A1
Authority
ES
Spain
Prior art keywords
intermediates
preparation
isoquinolin
sulfur
ones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES485489A
Other languages
English (en)
Other versions
ES485489A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES485489A0 publication Critical patent/ES485489A0/es
Publication of ES8102125A1 publication Critical patent/ES8102125A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIMIDO-(6,1-A)-ISOQUINOLEIN-4-ONAS. TIENEN LA SIGUIENTE FORMULA GENERAL (I), EN DONDE R ELEVADO A 1, R ELEVADO A 2 Y R ELEVADO A 3 PUEDEN SER HIDROGENO, HIDROXI, ALCOXI O HALOGENO; R ELEVADO A 4 PUEDE SER HIDROGENO, ALCOHILO, CICLO ALCOHILO U OTROS DIVERSOS RADICALES, Y X SIGNIFICA OXIGENO, AZUFRE O HALOGENO. EL PROCEDIMIENTO DE OBTENCION SE FUNDAMENTA EN LA REACCION DE CNDESACION DEL DERIVADO DEL ACIDO BARBITURICO ADECUADO A CADA CASO, EN PRESENCIA DE UN AGENTE SEPARADOR DE AGUA O EN PRESENCIA DE UN HALOGENURO DE ACIDO. ESTOS COMPUESTOS PRESENTAN LAS SIGUIENTES ACTIVIDADES; HIPOTENSORA, BRONCODILATADORA Y ANTIALERGICA. *FORMULA*
ES485489A 1978-11-03 1979-10-29 Procedimiento para la preparacion de derivados de pirimido-(6,1-a)-isoquinolein-4-onas Expired ES8102125A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782847693 DE2847693A1 (de) 1978-11-03 1978-11-03 Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen

Publications (2)

Publication Number Publication Date
ES485489A0 ES485489A0 (es) 1980-12-16
ES8102125A1 true ES8102125A1 (es) 1980-12-16

Family

ID=6053766

Family Applications (2)

Application Number Title Priority Date Filing Date
ES485489A Expired ES8102125A1 (es) 1978-11-03 1979-10-29 Procedimiento para la preparacion de derivados de pirimido-(6,1-a)-isoquinolein-4-onas
ES493011A Expired ES8103083A1 (es) 1978-11-03 1980-07-01 Procedimiento para la preparacion de derivados de pirimi- do-(6,1-a)-isoquinolein-4-onas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES493011A Expired ES8103083A1 (es) 1978-11-03 1980-07-01 Procedimiento para la preparacion de derivados de pirimi- do-(6,1-a)-isoquinolein-4-onas

Country Status (18)

Country Link
US (1) US4400506A (es)
EP (1) EP0010759B1 (es)
JP (1) JPS5564587A (es)
AT (1) ATE21104T1 (es)
AU (1) AU538039B2 (es)
CA (1) CA1123434A (es)
DE (2) DE2847693A1 (es)
DK (1) DK465879A (es)
ES (2) ES8102125A1 (es)
FI (1) FI66865C (es)
GR (1) GR74082B (es)
HU (1) HU181884B (es)
IL (1) IL58609A0 (es)
NO (1) NO793537L (es)
NZ (1) NZ191994A (es)
PH (1) PH15281A (es)
PT (1) PT70401A (es)
ZA (1) ZA795888B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI64370C (fi) * 1977-05-05 1983-11-10 Hoechst Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat
DE2847693A1 (de) 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
FR2470130A2 (fr) * 1979-11-21 1981-05-29 Hoechst Ag Derives de pyrimido (6,1-a) isoquinoleine-4-one, leur procede de preparation et leur application en therapeutique
DE3126837A1 (de) * 1981-07-08 1983-01-27 Hoechst Ag, 6000 Frankfurt Triazino-(2,1-a)isochinolinderivate
DE3135831A1 (de) * 1981-09-10 1983-04-28 Hoechst Ag, 6230 Frankfurt 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4612376A (en) * 1983-03-25 1986-09-16 Fujisawa Pharmaceutical Co., Ltd. Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent
CA1237429A (en) * 1983-05-05 1988-05-31 Frank Kienzle Pyrimidone derivatives
CA2368413C (en) * 1999-03-31 2008-07-29 Vernalis Limited Derivatives of pyrimido[6,1-a]isoquinolin-4-one
CZ302882B6 (cs) * 1999-08-21 2012-01-04 Nycomed Gmbh Farmaceutický prostredek
TWI347845B (en) * 2002-03-06 2011-09-01 Nycomed Gmbh Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP5546451B2 (ja) 2007-06-04 2014-07-09 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
EP3718557A3 (en) 2013-02-25 2020-10-21 Bausch Health Ireland Limited Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
HK1220696A1 (zh) 2013-03-15 2017-05-12 Bausch Health Ireland Limited 鸟苷酸环化酶激动剂及其用途
EP4424697A3 (en) 2013-06-05 2024-12-25 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス，インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
GB201613054D0 (en) 2016-07-28 2016-09-14 Verona Pharma Plc New compound and process
EP3972599B1 (en) 2019-05-21 2025-10-22 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
GB202202297D0 (en) 2022-02-21 2022-04-06 Verona Pharma Plc Formulation production process
US12194045B1 (en) 2023-06-26 2025-01-14 Verona Pharma Plc Particulate composition

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE590405A (es) * 1959-05-02
US3081306A (en) * 1959-11-04 1963-03-12 Pfizer & Co C 2, 4-dioxo-3-aralkylaza-9, 10-di(lower alkoxy)-1, 2, 3, 4, 6, 7-hexahydro-11b-h-benzopyridocolines
GB1062357A (en) * 1965-03-23 1967-03-22 Pfizer & Co C Quinazolone derivatives
US3476755A (en) * 1967-01-17 1969-11-04 Edward C Taylor 8,13-diazasteroids
US3594379A (en) * 1968-09-16 1971-07-20 Sandoz Ag 2,3-dihydroimidazo(1,2-c)quinazolines
US3876788A (en) * 1970-08-27 1975-04-08 Burroughs Wellcome Co Heterocyclic compounds in the treatment of inflammatory of arthritic conditions
DE2720085A1 (de) 1977-05-05 1978-11-16 Hoechst Ag Pyrimido(6,1-a)isochinolin-2-on- derivate
IN147624B (es) 1976-12-10 1980-05-03 Hoechst Pharma
FI64370C (fi) * 1977-05-05 1983-11-10 Hoechst Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat
DE2847693A1 (de) 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen

Also Published As

Publication number Publication date
PT70401A (de) 1979-12-01
EP0010759A2 (de) 1980-05-14
JPS5564587A (en) 1980-05-15
ES493011A0 (es) 1981-02-16
ZA795888B (en) 1980-10-29
ES485489A0 (es) 1980-12-16
FI66865B (fi) 1984-08-31
HU181884B (en) 1983-11-28
CA1123434A (en) 1982-05-11
DE2847693A1 (de) 1980-05-22
FI793430A7 (fi) 1980-05-04
AU5245379A (en) 1980-05-08
IL58609A0 (en) 1980-02-29
DK465879A (da) 1980-05-04
AU538039B2 (en) 1984-07-26
DE2967610D1 (en) 1986-09-04
EP0010759A3 (en) 1981-08-19
ES8103083A1 (es) 1981-02-16
US4400506A (en) 1983-08-23
PH15281A (en) 1982-11-02
GR74082B (es) 1984-06-06
NZ191994A (en) 1982-09-07
EP0010759B1 (de) 1986-07-30
NO793537L (no) 1980-05-06
ATE21104T1 (de) 1986-08-15
FI66865C (fi) 1984-12-10

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