ES8101610A1 - Un procedimiento para la preparacion de acido 7-metoxi-5-oxo-5h-tiazolo (2,3-b)quinazolin-2-carboxilico - Google Patents
Un procedimiento para la preparacion de acido 7-metoxi-5-oxo-5h-tiazolo (2,3-b)quinazolin-2-carboxilicoInfo
- Publication number
- ES8101610A1 ES8101610A1 ES488142A ES488142A ES8101610A1 ES 8101610 A1 ES8101610 A1 ES 8101610A1 ES 488142 A ES488142 A ES 488142A ES 488142 A ES488142 A ES 488142A ES 8101610 A1 ES8101610 A1 ES 8101610A1
- Authority
- ES
- Spain
- Prior art keywords
- carboxylic acid
- oxo
- methoxy
- thiazolo
- quinazolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- KCBXEIHHACGOJC-UHFFFAOYSA-N 7-methoxy-5-oxo-[1,3]thiazolo[2,3-b]quinazoline-2-carboxylic acid Chemical compound N1=C2SC(C(O)=O)=CN2C(=O)C2=CC(OC)=CC=C21 KCBXEIHHACGOJC-UHFFFAOYSA-N 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- OKXPYKHKJCATPX-UHFFFAOYSA-N quinazoline-2-carboxylic acid Chemical compound C1=CC=CC2=NC(C(=O)O)=NC=C21 OKXPYKHKJCATPX-UHFFFAOYSA-N 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 229910000000 metal hydroxide Inorganic materials 0.000 abstract 1
- 150000004692 metal hydroxides Chemical class 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE ACIDO 7-METOXI-5-OXO-5H-TIAZOLO(2,3-B)QUINAZOLIN-2-CARBOXILICO. CONSISTE EN HIDROLIZAR UN COMPUESTO DE FORMULA GENERAL (I) EN UN EXCESO DE HIDROXIDO DE METAL ALACALINO, TAL COMO HIDROXIDO SODICO, POTASICO A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 30GC. LA HIDROLISIS ES SEGUIDA DE REFLUJO CON UN ACIDO CARBOXILICO ORGANICO, TAL COMO ACETICO O PROPIONICO. *FORMULA* EL ACIDO 7-METOXI-5-OXO-5H-TIAZOLO(2,3-B)QUINAZOLIN-2-CARBOXILICO SE RECUPERA POR PROCEDIMIENTO CONVENCIONALES, TAL COMO RECRISTALIZACION. AGENTE ANTIALERGICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/898,344 US4168380A (en) | 1978-04-21 | 1978-04-21 | 7-Methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8101610A1 true ES8101610A1 (es) | 1980-12-16 |
| ES488142A0 ES488142A0 (es) | 1980-12-16 |
Family
ID=25409314
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES479759A Expired ES479759A1 (es) | 1978-04-21 | 1979-04-20 | Un procedimiento para la preparacion de acido 7-metoxi-5-oxo-5h-tiazolo 2,3,-d quinazolin-2-carboxilico. |
| ES488142A Granted ES488142A0 (es) | 1978-04-21 | 1980-01-31 | Un procedimiento para la preparacion de acido 7-metoxi-5-oxo-5h-tiazolo (2,3-b)quinazolin-2-carboxilico |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES479759A Expired ES479759A1 (es) | 1978-04-21 | 1979-04-20 | Un procedimiento para la preparacion de acido 7-metoxi-5-oxo-5h-tiazolo 2,3,-d quinazolin-2-carboxilico. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4168380A (es) |
| EP (1) | EP0006114B1 (es) |
| JP (1) | JPS54145681A (es) |
| AR (1) | AR224246A1 (es) |
| AU (1) | AU4615179A (es) |
| CA (1) | CA1100132A (es) |
| DE (1) | DE2962430D1 (es) |
| DK (1) | DK164379A (es) |
| ES (2) | ES479759A1 (es) |
| FI (1) | FI791283A7 (es) |
| GR (1) | GR72888B (es) |
| IL (1) | IL57079A0 (es) |
| MC (1) | MC1255A1 (es) |
| PT (1) | PT69522A (es) |
| ZA (1) | ZA791778B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2557425C2 (de) * | 1975-12-19 | 1987-03-19 | C.H. Boehringer Sohn, 6507 Ingelheim | 11-Oxo-11-H-pyrido[2,1-b]-chinazolin-2-carbonsäure und ihre Salze, Verfahren zu ihrer Herstellung und Arzneimittel |
| US4282360A (en) * | 1979-10-12 | 1981-08-04 | Hoffmann-La Roche Inc. | 7-Methylthio or methylsulfinyl-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid |
| US4302585A (en) * | 1980-12-22 | 1981-11-24 | American Home Products Corporation | 3-Hydroxy-3-substituted phenylthiazolo[2,3-b]quinazoline-2-alkanoic acids and their lactones |
| DE3142728A1 (de) * | 1981-10-28 | 1983-05-05 | Basf Ag, 6700 Ludwigshafen | Herbizide, enthaltend thiazolo(2,3-b)-chinazolone als wirkstoffe, und ihre verwendung zur beeinflussung des pflanzenwachstums |
| DE3142727A1 (de) * | 1981-10-28 | 1983-05-05 | Basf Ag, 6700 Ludwigshafen | Thiazolo (2,3-b)-chinazolone, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des pflanzenwachstums |
| GB8300728D0 (en) * | 1983-01-12 | 1983-02-16 | Erba Farmitalia | Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives |
| EP0142057A3 (en) * | 1983-11-04 | 1988-03-30 | F. Hoffmann-La Roche Ag | Thiazoloquinazoline derivatives, their preparation and pharmaceutical compositions containing same |
| DE3634532A1 (de) * | 1986-10-10 | 1988-04-14 | Basf Ag | Verfahren zur herstellung von thiazolo-(2,3-b)chinazolonen |
| AU2011376746B2 (en) | 2011-09-12 | 2017-06-15 | Sanofi | Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals |
| US8912224B2 (en) | 2011-09-12 | 2014-12-16 | Sanofi | Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals |
| PT2567958E (pt) | 2011-09-12 | 2015-01-14 | Sanofi Sa | 2-(croman-6-iloxi)-tiazoles substituídos e sua utilização como produtos farmacêuticos |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2557425C2 (de) | 1975-12-19 | 1987-03-19 | C.H. Boehringer Sohn, 6507 Ingelheim | 11-Oxo-11-H-pyrido[2,1-b]-chinazolin-2-carbonsäure und ihre Salze, Verfahren zu ihrer Herstellung und Arzneimittel |
-
1978
- 1978-04-21 US US05/898,344 patent/US4168380A/en not_active Expired - Lifetime
-
1979
- 1979-04-12 ZA ZA791778A patent/ZA791778B/xx unknown
- 1979-04-16 IL IL57079A patent/IL57079A0/xx unknown
- 1979-04-17 GR GR58929A patent/GR72888B/el unknown
- 1979-04-19 AU AU46151/79A patent/AU4615179A/en not_active Abandoned
- 1979-04-19 FI FI791283A patent/FI791283A7/fi not_active Application Discontinuation
- 1979-04-19 MC MC791373A patent/MC1255A1/fr unknown
- 1979-04-19 JP JP4735979A patent/JPS54145681A/ja active Pending
- 1979-04-19 CA CA325,842A patent/CA1100132A/en not_active Expired
- 1979-04-20 AR AR276257A patent/AR224246A1/es active
- 1979-04-20 ES ES479759A patent/ES479759A1/es not_active Expired
- 1979-04-20 DE DE7979101205T patent/DE2962430D1/de not_active Expired
- 1979-04-20 EP EP79101205A patent/EP0006114B1/de not_active Expired
- 1979-04-20 DK DK164379A patent/DK164379A/da not_active IP Right Cessation
- 1979-04-20 PT PT69522A patent/PT69522A/pt unknown
-
1980
- 1980-01-31 ES ES488142A patent/ES488142A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| AU4615179A (en) | 1979-10-25 |
| ZA791778B (en) | 1980-04-30 |
| FI791283A7 (fi) | 1981-01-01 |
| EP0006114B1 (de) | 1982-04-07 |
| US4168380A (en) | 1979-09-18 |
| DE2962430D1 (en) | 1982-05-19 |
| AR224246A1 (es) | 1981-11-13 |
| ES479759A1 (es) | 1980-10-01 |
| MC1255A1 (fr) | 1980-01-14 |
| JPS54145681A (en) | 1979-11-14 |
| EP0006114A1 (de) | 1980-01-09 |
| GR72888B (es) | 1984-01-02 |
| PT69522A (en) | 1979-05-01 |
| ES488142A0 (es) | 1980-12-16 |
| IL57079A0 (en) | 1979-07-25 |
| CA1100132A (en) | 1981-04-28 |
| DK164379A (da) | 1979-10-22 |
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