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ES552398A0 - Procedimiento para la obtencion de poli-hidro piridazo diacepinas, triacepinas o diazocinas - Google Patents

Procedimiento para la obtencion de poli-hidro piridazo diacepinas, triacepinas o diazocinas

Info

Publication number
ES552398A0
ES552398A0 ES552398A ES552398A ES552398A0 ES 552398 A0 ES552398 A0 ES 552398A0 ES 552398 A ES552398 A ES 552398A ES 552398 A ES552398 A ES 552398A ES 552398 A0 ES552398 A0 ES 552398A0
Authority
ES
Spain
Prior art keywords
triacepines
piridazo
diacepines
diazocines
hydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES552398A
Other languages
English (en)
Other versions
ES8705444A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848421493A external-priority patent/GB8421493D0/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES552398A0 publication Critical patent/ES552398A0/es
Publication of ES8705444A1 publication Critical patent/ES8705444A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
ES552398A 1984-08-24 1986-02-17 Procedimiento para la obtencion de poli-hidro piridazo diacepinas, triacepinas o diazocinas Expired ES8705444A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848421493A GB8421493D0 (en) 1984-08-24 1984-08-24 Bicyclic compounds
GB858513541A GB8513541D0 (en) 1984-08-24 1985-05-29 Bicyclic compounds

Publications (2)

Publication Number Publication Date
ES552398A0 true ES552398A0 (es) 1987-05-01
ES8705444A1 ES8705444A1 (es) 1987-05-01

Family

ID=26288155

Family Applications (3)

Application Number Title Priority Date Filing Date
ES546360A Expired ES8700258A1 (es) 1984-08-24 1985-08-23 Procedimiento para la obtencion de poli-hidro piridazo dia- cepinas triacepinas o diazocinas
ES552397A Expired ES8705443A1 (es) 1984-08-24 1986-02-17 Procedimiento para la obtencion de poli-hidro piridazo diacepinas, triacepinas o diazocinas
ES552398A Expired ES8705444A1 (es) 1984-08-24 1986-02-17 Procedimiento para la obtencion de poli-hidro piridazo diacepinas, triacepinas o diazocinas

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES546360A Expired ES8700258A1 (es) 1984-08-24 1985-08-23 Procedimiento para la obtencion de poli-hidro piridazo dia- cepinas triacepinas o diazocinas
ES552397A Expired ES8705443A1 (es) 1984-08-24 1986-02-17 Procedimiento para la obtencion de poli-hidro piridazo diacepinas, triacepinas o diazocinas

Country Status (14)

Country Link
US (4) US4692438A (es)
EP (1) EP0172552A3 (es)
AU (1) AU583843B2 (es)
CS (1) CS255893B2 (es)
DK (1) DK384385A (es)
ES (3) ES8700258A1 (es)
FI (1) FI853174L (es)
HU (1) HU193446B (es)
IL (1) IL76133A (es)
MC (1) MC1694A1 (es)
NO (1) NO161914C (es)
NZ (1) NZ213130A (es)
PH (1) PH21749A (es)
PT (1) PT81015B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
EP0534363B1 (en) * 1991-09-27 1997-07-09 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
JP3460838B2 (ja) * 1992-02-14 2003-10-27 メレルファーマスーティカルズインコーポレイテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な，アミノアセチルメルカプトアセチルアミド誘導体類
KR100281450B1 (ko) * 1992-05-15 2001-02-01 슈테펜 엘. 네스비트 엔케팔리나제 및 안지오텐신 전환 효소의 억제제로서 유용한 신규 메르캅토아세틸아미도 피리다조[1,2]피리다진, 피라졸로[1,2]피리다진, 피리다조[1,2-a][1,2]디아제핀 및 피라졸로[1,2-a][1,2]디아제핀 유도체
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
NZ256589A (en) * 1992-10-30 1996-05-28 Merrell Dow Pharma Condensed azepine analogues and medicaments (where a is c, o or s and b is o or s)
WO1994022440A1 (en) * 1993-03-29 1994-10-13 Smithkline Beecham Corporation Bicyclic compounds which inhibit platelet aggregation
JP3561753B2 (ja) * 1994-02-14 2004-09-02 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規な２−置換インダン−２−メルカプトアセチルアミドジスルフィド誘導体類
US5750521A (en) * 1994-02-14 1998-05-12 Hoechst Marion Roussel Inc. Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
NZ279397A (en) * 1994-02-14 1997-08-22 Merrell Pharma Inc Mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives and pharmaceutucal compositions
EP0745081B1 (en) * 1994-02-14 2001-11-21 Merrell Pharmaceuticals Inc. indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
HUP9774624A2 (en) * 1994-03-24 1997-01-28 Merrell Pharma Inc Hypocholesterolemic, antiatheroclerotic and hypotriglyceridemic condensed benzazepine mercaptoacetylamide disulfide derivatives
PT751783E (pt) * 1994-03-24 2000-05-31 Merrell Pharma Inc Derivados aminoacetilmercapto hipocolesterolemicos antiateroscleroticos e hipotrigliceridemicos
US6559304B1 (en) 1998-08-19 2003-05-06 Vertex Pharmaceuticals Incorporated Method for synthesizing caspase inhibitors
US6703500B2 (en) 1998-08-19 2004-03-09 Vertex Pharmaceuticals, Incorporated Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
US6177565B1 (en) * 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
RU2002135314A (ru) 2000-05-04 2004-05-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Асимметричный синтез пиперазиновой кислоты и ее производных
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
US8408396B2 (en) * 2008-07-25 2013-04-02 Chuluun Enkhbold Method of solid fuel beneficiation and transportation to thermoelectric power stations
EP2513116B1 (en) * 2009-12-16 2015-08-19 Hetero Research Foundation Polymorphs of darunavir
PT2571355T (pt) 2010-05-20 2016-10-17 Hetero Research Foundation Sal de cloridrato cristalino de darunavir

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308094A (en) * 1977-02-02 1981-12-29 Sanyo Electric Co., Ltd. Diaphragm for speaker and method of producing same
IL60617A0 (en) * 1979-07-23 1980-09-16 Sparamedica Ag Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them
DE3062972D1 (en) * 1979-09-19 1983-06-09 Hoffmann La Roche Pyridazopyridazine derivatives, processes for their preparation and pharmaceutical compositions containing these pyridazopyridazine derivatives
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity

Also Published As

Publication number Publication date
DK384385A (da) 1986-02-25
PT81015B (en) 1987-08-24
HUT38644A (en) 1986-06-30
HU193446B (en) 1987-10-28
US4692438A (en) 1987-09-08
IL76133A (en) 1989-12-15
ES546360A0 (es) 1986-10-01
PT81015A (en) 1985-09-01
EP0172552A2 (de) 1986-02-26
ES8705444A1 (es) 1987-05-01
CS592885A2 (en) 1987-07-16
US4826980A (en) 1989-05-02
NZ213130A (en) 1988-05-30
MC1694A1 (fr) 1986-07-18
NO853336L (no) 1986-02-25
ES8705443A1 (es) 1987-05-01
ES552397A0 (es) 1987-05-01
DK384385D0 (da) 1985-08-23
US4762924A (en) 1988-08-09
EP0172552A3 (de) 1989-01-11
FI853174A7 (fi) 1986-02-25
IL76133A0 (en) 1985-12-31
NO161914C (no) 1989-10-11
FI853174L (fi) 1986-02-25
AU583843B2 (en) 1989-05-11
NO161914B (no) 1989-07-03
PH21749A (en) 1988-02-18
FI853174A0 (fi) 1985-08-19
AU4641585A (en) 1986-02-27
US4785093A (en) 1988-11-15
CS255893B2 (en) 1988-03-15
ES8700258A1 (es) 1986-10-01

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