ES557466A0 - Un procedimiento para la preparacion de androsta-1,4-dien-3,17-dionas - Google Patents

Un procedimiento para la preparacion de androsta-1,4-dien-3,17-dionas

Info

Publication number: ES557466A0
Authority: ES; Spain
Prior art keywords: dionas; androsta; dien; procedure; preparation
Prior art date: 1985-07-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES557466A

Other languages

English (en)

Other versions

ES8802429A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Italia SRL

Original Assignee

Farmitalia Carlo Erba SRL

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-09

Filing date

1987-03-26

Publication date

1988-06-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES557466(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1987-03-26 Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL

1988-06-01 Publication of ES8802429A1 publication Critical patent/ES8802429A1/es

1988-06-01 Publication of ES557466A0 publication Critical patent/ES557466A0/es

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ES557466A 1985-07-09 1987-03-26 Un procedimiento para la preparacion de androsta-1,4-dien-3,17-dionas Expired ES8802429A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB858517360A GB8517360D0 (en)	1985-07-09	1985-07-09	Substituted androsta-1,4-diene-3,17-diones

Publications (2)

Publication Number	Publication Date
ES8802429A1 ES8802429A1 (es)	1988-06-01
ES557466A0 true ES557466A0 (es)	1988-06-01

Family

ID=10582036

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ES556550A Expired ES8801304A1 (es)	1985-07-09	1986-06-24	Un procedimiento para la preparacion de androsta -1-4-dien-3,17-dionas.
ES557466A Expired ES8802429A1 (es)	1985-07-09	1987-03-26	Un procedimiento para la preparacion de androsta-1,4-dien-3,17-dionas

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ES556550A Expired ES8801304A1 (es)	1985-07-09	1986-06-24	Un procedimiento para la preparacion de androsta -1-4-dien-3,17-dionas.

Country Status (38)

Country	Link
US (2)	US4808616A (es)
JP (1)	JPS6212797A (es)
KR (1)	KR950003614B1 (es)
CN (1)	CN86104664B (es)
AT (1)	AT395157B (es)
AU (1)	AU578840B2 (es)
BE (1)	BE905067A (es)
BG (1)	BG61370B2 (es)
BR (1)	BR1100240A (es)
CA (1)	CA1277656C (es)
CH (1)	CH668599A5 (es)
CS (2)	CS257794B2 (es)
CZ (1)	CZ413591A3 (es)
DE (1)	DE10199030I1 (es)
DK (1)	DK163520C (es)
ES (2)	ES8801304A1 (es)
FI (1)	FI83424C (es)
FR (1)	FR2584725B1 (es)
GB (2)	GB8517360D0 (es)
GR (1)	GR861780B (es)
HK (1)	HK94190A (es)
HU (1)	HU194274B (es)
IE (1)	IE58949B1 (es)
IL (1)	IL79336A (es)
IT (1)	IT1196436B (es)
MY (1)	MY102294A (es)
NL (2)	NL193616C (es)
NO (2)	NO165547C (es)
NZ (1)	NZ216763A (es)
PH (1)	PH21785A (es)
PT (1)	PT82944B (es)
SE (1)	SE468988B (es)
SG (1)	SG80490G (es)
SK (1)	SK413591A3 (es)
SU (2)	SU1442077A3 (es)
UA (1)	UA6046A1 (es)
YU (2)	YU44585B (es)
ZA (1)	ZA865079B (es)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8517360D0 (en) *	1985-07-09	1985-08-14	Erba Farmitalia	Substituted androsta-1,4-diene-3,17-diones
GB8617107D0 (en) *	1986-07-14	1986-08-20	Erba Farmitalia	6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
GB8622330D0 (en) *	1986-09-17	1986-10-22	Erba Farmitalia	4-substituted 6-alkylidenandrostene-3,17-dione derivatives
DE3715869A1 (de) *	1987-05-07	1988-11-17	Schering Ag	Verfahren zur herstellung von 1-methyl-androsta-1,4-dien-3,17-dion und die neuen zwischenprodukte fuer dieses verfahren
GB8721383D0 (en) *	1987-09-11	1987-10-21	Erba Farmitalia	Preparation of methylene derivatives
GB8721384D0 (en) *	1987-09-11	1987-10-21	Erba Farmitalia	17-substituted andro-sta-1 4-dien-3-one derivatives
GB8801697D0 (en) *	1988-01-26	1988-02-24	Erba Farmitalia	Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
CA2107102A1 (en) *	1991-03-28	1992-09-29	Naoyuki Koizumi	Novel oxa- or azasteroid derivatives
CH683151A5 (de) *	1991-04-24	1994-01-31	Ciba Geigy Ag	Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
GB9201224D0 (en) *	1992-01-21	1992-03-11	Erba Carlo Spa	Difluoromethylenandrostenone derivatives and process for their preparation
CA2145643A1 (en) *	1992-09-30	1994-04-14	Naoyuki Koizumi	Novel 7-substituted oxa-or azasteroid compound
US6407082B1 (en) *	1996-09-13	2002-06-18	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) *	1993-06-29	1993-08-11	Erba Carlo Spa	Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6028064A (en) *	1996-09-13	2000-02-22	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of progestin products
US6034074A (en)	1996-09-13	2000-03-07	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a Vitamin D compound
US6511970B1 (en)	1996-09-13	2003-01-28	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6765002B2 (en)	2000-03-21	2004-07-20	Gustavo Rodriguez	Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
WO2001004342A1 (en) *	1999-07-07	2001-01-18	Pharmacia & Upjohn Company	Process to prepare exemestane
GB9930839D0 (en) *	1999-12-30	2000-02-16	Pharmacia & Upjohn Spa	Process for treating gynecomastia
GB0005257D0 (en) *	2000-03-03	2000-04-26	Pharmacia & Upjohn Spa	Breast cancer hormonal therapy
US20010044431A1 (en) *	2000-03-21	2001-11-22	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) *	2000-07-18	2000-09-06	Pharmacia & Upjohn Spa	Antitumor combined therapy
US20030158168A1 (en) *	2000-08-09	2003-08-21	Giorgio Massimini	Composition for combined use of aromatase inhibitors
BR0113625A (pt) *	2000-09-08	2003-07-22	Pharmacia Italia Spa	Exemestano como agente de quimioprevenção
WO2002072106A2 (en) *	2001-01-26	2002-09-19	Pharmacia Italia Spa	Combined method for treating hormono-dependent disorders with exemestane
US20040082557A1 (en) *	2001-01-26	2004-04-29	Wajszczuk Charles Paul	Methods for treating estrogen-dependent disorders
PT2269603E (pt)	2001-02-19	2015-09-09	Novartis Ag	Tratamento de tumores da mama com um derivado de rapamicina em combinação com exemestano
PT1392313E (pt)	2001-05-16	2007-07-17	Novartis Ag	Combinação que compreende n - ( 5- [ 4- ( metil-piperazinomrtil ) - benxoilamido ] - 2 -metilfenil ) - 4 -( 3 - piridil ) - 2 - pirimidina-amina e um agente quimioterapêutico
GB0120147D0 (en) *	2001-08-17	2001-10-10	Metris Therapeutics Ltd	Treatment method
US20040043938A1 (en) *	2001-11-06	2004-03-04	Dinesh Purandare	Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) *	2001-11-28	2002-01-23	Novartis Ag	Organic compounds
PL372103A1 (en)	2002-05-16	2005-07-11	Novartis Ag	Use of edg receptor binding agents in cancer
CN1304413C (zh) *	2002-10-24	2007-03-14	上海华拓医药科技发展有限公司	一种抗癌药物依西美坦制备方法
CN1317293C (zh) *	2002-10-24	2007-05-23	南京长澳医药科技有限公司	一种依西美坦的合成工艺
US20040186160A1 (en) *	2002-12-13	2004-09-23	Sugen, Inc.	Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) *	2003-09-19	2005-03-31	Pfizer Products Inc.	Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) *	2003-11-06	2005-05-12	Shippen Eugene R.	Endometriosis treatment protocol
WO2005070951A1 (en)	2004-01-16	2005-08-04	Cedarburg Pharmaceuticals, Inc.	Exemestane and its intermediates and methods of making the same
US7435757B2 (en) *	2004-07-02	2008-10-14	Schering Ag	2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
BRPI0616639A2 (pt)	2005-09-30	2011-06-28	Endece Llc	compostos de exemestano de (s)-6-metiloxaalquila e métodos de uso relacionados
US20080119447A1 (en) *	2005-09-30	2008-05-22	James Yarger	6-alkoxyalkyl estradiol derivatives and methods of use
US10174070B2 (en)	2005-09-30	2019-01-08	Endece Llc	6-substituted estradiol derivatives and methods of use
US8168621B2 (en)	2005-09-30	2012-05-01	Endece, Llc	6-substituted estradiol derivatives and methods of use
DE102006008074B4 (de) *	2006-02-22	2013-08-14	RUHR-UNIVERSITäT BOCHUM	Behandlung von Krebs mit Geruchsrezeptor-Liganden
EP2026800A1 (en)	2006-05-09	2009-02-25	Novartis AG	Combination comprising an iron chelator and an anti-neoplastic agent and use thereof
WO2008033466A2 (en) *	2006-09-14	2008-03-20	Combinatorx (Singapore) Pre. Ltd.	Compositions and methods for treatment of viral diseases
US20080275259A1 (en) *	2007-05-04	2008-11-06	Scinopharm Taiwan, Ltd	Process for preparing aromatase inhibitors
ES2718912T3 (es)	2007-10-16	2019-07-05	Repros Therapeutics Inc	Trans-clomifeno para el tratamiento de la diabetes en hombres hipogonadales
EP2070943A1 (en) *	2007-12-14	2009-06-17	Crystal Pharma, S.A.	Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
CN101468023B (zh) *	2007-12-26	2011-02-02	上海复星医药（集团）股份有限公司	依西美坦片及其制备工艺
WO2009093262A2 (en) *	2008-01-21	2009-07-30	Cadila Healthcare Limited	Process for preparing aromatase inhibitor exemestane
GB0813628D0 (en) *	2008-07-25	2008-09-03	Arrow Int Ltd	Stable coated anti-cancer agent
WO2010076811A2 (en) *	2008-12-30	2010-07-08	Ind-Swift Laboratories Limited	Process for the preparation of exemestane
EP2429299B1 (en)	2009-05-01	2016-06-01	Celloxess Llc	Treating male infertility secondary to sperm oxidative stress
RU2425052C1 (ru) *	2010-03-04	2011-07-27	Татьяна Степановна Савинова	Способ получения 6-метиленандрост-4-ен-3,17-диона из андрост-4-ен-3,17-диона, способ получения 6-метиленандроста-1,4-диен-3,17-диона (эксеместана) с использованием полученного 6-метиленандрост-4-ен-3,17-диона
DE102010003494A1 (de) *	2010-03-31	2011-10-06	Bayer Schering Pharma Aktiengesellschaft	Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
US8969327B2 (en)	2010-04-08	2015-03-03	Emory University	Substituted androst-4-ene diones
EP2558098A2 (en)	2010-04-16	2013-02-20	Novartis AG	Treatment of endocrine resistant breast cancer
BR112013005843A2 (pt)	2010-09-14	2019-12-10	Endece Llc	derivativos de er-beta 6-substituído por desmetil-estradiol
ES2681023T3 (es)	2012-02-29	2018-09-11	Repros Therapeutics Inc.	Terapia de combinación para tratar el déficit de andrógenos
EP3104890A1 (en) *	2014-02-11	2016-12-21	Novartis AG	Pharmaceutical combinations comprising a pi3k inhibitor for the treatment of cancer
AU2016352592B2 (en)	2015-11-10	2023-04-27	Paracrine Therapeutics Ab	Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and an anti estrogen
CN112409432B (zh) *	2020-11-16	2023-07-07	陕西理工大学	一种依西美坦的合成方法

Family Cites Families (11)

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Publication number	Priority date	Publication date	Assignee	Title
GB929985A (es) *
US2744120A (en) *	1953-01-14	1956-05-01	Olin Mathieson	1-dehydrotestololactone
US3112305A (en) *	1960-11-07	1963-11-26	British Drug Houses Ltd	6-methylene-3-oxo-delta4-steroids and process for their preparation
GB1042291A (en) *	1961-11-08	1966-09-14	Organon Labor Ltd	í¸-6ª‡-amino steroids and the preparation thereof
DK120154B (da) *	1968-02-29	1971-04-19	Schering Ag	Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
BE759143A (fr) *	1969-11-19	1971-05-19	Upjohn Co	Procede de preparation d'un nouveau compose steroide
US4235893A (en) *	1978-05-08	1980-11-25	Brodie Angela M	Ester derivatives of 4-hydroxy-4-androstene-3,17-dione and a method for inhibiting estrogen biosynthesis
DE3004508C2 (de) *	1980-02-05	1981-12-10	Schering Ag Berlin Und Bergkamen, 1000 Berlin	Verfahren zur Herstellung von 6-Methylensteroiden
DE3322285A1 (de) *	1983-06-18	1984-12-20	Schering AG, 1000 Berlin und 4709 Bergkamen	1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4512986A (en) *	1983-07-26	1985-04-23	Research Triangle Institute	Progrestationally active steroids
GB8517360D0 (en) *	1985-07-09	1985-08-14	Erba Farmitalia	Substituted androsta-1,4-diene-3,17-diones

1985
- 1985-07-09 GB GB858517360A patent/GB8517360D0/en active Pending
1986
- 1986-06-24 ES ES556550A patent/ES8801304A1/es not_active Expired
- 1986-07-02 IT IT21004/86A patent/IT1196436B/it active Protection Beyond IP Right Term
- 1986-07-04 IL IL79336A patent/IL79336A/xx not_active IP Right Cessation
- 1986-07-04 HU HU862820A patent/HU194274B/hu unknown
- 1986-07-04 CH CH2706/86A patent/CH668599A5/de not_active IP Right Cessation
- 1986-07-04 AT AT0181986A patent/AT395157B/de not_active IP Right Cessation
- 1986-07-07 FI FI862871A patent/FI83424C/fi not_active IP Right Cessation
- 1986-07-07 AU AU59799/86A patent/AU578840B2/en not_active Expired
- 1986-07-07 NZ NZ216763A patent/NZ216763A/en unknown
- 1986-07-07 IE IE182186A patent/IE58949B1/en not_active IP Right Cessation
- 1986-07-07 US US06/882,364 patent/US4808616A/en not_active Expired - Lifetime
- 1986-07-08 DK DK324386A patent/DK163520C/da not_active IP Right Cessation
- 1986-07-08 CA CA000513267A patent/CA1277656C/en not_active Expired - Lifetime
- 1986-07-08 UA UA4027793A patent/UA6046A1/uk unknown
- 1986-07-08 NL NL8601785A patent/NL193616C/nl not_active IP Right Cessation
- 1986-07-08 JP JP61158891A patent/JPS6212797A/ja active Granted
- 1986-07-08 PT PT82944A patent/PT82944B/pt unknown
- 1986-07-08 ZA ZA865079A patent/ZA865079B/xx unknown
- 1986-07-08 KR KR1019860005489A patent/KR950003614B1/ko not_active Expired - Lifetime
- 1986-07-08 GB GB08616585A patent/GB2177700B/en not_active Expired
- 1986-07-08 YU YU1201/86A patent/YU44585B/xx unknown
- 1986-07-08 SE SE8603046A patent/SE468988B/sv not_active IP Right Cessation
- 1986-07-08 PH PH33989A patent/PH21785A/en unknown
- 1986-07-08 SU SU864027793A patent/SU1442077A3/ru active
- 1986-07-08 NO NO862753A patent/NO165547C/no not_active IP Right Cessation
- 1986-07-08 BE BE0/216890A patent/BE905067A/fr not_active IP Right Cessation
- 1986-07-08 FR FR8609922A patent/FR2584725B1/fr not_active Expired
- 1986-07-08 DE DE2001199030 patent/DE10199030I1/de active Pending
- 1986-07-08 GR GR861780A patent/GR861780B/el unknown
- 1986-07-08 CN CN86104664A patent/CN86104664B/zh not_active Expired
- 1986-07-09 CS CS865214A patent/CS257794B2/cs not_active IP Right Cessation
- 1986-07-09 CS CS873216A patent/CS258498B2/cs not_active IP Right Cessation
1987
- 1987-03-26 ES ES557466A patent/ES8802429A1/es not_active Expired
- 1987-06-05 YU YU1036/87A patent/YU44628B/xx unknown
- 1987-10-15 SU SU874203488A patent/SU1501923A3/ru active
1988
- 1988-07-26 US US07/225,674 patent/US4904650A/en not_active Expired - Lifetime
- 1988-12-30 MY MYPI88001585A patent/MY102294A/en unknown
1990
- 1990-10-03 SG SG804/90A patent/SG80490G/en unknown
- 1990-11-15 HK HK941/90A patent/HK94190A/xx not_active IP Right Cessation
1991
- 1991-12-30 SK SK4135-91A patent/SK413591A3/sk unknown
- 1991-12-30 CZ CS914135A patent/CZ413591A3/cs unknown
1994
- 1994-02-22 BG BG098516A patent/BG61370B2/bg unknown
1997
- 1997-04-08 BR BR1100240-9A patent/BR1100240A/pt active IP Right Grant
2000
- 2000-09-14 NL NL300017C patent/NL300017I2/nl unknown
- 2000-10-05 NO NO2000009C patent/NO2000009I1/no unknown

Also Published As

Publication number	Publication date
IL79336A (en)	1991-06-10
ZA865079B (en)	1987-03-25
YU44585B (en)	1990-10-31
GB2177700A (en)	1987-01-28
GR861780B (en)	1986-11-11
FR2584725A1 (fr)	1987-01-16
MY102294A (en)	1992-05-15
DK324386A (da)	1987-01-10
GB8616585D0 (en)	1986-08-13
IT1196436B (it)	1988-11-16
HU194274B (en)	1988-01-28
CH668599A5 (de)	1989-01-13
CS521486A2 (en)	1987-09-17
BG61370B2 (bg)	1997-06-30
NZ216763A (en)	1988-05-30
CA1277656C (en)	1990-12-11
KR870001140A (ko)	1987-03-11
NL300017I2 (nl)	2001-01-02
ES8801304A1 (es)	1987-12-16
AU578840B2 (en)	1988-11-03
CZ413591A3 (en)	1994-03-16
NL300017I1 (nl)	2000-11-01
PT82944B (pt)	1989-01-30
ATA181986A (de)	1992-02-15
IL79336A0 (en)	1986-10-31
DE10199030I1 (de)	2001-10-04
JPH0443919B2 (es)	1992-07-20
US4808616A (en)	1989-02-28
DK163520C (da)	1992-07-27
DK324386D0 (da)	1986-07-08
IT8621004A0 (it)	1986-07-02
CN86104664A (zh)	1987-02-18
NO862753L (no)	1987-01-12
CS257794B2 (en)	1988-06-15
SU1501923A3 (ru)	1989-08-15
NL193616B (nl)	1999-12-01
BR1100240A (pt)	1999-12-28
SE8603046L (sv)	1987-01-10
ES556550A0 (es)	1987-12-16
NL8601785A (nl)	1987-02-02
SG80490G (en)	1990-11-23
HUT42780A (en)	1987-08-28
GB2177700B (en)	1988-12-07
UA6046A1 (uk)	1994-12-29
FI862871A7 (fi)	1987-01-10
NL193616C (nl)	2000-04-04
DK163520B (da)	1992-03-09
FI83424B (fi)	1991-03-28
PT82944A (en)	1986-08-01
SE8603046D0 (sv)	1986-07-08
AT395157B (de)	1992-10-12
NO862753D0 (no)	1986-07-08
NO165547C (no)	1991-02-27
FI862871A0 (fi)	1986-07-07
NO165547B (no)	1990-11-19
FR2584725B1 (fr)	1988-05-13
SK413591A3 (en)	1995-07-11
YU120186A (en)	1988-02-29
PH21785A (en)	1988-02-24
HK94190A (en)	1990-11-23
IE58949B1 (en)	1993-12-01
ES8802429A1 (es)	1988-06-01
BE905067A (fr)	1987-01-08
NO2000009I1 (no)	2000-10-05
KR950003614B1 (ko)	1995-04-17
CN86104664B (zh)	1988-06-29
AU5979986A (en)	1987-01-15
YU103687A (en)	1988-08-31
IE861821L (en)	1987-01-09
SE468988B (sv)	1993-04-26
GB8517360D0 (en)	1985-08-14
YU44628B (en)	1990-10-31
JPS6212797A (ja)	1987-01-21
SU1442077A3 (ru)	1988-11-30
US4904650A (en)	1990-02-27
CS258498B2 (en)	1988-08-16
FI83424C (fi)	1991-07-10

Publication	Publication Date	Title
ES557466A0 (es)	1988-06-01	Un procedimiento para la preparacion de androsta-1,4-dien-3,17-dionas
ES551249A0 (es)	1987-11-01	Un procedimiento para la preparacion de peptidilaminodioles.
ES555834A0 (es)	1988-02-16	Un procedimiento para la preparacion de nuevas piranopiridinas.
ES554405A0 (es)	1987-09-01	Un procedimiento para la preparacion de derivados de aza-indol.
ES553044A0 (es)	1987-05-01	Un procedimiento para la preparacion de nuevos derivados de fenoxialquilaminopirimidina.
ES556738A0 (es)	1988-04-01	Un procedimiento para la preparacion de nuevos piridazinaminas.
ES544644A0 (es)	1986-09-01	Un procedimiento para la preparacion de derivados de carboxamidoadenosina.
MX162864B (es)	1991-07-02	Procedimiento para la preparacion de 2,2,6,6-tetraalquil-4-piperidilaminas
ES546236A0 (es)	1986-10-16	Un procedimiento para la preparacion de derivados de bencimidasol.
ES554983A0 (es)	1987-11-01	Un procedimiento para la preparacion de silileteres.
ES552189A0 (es)	1987-04-16	Un procedimiento para la preparacion de derivados de piridimilmidazolidiona.
ES552297A0 (es)	1987-09-01	Un procedimiento para la preparacion de nuevos derivados de disacaridos o trisacaridos.
ES550504A0 (es)	1986-12-01	Un procedimiento para la preparacion de derivados de podofilotoxina.
ES553874A0 (es)	1988-01-01	Un procedimiento para la preparacion de metanosulfonatos de dioxolano.
ES555369A0 (es)	1987-11-16	Un procedimiento para la preparacion de un polialquenoilisocianato.
ES556514A0 (es)	1988-05-01	Procedimiento para la preparacion de derivados de 2-oxi-4h-3, 1-benzoxazin-4-ona
ES557772A0 (es)	1988-11-16	Un procedimiento para la preparacion de epipodofilotoxina
ES554661A0 (es)	1988-02-16	Un procedimiento para la preparacion de un hidralizado proteico.
ES555723A0 (es)	1987-09-16	Un procedimiento para la preparacion de tetrahidroimidazoquinazolinonas.
ES555298A0 (es)	1987-09-01	Un procedimiento para la preparacion de nuevos esteroides 11-b-sustituidos.
AR243887A1 (es)	1993-09-30	Procedimiento para la preparacion de piridilcarbonil-tiazolonas cardiotonicas.
ES555670A0 (es)	1987-08-16	Un procedimiento para la preparacion de hexahidroarilquinolizinas sustituidas.
ES557822A0 (es)	1988-05-01	Un procedimiento para la preparacion de aminoalquil secocantinas.
ES548244A0 (es)	1987-02-16	Un procedimiento para la preparacion de derivados de 5-cetomilbemicina.
ES555109A0 (es)	1987-08-16	Un procedimiento para la preparacion de nuevos derivados de propanodiona.

Legal Events

Date	Code	Title	Description
1997-06-16	PC1A	Transfer granted
2008-10-16	FD1A	Patent lapsed	Effective date: 20080407