ES547326A0 - Un metodo para preparar esterol-liposomas - Google Patents
Un metodo para preparar esterol-liposomasInfo
- Publication number
- ES547326A0 ES547326A0 ES547326A ES547326A ES547326A0 ES 547326 A0 ES547326 A0 ES 547326A0 ES 547326 A ES547326 A ES 547326A ES 547326 A ES547326 A ES 547326A ES 547326 A0 ES547326 A0 ES 547326A0
- Authority
- ES
- Spain
- Prior art keywords
- liposomes
- preparing sterol
- sterol
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002502 liposome Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/829—Liposomes, e.g. encapsulation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Seal Device For Vehicle (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/721,630 US4721612A (en) | 1984-04-12 | 1985-04-10 | Steroidal liposomes |
| US06/773,429 US4891208A (en) | 1985-04-10 | 1985-09-10 | Steroidal liposomes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES547326A0 true ES547326A0 (es) | 1986-11-16 |
| ES8700933A1 ES8700933A1 (es) | 1986-11-16 |
Family
ID=27110456
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES547326A Expired ES8700933A1 (es) | 1985-04-10 | 1985-09-26 | Un metodo para preparar esterol-liposomas |
| ES553808A Expired ES8801085A1 (es) | 1985-04-10 | 1986-04-09 | Un metodo para preparar una crema antifungica |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES553808A Expired ES8801085A1 (es) | 1985-04-10 | 1986-04-09 | Un metodo para preparar una crema antifungica |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4891208A (es) |
| EP (1) | EP0222771A4 (es) |
| JP (1) | JPH0798741B2 (es) |
| KR (1) | KR890001882B1 (es) |
| AU (2) | AU596953B2 (es) |
| CA (1) | CA1262334C (es) |
| DK (1) | DK591086D0 (es) |
| ES (2) | ES8700933A1 (es) |
| FI (1) | FI92463C (es) |
| HU (1) | HU203205B (es) |
| IE (1) | IE66709B1 (es) |
| IL (1) | IL76600A (es) |
| NO (1) | NO173213C (es) |
| NZ (1) | NZ213601A (es) |
| PT (1) | PT81242B (es) |
| WO (1) | WO1986005977A1 (es) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6090406A (en) * | 1984-04-12 | 2000-07-18 | The Liposome Company, Inc. | Potentiation of immune responses with liposomal adjuvants |
| US5231112A (en) * | 1984-04-12 | 1993-07-27 | The Liposome Company, Inc. | Compositions containing tris salt of cholesterol hemisuccinate and antifungal |
| US5916588A (en) * | 1984-04-12 | 1999-06-29 | The Liposome Company, Inc. | Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use |
| US5736155A (en) * | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US4861580A (en) * | 1985-10-15 | 1989-08-29 | The Liposome Company, Inc. | Composition using salt form of organic acid derivative of alpha-tocopheral |
| US5041278A (en) * | 1985-10-15 | 1991-08-20 | The Liposome Company, Inc. | Alpha tocopherol-based vesicles |
| JPH0761940B2 (ja) * | 1986-11-17 | 1995-07-05 | 株式会社資生堂 | 外皮用リポソ−ム製剤 |
| US5009819A (en) * | 1987-11-12 | 1991-04-23 | The Liposome Company, Inc. | Taste moderating composition |
| AU631377B2 (en) * | 1988-08-25 | 1992-11-26 | Liposome Company, Inc., The | Affinity associated vaccine |
| NZ230424A (en) * | 1988-08-25 | 1992-05-26 | Liposome Co Inc | Liposomal composition comprising an externally disposed antigen |
| US5055303A (en) * | 1989-01-31 | 1991-10-08 | Kv Pharmaceutical Company | Solid controlled release bioadherent emulsions |
| WO1992020323A1 (en) * | 1991-05-16 | 1992-11-26 | Vestar, Inc. | Methods for the administration of drugs |
| GB9111611D0 (en) * | 1991-05-30 | 1991-07-24 | Sandoz Ltd | Liposomes |
| US5643600A (en) * | 1991-09-17 | 1997-07-01 | Micro-Pak, Inc. | Lipid vesicles containing avocado oil unsaponifiables |
| DE4131878A1 (de) * | 1991-09-25 | 1993-04-01 | Henkel Kgaa | Verfahren zur herstellung von liposomen |
| AU6365894A (en) * | 1993-03-16 | 1994-10-11 | Alliance Pharmaceutical Corporation | Fluorocarbon compositions containing a visible or fluorescent label |
| AU676906B2 (en) * | 1993-04-02 | 1997-03-27 | Transave, Inc. | Method of producing liposomes |
| US5415869A (en) * | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
| US5468224A (en) * | 1993-11-30 | 1995-11-21 | Souryal; Tarek O. | Methods of color coding injectable medications |
| AU693488B2 (en) * | 1993-12-15 | 1998-07-02 | Novavax, Inc. | Lipid vesicles containing avocado oil unsaponifiables |
| US5716526A (en) * | 1994-01-14 | 1998-02-10 | The Liposome Company, Inc. | Method of separating materials from liposomes or lipid complexes |
| US5646131A (en) * | 1994-02-22 | 1997-07-08 | The Arab Company For Drug Industries And Medical Applicances (Acdima) | Method for solubilizing drugs using cyclodextrins and carboxylic acids |
| US5554379A (en) * | 1994-06-20 | 1996-09-10 | Kv Pharmaceutical Company | Long acting GI and esophageal protectant |
| US5670163A (en) * | 1994-06-20 | 1997-09-23 | Kv Pharmaceuticals Company | Long acting GI and esophageal protectant |
| US5595752A (en) * | 1994-07-01 | 1997-01-21 | Monsanto Company | Increasing dressing percentage and carcass weight in finishing beef cattle |
| US5672357A (en) * | 1994-07-01 | 1997-09-30 | Monsanto Company | Method and device for implantation of large diameter objects in bovines |
| US5554380A (en) * | 1994-08-04 | 1996-09-10 | Kv Pharmaceutical Company | Bioadhesive pharmaceutical delivery system |
| EP0796112A4 (en) * | 1994-11-30 | 1999-12-01 | Amur Research Corp | MEDICINAL DERIVATIVES OF PHOSPHOCHOLIN |
| US5756352A (en) * | 1995-06-07 | 1998-05-26 | Gen-Probe Incorporated | Thiocationic lipid-nucleic acid conjugates |
| US5739271A (en) * | 1995-06-07 | 1998-04-14 | Gen-Probe Incorporated | Thiocationic lipids |
| US5759519A (en) * | 1995-06-07 | 1998-06-02 | Gen-Probe Incorporated | Method for the intracellular delivery of biomolecules using thiocationic lipids |
| US5711964A (en) * | 1995-06-07 | 1998-01-27 | United States Of America | Method for the intracellular delivery of biomolecules using liposomes containing cationic lipids and vitamin D |
| US5851548A (en) * | 1995-06-07 | 1998-12-22 | Gen-Probe Incorporated | Liposomes containing cationic lipids and vitamin D |
| US5763423A (en) * | 1996-01-04 | 1998-06-09 | Clarion Pharmaeuticals Inc. | Pharmaceutical compositions, novel uses, and novel form of tocopherylphosphocholine |
| AU4892897A (en) * | 1996-09-17 | 1998-04-14 | Amur Pharmaceuticals, Inc. | Phospholipid drug derivatives |
| US5830432A (en) * | 1997-03-31 | 1998-11-03 | Amur Pharmacuticals, Inc. | Phospholipid drug derivatives |
| US7169410B1 (en) * | 1998-05-19 | 2007-01-30 | Sdg, Inc. | Targeted liposomal drug delivery system |
| RU2003128533A (ru) * | 2001-02-21 | 2005-04-10 | БАСФ Акциенгезельшафт (DE) | Способ получения d-пантотеновой кислоты и/или ее солей, используемых в качестве добавок при производстве кормов для животных |
| DE10109898A1 (de) * | 2001-02-21 | 2002-09-05 | Novosom Gmbh | Lipide mit veränderlicher Ladung |
| DE10109897A1 (de) * | 2001-02-21 | 2002-11-07 | Novosom Ag | Fakultativ kationische Liposomen und Verwendung dieser |
| US7858117B2 (en) * | 2002-02-21 | 2010-12-28 | Novosom Ag | Amphoteric liposomes and their use |
| HU226519B1 (en) * | 2002-11-26 | 2009-03-30 | Istvan Dr Horvath | Artificial blood made of hemoglobin encapsulated in membrane |
| WO2005063212A1 (en) * | 2003-12-31 | 2005-07-14 | Amorepacific Corporation | Cholesteryl hemisuccinate incorporated lipid-based nano-carriers and skin-care compositions for external application containing the same |
| EP1722762A2 (en) * | 2004-03-02 | 2006-11-22 | Massachusetts Institute of Technology | Nanocell drug delivery system |
| US20070053845A1 (en) * | 2004-03-02 | 2007-03-08 | Shiladitya Sengupta | Nanocell drug delivery system |
| EP1861072A2 (en) * | 2005-03-14 | 2007-12-05 | Massachusetts Institute Of Technology | Nanocells for diagnosis and treatment of diseases and disorders |
| KR101172066B1 (ko) | 2005-09-30 | 2012-08-10 | (주)아모레퍼시픽 | 스티그마스테릴 헤미숙시네이트를 포함한 지질-기반 약물전달체 및 이를 함유하는 피부 외용제 조성물 |
| US20100068264A1 (en) * | 2006-07-12 | 2010-03-18 | University Of South Florida | Niosome-hydrogel drug delivery system |
| US20080317768A1 (en) * | 2007-06-21 | 2008-12-25 | Boeing Company | Bioconjugated nanoparticles |
| US9814657B2 (en) * | 2009-04-27 | 2017-11-14 | Premier Dental Products Company | Buffered microencapsulated compositions and methods |
| US10688026B2 (en) * | 2009-04-27 | 2020-06-23 | Premier Dental Products Company | Buffered microencapsulated compositions and methods |
| WO2013052167A2 (en) | 2011-06-02 | 2013-04-11 | The Regents Of The University Of California | Membrane encapsulated nanoparticles and method of use |
| WO2015084677A1 (en) * | 2013-12-02 | 2015-06-11 | Arytha Biosciences, Llc | Toxoid preparation and uses thereof |
| US9522114B1 (en) | 2014-03-27 | 2016-12-20 | University Of South Florida | Enhanced targeted drug delivery system via chitosan hydrogel and chlorotoxin |
| CN118078755A (zh) * | 2024-04-19 | 2024-05-28 | 赣州市人民医院 | 一种单链双亲小分子/维生素d3甾醇脂质体及其制备方法和应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1142147A (en) * | 1965-05-28 | 1969-02-05 | Glaxo Lab Ltd | A process for making free-flowing gel particles |
| US3932657A (en) * | 1973-11-12 | 1976-01-13 | The United States Of America As Represented By The United States Energy Research And Development Administration | Liposome encapsulation of chelating agents |
| DE2404047A1 (de) * | 1974-01-29 | 1975-08-14 | Henkel & Cie Gmbh | Hautpflege- und hautschutzmittel mit einem gehalt an haut-feuchthaltemitteln |
| US3957971A (en) * | 1974-07-29 | 1976-05-18 | Lever Brothers Company | Moisturizing units and moisturizing compositions containing the same |
| US4042330A (en) * | 1976-08-23 | 1977-08-16 | Deshmukh Arvind D | In a method for checking the accuracy of a test using an enzymatically hydrolyzable, serum-soluble cholesterol compound |
| US4040784A (en) * | 1976-08-23 | 1977-08-09 | Deshmukh Arvind D | Method for checking the accuracy of a test, using a serum-soluble cholesterol compound |
| US4183847A (en) * | 1976-08-23 | 1980-01-15 | Deshmukh Arvind D | Enzymatically hydrolyzable, serum-soluble cholesterol compounds and method for their preparation |
| EP0001654B1 (de) * | 1977-10-13 | 1981-07-22 | Siegfried Aktiengesellschaft | Imidazolyläthyl-oxyalkoxy-Derivate und ihre Thio-Analoge, pharmazeutische Zubereitungen mit diesen Stoffen und Verfahren zu ihrer Herstellung |
| US4356167A (en) * | 1978-01-27 | 1982-10-26 | Sandoz, Inc. | Liposome drug delivery systems |
| US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4298594A (en) * | 1978-04-14 | 1981-11-03 | Arthur D. Little, Inc. | Xenobiotic delivery vehicles, method of forming them and method of using them |
| US4193983A (en) * | 1978-05-16 | 1980-03-18 | Syva Company | Labeled liposome particle compositions and immunoassays therewith |
| GR73668B (es) * | 1978-11-21 | 1984-03-28 | Hoffmann La Roche | |
| US4342739A (en) * | 1979-01-09 | 1982-08-03 | Fuji Photo Film Co., Ltd. | Novel material for immunological assay of biochemical components and a process for the determination of said components |
| CA1173360A (en) * | 1979-06-22 | 1984-08-28 | Jurg Schrank | Pharmaceutical preparations |
| EP0032578B1 (de) * | 1980-01-16 | 1984-07-25 | Hans Georg Prof. Dr. Weder | Verfahren und Dialysiereinrichtung zur Herstellung von Bilayer-Vesikeln und Verwendung der Bilayer-Vesikel |
| US4621053A (en) * | 1980-07-30 | 1986-11-04 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Process for the production of human peptide hormones |
| FR2521565B1 (fr) * | 1982-02-17 | 1985-07-05 | Dior Sa Parfums Christian | Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees |
| US4617161A (en) * | 1983-09-06 | 1986-10-14 | Baxter Travenol Laboratories, Inc. | Method of manufacture for a dialyzer having improved side ports |
| US4721612A (en) * | 1984-04-12 | 1988-01-26 | The Liposome Company, Inc. | Steroidal liposomes |
-
1985
- 1985-09-10 US US06/773,429 patent/US4891208A/en not_active Expired - Lifetime
- 1985-09-23 CA CA491321A patent/CA1262334C/en not_active Expired
- 1985-09-23 IE IE233685A patent/IE66709B1/en not_active IP Right Cessation
- 1985-09-24 NZ NZ213601A patent/NZ213601A/xx unknown
- 1985-09-26 ES ES547326A patent/ES8700933A1/es not_active Expired
- 1985-10-02 PT PT81242A patent/PT81242B/pt not_active IP Right Cessation
- 1985-10-06 IL IL76600A patent/IL76600A/xx not_active IP Right Cessation
- 1985-10-10 HU HU855039A patent/HU203205B/hu unknown
- 1985-10-10 KR KR1019860700881A patent/KR890001882B1/ko not_active Expired
- 1985-10-10 AU AU49528/85A patent/AU596953B2/en not_active Expired
- 1985-10-10 JP JP60504547A patent/JPH0798741B2/ja not_active Expired - Lifetime
- 1985-10-10 EP EP19850905180 patent/EP0222771A4/en not_active Withdrawn
- 1985-10-10 WO PCT/US1985/001983 patent/WO1986005977A1/en not_active Ceased
-
1986
- 1986-04-09 ES ES553808A patent/ES8801085A1/es not_active Expired
- 1986-12-09 DK DK591086A patent/DK591086D0/da not_active Application Discontinuation
- 1986-12-09 NO NO864960A patent/NO173213C/no not_active IP Right Cessation
- 1986-12-10 FI FI865021A patent/FI92463C/fi not_active IP Right Cessation
-
1989
- 1989-11-02 AU AU44345/89A patent/AU609647B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| PT81242B (pt) | 1987-10-20 |
| JPH0798741B2 (ja) | 1995-10-25 |
| FI865021L (fi) | 1986-12-10 |
| IE66709B1 (en) | 1996-01-24 |
| FI92463B (fi) | 1994-08-15 |
| FI92463C (fi) | 1994-11-25 |
| CA1262334A (en) | 1989-10-17 |
| DK591086A (da) | 1986-12-09 |
| KR870700347A (ko) | 1987-12-28 |
| US4891208A (en) | 1990-01-02 |
| CA1262334C (en) | 1989-10-17 |
| WO1986005977A1 (en) | 1986-10-23 |
| HU203205B (en) | 1991-06-28 |
| DK591086D0 (da) | 1986-12-09 |
| AU4952885A (en) | 1986-11-05 |
| EP0222771A4 (en) | 1988-06-08 |
| HUT42322A (en) | 1987-07-28 |
| ES8700933A1 (es) | 1986-11-16 |
| NZ213601A (en) | 1990-03-27 |
| NO173213C (no) | 1993-11-17 |
| KR890001882B1 (ko) | 1989-05-29 |
| EP0222771A1 (en) | 1987-05-27 |
| AU4434589A (en) | 1990-05-17 |
| IL76600A0 (en) | 1986-02-28 |
| AU596953B2 (en) | 1990-05-24 |
| AU609647B2 (en) | 1991-05-02 |
| ES553808A0 (es) | 1988-01-01 |
| IL76600A (en) | 1992-12-01 |
| ES8801085A1 (es) | 1988-01-01 |
| PT81242A (en) | 1985-11-01 |
| IE852336L (en) | 1986-10-10 |
| FI865021A0 (fi) | 1986-12-10 |
| JPS62502464A (ja) | 1987-09-24 |
| NO173213B (no) | 1993-08-09 |
| NO864960L (no) | 1986-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20050820 |